Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

Nature Medicine

Volumn 18, Issue 5, 2012, Pages 774-782

  Eckle, Tobias ^a   Hartmann, Katherine ^a   Bonney, Stephanie ^a   Reithel, Susan ^a   Mittelbronn, Michel ^b   Walker, Lori A ^c   Lowes, Brian D ^c   Han, Jun ^d   Borchers, Christoph H ^d   Buttrick, Peter M ^c   Kominsky, Douglas J ^a   Colgan, Sean P ^a   Eltzschig, Holger K ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF VICTORIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2B RECEPTOR; CARBOHYDRATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PER2 PROTEIN; PROTEASOME;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLYCOLYSIS; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART PROTECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGHT EXPOSURE; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; TRANSCRIPTION INITIATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CELLS, CULTURED; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PERIOD CIRCADIAN PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTOR, ADENOSINE A2B;

MUS;

EID: 84860663922     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2728     Document Type: Article

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