Induction of human γ globin gene expression by histone deacetylase inhibitors

Blood

Volumn 103, Issue 2, 2004, Pages 701-709

  Cao, Hua ^b   Stamatoyannopoulos, George ^a   Jung, Manfred ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO) 3 (4 METHOXYBIPHENYL 4 YL)PROPIONIC ACID METHYL ESTER; 2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO) 3 THIOPHEN 2 YLPROPIONIC ACID METHYL ESTER; 3 (3',4' DICHLOROBIPHENYL 4 YL) 2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO)PROPIONIC ACID METHYL ESTER; 3 (4 METHOXYPHENYL) 2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO)PROPIONIC ACID METHYL ESTER; 3 (4' CHLOROBIPHENYL 4 YL) 2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO)PROPIONIC ACID METHYL ESTER; 3 PHENYL 2 (7 HYDROXYCARBAMOYLHEPTANOYLAMINO)PROPIONIC ACID METHYL ESTER; 6 (1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL)HEXANOIC ACID HYDROXYAMIDE; 6 (1,3 DIOXO 1H,3H BENZO[DE]ISOQUINOLIN 2 YL) N HYDROXYHEXANAMIDE; 6 (4,5,6,7 TETRACHLORO 1,3 DIOXO 1,3 DIHYDROISOINDOL 2 YL)HEXANOIC ACID HYDROXYAMIDE; AMIDE; GAMMA GLOBIN; HEMOGLOBIN F; HEXANOIC ACID DERIVATIVE; HISTONE DEACETYLASE INHIBITOR; HISTONE H4; HYDROXAMIC ACID DERIVATIVE; LUCIFERASE; MESSENGER RNA; N HYDROXY 6 (4 BIPHENYLCARBONYL)AMINOCRAPRAMIDE; N HYDROXY 6 (4 DIMETHYLAMINOBENZOYLAMINO)CAPRAMIDE; N HYDROXY 7 (4 DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE; N HYDROXY 8 (4 DIMETHYLAMINOBENZOYL)AMINOOCTANAMIDE; OCTANEDIOIC ACID HYDROXYAMIDE (1 BENZYLCARBAMOYLPHENYLETHYL)AMIDE; OCTANEDIOIC ACID HYDROXYAMIDE (1 PHENETHYLCARBAMOYL 2 PHENYLETHYL)AMIDE; PROPIONIC ACID DERIVATIVE; TRAPOXIN; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BURST FORMING UNIT E; CELL CULTURE; CELL LINE; CHROMATIN; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG SCREENING; DRUG SELECTIVITY; ENZYMATIC ASSAY; ERYTHROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION;

EID: 0942266022     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-02-0478     Document Type: Article

References (54)

1. Stamatoyannopoulos G, Grosveld F. Hemoglobin switching. In: Stamatoyannopoulos G, Majerus PW, Perlmutter RM, Varmus H, eds. The Molecular Basis of Blood Diseases. Philadelphia, PA: Saunders; 2001:135-185.
2. Filipe A, Li Q, Deveaux S, et al. Regulation of embryonic/fetal globin genes by nuclear hormone receptors: a novel perspective on hemoglobin switching. EMBO J. 1999;18:687-697.
3. Tanimoto K, Liu Q, Grosveld F, Bungert J, Engel JD. Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice. Genes Dev. 2000;14:2778-2794.
4. Marianna P, Kollia P, Akel S, Papassotiriou Y, Stamoulakatou A, Loukopoulos D. Valproic acid, trichostatin and their combination with hemin preferentially enhance gamma-globin gene expression in human erythroid liquid cultures. Haematologica. 2001;86:700-705.
5. Swank RA, Skarpidi E, Papayannopoulou T, Stamatoyannopoulos G. The histone deacetylase inhibitor, Trichostatin A, reactivates the developmentally silenced γ globin expression in somatic cell hybrids and induces γ gene expression in adult BFUe cultures. Blood Cells Mol Dis. 2003;30:254-257.
6. Witt O, Moenkemeyer S, Roenndahl G, et al. Induction of fetal hemoglobin expression by the histone-deacetylase inhibitor apicidin. Blood. 2003;101:2001-2007.
7. Skarpidi E, Cao H, Heltweg B, et al. Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression. Exp Hematol. 2003;31:197-203.
8. Jung M, Brosch G, Kolle D, Scherf H, Gerhauser C, Loidl P. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem. 1999;42:4669-4679.
9. Schmidt K, Gust R, Jung M. Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells. Arch Pharm. 1999;332:353-357.
10. Wittich S, Scherf H, Xie C, et al. Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells. J Med Chem. 2002;45:3296-3309.
11. Remiszewski SW, Sambucetti LC, Atadja P, et al. Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002;45:753-757.
12. Heltweg B, Jung M. A micro plate reader based non-isotopic histone deacetylase activity assay. Anal Biochem. 2002;302:175-183.
13. Skarpidi E, Vassilopoulos G, Li Q, Stamatoyannopoulos G. Novel in vitro assay for the detection of pharmacologic inducers of fetal hemoglobin. Blood. 2000;96:321-326.
14. Ryan CA, Annunziato AT. Separation of histone variants and post-translationally modified isoforms by triton/acetic acid/urea polyacrylamide gel electrophoresis. Curr Prot Mol Biol. 1999;21.2.1-21.2.10.
15. Fibach E, Manor D, Oppenheim A, Rachmilewitz EA. Proliferation and maturation of human erythroid progenitors in liquid culture. Blood. 1989;73:100-103.
16. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanatephenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
17. Li Q, Stamatoyannopoulos JA. Position independence and proper developmental control of gamma-globin gene expression require both a 5′ locus control region and a downstream sequence element. Mol Cell Biol. 1994;14:6087-6096.
18. Su GH, Sohn TA, Ryu B, Kern SE. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 2000;60:3137-3142.
19. Ikawa Y, Aida M, Inoue Y. Isolation and characterization of high and low differentation-inducible Friend leukemia lines. Gann. 1976;67:767-770.
20. Zitnik G, Hines P, Stamatoyannopoulos G, Papayannopoulou T. Murine erythroleukemia cell line GM979 contains factors that can activate silent chromosomal human gamma-globin genes. Proc Natl Acad Sci U S A. 1991;88:2530-2534.
21. Peterson KR, Stamatoyannopoulos G. Role of gene order in developmental control of human gamma- and beta-globin gene expression. Mol Cell Biol. 1993;13:4836-4843.
22. Papayannopoulou T, Brice M, Stamatoyannopoulos G. Hemoglobin F synthesis in vitro: evidence for control at the level of primitive erythroid stem cells. Proc Natl Acad Sci U S A. 1977;74:2923-2927.
23. Perrine SP, Ginder GD, Faller DV, et al. A short-term trial of butyrate to stimulate fetal-globin-gene expression in the beta-globin disorders. N Engl J Med. 1993;328:81-86.
24. Sher GD, Ginder GD, Little J, Yang S, Dover GJ, Olivieri NF. Extended therapy with intravenous arginine butyrate in patients with beta-hemoglobinopathies. N Engl J Med. 1995;332:1606-1610.
25. Dover GJ, Brusilow S, Charache S. Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate. Blood. 1994;84:339-343.
26. Collins AF, Pearson HA, Giardina P, McDonagh KT, Brusilow SW, Dover GJ. Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial. Blood. 1995;85:43-49.
27. Cappellini M, Graziadei G, Ciceri L, et al. Oral isobutyramide therapy in patients with thalassemia intermedia: results of a phase II open study. Blood Cells Mol Dis. 2000;26:105-111.
28. Reich S, Buhrer C, Henz G, et al. Oral isobutyramide reduces transfusion requirements in some patients with homozygous beta-thalassemia. Blood. 2000;96:3357-3363.
29. DeSimone J, Biel SI, Heller P. Stimulation of fetal hemoglobin synthesis in baboons by hemolysis and hypoxia. Proc Natl Acad Sci U S A. 1978;75:2937-2940.
30. Papayannopoulou T, Vichinsky E, Stamatoyannopoulos G. Fetal Hb production during acute erythroid expansion, I: observations in patients with transient erythroblastopenia and post-phlebotomy. Br J Haematol. 1980;44:535-546.
31. Alter BP. Fetal erythropoiesis in stress hematopoiesis. Exp Hematol. 1979;7(suppl 5):200-209.
32. Alter BP, Rappeport JM, Huisman TH, Schroeder WA, Nathan DG. Fetal erythropoiesis following bone marrow transplantation. Blood. 1976;48:843-853.
33. Ferster A, Corazza F, Vertongen F, et al. Transplanted sickle-cell disease patients with autologous bone marrow recovery after graft failure develop increased levels of fetal haemoglobin which corrects disease severity. Br J Haematol. 1995;90:804-808.
34. Dover GJ, Boyer SH, Zinkham WH. Production of erythrocytes that contain fetal hemoglobin in anemia: transient in vivo changes. J Clin Invest. 1979;63:173-176.
35. Al-Khatti A, Veith RW, Papayannopoulou T, Fritsch EF, Goldwasser E, Stamatoyannopoulos G. Stimulation of fetal hemoglobin synthesis by erythropoietin in baboons. N Engl J Med. 1987;317:415-420.
36. Stamatoyannopoulos G, Papayannopoulou T. Fetal hemoglobin and the erythroid stem cell differentiation process. In: Stamatoyannopoulos G, Nienhuis AW, eds. Cellular and Molecular Regulation of Hemoglobin Switching. New York, NY: Grune & Stratton; 1989:323-349.
37. Umemura T, Al-Khatti A, Papayannopoulou T, Stamatoyannopoulos G. Fetal hemoglobin synthesis in vivo: direct evidence for control at the level of erythroid progenitors. Proc Natl Acad Sci U S A. 1988;85:9278-9282.
38. Papayannopoulou T, Torrealba de Ron A, Veith R, Knitter G, Stamatoyannopoulos G. Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics. Science. 1984;224:617-619.
39. Letvin NL, Linch DC, Beardsley GP, McIntyre KW, Nathan DG. Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea. N Engl J Med. 1984;310:869-873.
40. Platt OS, Orkin SH, Dover G, Beardsley GP, Miller B, Nathan DG. Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. J Clin Invest. 1984;74:652-656.
41. Veith R, Galanello R, Papayannopoulou T, Stamatoyannopoulos G. Stimulation of F-cell production in patients with sickle-cell anemia treated with cytarabine or hydroxyurea. N Engl J Med. 1985;313:1571-1575.
42. Rodgers GP, Dover GJ, Noguchi CT, Schechter AN, Nienhuis AW. Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea. N Engl J Med. 1990;322:1037-1045.
43. Charache S, Dover GJ, Moore RD, et al. Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia. Blood. 1992;79:2555-2565.
44. Charache S, Terrin ML, Moore RD, et al. Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med. 1995;332:1317-1322.
45. Perrine SP, Rudolph A, Faller DV, et al. Butyrate infusions in the ovine fetus delay the biologic clock for globin gene switching. Proc Natl Acad Sci U S A. 1988;85:8540-8542.
46. Perrine SP, Miller BA, Faller DV, et al. Sodium butyrate enhances fetal globin gene expression in erythroid progenitors of patients with Hb SS and beta thalassemia. Blood. 1989;74:454-459.
47. Constantoulakis P, Papayannopoulou T, Stamatoyannopoulos G. alpha-Amino-N-butyric acid stimulates fetal hemoglobin in the adult. Blood. 1988;72:1961-1967.
48. Constantoulakis P, Knitter G, Stamatoyannopoulos G. On the induction of fetal hemoglobin by butyrates: in vivo and in vitro studies with sodium butyrate and comparison of combination treatments with 5-AzaC and AraC. Blood. 1989;74:1963-1971.
49. Atweh GF, Sutton M, Nassif I, et al. Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. Blood. 1999;93:1790-1797.
50. Stemson SM, Wong JC, Grozinger CM, Schreiber SL. Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin. Org Lett. 2001;3:4239-4242.
51. Furumai R, Komatsu Y, Nishino N, Khochbin S, Yoshida M, Horinouchi S. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc Natl Acad Sci U S A. 2001;98:87-92.
52. Bulger M, Sawado T, Schubeler D, Groudine M. ChlPs of the beta-globin locus: unraveling gene regulation within an active domain. Curr Opin Genet Dev. 2002;12:170-177.
53. Forsberg EC, Bresnick EH, Histone acetylation beyond promoters: long-range acetylation patterns in the chromatin world. Bioessays. 2001;23:820-830.
54. Wittich S. Struktur-Wirkungs-Beziehungen an phenylalaninhaltigen Hemmstoffen der Histon-Deacetylase [thesis]. Münster, Germany: University of Münster; 2002.