The possible role of vitamin K deficiency in the pathogenesis of Alzheimer's disease and in augmenting brain damage associated with cardiovascular disease

Medical Hypotheses

Volumn 57, Issue 2, 2001, Pages 151-155

  Allison, A C ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; COUMARIN DERIVATIVE; GROWTH FACTOR; SULFOTRANSFERASE; TYROSINE KINASE RECEPTOR; VITAMIN K GROUP;

ALZHEIMER DISEASE; BRAIN INJURY; CARDIOVASCULAR DISEASE; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GENOTYPE; HUMAN; HYPOTHESIS; MALE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SULFATION; VITAMIN K DEFICIENCY; VITAMIN SUPPLEMENTATION;

EID: 0034924606     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.2001.1307     Document Type: Article

References (29)

1. Estimated prevalence of Alzheimer's disease in the United States
2. Consensus report of the working group on: "Molecular and biochemical markers of Alzheimer's disease"
3. Utility of the apolipoprotein-E genotype in the diagnosis of Alzheimer's disease
4. Pharmacologic management of Alzheimer's disease
5. Advances in methodology and current prospects for primary drug therapies for Alzheimer's disease
6. Role of vitamin K in metabolic bone disease
7. Decreased circulating levels of vitamin K and 25-hydroxyvitamin D in osteopenic elderly men
8. Transport of vitamin K to bones in humans
9. Phylloquinone transport and its influence on γ-carboxyglutamate residues of osteocalcin in patients on hemodialysis
10. Apolipoprotein E polymorphism: A new genetic marker of hip fracture risk - The study of osteoporotic fractures
11. APOE 4 and hip fracture risk in a community-based study of older adults
12. Vitamin K distribution in rat tissues: Dietary phylloquinone is a source of tissue menaquinone-4
13. Vitamin K status influences brain sulfatide metabolism in young mice and rats
14. Intrauterine effects of coumarin derivatives
15. Effect of vitamin K depletion and restoration on sphingolipid metabolism in Bacteroides melaninogenicus
16. Warfarin administration reduces synthesis of sulfatides and other sphingolipids in brain
17. Regulation of sulfotransferase activity by vitamin K in mouse brain
18. Selective loss of cerebral keratan sulfate in Alzheimer's disease
19. Nervous tissue proteoglycans
20. The SV-2 protein of synaptic vesicles is a keratan sulfate proteoglycan
21. Linkage of the acetylcholine transporter-vesamicol receptor to proteoglycan in synaptic vesicles
22. Identification and immunolocalization of a new class of proteoglycan (keratan sulfate) to the neuritic plaques of Alzheimer's disease
23. Gas 6, a ligand for the receptor tyrosine kinase tyro 3, is widely expressed in the central nervous system
24. Requirement of γ-carboxyglutamic acid residues for the biological activity of Gas 6: Contribution of endogenous Gas 6 to the proliferation of vascular smooth muscle cells
25. Identification of Gas 6 as a growth factor for human Schwann cells
26. Growth arrest-specific gene 6 (gas 6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal related kinase (ERK) and Akt
27. 1 in a tyrosine phosphorylation cascade during chick embryogenesis
28. Vitamin K-dependent proteins in the developing and aging nervous system
29. Impact of apolipoprotein E4 and vascular disease on brain morphology in men from the NHLBI twin study