Corneal cross-linking - a review

Ophthalmic and Physiological Optics

Volumn 33, Issue 2, 2013, Pages 78-93

  Meek, Keith M ^a   Hayes, Sally ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Collagen cross linking; Cornea; Ectasia; Keratoconus; UVA

Indexed keywords

CROSS LINKING REAGENT; PHOTOSENSITIZING AGENT; RIBOFLAVIN;

CLINICAL TRIAL (TOPIC); CORNEA; DRUG EFFECT; HUMAN; KERATOCONUS; METHODOLOGY; PHOTOCHEMOTHERAPY; REVIEW; ULTRAVIOLET RADIATION;

CLINICAL TRIALS AS TOPIC; CORNEA; CROSS-LINKING REAGENTS; HUMANS; KERATOCONUS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; RIBOFLAVIN; ULTRAVIOLET RAYS;

MLCS; MLOWN;

EID: 84873907979     PISSN: 02755408     EISSN: 14751313     Source Type: Journal    
DOI: 10.1111/opo.12032     Document Type: Review

References (148)

1. Wollensak G & Iomdina E. Long-term biomechanical properties of rabbit cornea after photodynamic collagen crosslinking. Acta Ophthalmol 2009; 87: 48-51.
2. Spoerl E, Wollensak G & Seiler T. Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 2004; 29: 35-40.
3. Stewart J, Lee O-T, Wong F, Schultz D & Lamy R. Cross-linking with ultraviolet-A and riboflavin reduces corneal permeability. Invest Ophthalmol Vis Sci 2011; 52: 9275-9278.
4. Wollensak G & Redl B. Gel electrophoretic analysis of corneal collagen after photodynamic cross-linking treatment. Cornea 2008; 27: 353-356.
5. Wollensak G. Crosslinking treatment for progressive keratoconus: new hope. Curr Opin Ophthalmol 2006; 17: 356-360.
6. Kamaev P, Friedman M, Sherr E & Muller D. Photochemical kinetics of corneal cross-linking with riboflavin. Invest Ophthalmol Vis Sci 2012; 53: 2360-2367.
7. Kymionis G & Portaliou D. Use of isoptocarpine in corneal collagen crosslinking. J Cataract Refract Surg 2008; 34: 2008-2009.
8. McCall A, Kraft S, Edelhauser H et al. Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA). Invest Ophthalmol Vis Sci 2010; 51: 129-138.
9. Brummer G, Littlechild S, McCall S, Zhang Y & Conrad G. The role of nonenzymatic glycation and carbonyls in collagen. Invest Ophthalmol Vis Sci 2011; 52: 6363-6369.
10. Zhang Y, Conrad A & Conrad G. Effects of Ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking. The J Biol Chem 2011; 286: 13011-13022.
11. Wollensak G, Aurich H, Pham D & Wirbelauer C. Hydration behaviour of porcine cornea crosslinked with riboflavin and ultraviolet A. J Cataract Refract Surg 2007; 33: 516-521.
12. Hayes S, Kamma-Lorger C, Boote C et al. The effect of riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma. PLoS ONE 2013; doi: 10.1371/journal.pone.0052860, accessed 22/01/2013.
13. Wollensak G, Spoerl E & Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg 2003; 29: 1780-1785.
14. Kohlhaas M, Spoerl E, Schilde T, Unger G, Wittig C & Pillunat L. Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg 2006; 32: 279-283.
15. Sondergaard A, Hjortdal J, Breitenbach T & Ivarsen A. Corneal distribution of riboflavin prior to collagen cross-linking. Curr Eye Res 2010; 35: 116-121.
16. Spoerl E, Wollensak G, Dittert D & Seiler T. Thermomechanical behaviour of collagen crosslinked porcine cornea. Ophthalmol 2004; 218: 136-140.
17. Sedaghat M, Naderi M & Zarei-Ghanavati M. Biomechanical parameters of the cornea after collagen crosslinking measures by waveform analysis. J Cataract Refract Surg 2010; 36: 1728-1731.
18. Wollensak G, Spörl E, Mazzotta C, Kalinski T & Sel S. Interlamellar cohesion after corneal crosslinking using riboflavin and ultraviolet A light. Br J Ophthalmol 2011; 95: 876-880.
19. Elsheikh A, Ross S, Alhasso D & Rama P. Numerical study of the effect of corneal layered structure on ocular biomechanics. Curr Eye Res 2009; 34: 26-35.
20. Bottós K, Dreyfuss J, Regatieri C et al. Immunofluorescence confocal microscopy of porcine corneas following collagen cross-linking treatment with riboflavin and ultraviolet A. J Refract Surg 2008; 24: S715-S719.
21. Wollensak G, Wilsch M, Spoerl E & Seiler T. Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA. Cornea 2004; 23 (5): 503-507.
22. Chai D, Gaster R, Roizenblatt R, Juhasz T, Brown D & Jester J. Quantitative assessment of UVA-riboflavin corneal cross-linking using nonlinear optical microscopy. Invest Ophthalmol Vis Sci 2011; 52: 4231-4238.
23. Steven P, Hovakimyan M, Guthoff R, Huttmann G & Stachs O. Imaging corneal crosslinking by autofluorescence 2-photon microscopy, second harmonic generation, and fluorescence lifetime measurements. J Cataract Refract Surg 2010; 36: 2150-2159.
24. Seiler T & Hafezi F. Corneal cross-linking-induced stromal demarcation line. Cornea 2006; 25: 1057-1059.
25. Filippello M, Stagni E & O'Brart D. Transepithelial corneal collagen cross-linking: bilateral study. J Cataract Refract Surg 2012; 38: 283-291.
26. Wollensak G, Spoerl E, Reber F & Seiler T. Keratocyte cytotoxicity of riboflavin/UVA-treatment in vitro. Eye 2004; 18: 718-722.
27. Wollensak G, Spoerl E, Wilsch M & Seiler T. Keratocyte apoptosis after corneal collagen cross-linking using Riboflavin/UVA treatment. Cornea 2004; 23: 43-49.
28. Mazzotta C, Balestrazzi A, Traversi C et al. Treatment of Progressive Keratoconus by Riboflavin-UVA-Induced Cross-Linking of Corneal Collagen: ultrastructural analysis by heidelberg retinal tomograph ii in vivo confocal microscopy in humans. Cornea 2007; 26: 390-397.
29. Buddecke E & Wollensak J. Acid mucopolysaccharide and glycoprotein in the human cornea in relation to age and keratoconus. Albrecvht von Graefes Arch Klin Exp Ophthalomology 1966; 172: 105-120.
30. Funderburgh JL, Panjwani N, Conrad GW & Baum J. Altered keratan sulphate epitopes in keratoconus. Invest Ophthalmol Vis Sci 1989; 30: 2278-2281.
31. Meek KM, Tuft SJ, Huang Y et al. Changes in collagen orientation and distribution in keratoconus corneas. Invest Ophthalmol Vis Sci 2005; 46: 1948-1956.
32. Spoerl E, Mrochen M, Sliney D, Trokel S & Seiler T. Safety of UVA-riboflavin cross-linking of the cornea. Cornea 2007; 26: 385-389.
33. Wollensak G, Spoerl E & Seiler T. Endothelial cell damage after riboflavin-ultra-violet-A-treatment in the rabbit. J Cataract Refract Surg 2003; 29: 1786-1790.
34. Mazzotta C, Traversi C, Baiocchi S et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 2008; 146: 527-533.
35. Wollensak G, Aurich H, Wirbelauer C & Sel S. Significance of the riboflavin film in corneal collagen crosslinking. J Cataract Refract Surg 2010; 36: 114-120.
36. Koppen C, Gobin L & Tassignon M. The absorption characteristics of the human cornea in ultraviolet-A crosslinking. Eye Contact Lens 2010; 36: 77-80.
37. Thorsrud A, Nicolaissen B & Drolsum L. Corneal collagen crosslinking in vitro: inhibited regeneration of human limbal epithelial cells after riboflavin-ultraviolet-A exposure. J Cataract Refract Surg 2012; 38: 1072-1076.
38. Xia Y, Chai X, Zhou C & Ren Q. Corneal nerve morphology and sensitivity changes after ultraviolet A/riboflavin treatment. Exp Eye Res 2011; 93: 541-547.
39. Filippello M, Stagni E, Buccoliero D, Bonfiglio V & Avitabile T. Transepithelial cross-linking in keratoconus patients: confocal analysis. Optom Vis Sci 2012; 89: 1-7.
40. Mazzotta C, Traversi C, Baiocchi S, Sergio P, Caporossi T & Caporossi A. Conservative treatment of keratoconus by riboflavin-uva-induced cross-linking of corneal collagen: quantitative investigation. Eur J Ophthalmol 2006; 16: 530-535.
41. Hafezi F, Mrochen M, Iseli H & Seiler T. Collagen crosslinking with ultraviolet A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg 2009; 35: 621-624.
42. Abad J & Panesso J. Corneal collagen cross-linking induced by UVA and riboflavin (CXL). Techniques in Ophthalmology 2008; 6: 8-12.
43. Mazzotta C, Baiocchi S, Denaro R, Tosi G & Caporossi T. Corneal collagen cross-linking to stop corneal ectasia exacerbated by radial keratotomy. Cornea 2011; 30: 225-228.
44. Arora R, Jain P, Gupta D & Goyal J. Sterile keratitis after corneal collagen crosslinking in a child. Cont Lens Anterior Eye 2012; 35: 233-235.
45. Eberwein P, Auw-Hädrich C, Birnbaum F, Maier P & Reinhard T. Corneal melting after cross-linking and deep lamellar keratoplasty in a keratoconus patient. Klin Monbl Augenheilkd 2008; 225: 96-98.
46. Koller T, Mrochen M & Seiler T. Complication and failure rates after corneal crosslinking. J Cataract Refract Surg 2009; 35: 1358-1362.
47. Raiskup F, Hoyer A & Spoerl E. Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. J Refract Surg 2009; 25: S824-S828.
48. Reeves S, Stinnett S, Adelman R & Afshari N. Risk factors for progression to penetrating keratoplasty in patients with keratoconus. Am J Ophthalmol 2005; 140: 601-607.
49. Caporossi A, Mazzotta C, Baiocchi S & Caporossi T. Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 2010; 149: 585-593.
50. Caporossi A, Mazzotta C, Baiocchi S, Caporossi T & Denaro R. Age-related long-term functional results after riboflavin UV A corneal cross-linking. J Ophthalmol 2011; doi:10.1155/2011/608041, accessed 13/12/12.
51. Wollensak G, Spoerl E & Seiler T. Riboflavin/Ultraviolet-A-induced collagen crosslinking for the treatment of keratococnus. Am J Ophthalmol 2003; 135: 620-627.
52. Baiocchi S, Mazzotta C, Cerretani D, Caporossi T & Caporossi A. Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium. J Cataract Refract Surg 2009; 35: 893-899.
53. Samaras KE. Corneal collagen cross linking (CXL): a review. Int Ophthalmol Clin 2010; 50: 89-100.
54. Leccisotti A & Islam T. Transepithelial corneal cross-linking in keratoconus. J Refract Surg 2010; 26: 942-948.
55. Jinabhai A, O'Donnell C, Radhakrishnan H & Nourrit V. Forward light scatter and contrast sensitivity in keratoconic patients. Cont Lens Anterior Eye 2012; 35: 22-27.
56. Jinabhai A, O'Donnell C & Radhakrishnan H. A comparison between subjective refraction and aberrometry-derived refraction in keratoconus patients and control subjects. Curr Eye Res 2010; 35: 703-714.
57. Radhakrishnan H, Jinabhai A & O'Donnell C. Dynamics of ocular aberrations in keratoconus. Clin Exp Optom 2010; 93: 164-174.
58. Raasch T, Schechtman K, Davis L, Zadnik K & Group CS. Repeatability of subjective refraction in myopic and keratoconic subjects: results of vector analysis. Ophthalmic Physiol Opt 2001; 21: 376-383.
59. Jinabhai A, Radhakrishnan H & O'Donnell C. Repeatability of ocular aberration measurements in patients with keratoconus. Ophthalmic Physiol Opt 2011; 31: 588-594.
60. Raiskup-Wolf F, Hoyer A, Spoerl E & Pillunat L. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 2008; 34: 796-801.
61. Caporossi A, Baiocchi S, Mazzotta C, Traversi C & Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Refract Surg 2006; 32: 837-845.
62. Coskunseven E, Jankov M & Hafezi F. Contralateral eye study of corneal cross-linking with riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg 2009; 25: 371-376.
63. Derakhshan A, Shandiz J, Ahadi M, Daneshvar R & Esmaily H. Short-term Outcomes of Collagen Crosslinking for Early Keratoconus. J Ophthalmic Vis Res 2011; 6: 155-159.
64. Greenstein S, Shah V, Fry K & Hersh P. Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 2011; 37: 691-700.
65. Vinciguerra P, Trazza S, Rosetta P, Vinciguerra R, Seiler T & Epstein D. Refractive, topographic, tomographic and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 2009; 116: 369-378.
66. Guber I, Guber J, Kaufman C, Bachmann L & Theil M. Visual recovery after corneal crosslinking for keratoconus: a 1-year follow-up study. Graefes Archives of Clinical and Experimental Ophthalmology 2012; PMID: 2892583; accessed 10/12/12.
67. Jankov M II, Jovanovic V, Delevic S & Coskunseven E. Corneal collagen cross-linking:review. The Open Ophthalmology Journal 2011; 5: 19-20.
68. Tu K & Aslanides I. Orbscan II anterior elevation changes following corneal collagen cross-linking treatment for keratoconus. J Refract Surg 2009; 25: 715-722.
69. Roy A & Dupps W Jr. Patient-specific computational modeling of keratoconus progression and differential responses to collagen cross-linking. Invest Ophthalmol Vis Sci 2011; 52: 9174-9187.
70. Richoz O, Schutz J, Pajic B, Coskunseven E & Hafezi F. Crosslinking for recurrent keratoconus. Ophthalmology 2012; 119: 878.
71. Mazzotta C, Balestrazzi S, Baiocchi S, Traversi C & Caporossi A. Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus:in vivo confocal microscopic evaluation. Clin Experiment Ophthalmol 2007; 35: 580-582.
72. Greenstein S, Fry K, Bhatt J & Hersh P. Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia:scheimpflug and biomicroscopic analysis. J Cataract Refract Surg 2010; 36: 2105-2114.
73. Beckman Rehnman J, Janbaz C, Behndig A & Lindén C. Spatial distribution of corneal light scattering after corneal collagen crosslinking. J Cataract Refract Surg 2011; 37: 1939-1944.
74. Pollhammer M & Cursiefen C. Bacterial keratitis early after corneal crosslinking with riboflavin and ultraviolet-A. J Cataract Refract Surg 2009; 35: 588-589.
75. Kymionis G, Portaliou D, Bouzoukis D et al. Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. J Cataract Refract Surg 2007; 33: 1982-1984.
76. Sharma N, Maharana P, Singh G & Titiyal J. Pseudomonas keratitis after collagen crosslinking for keratoconus: case report and review of literature. J Cataract Refract Surg 2010; 36: 517-520.
77. Pérez-Santonja J, Artola A, Javaloy J, Alió J & Abad J. Microbial keratitis after corneal collagen crosslinking. J Cataract Refract Surg 2009; 35: 1138-1140.
78. Rama P, Di Matteo F, Matuska S, Paganoni G & Spinelli A. Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use. J Cataract Refract Surg 2009; 35: 788-791.
79. Angunawela R, Arnalich-Montiel F & Allan B. Peripheral sterile corneal infiltrates and melting after collagen crosslinking for keratoconus. J Cataract Refract Surg 2009; 35: 606-607.
80. Labiris G, Kaloghianni E, Koukoula S, Zissimopoulos A & Kozobolis V. Corneal melting after collagen cross-linking for keratoconus: A case report. J Med Case Rep 2011; 5: 152.
81. Gokhale N & Vemuganti G. Diclofenac-induced acute corneal melt after collagen crosslinking for keratoconus. Cornea 2010; 29: 117-119.
82. Lange C, Böhringer D & Reinhard T. Corneal endothelial loss after crosslinking with riboflavin and ultraviolet-A. Graefes Archives of Clinical and Experimental Ophthalmology 2012; 250: 1689-1691.
83. Wollensak G, Sporl E & Seiler T. Behandlung von keratokonus durch kollagenvernetzung. Ophthalmologe 2003; 100: 44-49.
84. Kymionis G, Grentzelos M, Kounis G et al. Intraocular pressure measurements after corneal collagen crosslinking with riboflavin and ultraviolet A in eyes with keratoconus. J Cataract Refract Surg 2010; 36: 1724-1727.
85. Boxer Wachler B. Corneal crosslinking with riboflavin. Cataract and Refractive Surgery Today 2005; January:73-74, http://www.crstoday.com/PDF%20Articles/0105/f12_boxerwachler.html, accessed 1/11/12.
86. Pinelli R & Mometto C. Corneal epithelium: should it stay or should it go? Ophthalmology Times Europe 2007; 3, http://www.oteurope.com/ophthalmologytimeseuorope/Cornea/Corneal_epithelium_should_it_stay_or_should_it_go/ArticleStandard/Article/detail/415196, accessed 3/11/12.
87. Hayes S, O'Brart D, Lamdin L et al. Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy. J Cataract Refract Surg 2008; 34: 657-661.
88. Samaras K, O'Brart D, Doutch J, Hayes S, Marshall J & Meek K. Effect of epithelial retention and removal on riboflavin absorption in porcine corneas. J Refract Surg 2009; 25: 771-775.
89. Hafezi F. Corneal collagen crosslinking: potential pitfalls when modifying the technique. Cataract and Refractive Surgery Today Europe 2008; October:65-66, http://bmctoday.net/crstodayeurope/2008/10/article.asp?f=1008_18.php, accessed 15/10/12.
90. Boxer Wachler B, Pinelli R, Ertan A & Chan C. Safety and efficacy of transepithelial crosslinking (C3-R/CXL). J Cataract Refract Surg 2009; 36: 186-187.
91. Marzouky M, El-Shawaf H & Pinelli R. Tensioactive-mediated transepithelial corneal cross-linking - first laboratory report European Ophthalmic Review 2009; 3: 67-70.
92. Wollensak G & Iomdina E. Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg 2009; 35: 540-546.
93. Kissner A, Spoerl E, Jung R, Spekl K, Pillunat L & Raiskup F. Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA/riboflavin corneal collagen cross-linking. Curr Eye Res 2010; 35: 715-721.
94. Stojanovic A, Chen X, Jin N et al. Safety and efficacy of epithelium-on corneal collagen cross-linking using a multifactorial approach to achieve proper stromal riboflavin saturation. J Ophthalmol 2012; doi: 10.1155/2012/498435; acessed 8/1/13.
95. Daxer A, Mahmoud H & Venkateswaran R. Corneal crosslinking and visual rehabilitation in keratoconus in one session without epithelial debridement: new technique. Cornea 2010; 29: 1176-1179.
96. Iontophoresis cuts riboflavin treatment time for corneal crosslinking. EUROTIMES. 2011.
97. Schumacher S, Oeftiger L & Mrochen M. Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation. Invest Ophthalmol Vis Sci 2011; 52: 9048-9052.
98. Kymionis G, Diakonis V, Coskunseven E, Jankov M, Yoo S & Pallikaris I. Customized pachymetric guided epithelial debridement for corneal collagen cross linking. BMC Ophthalmology 2009; 9: 10.
99. Hayes S, Boote C, Kamma-Lorger C et al. Riboflavin/UVA collagen cross-linking-induced changes in normal and keratoconus corneal stroma. PLoS ONE 2011; 6: e22405.
100. Hafezi F. Limitation of collagen cross-linking with hypoosmolar riboflavin solution: failure in an extremely thin cornea. Cornea 2011; 30: 917-919.
101. Spadea L. Corneal collagen cross-linking with riboflavin and UVA irradiation in pellucid marginal degeneration. J Refract Surg 2010; 26: 375-377.
102. Kymionis G, Karavitaki A, Kounis G, Portaliou D, Yoo S & Pallikaris I. Management of pellucid marginal corneal degeneration with simultaneous customized photorefractive keratectomy and collagen crosslinking. J Cataract Refract Surg 2009; 35: 1298-1301.
103. Stojanovic A, Zhang J, Chen X, Nitter T, Chen S & Wang Q. Topography-guided transepithelial surface ablation followed by corneal collagen cross-linking performed in a single combined procedure for the treatment of keratoconus and pellucid marginal degeneration. J Refract Surg 2010; 26: 145-152.
104. Kymionis G, Grentzelos M, Portaliou D et al. Photorefractive keratectomy followed by same-day corneal collagen crosslinking after intrastromal corneal ring segment implantation for pellucid marginal degeneration. J Cataract Refract Surg 2010; 36: 1783-1785.
105. Kohlhaas M, Spoerl E, Speck A, Schilde T, Sander D & Pillunat L. [A new treatment of keratectasia after LASIK by using collagen with riboflavin/UVA cross-linking]. Article in German. Klin Monastbl Augenheilkd 2005; 222: 430-436.
106. Hafezi F, Kanellopoulos J, Wiltfang R & Seiler T. Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis. J Cataract Refract Surg 2007; 33: 2035-2040.
107. Salgado J, Khoramnia R, Lohmann C & Winkler von Mohrenfels C. Corneal collagen crosslinking in post-LASIK keratectasia. Br J Ophthalmol 2011; 95: 493-497.
108. Li G, Fan Z & Peng X. Corneal collagen crosslinking for corneal ectasia of post-LASIK: one-year results. Int J Ophthalmol 2012; 5: 190-195.
109. Hafezi F & Iseli H. Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking. J Refract Surg 2008; 34: 1219-1221.
110. Bedi R, Touboul D, Pinsard L & Colin J. Refractive and topographic stability of Intacs in eyes with progressive keratoconus: five-year follow-up. J Refract Surg 2012; 28: 392-396.
111. Ertan A, Karacal H & Kamburoglu G. Refractive and topographic results of transepithelial cross-linking treatment in eyes with Intacs. Cornea 2009; 28: 719-723.
112. Chan C, Sharma M & Boxer Wachler B. Effect of inferior-segment Intacs with and without C3-R on keratoconus. J Cataract Refract Surg 2007; 23: 75-80.
113. Iovieno A, Légaré M, Rootman D, Yeung S, Kim P & Rootman D. Intracorneal ring segments implantation followed by same-day photorefractive keratectomy and corneal collagen cross-linking in keratoconus. J Refract Surg 2011; 27: 915-918.
114. Celik H, Alagöz N, Yildirim Y et al. Accelerated corneal crosslinking concurrent with laser in situ keratomileusis. J Cataract Refract Surg 2012; 38: 1424-1431.
115. Kanellopoulos A & Binder P. Collagen cross-linking (CCL) with sequential topography-guided PRK: a temporizing alternative for keratoconus to penetrating keratoplasty. Cornea 2007; 26: 891-895.
116. Kymionis G, Portaliou D, Kounis G & et al. Simultaneous topography-guided photorefractive keratectomy followed by corneal collagen cross-linking for keratoconus. Am J Ophthalmol 2011; 152: 748-755.
117. Chen S, Li Y, Stojanovic A et al. Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea. PLoS ONE 2012; 7: e46232.
118. Vega-Estrada A, Alió J, Plaza Puche A & Marshall J. Outcomes of a new microwave procedure followed by accelerated cross-linking for the treatment of keratoconus: a pilot study. J Refract Surg 2012; 28: 787-792.
119. Calossi A, Romano F, Ferraioli G & Romano V. Orthokeratology and riboflavin-UVA corneal collagen cross-linking in keratoconus. Journal of Emmetropia 2010; 1: 126-131.
120. Martins S, Combs J, Noguera G et al. Antimicrobial efficacy of riboflavin/UVA combination (365 n). In vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis. Invest Ophthalmol Vis Sci 2008; 49: 3402-3408.
121. Iseli H, Thiel M, Hafezi F, Kampmeier J & Seiler T. Ultraviolet A/riboflavin corneal cross-linking for infectious keratitis associated with corneal melts. Cornea 2008; 27: 590-594.
122. Price M, Tenkman L, Schrier A, Fairchild K, Trokel S & Price F. Photoactivated riboflavin treatment of infectious keratitis using collagen cross-linking technology. J Refract Surg 2012; 28: 706-713.
123. Makdoumi K, Mortensen J, Sorkhabi O, Malmvall B & Crafoord S. UVA-riboflavin photochemical therapy of bacterial keratitis: a pilot study. Graefe's Archive for Clinical and Experimental Ophthalmology 2012; 250: 95-102.
124. Cordeiro Barbosa M, Barbosa J, Hirai F & Hofling-Lima A. Effect of cross-linking on corneal thickness in patients with corneal edema. Cornea 2010; 29: 613-617.
125. Gadelha D, Cavalcanti B, Bravo Filho V et al. [Therapeutic effect of corneal cross-linking on symptomatic bullous keratopathy] Article in Portuguese. Arq Bras Oftalmol 2009; 72: 462-466.
126. Gharaee H, Ansari-Astaneh M & Armanfar F. The effects of riboflavin/Ultraviolet-A corneal cross-linking on the signs and symptoms of Bullous keratopathy. Middle East Afr J Ophthalmol 2011; 18: 58-60.
127. Ghanem R, Santhiago M, Berti T, Thomaz S & Netto M. Collagen crosslinking with riboflavin and ultraviolet-A in eyes with pseudophakic bullous keratopathy. J Cataract Refract Surg 2010; 36: 273-276.
128. Wollensak G, Aurich H & Wirbelauer C. Potential use of riboflavin/UVA cross-linking in bullous keratopathy. Ophthalmic Res 2009; 41: 114-117.
129. Hafezi F, Dejica P & Majo F. Modified corneal collagen crosslinking reduces corneal oedema and diurnal visual fluctuations in Fuchs dystrophy. Br J Ophthalmol 2010; 94: 660-661.
130. Spoerl E, Zubaty V, Raiskup-Wolf F & Pillunat L. Oestrogen-induced changes in biomechanics in the cornea as a possible reason for keratectasia. Br J Ophthalmol 2007; 91: 1547-1550.
131. Bilgihan K, Hondur A, Sul S & Ozturk S. Pregnancy-induced progression of keratoconus. Cornea 2011; 30: 991-994.
132. Gatzioufas Z & Thanos S. Acute keratoconus induced by hypothyroxinemia during pregnancy. J Endocrinol Invest 2008; 31: 262-266.
133. Padmanabhan P, Radhakrishnan A & Natarajan R. Pregnancy-triggered iatrogenic (post-laser in situ keratomileusis) corneal ectasia-a case report. Cornea 2010; 29: 569-572.
134. Soeters N, Tahzib N, Bakker L & Van derLelij A. Two cases of keratoconus diagnosed after pregnancy. Optom Vis Sci 2012; 89: 112-116.
135. Spoerl E, Zubaty V, Terai N, Pillunat L & Raiskup F. Influence of high-dose cortisol on the biomechanics of incubated porcine corneal strips. J Refract Surg 2009; 25: S794-S798.
136. Kahan I, Varsanyi-Nagy M, Toth M & Nadrai A. The possible role of tear fluid thyroxine in keratoconus development. Exp Eye Res 1990; 50: 339-343.
137. Amano S, Nakai Y, Ko A, Inoue K & Wakakura M. A case of keratoconus progression associated with the use of topical latanoprost. Jpn J Ophthalmol 2008; 52: 334-336.
138. Honda N, Miyai T, Nejima R et al. Effect of latanoprost on the expression of matrix metalloproteinases and tissue inhibitor of metalloproteinase 1 on the ocular surface. Arch Ophthalmol 2010; 128: 466-471.
139. Jankov Mn, Hafezi F, Beko M et al. [Corneal Cross-linking for the treatment of keratoconus: preliminary results]. Article in Portuguese. Arquivos Brasileiros de Oftalmologica 2008; 71: 813-818.
140. Wittig-Silva C, Whiting M, Lamoureux E, Lindsay R, Sullivan L & Snibson G. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results. J Refract Surg 2008; 24: S270-S275.
141. Vinciguerra P, Albè E, Trazza S, Seiler T & Epstein D. Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmol 2009; 127: 1258-1265.
142. Agrawal V. Corneal collagen cross-linking with riboflavin and ultraviolet - a light for keratoconus: results in Indian eyes. Indian J Ophthalmol 2009; 57: 111-114.
143. El-Raggal T. Riboflavin-ultraviolet a corneal cross-linking for keratoconus. Middle East Afr J Ophthalmol 2009; 16: 256-259.
144. Koller T, Pajic B, Vinciguerra P & Seiler T. Flattening of the cornea after collagen crosslinking for keratoconus. J Cataract Refract Surg 2011; 37: 1488-1492.
145. Asri D, Touboul D, Fournié P et al. Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus. J Cataract Refract Surg 2011; 37: 2137-2143.
146. Hersh P, Greenstein S & Fry K. Corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 2011; 37: 149-160.
147. O'Brart D, Chan E, Samaras K, Patel P & Shah S. A randomised, prospective study to investigate the efficacy of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linkage to halt the progression of keratoconus. Br J Ophthalmol 2011; 95: 1519-1524.
148. Viswanathan D & Males J. Prospective longitudinal study of corneal collagen crosslinking in progressive keratoconus. Clin Experiment Ophthalmol 2012; doi: 10.1111/ceo.12035, accessed 20/12/12.