Structure-activity relationship study of vitamin K derivatives yields highly potent neuroprotective agents

Journal of Medicinal Chemistry

Volumn 56, Issue 3, 2013, Pages 1007-1022

  Josey, Benjamin J ^a   Inks, Elizabeth S ^a   Wen, Xuejun ^b   Chou, C James ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Virginia Commonwealth University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ((3 (TRIFLUOROMETHYL)BENZYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((3 CHLOROBENZYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((3 PHENETHYLPROPYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((3,4 DICHLOROBENZYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((4 CHLOROBENZYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((4 METHOXYBENZYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((4 METHYLBENZYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((CYCLOHEXYLMETHYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((PYRIDIN 2 YLMETHYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((PYRIDIN 3 YLMETHYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 ((PYRIDIN 4 YLMETHYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 (BENZYL(METHYL)AMINO)NAPHTHALENE 1,4 DIONE; 2 (BENZYLAMINO)NAPHTHALENE 1,4 DIONE; 2 (CYCLOPENTYLAMINO)NAPHTHALENE 1,4 DIONE; 2 (ETHYLAMINO)NAPHTHALENE 1,4 DIONE; 2 (ISOPROPYLAMINO)NAPHTHALENE 1,4 DIONE; 2 (METHYLAMINO)NAPHTHALENE 1,4 DIONE; 2 (NAPHTHALEN 1 YLAMINO)NAPHTHALENE 1,4 DIONE; 2 (PHENYLAMINO)NAPHTHALENE 1,4 DIONE; 2 (PROP 2 YN 1 YLAMINO)NAPHTHALENE 1,4 DIONE; 2 (PROPYLAMINO)NAPHTHALENE 1,4 DIONE; 2 AMINO 1,4 NAPHTHOQUINONE; 2 AMINO 3 METHYL 1,4 NAPHTHOQUINONE; METHYL (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL)CARBAMATE; METHYL 4 (((1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL)AMINO)METHYL)BENZOATE; N (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL)ACETAMIDE; N (1,4 DIOXO 1,4 DIHYDRONAPHTHALEN 2 YL)PROPIONAMIDE; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VITAMIN K GROUP;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL CULTURE; CELL DEATH; CELL VIABILITY; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

BASE SEQUENCE; CELL LINE; DNA PRIMERS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN K;

EID: 84873934098     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301485d     Document Type: Article

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