메뉴 건너뛰기




Volumn 18, Issue 2, 2012, Pages 178-185

Hypoxia signaling during intestinal ischemia and inflammation

Author keywords

A2BAR; adenosine receptor; HIF; hypoxia inducible factor; netrin 1; PHD; prolyl hydroxylase

Indexed keywords

ADENOSINE; ADENOSINE A2 RECEPTOR; HYPOXIA INDUCIBLE FACTOR; NETRIN 1;

EID: 84858797646     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e3283514bd0     Document Type: Review
Times cited : (51)

References (72)
  • 1
    • 84857076647 scopus 로고    scopus 로고
    • Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery
    • Colgan SP, Eltzschig HK. Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery. Annu Rev Physiol 2012; 74:7.1-7.23.
    • (2012) Annu Rev Physiol , vol.74 , pp. 71-723
    • Colgan, S.P.1    Eltzschig, H.K.2
  • 2
    • 70349658872 scopus 로고    scopus 로고
    • Adenosine: An old drug newly discovered
    • Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology 2009; 111:904-915.
    • (2009) Anesthesiology , vol.111 , pp. 904-915
    • Eltzschig, H.K.1
  • 3
    • 73449115750 scopus 로고    scopus 로고
    • Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
    • Eltzschig HK, Rivera-Nieves J, Colgan SP. Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation. Expert Opin Ther Targets 2009; 13:1267-1277.
    • (2009) Expert Opin Ther Targets , vol.13 , pp. 1267-1277
    • Eltzschig, H.K.1    Rivera-Nieves, J.2    Colgan, S.P.3
  • 4
    • 39749109509 scopus 로고    scopus 로고
    • Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores
    • Hartmann H, Eltzschig HK, Wurz H, et al. Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores. Gastroenterology 2008; 134:756-767.
    • (2008) Gastroenterology , vol.134 , pp. 756-767
    • Hartmann, H.1    Eltzschig, H.K.2    Wurz, H.3
  • 5
    • 79960700105 scopus 로고    scopus 로고
    • The hypoxia-inflammation link and potential drug targets
    • Koeppen M, Eckle T, Eltzschig HK. The hypoxia-inflammation link and potential drug targets. Curr Opin Anaesthesiol 2011; 24:363-369.
    • (2011) Curr Opin Anaesthesiol , vol.24 , pp. 363-369
    • Koeppen, M.1    Eckle, T.2    Eltzschig, H.K.3
  • 6
    • 33845604971 scopus 로고    scopus 로고
    • HIF-dependent induction of adenosine A2B receptor in hypoxia
    • DOI 10.1096/fj.06-6419com
    • Kong T, Westerman KA, Faigle M, et al. HIF-dependent induction of adenosine A2B receptor in hypoxia. FASEB J 2006; 20:2242-2250. (Pubitemid 44953854)
    • (2006) FASEB Journal , vol.20 , Issue.13 , pp. 2242-2250
    • Kong, T.1    Westerman, K.A.2    Faigle, M.3    Eltzschig, H.K.4    Colgan, S.P.5
  • 7
    • 44449174536 scopus 로고    scopus 로고
    • Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
    • Kuhlicke J, Frick JS, Morote-Garcia JC, et al. Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS ONE 2007; 2:e1364.
    • (2007) PLoS ONE , vol.2
    • Kuhlicke, J.1    Frick, J.S.2    Morote-Garcia, J.C.3
  • 8
    • 85047685683 scopus 로고    scopus 로고
    • Ecto-50-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
    • Synnestvedt K, Furuta GT, Comerford KM, et al. Ecto-50-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 2002; 110:993-1002.
    • (2002) J Clin Invest , vol.110 , pp. 993-1002
    • Synnestvedt, K.1    Furuta, G.T.2    Comerford, K.M.3
  • 9
    • 58249123287 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium
    • Zheng W, Kuhlicke J, Jackel K, et al. Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium. FASEB J 2009; 23:204-213.
    • (2009) FASEB J , vol.23 , pp. 204-213
    • Zheng, W.1    Kuhlicke, J.2    Jackel, K.3
  • 10
    • 79955124412 scopus 로고    scopus 로고
    • Paneth cell-derived IL-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury
    • Park SW, Kim M, Brown KM, et al. Paneth cell-derived IL-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury. Hepatology 2011; 53:1662-1675.
    • (2011) Hepatology , vol.53 , pp. 1662-1675
    • Park, S.W.1    Kim, M.2    Brown, K.M.3
  • 11
    • 56149083214 scopus 로고    scopus 로고
    • Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice
    • Eckle T, Fullbier L, Grenz A, et al. Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol 2008; 295:L718-L724.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295
    • Eckle, T.1    Fullbier, L.2    Grenz, A.3
  • 13
    • 55849114101 scopus 로고    scopus 로고
    • A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice
    • Eckle T, Grenz A, Laucher S, et al. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest 2008; 118:3301-3315.
    • (2008) J Clin Invest , vol.118 , pp. 3301-3315
    • Eckle, T.1    Grenz, A.2    Laucher, S.3
  • 14
  • 15
    • 77952092406 scopus 로고    scopus 로고
    • Hypoxia: An alarm signal during intestinal inflammation
    • Colgan SP, Taylor CT. Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol 2010; 7:281-287.
    • (2010) Nat Rev Gastroenterol Hepatol , vol.7 , pp. 281-287
    • Colgan, S.P.1    Taylor, C.T.2
  • 16
    • 51749089798 scopus 로고    scopus 로고
    • Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation
    • Taylor CT. Interdependent roles for hypoxia inducible factor and nuclear factor-kappaB in hypoxic inflammation. J Physiol 2008; 586:4055-4059.
    • (2008) J Physiol , vol.586 , pp. 4055-4059
    • Taylor, C.T.1
  • 17
    • 36849055112 scopus 로고    scopus 로고
    • Hypoxia and gastrointestinal disease
    • DOI 10.1007/s00109-007-0277-z, Special Issue (Ed. G. Semenza): Hypoxia and Human Disease
    • Taylor CT, Colgan SP. Hypoxia and gastrointestinal disease. J Mol Med 2007; 85:1295-1300. (Pubitemid 50004090)
    • (2007) Journal of Molecular Medicine , vol.85 , Issue.12 , pp. 1295-1300
    • Taylor, C.T.1    Colgan, S.P.2
  • 18
    • 81255195550 scopus 로고    scopus 로고
    • Ischemia and reperfusion: From mechanism to translation
    • Eltzschig HK, Eckle T. Ischemia and reperfusion: from mechanism to translation. Nat Med 2011; 17:1391-1401.
    • (2011) Nat Med , vol.17 , pp. 1391-1401
    • Eltzschig, H.K.1    Eckle, T.2
  • 20
    • 41349114840 scopus 로고    scopus 로고
    • A2B adenosine receptor dampens hypoxia-induced vascular leak
    • DOI 10.1182/blood-2007-10-117044
    • Eckle T, Faigle M, Grenz A, et al. A2B adenosine receptor dampens hypoxiainduced vascular leak. Blood 2008; 111:2024-2035. (Pubitemid 351451513)
    • (2008) Blood , vol.111 , Issue.4 , pp. 2024-2035
    • Eckle, T.1    Faigle, M.2    Grenz, A.3    Laucher, S.4    Thompson, L.F.5    Eltzschig, H.K.6
  • 25
    • 10244222236 scopus 로고    scopus 로고
    • Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: Coordination by extracellular nucleotide metabolism
    • DOI 10.1182/blood-2004-06-2066
    • Eltzschig HK, Thompson LF, Karhausen J, et al. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood 2004; 104:3986-3992. (Pubitemid 39620148)
    • (2004) Blood , vol.104 , Issue.13 , pp. 3986-3992
    • Eltzschig, H.K.1    Thompson, L.F.2    Karhausen, J.3    Cotta, R.J.4    Ibla, J.C.5    Robson, S.C.6    Colgan, S.P.7
  • 26
    • 50949116679 scopus 로고    scopus 로고
    • ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia
    • Faigle M, Seessle J, Zug S, et al. ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. PLoS ONE 2008; 3:e2801.
    • (2008) PLoS ONE , vol.3
    • Faigle, M.1    Seessle, J.2    Zug, S.3
  • 27
    • 77954519851 scopus 로고    scopus 로고
    • Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury
    • Schingnitz U, Hartmann K, Macmanus CF, et al. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol 2010; 184:5271-5279.
    • (2010) J Immunol , vol.184 , pp. 5271-5279
    • Schingnitz, U.1    Hartmann, K.2    Macmanus, C.F.3
  • 29
    • 33947225356 scopus 로고    scopus 로고
    • Physiological roles of 50-ectonucleotidase (CD73)
    • Colgan SP, Eltzschig HK, Eckle T, et al. Physiological roles of 50-ectonucleotidase (CD73). Purinergic Signal 2006; 2:351-360.
    • (2006) Purinergic Signal , vol.2 , pp. 351-360
    • Colgan, S.P.1    Eltzschig, H.K.2    Eckle, T.3
  • 30
    • 65249138361 scopus 로고    scopus 로고
    • Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis
    • Frick JS, MacManus CF, Scully M, et al. Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol 2009; 182:4957-4964.
    • (2009) J Immunol , vol.182 , pp. 4957-4964
    • Frick, J.S.1    MacManus, C.F.2    Scully, M.3
  • 31
    • 43049105018 scopus 로고    scopus 로고
    • Neutrophils as Sources of Extracellular Nucleotides: Functional Consequences at the Vascular Interface
    • DOI 10.1016/j.tcm.2008.01.006, PII S1050173808000224
    • Eltzschig HK, Macmanus CF, Colgan SP. Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface. Trends Cardiovasc Med 2008; 18:103-107. (Pubitemid 351626607)
    • (2008) Trends in Cardiovascular Medicine , vol.18 , Issue.3 , pp. 103-107
    • Eltzschig, H.K.1    MacManus, C.F.2    Colgan, S.P.3
  • 32
    • 59449096105 scopus 로고    scopus 로고
    • Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
    • Eltzschig HK, Kohler D, Eckle T, et al. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood 2009; 113:224-232.
    • (2009) Blood , vol.113 , pp. 224-232
    • Eltzschig, H.K.1    Kohler, D.2    Eckle, T.3
  • 33
    • 11244261365 scopus 로고    scopus 로고
    • Vascular ischaemia and reperfusion injury
    • DOI 10.1093/bmb/ldh025
    • Eltzschig HK, Collard CD. Vascular ischaemia and reperfusion injury. Br Med Bull 2004; 70:71-86. (Pubitemid 40069373)
    • (2004) British Medical Bulletin , vol.70 , pp. 71-86
    • Eltzschig, H.K.1    Collard, C.D.2
  • 34
    • 52449090560 scopus 로고    scopus 로고
    • Direct treatment of mouse or human blood with soluble 50-nucleotidase inhibits platelet aggregation
    • Hart ML, Kohler D, Eckle T, et al. Direct treatment of mouse or human blood with soluble 50-nucleotidase inhibits platelet aggregation. Arterioscler Thromb Vasc Biol 2008; 28:1477-1483.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1477-1483
    • Hart, M.L.1    Kohler, D.2    Eckle, T.3
  • 36
    • 78651411645 scopus 로고    scopus 로고
    • Adenosine generation and signaling during acute kidney injury
    • Bauerle JD, Grenz A, Kim JH, et al. Adenosine generation and signaling during acute kidney injury. J Am Soc Nephrol 2011; 22:14-20.
    • (2011) J Am Soc Nephrol , vol.22 , pp. 14-20
    • Bauerle, J.D.1    Grenz, A.2    Kim, J.H.3
  • 37
    • 79955948343 scopus 로고    scopus 로고
    • Interplay of hypoxia and A2B adenosine receptors in tissue protection
    • Koeppen M, Eckle T, Eltzschig HK. Interplay of hypoxia and A2B adenosine receptors in tissue protection. Adv Pharmacol 2011; 61:145-186.
    • (2011) Adv Pharmacol , vol.61 , pp. 145-186
    • Koeppen, M.1    Eckle, T.2    Eltzschig, H.K.3
  • 38
    • 79960698249 scopus 로고    scopus 로고
    • Extracellular adenosine: A safety signal that dampens hypoxia-induced inflammation during ischemia
    • Grenz A, Homann D, Eltzschig HK. Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia. Antioxid Redox Signal 2011; 15:2221-2234.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 2221-2234
    • Grenz, A.1    Homann, D.2    Eltzschig, H.K.3
  • 39
    • 84859576711 scopus 로고    scopus 로고
    • Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis
    • [Epub ahead of print]
    • Aherne CM, Collins CB, Masterson JC, et al. Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis. Gut 2011. [Epub ahead of print]
    • (2011) Gut
    • Aherne, C.M.1    Collins, C.B.2    Masterson, J.C.3
  • 40
    • 58549096884 scopus 로고    scopus 로고
    • Hypoxia-inducible factordependent induction of netrin-1 dampens inflammation caused by hypoxia
    • Rosenberger P, Schwab JM, Mirakaj V, et al. Hypoxia-inducible factordependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol 2009; 10:195-202.
    • (2009) Nat Immunol , vol.10 , pp. 195-202
    • Rosenberger, P.1    Schwab, J.M.2    Mirakaj, V.3
  • 41
    • 80054852928 scopus 로고    scopus 로고
    • Retinoic acid attenuates ileitis by restoring the balance between T-helper 17 and T regulatory cells
    • Collins CB, Aherne CM, Kominsky D, et al. Retinoic acid attenuates ileitis by restoring the balance between T-helper 17 and T regulatory cells. Gastroenterology 2011; 141:1821-1831.
    • (2011) Gastroenterology , vol.141 , pp. 1821-1831
    • Collins, C.B.1    Aherne, C.M.2    Kominsky, D.3
  • 42
    • 84863723845 scopus 로고    scopus 로고
    • Flt3 ligand expands CD103+ dendritic cells and FoxP3+ T regulatory cells, and attenuates Crohn's-like murine ileitis
    • [Epub ahead of print]
    • Collins CB, Aherne CM, McNamee EN, et al. Flt3 ligand expands CD103+ dendritic cells and FoxP3+ T regulatory cells, and attenuates Crohn's-like murine ileitis. Gut 2011. [Epub ahead of print]
    • (2011) Gut
    • Collins, C.B.1    Aherne, C.M.2    McNamee, E.N.3
  • 43
    • 20444467085 scopus 로고    scopus 로고
    • Inflammatory hypoxia: Role of hypoxiainducible factor
    • Karhausen J, Haase VH, Colgan SP. Inflammatory hypoxia: role of hypoxiainducible factor. Cell Cycle 2005; 4.
    • (2005) Cell Cycle , vol.4
    • Karhausen, J.1    Haase, V.H.2    Colgan, S.P.3
  • 45
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
    • DOI 10.1016/j.molcel.2008.04.009, PII S109727650800292X
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 2008; 30:393-402. (Pubitemid 351681994)
    • (2008) Molecular Cell , vol.30 , Issue.4 , pp. 393-402
    • Kaelin Jr., W.G.1    Ratcliffe, P.J.2
  • 46
    • 22244440847 scopus 로고    scopus 로고
    • Proline hydroxylation and gene expression
    • Kaelin WG. Proline hydroxylation and gene expression. Annu Rev Biochem 2005; 74:115-128.
    • (2005) Annu Rev Biochem , vol.74 , pp. 115-128
    • Kaelin, W.G.1
  • 47
    • 33947528891 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Kaelin WG. Von Hippel-Lindau disease. Annu Rev Pathol 2007; 2:145-173.
    • (2007) Annu Rev Pathol , vol.2 , pp. 145-173
    • Kaelin, W.G.1
  • 48
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
    • DOI 10.1101/gad.924501
    • Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 2001; 15:2675-2686. (Pubitemid 32988878)
    • (2001) Genes and Development , vol.15 , Issue.20 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 49
    • 59349098621 scopus 로고    scopus 로고
    • Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
    • Fraisl P, Aragones J, Carmeliet P. Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. Nat Rev Drug Discov 2009; 8:139-152.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 139-152
    • Fraisl, P.1    Aragones, J.2    Carmeliet, P.3
  • 50
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • Wenger RH, Stiehl DP, Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005; 2005:re12.
    • (2005) Sci STKE , vol.2005
    • Wenger, R.H.1    Stiehl, D.P.2    Camenisch, G.3
  • 51
    • 35148888161 scopus 로고    scopus 로고
    • Life with oxygen
    • DOI 10.1126/science.1147949
    • Semenza GL. Life with oxygen. Science 2007; 318:62-64. (Pubitemid 47538005)
    • (2007) Science , vol.318 , Issue.5847 , pp. 62-64
    • Semenza, G.L.1
  • 52
    • 0035877163 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor α expression during hypoxia
    • Narravula S, Colgan SP. Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia. J Immunol 2001; 166:7543-7548. (Pubitemid 32525634)
    • (2001) Journal of Immunology , vol.166 , Issue.12 , pp. 7543-7548
    • Narravula, S.1    Colgan, S.P.2
  • 53
    • 47049088629 scopus 로고    scopus 로고
    • HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
    • Morote-Garcia JC, Rosenberger P, Kuhlicke J, et al. HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak. Blood 2008; 111:5571-5580.
    • (2008) Blood , vol.111 , pp. 5571-5580
    • Morote-Garcia, J.C.1    Rosenberger, P.2    Kuhlicke, J.3
  • 54
    • 58649112595 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia
    • Morote-Garcia JC, Rosenberger P, Nivillac NM, et al. Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia. Gastroenterology 2009; 136:607-618.
    • (2009) Gastroenterology , vol.136 , pp. 607-618
    • Morote-Garcia, J.C.1    Rosenberger, P.2    Nivillac, N.M.3
  • 55
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza GL, Roth PH, Fang HM, et al. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994; 269:23757-23763. (Pubitemid 24293585)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.38 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.-M.3    Wang, G.L.4
  • 56
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
    • DOI 10.1016/j.cell.2007.01.047, PII S0092867407003078
    • Fukuda R, Zhang H, Kim JW, et al. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 2007; 129:111-122. (Pubitemid 46507584)
    • (2007) Cell , vol.129 , Issue.1 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.-w.3    Shimoda, L.4    Dang, C.V.5    Semenza, GreggL.6
  • 57
    • 44849143016 scopus 로고    scopus 로고
    • Metabolism and therapeutic angiogenesis
    • Carmeliet P, Baes M. Metabolism and therapeutic angiogenesis. N Engl J Med 2008; 358:2511-2512.
    • (2008) N Engl J Med , vol.358 , pp. 2511-2512
    • Carmeliet, P.1    Baes, M.2
  • 58
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension
    • Wang G, Jiang B, Rue E, et al. Hypoxia-inducible factor 1 is a basic-helix-loophelix-PAS heterodimer regulated by cellular O2 tension. PNAS 1995; 92:5510-5514.
    • (1995) PNAS , vol.92 , pp. 5510-5514
    • Wang, G.1    Jiang, B.2    Rue, E.3
  • 60
    • 57849163103 scopus 로고    scopus 로고
    • Oxygen sensors at the crossroad of metabolism
    • Aragones J, Fraisl P, Baes M, et al. Oxygen sensors at the crossroad of metabolism. Cell Metab 2009; 9:11-22.
    • (2009) Cell Metab , vol.9 , pp. 11-22
    • Aragones, J.1    Fraisl, P.2    Baes, M.3
  • 61
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • Kaelin WGJr. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 2008; 8:865-873.
    • (2008) Nat Rev Cancer , vol.8 , pp. 865-873
    • Kaelin Jr., W.G.1
  • 62
    • 79952131899 scopus 로고    scopus 로고
    • Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation
    • Riegel AK, Faigle M, Zug S, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood 2011; 117:2548-2555.
    • (2011) Blood , vol.117 , pp. 2548-2555
    • Riegel, A.K.1    Faigle, M.2    Zug, S.3
  • 63
    • 77957943307 scopus 로고    scopus 로고
    • Intravascular danger signals guide neutrophils to sites of sterile inflammation
    • McDonald B, Pittman K, Menezes GB, et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science 2010; 330:362-366.
    • (2010) Science , vol.330 , pp. 362-366
    • McDonald, B.1    Pittman, K.2    Menezes, G.B.3
  • 64
    • 77951649299 scopus 로고    scopus 로고
    • SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning
    • Hart ML, Gorzolla IC, Schittenhelm J, et al. SP1-dependent induction of CD39 facilitates hepatic ischemic preconditioning. J Immunol 2010; 184:4017-4024.
    • (2010) J Immunol , vol.184 , pp. 4017-4024
    • Hart, M.L.1    Gorzolla, I.C.2    Schittenhelm, J.3
  • 65
    • 70349745514 scopus 로고    scopus 로고
    • From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease
    • Friedman DJ, Kunzli BM, AR YI, et al. From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A 2009; 106:16788-16793.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 16788-16793
    • Friedman, D.J.1    Kunzli, B.M.2    Ar, Y.I.3
  • 69
    • 59649088866 scopus 로고    scopus 로고
    • Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs
    • Reutershan J, Vollmer I, Stark S, et al. Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs. FASEB J 2009; 23:473-482.
    • (2009) FASEB J , vol.23 , pp. 473-482
    • Reutershan, J.1    Vollmer, I.2    Stark, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.