메뉴 건너뛰기




Volumn 11, Issue 4, 2010, Pages 1526-1540

Injectable lipid emulsions-advancements, opportunities and challenges

Author keywords

biodisposition; lipid emulsions; microfluidization; parenteral formulations; sterilization

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; CLARITHROMYCIN; CLEVIDIPINE; CREMOPHOR; CYCLOSPORIN; CYCLOSPORIN A; DIAZEPAM; ETOMIDATE; FLUOSOL DA; LIPID EMULSION; LIPOPROSTAGLANDIN E1; LIPURO; NONSTEROID ANTIINFLAMMATORY AGENT; PACLITAXEL; PHENOBARBITAL; PHYSOSTIGMINE; PROPOFOL; RETINOIC ACID; SPHINGOMYELIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 78651470720     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9526-5     Document Type: Review
Times cited : (204)

References (159)
  • 1
    • 4544385159 scopus 로고    scopus 로고
    • 25th Arvid Wretlind's Lecture - Silver anniversary, 25 years with ESPEN, the history of nutrition
    • DOI 10.1016/j.clnu.2004.06.001, PII S0261561404000895
    • E Vinnars F Hammarqvist 2004 25th Arvid Wretlind's Lecture-Silver anniversary, 25 years with ESPEN, the history of nutrition Clin Nutr 23 955 62 15380883 10.1016/j.clnu.2004.06.001 (Pubitemid 39243007)
    • (2004) Clinical Nutrition , vol.23 , Issue.5 , pp. 955-962
    • Vinnars, E.1    Hammarqvist, F.2
  • 2
    • 0019569971 scopus 로고
    • Development of fat emulsions
    • 1:CAS:528:DyaL3MXltlWhtr8%3D 6788972 10.1177/0148607181005003230
    • A Wretlind 1981 Development of fat emulsions JPEN J Parenter Enteral Nutr 5 230 5 1:CAS:528:DyaL3MXltlWhtr8%3D 6788972 10.1177/0148607181005003230
    • (1981) JPEN J Parenter Enteral Nutr , vol.5 , pp. 230-5
    • Wretlind, A.1
  • 3
    • 0042072896 scopus 로고    scopus 로고
    • Jonathan roads symposium papers. History of parenteral nutrition
    • 12757118 10.1177/0148607103027003225
    • E Vinnars D Wilmore 2003 Jonathan roads symposium papers. History of parenteral nutrition JPEN J Parenter Enteral Nutr 27 225 31 12757118 10.1177/0148607103027003225
    • (2003) JPEN J Parenter Enteral Nutr , vol.27 , pp. 225-31
    • Vinnars, E.1    Wilmore, D.2
  • 4
    • 69949111727 scopus 로고    scopus 로고
    • Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: The Boston experience
    • 19571170 10.1177/0148607109332773
    • VE de Meijer KM Gura HD Le JA Meisel M Puder 2009 Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: the Boston experience JPEN J Parenter Enteral Nutr 33 541 7 19571170 10.1177/0148607109332773
    • (2009) JPEN J Parenter Enteral Nutr , vol.33 , pp. 541-7
    • De Meijer, V.E.1    Gura, K.M.2    Le, H.D.3    Meisel, J.A.4    Puder, M.5
  • 6
    • 77951205590 scopus 로고    scopus 로고
    • Lipid emulsions in parenteral nutrition of intensive care patients: Current thinking and future directions
    • 1:CAS:528:DC%2BC3cXktlCrsL8%3D 20072779 10.1007/s00134-009-1744-5
    • PC Calder GL Jensen BV Koletzko P Singer GJ Wanten 2010 Lipid emulsions in parenteral nutrition of intensive care patients: current thinking and future directions Intensive Care Med 36 735 49 1:CAS:528:DC%2BC3cXktlCrsL8%3D 20072779 10.1007/s00134-009-1744-5
    • (2010) Intensive Care Med , vol.36 , pp. 735-49
    • Calder, P.C.1    Jensen, G.L.2    Koletzko, B.V.3    Singer, P.4    Wanten, G.J.5
  • 7
    • 33846621595 scopus 로고    scopus 로고
    • New parenteral lipid emulsions for clinical use
    • 1:CAS:528:DC%2BD28XnsVGjtL8%3D 16804134 10.1177/0148607106030004351
    • DL Waitzberg RS Torrinhas TM Jacintho 2006 New parenteral lipid emulsions for clinical use JPEN J Parenter Enteral Nutr 30 351 67 1:CAS:528: DC%2BD28XnsVGjtL8%3D 16804134 10.1177/0148607106030004351
    • (2006) JPEN J Parenter Enteral Nutr , vol.30 , pp. 351-67
    • Waitzberg, D.L.1    Torrinhas, R.S.2    Jacintho, T.M.3
  • 8
    • 0034525245 scopus 로고    scopus 로고
    • Advances in intravenous lipid emulsions
    • DOI 10.1007/s002680010267
    • YA Carpentier IE Dupont 2000 Advances in intravenous lipid emulsions World J Surg 24 1493 7 1:STN:280:DC%2BD3M3gtFKgsA%3D%3D 11193713 10.1007/s002680010267 (Pubitemid 32047277)
    • (2000) World Journal of Surgery , vol.24 , Issue.12 , pp. 1493-1497
    • Carpentier, Y.A.1    Dupont, I.E.2
  • 9
    • 0034056615 scopus 로고    scopus 로고
    • Fish oil emulsions: What benefits can they bring?
    • DOI 10.1054/clnu.1999.0072
    • P Furst KS Kuhn 2000 Fish oil emulsions: what benefits can they bring? Clin Nutr 19 7 14 1:CAS:528:DC%2BD3cXisFertLg%3D 10700528 10.1054/clnu.1999.0072 (Pubitemid 30150803)
    • (2000) Clinical Nutrition , vol.19 , Issue.1 , pp. 7-14
    • Furst, P.1    Kuhn, K.S.2
  • 10
    • 70349261950 scopus 로고    scopus 로고
    • Hot topics in parenteral nutrition. Rationale for using new lipid emulsions in parenteral nutrition and a review of the trials performed in adults
    • 1:CAS:528:DC%2BD1MXhtV2gsrjP 19426581 10.1017/S0029665109001268
    • PC Calder 2009 Hot topics in parenteral nutrition. Rationale for using new lipid emulsions in parenteral nutrition and a review of the trials performed in adults Proc Nutr Soc 68 252 60 1:CAS:528:DC%2BD1MXhtV2gsrjP 19426581 10.1017/S0029665109001268
    • (2009) Proc Nutr Soc , vol.68 , pp. 252-60
    • Calder, P.C.1
  • 12
    • 0031976809 scopus 로고    scopus 로고
    • Intravenous lipid dose and incidence of bacteremia and fungemia in patients undergoing bone marrow transplantation
    • 1:CAS:528:DyaK1cXislaisrs%3D 9583851
    • P Lenssen BA Bruemmer RA Bowden T Gooley SN Aker D Mattson 1998 Intravenous lipid dose and incidence of bacteremia and fungemia in patients undergoing bone marrow transplantation Am J Clin Nutr 67 927 33 1:CAS:528:DyaK1cXislaisrs%3D 9583851
    • (1998) Am J Clin Nutr , vol.67 , pp. 927-33
    • Lenssen, P.1    Bruemmer, B.A.2    Bowden, R.A.3    Gooley, T.4    Aker, S.N.5    Mattson, D.6
  • 13
    • 0027141358 scopus 로고
    • Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease
    • 1:CAS:528:DyaK2cXhtVGltLY%3D 8253356
    • PT Clayton A Bowron KA Mills A Massoud M Casteels PJ Milla 1993 Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease Gastroenterology 105 1806 13 1:CAS:528:DyaK2cXhtVGltLY%3D 8253356
    • (1993) Gastroenterology , vol.105 , pp. 1806-13
    • Clayton, P.T.1    Bowron, A.2    Mills, K.A.3    Massoud, A.4    Casteels, M.5    Milla, P.J.6
  • 14
    • 0030130544 scopus 로고    scopus 로고
    • Parenteral use of medium-chain triglycerides: A reappraisal
    • DOI 10.1016/S0899-9007(96)00089-6
    • H Ulrich SM Pastores DP Katz V Kvetan 1996 Parenteral use of medium-chain triglycerides: a reappraisal Nutrition 12 231 8 1:CAS:528:DyaK28XkvVCnsr4%3D 8862527 10.1016/S0899-9007(96)00089-6 (Pubitemid 26286457)
    • (1996) Nutrition , vol.12 , Issue.4 , pp. 231-238
    • Ulrich, H.1    Pastures, S.M.2    Katz, D.P.3    Kvetan, V.4
  • 15
    • 85047699369 scopus 로고    scopus 로고
    • Effects of intravenous supplementation with alpha-tocopherol in patients receiving total parenteral nutrition containing medium- and long-chain triglycerides
    • 1:CAS:528:DC%2BD38XitVCruro%3D 11857045 10.1038/sj.ejcn.1601294
    • B Manuel-y-Keenoy L Nonneman H De Bosscher J Vertommen S Schrans K Klutsch, et al. 2002 Effects of intravenous supplementation with alpha-tocopherol in patients receiving total parenteral nutrition containing medium- and long-chain triglycerides Eur J Clin Nutr 56 121 8 1:CAS:528:DC%2BD38XitVCruro%3D 11857045 10.1038/sj.ejcn.1601294
    • (2002) Eur J Clin Nutr , vol.56 , pp. 121-8
    • Manuel-Y-Keenoy, B.1    Nonneman, L.2    De Bosscher, H.3    Vertommen, J.4    Schrans, S.5    Klutsch, K.6
  • 16
    • 0026795095 scopus 로고
    • Fat emulsions containing medium chain triglycerides in patients with sepsis syndrome: Effects on pulmonary hemodynamics and gas exchange
    • 1:STN:280:DyaK3s%2FlsFyrtQ%3D%3D 1430588 10.1007/BF01709838
    • P Radermacher B Santak H Strobach K Schror J Tarnow 1992 Fat emulsions containing medium chain triglycerides in patients with sepsis syndrome: effects on pulmonary hemodynamics and gas exchange Intensive Care Med 18 231 4 1:STN:280:DyaK3s%2FlsFyrtQ%3D%3D 1430588 10.1007/BF01709838
    • (1992) Intensive Care Med , vol.18 , pp. 231-4
    • Radermacher, P.1    Santak, B.2    Strobach, H.3    Schror, K.4    Tarnow, J.5
  • 17
    • 0025137120 scopus 로고
    • Effect of different types of total parenteral nutrition on T-lymphocyte subpopulations and NK cells
    • 1:STN:280:DyaK3c7hvFGjtw%3D%3D 2136970
    • CA Gogos FE Kalfarentzos NC Zoumbos 1990 Effect of different types of total parenteral nutrition on T-lymphocyte subpopulations and NK cells Am J Clin Nutr 51 119 22 1:STN:280:DyaK3c7hvFGjtw%3D%3D 2136970
    • (1990) Am J Clin Nutr , vol.51 , pp. 119-22
    • Gogos, C.A.1    Kalfarentzos, F.E.2    Zoumbos, N.C.3
  • 18
    • 0028118804 scopus 로고
    • Medium- and long-chain triglycerides have different effects on the synthesis of tumor necrosis factor by human mononuclear cells in patients under total parenteral nutrition
    • 1:STN:280:DyaK2c3gvFGgsQ%3D%3D 8157852
    • CA Gogos N Zoumbos M Makri F Kalfarentzos 1994 Medium- and long-chain triglycerides have different effects on the synthesis of tumor necrosis factor by human mononuclear cells in patients under total parenteral nutrition J Am Coll Nutr 13 40 4 1:STN:280:DyaK2c3gvFGgsQ%3D%3D 8157852
    • (1994) J Am Coll Nutr , vol.13 , pp. 40-4
    • Gogos, C.A.1    Zoumbos, N.2    Makri, M.3    Kalfarentzos, F.4
  • 19
    • 0020420292 scopus 로고
    • Medium-chain triglycerides: An update
    • 1:CAS:528:DyaL38XmtFClsbc%3D 6814231
    • AC Bach VK Babayan 1982 Medium-chain triglycerides: an update Am J Clin Nutr 36 950 62 1:CAS:528:DyaL38XmtFClsbc%3D 6814231
    • (1982) Am J Clin Nutr , vol.36 , pp. 950-62
    • Bach, A.C.1    Babayan, V.K.2
  • 20
    • 0024243011 scopus 로고
    • Medium-chain triglyceride-based fat emulsions: An alternative energy supply in stress and sepsis
    • 1:STN:280:DyaL1M7htFanuw%3D%3D 3063844 10.1177/014860718801200610
    • AC Bach D Storck Z Meraihi 1988 Medium-chain triglyceride-based fat emulsions: an alternative energy supply in stress and sepsis JPEN J Parenter Enteral Nutr 12 82S 8 1:STN:280:DyaL1M7htFanuw%3D%3D 3063844 10.1177/014860718801200610
    • (1988) JPEN J Parenter Enteral Nutr , vol.12
    • Bach, A.C.1    Storck, D.2    Meraihi, Z.3
  • 21
    • 34248389437 scopus 로고    scopus 로고
    • Structured triglyceride emulsions in parenteral nutrition
    • 1:STN:280:DC%2BD28vkslGiug%3D%3D 16870802 10.1177/0115426506021004342
    • C Chambrier M Lauverjat P Bouletreau 2006 Structured triglyceride emulsions in parenteral nutrition Nutr Clin Pract 21 342 50 1:STN:280: DC%2BD28vkslGiug%3D%3D 16870802 10.1177/0115426506021004342
    • (2006) Nutr Clin Pract , vol.21 , pp. 342-50
    • Chambrier, C.1    Lauverjat, M.2    Bouletreau, P.3
  • 22
    • 0035132084 scopus 로고    scopus 로고
    • Nitrogen sparing effect of structured triglycerides containing both medium-and long-chain fatty acids in critically ill patients; A double blind randomized controlled trial
    • 1:CAS:528:DC%2BD3MXhsVCrsrw%3D 11161543 10.1054/clnu.2000.0156
    • BF Lindgren E Ruokonen K Magnusson-Borg J Takala 2001 Nitrogen sparing effect of structured triglycerides containing both medium-and long-chain fatty acids in critically ill patients; a double blind randomized controlled trial Clin Nutr 20 43 8 1:CAS:528:DC%2BD3MXhsVCrsrw%3D 11161543 10.1054/clnu.2000.0156
    • (2001) Clin Nutr , vol.20 , pp. 43-8
    • Lindgren, B.F.1    Ruokonen, E.2    Magnusson-Borg, K.3    Takala, J.4
  • 23
    • 56949102075 scopus 로고    scopus 로고
    • Effects of parenteral structured lipid emulsion on modulating the inflammatory response in rats undergoing a total gastrectomy
    • 1:CAS:528:DC%2BD1cXhsVKltrvL 18834719 10.1016/j.nut.2008.07.015
    • M-T Lin S-L Yeh S-S Tsou M-Y Wang W-J Chen 2009 Effects of parenteral structured lipid emulsion on modulating the inflammatory response in rats undergoing a total gastrectomy Nutrition 25 115 21 1:CAS:528:DC%2BD1cXhsVKltrvL 18834719 10.1016/j.nut.2008.07.015
    • (2009) Nutrition , vol.25 , pp. 115-21
    • Lin, M.-T.1    Yeh, S.-L.2    Tsou, S.-S.3    Wang, M.-Y.4    Chen, W.-J.5
  • 24
    • 34248344638 scopus 로고    scopus 로고
    • Immune modulation by parenteral lipid emulsions
    • 1:CAS:528:DC%2BD2sXls1KitLg%3D 17490951
    • GJ Wanten PC Calder 2007 Immune modulation by parenteral lipid emulsions Am J Clin Nutr 85 1171 84 1:CAS:528:DC%2BD2sXls1KitLg%3D 17490951
    • (2007) Am J Clin Nutr , vol.85 , pp. 1171-84
    • Wanten, G.J.1    Calder, P.C.2
  • 26
    • 33744482046 scopus 로고    scopus 로고
    • Monounsaturated fatty acid-based lipid emulsions in critically ill patients are associated with fewer complications [2]
    • DOI 10.1079/BJN20061760
    • A Garcia-de-Lorenzo 2006 Monounsaturated fatty acid-based lipid emulsions in critically ill patients are associated with fewer complications Br J Nutr 95 1029 1:CAS:528:DC%2BD28XkvFOltLc%3D 16611398 10.1079/BJN20061760 (Pubitemid 43805394)
    • (2006) British Journal of Nutrition , vol.95 , Issue.5 , pp. 1029
    • Garcia-de-Lorenzo, A.1
  • 27
    • 70349568379 scopus 로고    scopus 로고
    • Fish oil lipid emulsions and immune response: What clinicians need to know
    • 19605803 10.1177/0884533609339071
    • DL Waitzberg RS Torrinhas 2009 Fish oil lipid emulsions and immune response: what clinicians need to know Nutr Clin Pract 24 487 99 19605803 10.1177/0884533609339071
    • (2009) Nutr Clin Pract , vol.24 , pp. 487-99
    • Waitzberg, D.L.1    Torrinhas, R.S.2
  • 28
    • 78651494090 scopus 로고    scopus 로고
    • Diprivan Injectable Emulsion. AstraZeneca. Available at: Accessed23March2010
    • Diprivan Injectable Emulsion. AstraZeneca. Available at: http://www1.astrazeneca-us.com/pi/diprivan.pdf. Accessed 23 March 2010.
  • 30
    • 0001754870 scopus 로고    scopus 로고
    • Injectable emulsions and suspensions
    • H.A. Lieberman M.M. Rieger G.S. Banker (eds). Marcel Dekker New York
    • Floyd AG, Jain S. Injectable emulsions and suspensions. In: Lieberman HA, Rieger MM, Banker GS, editors. Pharmaceutical dosage forms: dispersed systems. New York: Marcel Dekker; 1996. p. 261-310.
    • (1996) Pharmaceutical Dosage Forms: Dispersed Systems , pp. 261-310
    • Floyd, A.G.1    Jain, S.2
  • 31
    • 0024372496 scopus 로고
    • Side-effect evaluation of a new diazepam formulation: Venous sequela reduction following intravenous (i.v.) injection of a diazepam emulsion in rabbits
    • 1:CAS:528:DyaL1MXltValsr0%3D 2762228 10.1023/A:1015928825882
    • MY Levy L Langerman S Gottschalk-Sabag S Benita 1989 Side-effect evaluation of a new diazepam formulation: venous sequela reduction following intravenous (i.v.) injection of a diazepam emulsion in rabbits Pharm Res 6 510 6 1:CAS:528:DyaL1MXltValsr0%3D 2762228 10.1023/A:1015928825882
    • (1989) Pharm Res , vol.6 , pp. 510-6
    • Levy, M.Y.1    Langerman, L.2    Gottschalk-Sabag, S.3    Benita, S.4
  • 32
    • 0020674559 scopus 로고
    • Fat emulsion as a vehicle for diazepam. A study of 9492 patients
    • 10.1093/bja/55.1.41
    • O von Dardel C Mebius T Mossberg B Svensson 1983 Fat emulsion as a vehicle for diazepam. A study of 9492 patients Br J Anaesth 55 41 7 10.1093/bja/55.1.41
    • (1983) Br J Anaesth , vol.55 , pp. 41-7
    • Von Dardel, O.1    Mebius, C.2    Mossberg, T.3    Svensson, B.4
  • 34
    • 0024397420 scopus 로고
    • A new formulation of etomidate in lipid emulsion-bioavailability and venous provocation
    • 1:CAS:528:DyaL1MXlvVSmu7Y%3D 2675669
    • H Suttmann A Doenicke J Kugler M Laub 1989 A new formulation of etomidate in lipid emulsion-bioavailability and venous provocation Anaesthesist 38 421 3 1:CAS:528:DyaL1MXlvVSmu7Y%3D 2675669
    • (1989) Anaesthesist , vol.38 , pp. 421-3
    • Suttmann, H.1    Doenicke, A.2    Kugler, J.3    Laub, M.4
  • 35
    • 0019837174 scopus 로고
    • Local discomfort and thrombophlebitis following intravenous injection of diazepam. A comparison between a glycoferol-water solution and a lipid emulsion
    • 1:STN:280:DyaL383otVCisw%3D%3D 7347079 10.1111/j.1399-6576.1981.tb01696.x
    • D Selander I Curelaru T Stefansson 1981 Local discomfort and thrombophlebitis following intravenous injection of diazepam. A comparison between a glycoferol-water solution and a lipid emulsion Acta Anaesthesiol Scand 25 516 8 1:STN:280:DyaL383otVCisw%3D%3D 7347079 10.1111/j.1399-6576.1981. tb01696.x
    • (1981) Acta Anaesthesiol Scand , vol.25 , pp. 516-8
    • Selander, D.1    Curelaru, I.2    Stefansson, T.3
  • 36
    • 0025220388 scopus 로고
    • Pharmacokinetics of two alternative dosage forms for cyclosporine: Liposomes and intralipid
    • 1:CAS:528:DyaK3cXitVCmu74%3D 2338629 10.1002/jps.2600790307
    • S Venkataram WM Awni K Jordan YE Rahman 1990 Pharmacokinetics of two alternative dosage forms for cyclosporine: liposomes and intralipid J Pharm Sci 79 216 9 1:CAS:528:DyaK3cXitVCmu74%3D 2338629 10.1002/jps.2600790307
    • (1990) J Pharm Sci , vol.79 , pp. 216-9
    • Venkataram, S.1    Awni, W.M.2    Jordan, K.3    Rahman, Y.E.4
  • 38
    • 0027406433 scopus 로고
    • Dissolving intravenous cyclosporin A in a fat emulsion carrier prevents acute renal side effects in the rat
    • 1:STN:280:DyaK3s7ptFyrsw%3D%3D 8447927 10.1111/j.1432-2277.1993.tb00753.x
    • A Tibell M Larsson A Alvestrand 1993 Dissolving intravenous cyclosporin A in a fat emulsion carrier prevents acute renal side effects in the rat Transpl Int 6 69 72 1:STN:280:DyaK3s7ptFyrsw%3D%3D 8447927 10.1111/j.1432-2277.1993. tb00753.x
    • (1993) Transpl Int , vol.6 , pp. 69-72
    • Tibell, A.1    Larsson, M.2    Alvestrand, A.3
  • 39
    • 0025905274 scopus 로고
    • Toxicity of amphotericin B emulsion to cultured canine kidney cell monolayers
    • 1:CAS:528:DyaK3MXkvF2itrw%3D 1682471
    • KA Lamb C Washington SS Davis SP Denyer 1991 Toxicity of amphotericin B emulsion to cultured canine kidney cell monolayers J Pharm Pharmacol 43 522 4 1:CAS:528:DyaK3MXkvF2itrw%3D 1682471
    • (1991) J Pharm Pharmacol , vol.43 , pp. 522-4
    • Lamb, K.A.1    Washington, C.2    Davis, S.S.3    Denyer, S.P.4
  • 40
    • 0023920068 scopus 로고
    • Toxicity of solubilized and colloidal amphotericin B formulations to human erythrocytes
    • 1:CAS:528:DyaL1cXkt1OmtL0%3D 2899626
    • D Forster C Washington SS Davis 1988 Toxicity of solubilized and colloidal amphotericin B formulations to human erythrocytes J Pharm Pharmacol 40 325 8 1:CAS:528:DyaL1cXkt1OmtL0%3D 2899626
    • (1988) J Pharm Pharmacol , vol.40 , pp. 325-8
    • Forster, D.1    Washington, C.2    Davis, S.S.3
  • 41
    • 65349120818 scopus 로고    scopus 로고
    • Emulsions and Microemulsions
    • J. Swarbrick (eds). Informa Healthcare USA. Inc New York
    • Eccleston GM. Emulsions and Microemulsions. In: Swarbrick J, editor. Encylopedia of Pharmaceutical Technology. New York: Informa Healthcare USA. Inc; 2007. p. 1548-65.
    • (2007) Encylopedia of Pharmaceutical Technology , pp. 1548-65
    • Eccleston, G.M.1
  • 42
    • 85123270321 scopus 로고    scopus 로고
    • Emulsions, microemulsions, and lipid-based drug delivery systems for drug solubilization and delivery-Part I: Parenteral applications
    • L. Rong (eds). Taylor & Francis New York. 10.1201/9781420009552.ch10
    • Cannon BJ, Shi Y, Gupta P. Emulsions, microemulsions, and lipid-based drug delivery systems for drug solubilization and delivery-Part I: parenteral applications. In: Rong L, editor. Water-Insoluble Drug Formulation. New York: Taylor & Francis; 2008. p. 195-226.
    • (2008) Water-Insoluble Drug Formulation , pp. 195-226
    • Cannon, B.J.1    Shi, Y.2    Gupta, P.3
  • 43
    • 84993913350 scopus 로고
    • Selective liver targeting of antivirals by recombinant chylomicrons-a new therapeutic approach to hepatitis B
    • 1:CAS:528:DyaK2MXksVGnsr0%3D 7585037 10.1038/nm0395-221
    • PC Rensen MC van Dijk EC Havenaar MK Bijsterbosch JK Kruijt TJ van Berkel 1995 Selective liver targeting of antivirals by recombinant chylomicrons-a new therapeutic approach to hepatitis B Nat Med 1 221 5 1:CAS:528:DyaK2MXksVGnsr0%3D 7585037 10.1038/nm0395-221
    • (1995) Nat Med , vol.1 , pp. 221-5
    • Rensen, P.C.1    Van Dijk, M.C.2    Havenaar, E.C.3    Bijsterbosch, M.K.4    Kruijt, J.K.5    Van Berkel, T.J.6
  • 44
    • 3042726700 scopus 로고    scopus 로고
    • Biodistribution characteristics of galactosylated emulsions and incorporated probucol for hepatocyte-selective targeting of lipophilic drugs in mice
    • DOI 10.1023/B:PHAM.0000029280.39882.ff
    • E Ishida C Managit S Kawakami M Nishikawa F Yamashita M Hashida 2004 Biodistribution characteristics of galactosylated emulsions and incorporated probucol for hepatocyte-selective targeting of lipophilic drugs in mice Pharm Res 21 932 9 1:CAS:528:DC%2BD2cXktlykuro%3D 15212156 10.1023/B:PHAM.0000029280. 39882.ff (Pubitemid 38870141)
    • (2004) Pharmaceutical Research , vol.21 , Issue.6 , pp. 932-939
    • Ishida, E.1    Managit, C.2    Kawakami, S.3    Nishikawa, M.4    Yamashita, F.5    Hashida, M.6
  • 45
    • 33644807900 scopus 로고    scopus 로고
    • Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice
    • DOI 10.1080/10611860500293367, PII N233214324840
    • W Yeeprae S Kawakami Y Higuchi F Yamashita M Hashida 2005 Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice J Drug Target 13 479 87 1:CAS:528:DC%2BD2MXht1ynsb3N 16332573 10.1080/10611860500293367 (Pubitemid 43347845)
    • (2005) Journal of Drug Targeting , vol.13 , Issue.8-9 , pp. 479-487
    • Yeeprae, W.1    Kawakami, S.2    Higuchi, Y.3    Yamashita, F.4    Hashida, M.5
  • 46
    • 0033120537 scopus 로고    scopus 로고
    • Top ten considerations in the development of parenteral emulsions
    • DOI 10.1016/S1461-5347(99)00141-8, PII S1461534799001418
    • AG Floyd 1999 Top ten considerations in the development of parenteral emulsions Pharm Sci Technol Today 2 134 43 1:CAS:528:DyaK1MXns1Gjsb8%3D 10.1016/S1461-5347(99)00141-8 (Pubitemid 29195746)
    • (1999) Pharmaceutical Science and Technology Today , vol.2 , Issue.4 , pp. 134-143
    • Floyd, A.G.1
  • 47
    • 0033026712 scopus 로고    scopus 로고
    • Development of nonionic surfactant/phospholipid o/w emulsion as a paclitaxel delivery system
    • DOI 10.1016/S0168-3659(98)00164-3, PII S0168365998001643
    • P Kan Z-B Chen C-J Lee IM Chu 1999 Development of nonionic surfactant/phospholipid o/w emulsion as a paclitaxel delivery system J Control Release 58 271 8 1:CAS:528:DyaK1MXitVKnsrk%3D 10099152 10.1016/S0168-3659(98) 00164-3 (Pubitemid 29142451)
    • (1999) Journal of Controlled Release , vol.58 , Issue.3 , pp. 271-278
    • Kan, P.1    Chen, Z.-B.2    Lee, C.-J.3    Chu, I.-M.4
  • 48
    • 1942518298 scopus 로고    scopus 로고
    • Tocol emulsions for drug solubilization and parenteral delivery
    • DOI 10.1016/j.addr.2003.12.005, PII S0169409X04000432
    • PP Constantinides A Tustian DR Kessler 2004 Tocol emulsions for drug solubilization and parenteral delivery Adv Drug Deliv Rev 56 1243 55 1:CAS:528:DC%2BD2cXjtl2ktrs%3D 15109767 10.1016/j.addr.2003.12.005 (Pubitemid 38510472)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.9 , pp. 1243-1255
    • Constantinides, P.P.1    Tustian, A.2    Kessler, D.R.3
  • 49
    • 0027185429 scopus 로고
    • Solubilization and stabilization of an anti-HIV thiocarbamate, NSC 629243, for parenteral delivery, using extemporaneous emulsions
    • DOI 10.1023/A:1018935311304
    • RG Strickley BD Anderson 1993 Solubilization and stabilization of an anti-HIV thiocarbamate, NSC 629243, for parenteral delivery, using extemporaneous emulsions Pharm Res 10 1076 82 1:CAS:528:DyaK3sXmtFSnt7s%3D 8378251 10.1023/A:1018935311304 (Pubitemid 23211435)
    • (1993) Pharmaceutical Research , vol.10 , Issue.7 , pp. 1076-1082
    • Strickley, R.G.1    Anderson, B.D.2
  • 50
    • 0026684607 scopus 로고
    • Hydrolysis kinetics of phospholipids in thermally stressed intravenous lipid emulsion formulations
    • 1:CAS:528:DyaK38XltFygtbs%3D 1357131
    • CJ Herman MJ Groves 1992 Hydrolysis kinetics of phospholipids in thermally stressed intravenous lipid emulsion formulations J Pharm Pharmacol 44 539 42 1:CAS:528:DyaK38XltFygtbs%3D 1357131
    • (1992) J Pharm Pharmacol , vol.44 , pp. 539-42
    • Herman, C.J.1    Groves, M.J.2
  • 51
    • 0028037175 scopus 로고
    • Polyethylene glycol modified phospholipids stabilize emulsions prepared from triacylglycerol
    • DOI 10.1002/jps.2600831108
    • JJ Wheeler KF Wong SM Ansell D Masin MB Bally 1994 Polyethylene glycol modified phospholipids stabilize emulsions prepared from triacylglycerol J Pharm Sci 83 1558 64 1:CAS:528:DyaK2cXmtlyhu7k%3D 7891274 10.1002/jps.2600831108 (Pubitemid 24348325)
    • (1994) Journal of Pharmaceutical Sciences , vol.83 , Issue.11 , pp. 1558-1564
    • Wheeler, J.J.1    Wong, K.F.2    Ansell, S.M.3    Masin, D.4    Bally, M.B.5
  • 52
    • 0026352832 scopus 로고
    • Sterically stabilized liposomes: Improvements in pharmacokinetics and antitumor therapeutic efficacy
    • 1:CAS:528:DyaK38XmslWjsg%3D%3D 1763060 10.1073/pnas.88.24.11460
    • D Papahadjopoulos TM Allen A Gabizon E Mayhew K Matthay SK Huang, et al. 1991 Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy Proc Natl Acad Sci USA 88 11460 4 1:CAS:528:DyaK38XmslWjsg%3D%3D 1763060 10.1073/pnas.88.24.11460
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 11460-4
    • Papahadjopoulos, D.1    Allen, T.M.2    Gabizon, A.3    Mayhew, E.4    Matthay, K.5    Huang, S.K.6
  • 53
    • 0029048759 scopus 로고
    • Long-circulating emulsions (oil-in-water) as carriers for lipophilic drugs
    • 1:CAS:528:DyaK2MXmvFCks7s%3D 7494803 10.1023/A:1016274801930
    • F Liu D Liu 1995 Long-circulating emulsions (oil-in-water) as carriers for lipophilic drugs Pharm Res 12 1060 4 1:CAS:528:DyaK2MXmvFCks7s%3D 7494803 10.1023/A:1016274801930
    • (1995) Pharm Res , vol.12 , pp. 1060-4
    • Liu, F.1    Liu, D.2
  • 54
    • 0022598146 scopus 로고
    • Physostigmine emulsion: A new injectable controlled release delivery system
    • DOI 10.1016/0378-5173(86)90134-1
    • S Benita D Friedman M Weinstock 1986 Physostigmine emulsion: a new injectable controlled release delivery system Int J Pharm 30 47 55 1:CAS:528:DyaL28Xkt12qurY%3D 10.1016/0378-5173(86)90134-1 (Pubitemid 16101995)
    • (1986) International Journal of Pharmaceutics , vol.30 , Issue.1 , pp. 47-55
    • Benita, S.1    Friedman, D.2    Weinstock, M.3
  • 55
    • 0024381166 scopus 로고
    • Design and characterization of a submicronized o/w emulsion of diazepam for parenteral use
    • DOI 10.1016/0378-5173(89)90329-3
    • MY Levy S Benita 1989 Design and characterization of a submicronized o/w emulsion of diazepam for parenteral use Int J Pharm 54 103 12 1:CAS:528:DyaL1MXls1Sisbo%3D 10.1016/0378-5173(89)90329-3 (Pubitemid 19205235)
    • (1989) International Journal of Pharmaceutics , vol.54 , Issue.2 , pp. 103-112
    • Levy, M.Y.1    Benita, S.2
  • 56
    • 0344654705 scopus 로고    scopus 로고
    • Physicochemical properties of chitosan-lipid emulsions and their stability during the autoclaving process
    • DOI 10.1016/S0378-5173(99)00086-1, PII S0378517399000861
    • M Jumaa BW Müller 1999 Physicochemical properties of chitosan-lipid emulsions and their stability during the autoclaving process Int J Pharm 183 175 84 1:CAS:528:DyaK1MXjsFKltr4%3D 10361168 10.1016/S0378-5173(99)00086-1 (Pubitemid 29257963)
    • (1999) International Journal of Pharmaceutics , vol.183 , Issue.2 , pp. 175-184
    • Jumaa, M.1    Muller, B.W.2
  • 57
    • 0000831098 scopus 로고    scopus 로고
    • Emulsions as drug delivery systems
    • F. Nielloud G. Marti-Mestres (eds). Marcel Dekker New York
    • Buszello K, Muller BW. Emulsions as drug delivery systems. In: Nielloud F, Marti-Mestres G, editors. Pharmaceutical Emulsions and Suspensions. New York: Marcel Dekker; 2000. p. 191-229.
    • (2000) Pharmaceutical Emulsions and Suspensions , pp. 191-229
    • Buszello, K.1    Muller, B.W.2
  • 58
    • 0020563794 scopus 로고
    • The preparation and properties of sterile intravenous emulsions
    • 1:CAS:528:DyaL2cXntlyhuw%3D%3D 6620048
    • PK Hansrani SS Davis MJ Groves 1983 The preparation and properties of sterile intravenous emulsions J Parenter Sci Technol 37 145 50 1:CAS:528:DyaL2cXntlyhuw%3D%3D 6620048
    • (1983) J Parenter Sci Technol , vol.37 , pp. 145-50
    • Hansrani, P.K.1    Davis, S.S.2    Groves, M.J.3
  • 59
    • 0030602783 scopus 로고    scopus 로고
    • Stability of lipid emulsions for drug delivery
    • DOI 10.1016/0169-409X(95)00116-O
    • C Washington 1996 Stability of lipid emulsions for drug delivery Adv Drug Deliv Rev 20 131 45 1:CAS:528:DyaK28XmtFaitbw%3D 10.1016/0169-409X(95)00116-O (Pubitemid 26284153)
    • (1996) Advanced Drug Delivery Reviews , vol.20 , Issue.2-3 , pp. 131-145
    • Washington, C.1
  • 60
    • 0027141071 scopus 로고
    • Submicron emulsions as colloidal drug carriers for intravenous administration: Comprehensive physicochemical characterization
    • DOI 10.1002/jps.2600821102
    • S Benita MY Levy 1993 Submicron emulsions as colloidal drug carriers for intravenous administration: comprehensive physicochemical characterization J Pharm Sci 82 1069 79 1:CAS:528:DyaK2cXhsVOjuw%3D%3D 8289116 10.1002/jps. 2600821102 (Pubitemid 24004434)
    • (1993) Journal of Pharmaceutical Sciences , vol.82 , Issue.11 , pp. 1069-1079
    • Benita, S.1    Levy, M.Y.2
  • 61
    • 11144301189 scopus 로고    scopus 로고
    • Partition of antimicrobial additives in an intravenous emulsion and their effect on emulsion physical stability
    • DOI 10.1016/j.ijpharm.2004.10.002, PII S0378517304005939
    • J Han C Washington 2005 Partition of antimicrobial additives in an intravenous emulsion and their effect on emulsion physical stability Int J Pharm 288 263 71 1:CAS:528:DC%2BD2cXhtFGhurrF 15620866 10.1016/j.ijpharm.2004.10.002 (Pubitemid 40038579)
    • (2005) International Journal of Pharmaceutics , vol.288 , Issue.2 , pp. 263-271
    • Han, J.1    Washington, C.2
  • 62
    • 78651493842 scopus 로고    scopus 로고
    • Propofol Injectable Emulsion 1%. Hospira Inc. Available at Accessed11July2010
    • Propofol Injectable Emulsion 1%. Hospira Inc. Available at: http://www.hospira.com/Products/productcatalog.aspx. Accessed 11 July 2010.
  • 63
    • 8344259170 scopus 로고    scopus 로고
    • Fat-globule size in a propofol emulsion containing sodium metabisulfite
    • 1:CAS:528:DC%2BD2cXlvFCltrs%3D 15259759
    • DF Driscoll JG Dunbar A Marmarou 2004 Fat-globule size in a propofol emulsion containing sodium metabisulfite Am J Health Syst Pharm 61 1276 80 1:CAS:528:DC%2BD2cXlvFCltrs%3D 15259759
    • (2004) Am J Health Syst Pharm , vol.61 , pp. 1276-80
    • Driscoll, D.F.1    Dunbar, J.G.2    Marmarou, A.3
  • 64
    • 0025087119 scopus 로고
    • Parenteral emulsions for drug delivery
    • DOI 10.1016/0169-409X(90)90016-L
    • LC Collins-Gold RT Lyons LC Bartholow 1990 Parenteral emulsions for drug delivery Adv Drug Deliv Rev 5 189 208 1:CAS:528:DyaK3MXivF2kuw%3D%3D 10.1016/0169-409X(90)90016-L (Pubitemid 20333024)
    • (1990) Advanced Drug Delivery Reviews , vol.5 , Issue.3 , pp. 189-208
    • Collins-Gold, L.C.1    Lyons, R.T.2    Bartholow, L.C.3
  • 65
    • 0023946332 scopus 로고
    • The production of parenteral feeding emulsions by Microfluidizer
    • 1:CAS:528:DyaL1cXksVens70%3D 10.1016/0378-5173(88)90113-5
    • C Washington SS Davis 1988 The production of parenteral feeding emulsions by Microfluidizer Int J Pharm 44 169 76 1:CAS:528:DyaL1cXksVens70%3D 10.1016/0378-5173(88)90113-5
    • (1988) Int J Pharm , vol.44 , pp. 169-76
    • Washington, C.1    Davis, S.S.2
  • 66
    • 67651154360 scopus 로고    scopus 로고
    • Effect of high-pressure homogenization on droplet size distribution and rheological properties of ice cream mixes
    • 1:CAS:528:DC%2BD1MXlsFynurs%3D 19389944 10.3168/jds.2008-1797
    • N Innocente M Biasutti E Venir M Spaziani G Marchesini 2009 Effect of high-pressure homogenization on droplet size distribution and rheological properties of ice cream mixes J Dairy Sci 92 1864 75 1:CAS:528: DC%2BD1MXlsFynurs%3D 19389944 10.3168/jds.2008-1797
    • (2009) J Dairy Sci , vol.92 , pp. 1864-75
    • Innocente, N.1    Biasutti, M.2    Venir, E.3    Spaziani, M.4    Marchesini, G.5
  • 69
    • 0038692100 scopus 로고    scopus 로고
    • Intravenous itraconazole emulsions produced by SolEmuls technology
    • DOI 10.1016/S0939-6411(03)00063-8
    • A Akkar RH Müller 2003 Intravenous itraconazole emulsions produced by SolEmuls technology Eur J Pharm Biopharm 56 29 36 1:CAS:528: DC%2BD3sXltVSrtrg%3D 12837478 10.1016/S0939-6411(03)00063-8 (Pubitemid 36802044)
    • (2003) European Journal of Pharmaceutics and Biopharmaceutics , vol.56 , Issue.1 , pp. 29-36
    • Akkar, A.1    Muller, R.H.2
  • 70
    • 0022622551 scopus 로고
    • Parenteral emulsions as drug carrier systems
    • 1:CAS:528:DyaL28XhslCnsbg%3D 3517276
    • M Singh LJ Ravin 1986 Parenteral emulsions as drug carrier systems J Parenter Sci Technol 40 34 41 1:CAS:528:DyaL28XhslCnsbg%3D 3517276
    • (1986) J Parenter Sci Technol , vol.40 , pp. 34-41
    • Singh, M.1    Ravin, L.J.2
  • 71
    • 0038061596 scopus 로고    scopus 로고
    • Formulation of intravenous Carbamazepine emulsions by SolEmuls® technology
    • DOI 10.1016/S0939-6411(03)00028-6
    • A Akkar RH Müller 2003 Formulation of intravenous Carbamazepine emulsions by SolEmuls® technology Eur J Pharm Biopharm 55 305 12 1:CAS:528:DC%2BD3sXjs1Gjt7Y%3D 12754005 10.1016/S0939-6411(03)00028-6 (Pubitemid 36561557)
    • (2003) European Journal of Pharmaceutics and Biopharmaceutics , vol.55 , Issue.3 , pp. 305-312
    • Akkar, A.1    Muller, R.H.2
  • 72
    • 0346729796 scopus 로고    scopus 로고
    • SolEmuls® - Novel technology for the formulation of i.v. emulsions with poorly soluble drugs
    • DOI 10.1016/j.ijpharm.2003.09.019
    • RH Müller S Schmidt I Buttle A Akkar J Schmitt S Brömer 2004 SolEmuls®-novel technology for the formulation of i.v. emulsions with poorly soluble drugs Int J Pharm 269 293 302 14706241 10.1016/j.ijpharm.2003.09.019 1:CAS:528:DC%2BD3sXhtVSqu7fN (Pubitemid 38045293)
    • (2004) International Journal of Pharmaceutics , vol.269 , Issue.2 , pp. 293-302
    • Muller, R.H.1    Schmidt, S.2    Buttle, I.3    Akkar, A.4    Schmitt, J.5    Bromer, S.6
  • 74
    • 51449117858 scopus 로고    scopus 로고
    • Influence of incorporation methods on partitioning behavior of lipophilic drugs into various phases of a parenteral lipid emulsion
    • 1:CAS:528:DC%2BC3cXnslGjurg%3D 18496755 10.1208/s12249-008-9089-x
    • W Sila-on N Vardhanabhuti B Ongpipattanakul P Kulvanich 2008 Influence of incorporation methods on partitioning behavior of lipophilic drugs into various phases of a parenteral lipid emulsion AAPS PharmSciTech 9 684 92 1:CAS:528:DC%2BC3cXnslGjurg%3D 18496755 10.1208/s12249-008-9089-x
    • (2008) AAPS PharmSciTech , vol.9 , pp. 684-92
    • Sila-On, W.1    Vardhanabhuti, N.2    Ongpipattanakul, B.3    Kulvanich, P.4
  • 75
    • 0032919714 scopus 로고    scopus 로고
    • Structure and metabolic fate of triacylglycerol- and phospholipid-rich particles of commercial parenteral fat emulsions
    • DOI 10.1016/S0899-9007(98)00130-0, PII S0899900798001300
    • J Ferezou AC Bach 1999 Structure and metabolic fate of triacylglycerol- and phospholipid-rich particles of commercial parenteral fat emulsions Nutrition 15 44 50 1:CAS:528:DyaK1MXmtVyhsQ%3D%3D 9918062 10.1016/S0899-9007(98)00130-0 (Pubitemid 29031944)
    • (1999) Nutrition , vol.15 , Issue.1 , pp. 44-50
    • Ferezou, J.1    Bach, A.C.2
  • 76
    • 2642643370 scopus 로고
    • October 11
    • Federal Register 56 (198); 51354, October 11, 1991.
    • (1991) Federal Register , vol.56 , Issue.198 , pp. 51354
  • 79
    • 0042383348 scopus 로고    scopus 로고
    • Systematic characterization of oil-in-water emulsions for formulation design
    • DOI 10.1016/S0378-5173(03)00364-8
    • I Roland G Piel L Delattre B Evrard 2003 Systematic characterization of oil-in-water emulsions for formulation design Int J Pharm 263 85 94 1:CAS:528:DC%2BD3sXmvValt7g%3D 12954183 10.1016/S0378-5173(03)00364-8 (Pubitemid 37087935)
    • (2003) International Journal of Pharmaceutics , vol.263 , Issue.1-2 , pp. 85-94
    • Roland, I.1    Piel, G.2    Delattre, L.3    Evrard, B.4
  • 80
    • 0000548832 scopus 로고
    • Rheological properties of emulsions
    • P. Becher (eds). Marcel Dekker New York
    • Sherman P. Rheological properties of emulsions. In: Becher P, editor. Encylopedia of Emulsion Technology. New York: Marcel Dekker; 1983. p. 405.
    • (1983) Encylopedia of Emulsion Technology , pp. 405
    • Sherman, P.1
  • 81
    • 0027216015 scopus 로고
    • The influence of free fatty acid formation on the pH of phospholipid-stabilized triglyceride emulsions
    • DOI 10.1023/A:1018932421357
    • CJ Herman MJ Groves 1993 The influence of free fatty acid formation on the pH of phospholipid-stabilized triglyceride emulsions Pharm Res 10 774 6 1:CAS:528:DyaK3sXksFGqtb0%3D 8321844 10.1023/A:1018932421357 (Pubitemid 23152328)
    • (1993) Pharmaceutical Research , vol.10 , Issue.5 , pp. 774-776
    • Herman, C.J.1    Groves, M.J.2
  • 82
    • 33750589581 scopus 로고    scopus 로고
    • Lipid injectable emulsions: Pharmacopeial and safety issues
    • 1:CAS:528:DC%2BD28XptVaisrs%3D 16951994 10.1007/s11095-006-9092-4
    • DF Driscoll 2006 Lipid injectable emulsions: pharmacopeial and safety issues Pharm Res 23 1959 69 1:CAS:528:DC%2BD28XptVaisrs%3D 16951994 10.1007/s11095-006-9092-4
    • (2006) Pharm Res , vol.23 , pp. 1959-69
    • Driscoll, D.F.1
  • 83
    • 0025020415 scopus 로고
    • Drug release from microdisperse systems: A critical review
    • DOI 10.1016/0378-5173(90)90280-H
    • C Washington 1990 Drug release from microdisperse systems: a critical review Int J Pharm 58 1 12 1:CAS:528:DyaK3cXhtVClsLY%3D 10.1016/0378-5173(90) 90280-H (Pubitemid 20034221)
    • (1990) International Journal of Pharmaceutics , vol.58 , Issue.1 , pp. 1-12
    • Washington, C.1
  • 84
    • 0024317312 scopus 로고
    • Evaluation of non-sink dialysis methods for the measurement of drug release from colloids: effects of drug partition
    • DOI 10.1016/0378-5173(89)90062-8
    • C Washington 1989 Evaluation of non-sink dialysis methods for the measurement of drug release from colloids: effects of drug partition Int J Pharm 56 71 4 1:CAS:528:DyaK3cXisFGitg%3D%3D 10.1016/0378-5173(89)90062-8 (Pubitemid 19274692)
    • (1989) International Journal of Pharmaceutics , vol.56 , Issue.1 , pp. 71-74
    • Washington, C.1
  • 85
    • 33947163024 scopus 로고    scopus 로고
    • A novel in vitro release method for submicron sized dispersed systems
    • 1:STN:280:DC%2BD3MjgtVKrsg%3D%3D 11741207 10.1208/ps010311
    • N Chidambaram DJ Burgess 1999 A novel in vitro release method for submicron sized dispersed systems AAPS PharmSci 1 E11 1:STN:280: DC%2BD3MjgtVKrsg%3D%3D 11741207 10.1208/ps010311
    • (1999) AAPS PharmSci , vol.1 , pp. 11
    • Chidambaram, N.1    Burgess, D.J.2
  • 87
    • 1842711882 scopus 로고    scopus 로고
    • Formation and stability of nano-emulsions
    • 15072948 10.1016/j.cis.2003.10.023 1:CAS:528:DC%2BD2cXivFGmsbw%3D
    • T Tadros P Izquierdo J Esquena C Solans 2004 Formation and stability of nano-emulsions Adv Colloid Interface Sci 108-109 303 18 15072948 10.1016/j.cis.2003.10.023 1:CAS:528:DC%2BD2cXivFGmsbw%3D
    • (2004) Adv Colloid Interface Sci , vol.108-109 , pp. 303-18
    • Tadros, T.1    Izquierdo, P.2    Esquena, J.3    Solans, C.4
  • 88
    • 0025160614 scopus 로고
    • Effect of phospholipid emulsifiers on physicochemical properties of intravenous fat emulsions and/or drug carrier emulsions
    • 1:CAS:528:DyaK3cXlvFOrsbc%3D 1980297
    • F Ishii I Sasaki H Ogata 1990 Effect of phospholipid emulsifiers on physicochemical properties of intravenous fat emulsions and/or drug carrier emulsions J Pharm Pharmacol 42 513 5 1:CAS:528:DyaK3cXlvFOrsbc%3D 1980297
    • (1990) J Pharm Pharmacol , vol.42 , pp. 513-5
    • Ishii, F.1    Sasaki, I.2    Ogata, H.3
  • 89
    • 0024381166 scopus 로고
    • Design and characterization of a submicronized o/w emulsion of diazepam for parenteral use
    • DOI 10.1016/0378-5173(89)90329-3
    • S Benita MY Levy 1989 Design and characterization of a submicronized o/w emulsion of Diazepam for parenteral use Int J Pharm 54 103 12 10.1016/0378-5173(89)90329-3 (Pubitemid 19205235)
    • (1989) International Journal of Pharmaceutics , vol.54 , Issue.2 , pp. 103-112
    • Levy, M.Y.1    Benita, S.2
  • 90
    • 0345244827 scopus 로고    scopus 로고
    • The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions
    • DOI 10.1016/S0378-5173(97)00369-4, PII S0378517397003694
    • M Jumaa BW Müller 1998 The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions Int J Pharm 163 81 9 1:CAS:528:DyaK1cXitVeqtbk%3D 10.1016/S0378-5173(97)00369-4 (Pubitemid 28162622)
    • (1998) International Journal of Pharmaceutics , vol.163 , Issue.1-2 , pp. 81-89
    • Jumaa, M.1    Muller, B.W.2
  • 91
    • 0345044911 scopus 로고    scopus 로고
    • Lipid emulsions as a novel system to reduce the hemolytic activity of lytic agents: Mechanism of the protective effect
    • 1:CAS:528:DyaK1MXnslGrsLY%3D 10594386 10.1016/S0928-0987(99)00071-8
    • M Jumaa BW Muller 2000 Lipid emulsions as a novel system to reduce the hemolytic activity of lytic agents: mechanism of the protective effect Eur J Pharm Sci 9 285 90 1:CAS:528:DyaK1MXnslGrsLY%3D 10594386 10.1016/S0928-0987(99) 00071-8
    • (2000) Eur J Pharm Sci , vol.9 , pp. 285-90
    • Jumaa, M.1    Muller, B.W.2
  • 92
    • 0036185071 scopus 로고    scopus 로고
    • Stability of drug-carrier emulsions containing phosphatidylcholine mixtures
    • DOI 10.1016/S0939-6411(01)00230-2, PII S0939641101002302
    • M Trotta F Pattarino T Ignoni 2002 Stability of drug-carrier emulsions containing phosphatidylcholine mixtures Eur J Pharm Biopharm 53 203 8 1:CAS:528:DC%2BD38Xhs1yltro%3D 11880004 10.1016/S0939-6411(01)00230-2 (Pubitemid 34189795)
    • (2002) European Journal of Pharmaceutics and Biopharmaceutics , vol.53 , Issue.2 , pp. 203-208
    • Trotta, M.1    Pattarino, F.2    Ignoni, T.3
  • 93
    • 34248160590 scopus 로고    scopus 로고
    • Production of sub-micron emulsions by ultrasound and microfluidization techniques
    • DOI 10.1016/j.jfoodeng.2007.03.007, PII S0260877407001720
    • SM Jafari Y He B Bhandari 2007 Production of sub-micron emulsions by ultrasound and microfluidization techniques J Food Eng 82 478 88 10.1016/j.jfoodeng.2007.03.007 (Pubitemid 46726881)
    • (2007) Journal of Food Engineering , vol.82 , Issue.4 , pp. 478-488
    • Jafari, S.M.1    He, Y.2    Bhandari, B.3
  • 94
    • 51249195871 scopus 로고
    • Chromatographically homogeneous egg lecithin as stabilizer of emulsions for intravenous nutrition
    • 1:CAS:528:DyaF2cXkvVOms7Y%3D 10.1007/BF02661410
    • HJ Zeringue ML Brown WS Singleton 1964 Chromatographically homogeneous egg lecithin as stabilizer of emulsions for intravenous nutrition J Am Oil Chem Soc 41 688 91 1:CAS:528:DyaF2cXkvVOms7Y%3D 10.1007/BF02661410
    • (1964) J Am Oil Chem Soc , vol.41 , pp. 688-91
    • Zeringue, H.J.1    Brown, M.L.2    Singleton, W.S.3
  • 95
    • 14644407444 scopus 로고    scopus 로고
    • Properties of various phospholipid mixtures as emulsifiers or dispersing agents in nanoparticle drug carrier preparations
    • DOI 10.1016/j.colsurfb.2004.12.018, PII S0927776505000159
    • F Ishii T Nii 2005 Properties of various phospholipid mixtures as emulsifiers or dispersing agents in nanoparticle drug carrier preparations Colloids Surf B Biointerfaces 41 257 62 1:CAS:528:DC%2BD2MXhvVCgt78%3D 15748821 10.1016/j.colsurfb.2004.12.018 (Pubitemid 40312742)
    • (2005) Colloids and Surfaces B: Biointerfaces , vol.41 , Issue.4 , pp. 257-262
    • Ishii, F.1    Nii, T.2
  • 96
    • 84982610197 scopus 로고
    • The importance of the phase behaviour of phospholipids for emulsion stability
    • 1:CAS:528:DyaE1MXlt1ahtLk%3D 10.1002/lipi.19790810409
    • L Rydhag 1979 The importance of the phase behaviour of phospholipids for emulsion stability Fette Seifen Anstrichm 81 168 73 1:CAS:528:DyaE1MXlt1ahtLk%3D 10.1002/lipi.19790810409
    • (1979) Fette Seifen Anstrichm , vol.81 , pp. 168-73
    • Rydhag, L.1
  • 97
    • 0025201779 scopus 로고
    • The influence of charged lipids on the flocculation and coalescence of oil-in-water emulsions. II: Electrophoretic properties and monolayer film studies
    • 1:CAS:528:DyaK3MXhslWitLk%3D 2250200
    • JT Rubino 1990 The influence of charged lipids on the flocculation and coalescence of oil-in-water emulsions. II: electrophoretic properties and monolayer film studies J Parenter Sci Technol 44 247 52 1:CAS:528: DyaK3MXhslWitLk%3D 2250200
    • (1990) J Parenter Sci Technol , vol.44 , pp. 247-52
    • Rubino, J.T.1
  • 98
    • 8144221922 scopus 로고    scopus 로고
    • Properties of various phosphatidylcholines as emulsifiers or dispersing agents in microparticle preparations for drug carriers
    • DOI 10.1016/j.colsurfb.2004.08.017, PII S0927776504002632
    • T Nii F Ishii 2004 Properties of various phosphatidylcholines as emulsifiers or dispersing agents in microparticle preparations for drug carriers Colloids Surf B 39 57 63 1:CAS:528:DC%2BD2cXpslOqsbk%3D 10.1016/j.colsurfb. 2004.08.017 (Pubitemid 39473354)
    • (2004) Colloids and Surfaces B: Biointerfaces , vol.39 , Issue.1-2 , pp. 57-63
    • Nii, T.1    Ishii, F.2
  • 99
    • 38749148467 scopus 로고    scopus 로고
    • Physicochemical properties of structured phosphatidylcholine in drug carrier lipid emulsions for drug delivery systems
    • DOI 10.1016/j.colsurfb.2007.09.027, PII S0927776507003888
    • E Kawaguchi K-i Shimokawa F Ishii 2008 Physicochemical properties of structured phosphatidylcholine in drug carrier lipid emulsions for drug delivery systems Colloids Surf B Biointerfaces 62 130 5 1:CAS:528:DC%2BD1cXhsFygtb8%3D 17988839 10.1016/j.colsurfb.2007.09.027 (Pubitemid 351179249)
    • (2008) Colloids and Surfaces B: Biointerfaces , vol.62 , Issue.1 , pp. 130-135
    • Kawaguchi, E.1    Shimokawa, K.-i.2    Ishii, F.3
  • 100
    • 0033673996 scopus 로고    scopus 로고
    • Submicron emulsions as drug carriers. Studies on destabilization potential of various drugs
    • 1:CAS:528:DC%2BD3cXoslGhtL8%3D 11113636 10.1016/S0928-0987(00)00115-9
    • M Sznitowska S Janicki E Dabrowska K Zurowska-Pryczkowska 2001 Submicron emulsions as drug carriers. Studies on destabilization potential of various drugs Eur J Pharm Sci 12 175 9 1:CAS:528:DC%2BD3cXoslGhtL8%3D 11113636 10.1016/S0928-0987(00)00115-9
    • (2001) Eur J Pharm Sci , vol.12 , pp. 175-9
    • Sznitowska, M.1    Janicki, S.2    Dabrowska, E.3    Zurowska-Pryczkowska, K.4
  • 101
    • 0027219996 scopus 로고
    • The redistribution of bulk aqueous phase phospholipids during thermal stressing of phospholipid-stabilized emulsions
    • 1:CAS:528:DyaK3sXls1OlsL8%3D 8105050
    • MJ Groves CJ Herman 1993 The redistribution of bulk aqueous phase phospholipids during thermal stressing of phospholipid-stabilized emulsions J Pharm Pharmacol 45 592 6 1:CAS:528:DyaK3sXls1OlsL8%3D 8105050
    • (1993) J Pharm Pharmacol , vol.45 , pp. 592-6
    • Groves, M.J.1    Herman, C.J.2
  • 102
    • 0344653607 scopus 로고    scopus 로고
    • The stabilization of parenteral fat emulsion using non-ionic ABA copolymer surfactant
    • DOI 10.1016/S0378-5173(98)00222-1, PII S0378517398002221
    • M Jumaa BW Müller 1998 The stabilization of parenteral fat emulsion using non-ionic ABA copolymer surfactant Int J Pharm 174 29 37 1:CAS:528:DyaK1cXmsFGntLc%3D 10.1016/S0378-5173(98)00222-1 (Pubitemid 28486986)
    • (1998) International Journal of Pharmaceutics , vol.174 , Issue.1-2 , pp. 29-37
    • Jumaa, M.1    Muller, B.W.2
  • 103
    • 19044386704 scopus 로고    scopus 로고
    • Parenteral emulsions stabilized with a mixture of phospholipids and PEG-660-12-hydroxy-stearate: Evaluation of accelerated and long-term stability
    • DOI 10.1016/S0939-6411(02)00057-7, PII S0939641102000577
    • M Jumaa BW Muller 2002 Parenteral emulsions stabilized with a mixture of phospholipids and PEG-660-12-hydroxy-stearate: evaluation of accelerated and long-term stability Eur J Pharm Biopharm 54 207 12 1:CAS:528: DC%2BD38XmtlKjt7c%3D 12191693 10.1016/S0939-6411(02)00057-7 (Pubitemid 34919395)
    • (2002) European Journal of Pharmaceutics and Biopharmaceutics , vol.54 , Issue.2 , pp. 207-212
    • Jumaa, M.1    Muller, B.W.2
  • 104
    • 0026520002 scopus 로고
    • Effect of terminal heat sterilization on the stability of phospholipid-stabilized submicron emulsions
    • 1:CAS:528:DyaK38XktFCgu7s%3D 1515053
    • PR Chaturvedi NM Patel SA Lodhi 1992 Effect of terminal heat sterilization on the stability of phospholipid-stabilized submicron emulsions Acta Pharm Nord 4 51 5 1:CAS:528:DyaK38XktFCgu7s%3D 1515053
    • (1992) Acta Pharm Nord , vol.4 , pp. 51-5
    • Chaturvedi, P.R.1    Patel, N.M.2    Lodhi, S.A.3
  • 105
    • 0024319912 scopus 로고
    • Intravascular metabolism of fat emulsions: The Arvid Wretlind Lecture, ESPEN 1988
    • 1:STN:280:DC%2BD28vhsFGnsg%3D%3D 16837276 10.1016/0261-5614(89)90060-5
    • YA Carpentier 1989 Intravascular metabolism of fat emulsions: the Arvid Wretlind Lecture, ESPEN 1988 Clin Nutr 8 115 25 1:STN:280:DC%2BD28vhsFGnsg%3D%3D 16837276 10.1016/0261-5614(89)90060-5
    • (1989) Clin Nutr , vol.8 , pp. 115-25
    • Carpentier, Y.A.1
  • 107
    • 0029993739 scopus 로고    scopus 로고
    • Pharmacokinetics of highly lipophilic antitumor agent palmitoyl rhizoxin incorporated in lipid emulsions in rats
    • 1:CAS:528:DyaK28Xht1Ogsr8%3D 8850317
    • A Kurihara Y Shibayama A Mizota A Yasuno M Ikeda M Hisaoka 1996 Pharmacokinetics of highly lipophilic antitumor agent palmitoyl rhizoxin incorporated in lipid emulsions in rats Biol Pharm Bull 19 252 8 1:CAS:528:DyaK28Xht1Ogsr8%3D 8850317
    • (1996) Biol Pharm Bull , vol.19 , pp. 252-8
    • Kurihara, A.1    Shibayama, Y.2    Mizota, A.3    Yasuno, A.4    Ikeda, M.5    Hisaoka, M.6
  • 108
    • 0028816156 scopus 로고
    • Cyclosporin A in fat emulsion carriers: Experimental studies on pharmacokinetics and tissue distribution
    • 1:CAS:528:DyaK2MXjsl2ns7g%3D 7746794 10.1111/j.1600-0773.1995.tb00115.x
    • A Tibell A Lindholm J Sawe G Chen B Norrlind 1995 Cyclosporin A in fat emulsion carriers: experimental studies on pharmacokinetics and tissue distribution Pharmacol Toxicol 76 115 21 1:CAS:528:DyaK2MXjsl2ns7g%3D 7746794 10.1111/j.1600-0773.1995.tb00115.x
    • (1995) Pharmacol Toxicol , vol.76 , pp. 115-21
    • Tibell, A.1    Lindholm, A.2    Sawe, J.3    Chen, G.4    Norrlind, B.5
  • 110
    • 0019949024 scopus 로고
    • Parenteral formulation of hexamethylmelamine potentially suitable for use in man
    • 1:CAS:528:DyaL38XkslyrsL8%3D 6807543
    • MM Ames JS Kovach 1982 Parenteral formulation of hexamethylmelamine potentially suitable for use in man Cancer Treat Rep 66 1579 81 1:CAS:528:DyaL38XkslyrsL8%3D 6807543
    • (1982) Cancer Treat Rep , vol.66 , pp. 1579-81
    • Ames, M.M.1    Kovach, J.S.2
  • 111
    • 0024563129 scopus 로고
    • Propofol
    • 1:STN:280:DyaL1M3jtFKmtQ%3D%3D 2653816
    • JW Dundee RS Clarke 1989 Propofol Eur J Anaesthesiol 6 5 22 1:STN:280:DyaL1M3jtFKmtQ%3D%3D 2653816
    • (1989) Eur J Anaesthesiol , vol.6 , pp. 5-22
    • Dundee, J.W.1    Clarke, R.S.2
  • 112
    • 57849130704 scopus 로고    scopus 로고
    • Formulation of an intravenous emulsion loaded with a clarithromycin- phospholipid complex and its pharmacokinetics in rats
    • 1:CAS:528:DC%2BD1cXhsFCjurvJ 18835427 10.1016/j.ijpharm.2008.09.008
    • Y Lu Y Zhang Z Yang X Tang 2009 Formulation of an intravenous emulsion loaded with a clarithromycin-phospholipid complex and its pharmacokinetics in rats Int J Pharm 366 160 9 1:CAS:528:DC%2BD1cXhsFCjurvJ 18835427 10.1016/j.ijpharm.2008.09.008
    • (2009) Int J Pharm , vol.366 , pp. 160-9
    • Lu, Y.1    Zhang, Y.2    Yang, Z.3    Tang, X.4
  • 113
    • 0028010811 scopus 로고
    • Long circulating emulsion carrier systems for highly lipophilic drugs
    • 1:CAS:528:DyaK2cXivVSjurg%3D 8148799
    • T Takino K Konishi Y Takakura M Hashida 1994 Long circulating emulsion carrier systems for highly lipophilic drugs Biol Pharm Bull 17 121 5 1:CAS:528:DyaK2cXivVSjurg%3D 8148799
    • (1994) Biol Pharm Bull , vol.17 , pp. 121-5
    • Takino, T.1    Konishi, K.2    Takakura, Y.3    Hashida, M.4
  • 114
    • 0028805606 scopus 로고
    • O/W lipid emulsions for parenteral drug delivery. II. Effect of composition on pharmacokinetics of incorporated drug
    • 1:STN:280:DyaK283oslOjuw%3D%3D 8705256 10.3109/10611869509015949
    • T Sakaeda K Hirano 1995 O/W lipid emulsions for parenteral drug delivery. II. Effect of composition on pharmacokinetics of incorporated drug J Drug Target 3 221 30 1:STN:280:DyaK283oslOjuw%3D%3D 8705256 10.3109/10611869509015949
    • (1995) J Drug Target , vol.3 , pp. 221-30
    • Sakaeda, T.1    Hirano, K.2
  • 115
    • 0032437204 scopus 로고    scopus 로고
    • O/W lipid emulsions for parenteral drug delivery. III. Lipophilicity necessary for incorporation in oil particles even after intravenous injection
    • 1:CAS:528:DyaK1MXkvFKmsA%3D%3D 9886236 10.3109/10611869808997887
    • T Sakaeda K Hirano 1998 O/W lipid emulsions for parenteral drug delivery. III. Lipophilicity necessary for incorporation in oil particles even after intravenous injection J Drug Target 6 119 27 1:CAS:528:DyaK1MXkvFKmsA%3D%3D 9886236 10.3109/10611869808997887
    • (1998) J Drug Target , vol.6 , pp. 119-27
    • Sakaeda, T.1    Hirano, K.2
  • 116
    • 47049117837 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of chlorambucil delivered in parenteral emulsion
    • 1:CAS:528:DC%2BD1cXos12nu7o%3D 18508212 10.1016/j.ijpharm.2008.04.027
    • S Ganta JW Paxton BC Baguley S Garg 2008 Pharmacokinetics and pharmacodynamics of chlorambucil delivered in parenteral emulsion Int J Pharm 360 115 21 1:CAS:528:DC%2BD1cXos12nu7o%3D 18508212 10.1016/j.ijpharm.2008.04.027
    • (2008) Int J Pharm , vol.360 , pp. 115-21
    • Ganta, S.1    Paxton, J.W.2    Baguley, B.C.3    Garg, S.4
  • 117
    • 70449536486 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and safety of cinnarizine delivered in lipid emulsion
    • 1:CAS:528:DC%2BD1MXhsVCksrzL 19770029 10.1016/j.ijpharm.2009.09.025
    • S Shi H Chen X Lin X Tang 2010 Pharmacokinetics, tissue distribution and safety of cinnarizine delivered in lipid emulsion Int J Pharm 383 264 70 1:CAS:528:DC%2BD1MXhsVCksrzL 19770029 10.1016/j.ijpharm.2009.09.025
    • (2010) Int J Pharm , vol.383 , pp. 264-70
    • Shi, S.1    Chen, H.2    Lin, X.3    Tang, X.4
  • 118
    • 54349088541 scopus 로고    scopus 로고
    • Preparation and characterization of a submicron lipid emulsion of docetaxel: Submicron lipid emulsion of docetaxel
    • 1:CAS:528:DC%2BD1cXht1KrsbbJ 18720137 10.1080/03639040802005057
    • K Gao J Sun K Liu X Liu Z He 2008 Preparation and characterization of a submicron lipid emulsion of docetaxel: submicron lipid emulsion of docetaxel Drug Dev Ind Pharm 34 1227 37 1:CAS:528:DC%2BD1cXht1KrsbbJ 18720137 10.1080/03639040802005057
    • (2008) Drug Dev Ind Pharm , vol.34 , pp. 1227-37
    • Gao, K.1    Sun, J.2    Liu, K.3    Liu, X.4    He, Z.5
  • 119
    • 15544375477 scopus 로고    scopus 로고
    • Plasma kinetics and uptake by the tumor of a cholesterol-rich microemulsion (LDE) associated to etoposide oleate in patients with ovarian carcinoma
    • DOI 10.1016/j.ygyno.2004.12.015
    • CH Azevedo JP Carvalho CJ Valduga RC Maranhao 2005 Plasma kinetics and uptake by the tumor of a cholesterol-rich microemulsion (LDE) associated to etoposide oleate in patients with ovarian carcinoma Gynecol Oncol 97 178 82 1:CAS:528:DC%2BD2MXis1Grsb8%3D 15790455 10.1016/j.ygyno.2004.12.015 (Pubitemid 40403691)
    • (2005) Gynecologic Oncology , vol.97 , Issue.1 , pp. 178-182
    • Azevedo, C.H.M.1    Carvalho, J.P.2    Valduga, C.J.3    Maranhao, R.C.4
  • 120
    • 0031962483 scopus 로고    scopus 로고
    • Preliminary evaluation of AS-013 (prodrug of prostaglandin E1) administration for chronic peripheral arterial occlusive disease
    • H Matsuo 1998 Preliminary evaluation of AS-013 (prodrug of prostaglandin E1) administration for chronic peripheral arterial occlusive disease Int J Angiology 7 22 4
    • (1998) Int J Angiology , vol.7 , pp. 22-4
    • Matsuo, H.1
  • 121
    • 18744406323 scopus 로고    scopus 로고
    • Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion: In vitro and in vivo studies
    • DOI 10.1007/s00280-004-0930-y
    • DG Rodrigues DA Maria DC Fernandes CJ Valduga RD Couto OC Ibanez, et al. 2005 Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion: in vitro and in vivo studies Cancer Chemother Pharmacol 55 565 76 1:CAS:528:DC%2BD2MXjslOmt7g%3D 15726368 10.1007/s00280-004-0930-y (Pubitemid 40674632)
    • (2005) Cancer Chemotherapy and Pharmacology , vol.55 , Issue.6 , pp. 565-576
    • Rodrigues, D.G.1    Maria, D.A.2    Fernandes, D.C.3    Valduga, C.J.4    Couto, R.D.5    Ibanez, O.C.M.6    Maranhao, R.C.7
  • 122
    • 61649114706 scopus 로고    scopus 로고
    • Preparation and evaluation of 2-(allylthio)pyrazine-loaded lipid emulsion with enhanced stability and liver targeting
    • 1:CAS:528:DC%2BD1MXjsFGqtb8%3D 19016100 10.1080/03639040802363696
    • JH Jang CK Kim HG Choi JH Sung 2009 Preparation and evaluation of 2-(allylthio)pyrazine-loaded lipid emulsion with enhanced stability and liver targeting Drug Dev Ind Pharm 35 363 8 1:CAS:528:DC%2BD1MXjsFGqtb8%3D 19016100 10.1080/03639040802363696
    • (2009) Drug Dev Ind Pharm , vol.35 , pp. 363-8
    • Jang, J.H.1    Kim, C.K.2    Choi, H.G.3    Sung, J.H.4
  • 125
    • 0034872367 scopus 로고    scopus 로고
    • Parenteral structured triglyceride emulsion improves nitrogen balance and is cleared faster from the blood in moderately catabolic patients
    • 1:CAS:528:DC%2BD3MXmvVansr8%3D 11531213 10.1177/0148607101025005237
    • JW Kruimel TH Naber JA van der Vliet C Carneheim MB Katan JB Jansen 2001 Parenteral structured triglyceride emulsion improves nitrogen balance and is cleared faster from the blood in moderately catabolic patients JPEN J Parenter Enteral Nutr 25 237 44 1:CAS:528:DC%2BD3MXmvVansr8%3D 11531213 10.1177/0148607101025005237
    • (2001) JPEN J Parenter Enteral Nutr , vol.25 , pp. 237-44
    • Kruimel, J.W.1    Naber, T.H.2    Van Der Vliet, J.A.3    Carneheim, C.4    Katan, M.B.5    Jansen, J.B.6
  • 127
    • 33751078857 scopus 로고    scopus 로고
    • Triglycerides in fish oil affect the blood clearance of lipid emulsions containing long- and medium-chain triglycerides in mice
    • 1:CAS:528:DC%2BD28XhtFGqtLbJ 17056798
    • K Qi T Seo Z Jiang YA Carpentier RJ Deckelbaum 2006 Triglycerides in fish oil affect the blood clearance of lipid emulsions containing long- and medium-chain triglycerides in mice J Nutr 136 2766 72 1:CAS:528: DC%2BD28XhtFGqtLbJ 17056798
    • (2006) J Nutr , vol.136 , pp. 2766-72
    • Qi, K.1    Seo, T.2    Jiang, Z.3    Carpentier, Y.A.4    Deckelbaum, R.J.5
  • 128
    • 0037022812 scopus 로고    scopus 로고
    • Omega-3 triglycerides modify blood clearance and tissue targeting pathways of lipid emulsions
    • DOI 10.1021/bi015770h
    • K Qi T Seo M Al-Haideri TS Worgall T Vogel YA Carpentier, et al. 2002 Omega-3 triglycerides modify blood clearance and tissue targeting pathways of lipid emulsions Biochemistry 41 3119 27 1:CAS:528:DC%2BD38XhtVKisrg%3D 11863451 10.1021/bi015770h (Pubitemid 34184643)
    • (2002) Biochemistry , vol.41 , Issue.9 , pp. 3119-3127
    • Qi, K.1    Seo, T.2    Al-Haideri, M.3    Worgall, T.S.4    Vogel, T.5    Carpentier, Y.A.6    Deckelbaum, R.J.7
  • 129
    • 0022601923 scopus 로고
    • Effects of cholesterol content on the metabolism of protein-free emulsion models of lipoproteins
    • 1:CAS:528:DyaL28XhtVKrtbc%3D 3080026
    • RC Maranhao AM Tercyak TG Redgrave 1986 Effects of cholesterol content on the metabolism of protein-free emulsion models of lipoproteins Biochim Biophys Acta 875 247 55 1:CAS:528:DyaL28XhtVKrtbc%3D 3080026
    • (1986) Biochim Biophys Acta , vol.875 , pp. 247-55
    • Maranhao, R.C.1    Tercyak, A.M.2    Redgrave, T.G.3
  • 130
    • 0028060081 scopus 로고
    • Effects of cholesterol and cholesteryl oleate on lipolysis and liver uptake of triglyceride/phosphatidylcholine emulsions in rats
    • DOI 10.1023/A:1018990327466
    • T Handa Y Eguchi K Miyajima 1994 Effects of cholesterol and cholesteryl oleate on lipolysis and liver uptake of triglyceride/phosphatidylcholine emulsions in rats Pharm Res 11 1283 7 1:CAS:528:DyaK2cXmt1OjtLs%3D 7816757 10.1023/A:1018990327466 (Pubitemid 24287407)
    • (1994) Pharmaceutical Research , vol.11 , Issue.9 , pp. 1283-1287
    • Handa, T.1    Eguchi, Y.2    Miyajima, K.3
  • 131
    • 0026011078 scopus 로고
    • Plasma clearance of emulsified triolein in conscious rats: Effects of phosphatidylcholine species, cholesterol content and emulsion surface physical state
    • 1:CAS:528:DyaK3MXkt1Wmtrk%3D 2015073
    • SB Clark A Derksen DM Small 1991 Plasma clearance of emulsified triolein in conscious rats: effects of phosphatidylcholine species, cholesterol content and emulsion surface physical state Exp Physiol 76 39 52 1:CAS:528: DyaK3MXkt1Wmtrk%3D 2015073
    • (1991) Exp Physiol , vol.76 , pp. 39-52
    • Clark, S.B.1    Derksen, A.2    Small, D.M.3
  • 132
    • 0023935984 scopus 로고
    • Effects of phospholipid composition on the metabolism of triacylglycerol, cholesteryl ester and phosphatidylcholine from lipid emulsions injected intravenously in rats
    • 1:CAS:528:DyaL1cXktVCgsLc%3D 3358943
    • NP Lenzo I Martins BC Mortimer TG Redgrave 1988 Effects of phospholipid composition on the metabolism of triacylglycerol, cholesteryl ester and phosphatidylcholine from lipid emulsions injected intravenously in rats Biochim Biophys Acta 960 111 8 1:CAS:528:DyaL1cXktVCgsLc%3D 3358943
    • (1988) Biochim Biophys Acta , vol.960 , pp. 111-8
    • Lenzo, N.P.1    Martins, I.2    Mortimer, B.C.3    Redgrave, T.G.4
  • 133
    • 0023652641 scopus 로고
    • Phosphatidylcholine composition of emulsions influences triacylglycerol lipolysis and clearance from plasma
    • 1:CAS:528:DyaL2sXkvFGrsrw%3D 3593755
    • SB Clark A Derksen 1987 Phosphatidylcholine composition of emulsions influences triacylglycerol lipolysis and clearance from plasma Biochim Biophys Acta 920 37 46 1:CAS:528:DyaL2sXkvFGrsrw%3D 3593755
    • (1987) Biochim Biophys Acta , vol.920 , pp. 37-46
    • Clark, S.B.1    Derksen, A.2
  • 134
    • 0024308376 scopus 로고
    • The effect of stabilising agents on the organ distribution of lipid emulsions
    • DOI 10.1016/0378-5173(89)90163-4
    • L Illum C Washington SS Davis 1989 The effect of stabilising agents on the organ distribution of lipid emulsions Int J Pharm 54 41 9 1:CAS:528:DyaL1MXls1Sisrw%3D 10.1016/0378-5173(89)90163-4 (Pubitemid 19198399)
    • (1989) International Journal of Pharmaceutics , vol.54 , Issue.1 , pp. 41-49
    • Illum, L.1    West, P.2    Washington, C.3    Davis, S.S.4
  • 135
    • 0028936166 scopus 로고
    • Inverse targeting of drugs to reticuloendothelial system-rich organs by lipid microemulsion emulsified with poloxamer 338
    • DOI 10.1016/0378-5173(94)00193-9
    • M-J Lee M-H Lee C-K Shim 1995 Inverse targeting of drugs to reticuloendothelial system-rich organs by lipid microemulsion emulsified with poloxamer 338 Int J Pharm 113 175 87 1:CAS:528:DyaK2MXhvFCisbk%3D 10.1016/0378-5173(94)00193-9 (Pubitemid 24344225)
    • (1995) International Journal of Pharmaceutics , vol.113 , Issue.2 , pp. 175-187
    • Lee, M.-J.1    Lee, M.-H.2    Shim, C.-K.3
  • 136
    • 0037732580 scopus 로고    scopus 로고
    • Effect of oxyethylene moieties in hydrogenated castor oil on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with hydrogenated castor oil and soybean oil in rats
    • DOI 10.1080/1061186031000086081
    • K Ueda Y Yamazaki H Noto Y Teshima C Yamashita T Sakaeda, et al. 2003 Effect of oxyethylene moieties in hydrogenated castor oil on the pharmacokinetics of menatetrenone incorporated in O/W lipid emulsions prepared with hydrogenated castor oil and soybean oil in rats J Drug Target 11 37 43 1:CAS:528:DC%2BD3sXislyisbw%3D 12852439 10.1080/1061186031000086081 (Pubitemid 36527394)
    • (2003) Journal of Drug Targeting , vol.11 , Issue.1 , pp. 37-43
    • Ueda, K.1    Yamazaki, Y.2    Noto, H.3    Teshima, Y.4    Yamashita, C.5    Sakaeda, T.6    Iwakawa, S.7
  • 137
    • 0031839172 scopus 로고    scopus 로고
    • Surface composition regulates clearance from plasma and triolein lipolysis of lipid emulsions
    • 1:CAS:528:DyaK1cXlsFOhtLg%3D 9727607 10.1007/s11745-998-0269-8
    • I Arimoto C Matsumoto M Tanaka K Okuhira H Saito T Handa 1998 Surface composition regulates clearance from plasma and triolein lipolysis of lipid emulsions Lipids 33 773 9 1:CAS:528:DyaK1cXlsFOhtLg%3D 9727607 10.1007/s11745-998-0269-8
    • (1998) Lipids , vol.33 , pp. 773-9
    • Arimoto, I.1    Matsumoto, C.2    Tanaka, M.3    Okuhira, K.4    Saito, H.5    Handa, T.6
  • 138
    • 0037450958 scopus 로고    scopus 로고
    • Effects of sphingomyelin on apolipoprotein E- and lipoprotein lipase-mediated cell uptake of lipid particles
    • 1:CAS:528:DC%2BD3sXhvFaisbo%3D 12633683
    • SY Morita K Okuhira N Tsuchimoto A Vertut-Doi H Saito M Nakano, et al. 2003 Effects of sphingomyelin on apolipoprotein E- and lipoprotein lipase-mediated cell uptake of lipid particles Biochim Biophys Acta 1631 169 76 1:CAS:528:DC%2BD3sXhvFaisbo%3D 12633683
    • (2003) Biochim Biophys Acta , vol.1631 , pp. 169-76
    • Morita, S.Y.1    Okuhira, K.2    Tsuchimoto, N.3    Vertut-Doi, A.4    Saito, H.5    Nakano, M.6
  • 139
    • 0026628773 scopus 로고
    • Effects of sphingomyelin and phosphatidylcholine acyl chains on the clearance of triacylglycerol-rich lipoproteins from plasma. Studies with lipid emulsions in rats
    • 1:CAS:528:DyaK38XksVGhs7Y%3D 1606176
    • TG Redgrave V Rakic BC Mortimer JC Mamo 1992 Effects of sphingomyelin and phosphatidylcholine acyl chains on the clearance of triacylglycerol-rich lipoproteins from plasma. Studies with lipid emulsions in rats Biochim Biophys Acta 1126 65 72 1:CAS:528:DyaK38XksVGhs7Y%3D 1606176
    • (1992) Biochim Biophys Acta , vol.1126 , pp. 65-72
    • Redgrave, T.G.1    Rakic, V.2    Mortimer, B.C.3    Mamo, J.C.4
  • 140
    • 30844447403 scopus 로고    scopus 로고
    • Pharmacokinetics and tissue distribution of etoposide delivered in long circulating parenteral emulsion
    • DOI 10.1080/10611860500403156, PII U836482442555
    • PR Reddy V Venkateswarlu 2005 Pharmacokinetics and tissue distribution of etoposide delivered in long circulating parenteral emulsion J Drug Target 13 543 53 1:CAS:528:DC%2BD2MXhtlGht7zO 16390815 10.1080/10611860500403156 (Pubitemid 43101953)
    • (2005) Journal of Drug Targeting , vol.13 , Issue.10 , pp. 543-553
    • Reddy, P.R.1    Venkateswarlu, V.2
  • 141
    • 0035962389 scopus 로고    scopus 로고
    • Oil components modulate physical characteristics and function of the natural oil emulsions as drug or gene delivery system
    • DOI 10.1016/S0168-3659(00)00363-1, PII S0168365900003631
    • H Chung TW Kim M Kwon IC Kwon SY Jeong 2001 Oil components modulate physical characteristics and function of the natural oil emulsions as drug or gene delivery system J Control Release 71 339 50 1:CAS:528:DC%2BD3MXitlOhs70%3D 11295226 10.1016/S0168-3659(00)00363-1 (Pubitemid 32276053)
    • (2001) Journal of Controlled Release , vol.71 , Issue.3 , pp. 339-350
    • Chung, H.1    Kim, T.W.2    Kwon, M.3    Kwon, I.C.4    Jeong, S.Y.5
  • 142
    • 14644387506 scopus 로고    scopus 로고
    • Dialkylphosphatidylcholine and egg yolk lecithin for emulsification of various triglycerides
    • DOI 10.1016/j.colsurfb.2004.12.017, PII S0927776505000147
    • T Nii F Ishii 2005 Dialkylphosphatidylcholine and egg yolk lecithin for emulsification of various triglycerides Colloids Surf B Biointerfaces 41 305 11 1:CAS:528:DC%2BD2MXhvVCgtL0%3D 15748826 10.1016/j.colsurfb.2004.12.017 (Pubitemid 40312746)
    • (2005) Colloids and Surfaces B: Biointerfaces , vol.41 , Issue.4 , pp. 305-311
    • Nii, T.1    Ishii, F.2
  • 143
    • 0029970949 scopus 로고    scopus 로고
    • Lipid emulsions of palmitoylrhizoxin: Effects of composition on lipolysis and biodistribution
    • DOI 10.1002/(SICI)1099-081X(199605)17:4<331::AID-BDD959>3.0.CO;2-B
    • A Kurihara Y Shibayama A Mizota A Yasuno M Ikeda K Sasagawa, et al. 1996 Lipid emulsions of palmitoylrhizoxin: effects of composition on lipolysis and biodistribution Biopharm Drug Dispos 17 331 42 1:CAS:528:DyaK28Xjt1Ggu7Y%3D 8743404 10.1002/(SICI)1099-081X(199605)17:4<331::AID-BDD959>3.0.CO;2-B (Pubitemid 26178151)
    • (1996) Biopharmaceutics and Drug Disposition , vol.17 , Issue.4 , pp. 331-342
    • Kurihara, A.1    Shibayama, Y.2    Mizota, A.3    Yasuno, A.4    Ikeda, M.5    Sasagawa, K.6    Kobayashi, T.7    Hisaoka, M.8
  • 144
    • 0024835306 scopus 로고
    • Fat emulsion particle size: Influence on the clearance rate and the tissue lipolytic activity
    • 1:CAS:528:DyaK3cXnsFOguw%3D%3D 2596427
    • O Lutz Z Meraihi JL Mura A Frey GH Riess AC Bach 1989 Fat emulsion particle size: influence on the clearance rate and the tissue lipolytic activity Am J Clin Nutr 50 1370 81 1:CAS:528:DyaK3cXnsFOguw%3D%3D 2596427
    • (1989) Am J Clin Nutr , vol.50 , pp. 1370-81
    • Lutz, O.1    Meraihi, Z.2    Mura, J.L.3    Frey, A.4    Riess, G.H.5    Bach, A.C.6
  • 145
    • 0028936168 scopus 로고
    • Pharmacokinetic disposition analysis of lipophilic drugs injected with various lipid carriers in the single-pass rat liver perfusion system
    • DOI 10.1016/0378-5173(94)00211-M
    • T Takino E Nagahama T Sakaeda F Yamashita Y Takakura M Hashida 1995 Pharmacokinetic disposition analysis of lipophilic drugs injected with various lipid carriers in the single-pass rat liver perfusion system Int J Pharm 114 43 54 1:CAS:528:DyaK2MXivVKrtr8%3D 10.1016/0378-5173(94)00211-M (Pubitemid 24377028)
    • (1995) International Journal of Pharmaceutics , vol.114 , Issue.1 , pp. 43-54
    • Takino, T.1    Nagahama, E.2    Sakaeda, T.3    Yamashita, F.4    Takakura, Y.5    Hashida, M.6
  • 146
    • 0029914973 scopus 로고    scopus 로고
    • Enhanced tumor delivery and antitumor activity of palmitoyl rhizoxin using stable lipid emulsions in mice
    • DOI 10.1023/A:1016063719541
    • A Kurihara Y Shibayama A Mizota A Yasuno M Ikeda K Sasagawa, et al. 1996 Enhanced tumor delivery and antitumor activity of palmitoyl rhizoxin using stable lipid emulsions in mice Pharm Res 13 305 10 1:CAS:528:DyaK28Xht1Oku7Y%3D 8932454 10.1023/A:1016063719541 (Pubitemid 26074196)
    • (1996) Pharmaceutical Research , vol.13 , Issue.2 , pp. 305-310
    • Kurihara, A.1    Shibayama, Y.2    Mizota, A.3    Yasuno, A.4    Ikeda, M.5    Sasagawa, K.6    Kobayashi, T.7    Hisaoka, M.8
  • 147
    • 41049102225 scopus 로고    scopus 로고
    • Cleviprex Injectable Emulsion Available at: Accessed11July2010
    • Cleviprex Injectable Emulsion. Orange book. Available at: http://www.accessdata.fda.gov/scripts/cder/ob/docs/tempai.cfm. Accessed 11 July 2010.
    • Orange Book
  • 148
    • 77951754712 scopus 로고    scopus 로고
    • Clevidipine: A short-acting intravenous dihydropyridine calcium channel blocker for the management of hypertension
    • 1:CAS:528:DC%2BC3cXntVantLo%3D 20412001 10.1592/phco.30.5.515
    • AL Erickson JR DeGrado JR Fanikos 2010 Clevidipine: a short-acting intravenous dihydropyridine calcium channel blocker for the management of hypertension Pharmacotherapy 30 515 28 1:CAS:528:DC%2BC3cXntVantLo%3D 20412001 10.1592/phco.30.5.515
    • (2010) Pharmacotherapy , vol.30 , pp. 515-28
    • Erickson, A.L.1    Degrado, J.R.2    Fanikos, J.R.3
  • 149
    • 0002862833 scopus 로고    scopus 로고
    • Design and evaluation of submicron emulsions as colloidal drug carriers for intravenous adminsitration
    • S. Benita (eds). Harwood Academic Publishers Amsterdam
    • Klang S, Benita S. Design and evaluation of submicron emulsions as colloidal drug carriers for intravenous adminsitration. In: Benita S, editor. Submicron emulsions in drug targeting and delivery. Amsterdam: Harwood Academic Publishers; 1998. p. 119-52.
    • (1998) Submicron Emulsions in Drug Targeting and Delivery , pp. 119-52
    • Klang, S.1    Benita, S.2
  • 150
    • 0002907007 scopus 로고    scopus 로고
    • Emulsions as drug carriers-possibilities, limitations and future prespectives
    • R.H. Muller S. Benita B. Bohm (eds). Medpharm Scientific Publishers Stuttgart
    • Klang S, Parnas M, Benita S. Emulsions as drug carriers-possibilities, limitations and future prespectives. In: Muller RH, Benita S, Bohm B, editors. Emulsions and nanosuspensions for the formulation of poorly soluble drugs. Stuttgart: Medpharm Scientific Publishers; 1998. p. 31-60.
    • (1998) Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs , pp. 31-60
    • Klang, S.1    Parnas, M.2    Benita, S.3
  • 152
    • 0036286457 scopus 로고    scopus 로고
    • Antitumor effects and pharmacokinetics of aclacinomycin A carried by injectable emulsions composed of vitamin E, cholesterol, and PEG-lipid
    • DOI 10.1002/jps.10104
    • J Wang Y Maitani K Takayama 2002 Antitumor effects and pharmacokinetics of aclacinomycin A carried by injectable emulsions composed of vitamin E, cholesterol, and PEG-lipid J Pharm Sci 91 1128 34 1:CAS:528:DC%2BD38XjtFKhu7g%3D 11948551 10.1002/jps.10104 (Pubitemid 34640937)
    • (2002) Journal of Pharmaceutical Sciences , vol.91 , Issue.4 , pp. 1128-1134
    • Wang, J.1    Maitani, Y.2    Takayama, K.3
  • 153
    • 33747340819 scopus 로고    scopus 로고
    • Inhibition of liver metastasis by all-trans retinoic acid incorporated into O/W emulsions in mice
    • DOI 10.1016/j.ijpharm.2006.05.008, PII S0378517306003693
    • N Chansri S Kawakami F Yamashita M Hashida 2006 Inhibition of liver metastasis by all-trans retinoic acid incorporated into O/W emulsions in mice Int J Pharm 321 42 9 1:CAS:528:DC%2BD28Xos12rsbk%3D 16790329 10.1016/j.ijpharm.2006.05.008 (Pubitemid 44247410)
    • (2006) International Journal of Pharmaceutics , vol.321 , Issue.1-2 , pp. 42-49
    • Chansri, N.1    Kawakami, S.2    Yamashita, F.3    Hashida, M.4
  • 154
    • 33751202152 scopus 로고    scopus 로고
    • Inhibition of pulmonary metastasis in mice by all-trans retinoic acid incorporated in cationic liposomes
    • DOI 10.1016/j.jconrel.2006.08.025, PII S0168365906004378
    • S Suzuki S Kawakami N Chansri F Yamashita M Hashida 2006 Inhibition of pulmonary metastasis in mice by all-trans retinoic acid incorporated in cationic liposomes J Control Release 116 58 63 1:CAS:528:DC%2BD28Xht1emsrfJ 17067713 10.1016/j.jconrel.2006.08.025 (Pubitemid 44792300)
    • (2006) Journal of Controlled Release , vol.116 , Issue.1 , pp. 58-63
    • Suzuki, S.1    Kawakami, S.2    Chansri, N.3    Yamashita, F.4    Hashida, M.5
  • 155
    • 77955097506 scopus 로고    scopus 로고
    • Biorelevant media simulating fed state intestinal fluids: Colloid phase characterization and impact on solubilization capacity
    • 1:CAS:528:DC%2BC3cXnvFGrsrk%3D 20564382 10.1002/jps.22122
    • K Kleberg F Jacobsen DG Fatouros A Müllertz 2010 Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity J Pharm Sci 99 3522 32 1:CAS:528: DC%2BC3cXnvFGrsrk%3D 20564382 10.1002/jps.22122
    • (2010) J Pharm Sci , vol.99 , pp. 3522-32
    • Kleberg, K.1    Jacobsen, F.2    Fatouros, D.G.3    Müllertz, A.4
  • 156
    • 0024416049 scopus 로고
    • In vitro and in vivo activities of clarithromycin against Mycobacterium avium
    • 1:CAS:528:DyaL1MXlvVKqtLg%3D 2530933
    • PB Fernandes DJ Hardy D McDaniel CW Hanson RN Swanson 1989 In vitro and in vivo activities of clarithromycin against Mycobacterium avium Antimicrob Agents Chemother 33 1531 4 1:CAS:528:DyaL1MXlvVKqtLg%3D 2530933
    • (1989) Antimicrob Agents Chemother , vol.33 , pp. 1531-4
    • Fernandes, P.B.1    Hardy, D.J.2    McDaniel, D.3    Hanson, C.W.4    Swanson, R.N.5
  • 157
    • 0036805875 scopus 로고    scopus 로고
    • Improved oral bioavailability of cyclosporin A in male Wistar rats: Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension
    • DOI 10.1016/S0378-5173(02)00339-3, PII S0378517302003393
    • RC Bravo Gonzalez J Huwyler I Walter R Mountfield B Bittner 2002 Improved oral bioavailability of cyclosporin A in male Wistar rats. Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension Int J Pharm 245 143 51 1:CAS:528:DC%2BD38XntFygsrY%3D 12270251 10.1016/S0378-5173(02) 00339-3 (Pubitemid 35299900)
    • (2002) International Journal of Pharmaceutics , vol.245 , Issue.1-2 , pp. 143-151
    • Bravo Gonzalez, R.C.1    Huwyler, J.2    Walter, I.3    Mountfield, R.4    Bittner, B.5
  • 158
    • 46549083407 scopus 로고    scopus 로고
    • Enhancement of skin permeation of docetaxel: A novel approach combining microneedle and elastic liposomes
    • 1:CAS:528:DC%2BD1cXnsFaltbc%3D 18538885 10.1016/j.jconrel.2008.04.019
    • Y Qiu Y Gao K Hu F Li 2008 Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes J Control Release 129 144 50 1:CAS:528:DC%2BD1cXnsFaltbc%3D 18538885 10.1016/j.jconrel.2008.04.019
    • (2008) J Control Release , vol.129 , pp. 144-50
    • Qiu, Y.1    Gao, Y.2    Hu, K.3    Li, F.4
  • 159
    • 0032421954 scopus 로고    scopus 로고
    • O/W lipid emulsions for parenteral drug delivery. IV. Changes in the pharmacokinetics and pharmacodynamics of a highly lipophilic drug, menatetrenone
    • 1:CAS:528:DyaK1MXkvFKnsw%3D%3D 9888304 10.3109/10611869808997892
    • T Sakaeda H Kakushi T Shike K Takano T Harauchi M Hirata, et al. 1998 O/W lipid emulsions for parenteral drug delivery. IV. Changes in the pharmacokinetics and pharmacodynamics of a highly lipophilic drug, menatetrenone J Drug Target 6 183 9 1:CAS:528:DyaK1MXkvFKnsw%3D%3D 9888304 10.3109/10611869808997892
    • (1998) J Drug Target , vol.6 , pp. 183-9
    • Sakaeda, T.1    Kakushi, H.2    Shike, T.3    Takano, K.4    Harauchi, T.5    Hirata, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.