Increased resistance of crosslinked cornea against enzymatic digestion

Current Eye Research

Volumn 29, Issue 1, 2004, Pages 35-40

  Spoerl, Eberhard ^a,c   Wollensak, Gregor ^a   Seiler, Theo ^b  

^a Universitätsklinikum CGC   (Germany)

^b Inst F Refraktive Ophthalmo Chir   (Switzerland)

^c UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Collagen crosslinking; Collagenase; Cornea; Riboflavin; UVA

Indexed keywords

COLLAGEN; COLLAGENASE; ENZYME; PEPSIN A; PHOTOSENSITIZING AGENT; RIBOFLAVIN; TRYPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA ULCER; CROSS LINKING; ENUCLEATION; KERATOCONUS; MICROSCOPY; NONHUMAN; PHOTOCHEMISTRY; PRESERVATION; PRIORITY JOURNAL; SWINE; TREATMENT INDICATION; TREATMENT OUTCOME; ULTRAVIOLET A RADIATION;

ANIMALS; COLLAGEN; COLLAGENASES; CORNEA; CROSS-LINKING REAGENTS; ENDOPEPTIDASES; PEPSIN A; PHOTOSENSITIZING AGENTS; RIBOFLAVIN; SWINE; TRYPSIN; ULTRAVIOLET RAYS;

EID: 1542667179     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713680490513182     Document Type: Article

References (25)

1. Andley U. Photooxidative stress. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. 1, Philadelphia: WB Saunders; 1992:575-590.
2. Goosey JD, Zigler JS, Kinoshita JH. Cross-linking of lens crystalline in a photodynamic system: A process mediated by singlet oxygen. Science. 1980;208:1278-1280.
3. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627.
4. Wollensak G, Spoerl E, Seiler T, Wilsch M. Endothelial cell damage after combined riboflavin-UVA treatment. J Cataract Refract Surg. 2003;29:1786-1790.
5. Schnitzler E, Spörl E, Seiler T. Bestrahlung der Hornhaut mit UV-Licht und Riboflavingabe als neuer Behandlungsversuch bei einschmelzenden Hornhautprozessen, erste Ergebnisse mit Patienten. Klin Mbl Augenheilk. 2000;217:190-193.
6. Berman MB. Collagenase inhibitors: Rationale for their use in treating corneal ulceration. Int Ophthalmol Clinics. 1975;15:49-66.
7. Pleyer U, Bergmann L, Krause A, Hartmann C. Autoimmunerkrankungen der peripheren Hornhaut. Immunpathologie, Klinik und Therapie. Klin Mbl Augenheilkd. 1996;208:73-81.
8. Rehany U, Lahav M, Shoshan S. Collagenolytic activity in keratoconus. Ann Ophthalmol. 1982;14:751-754.
9. Kigasawa K, Murata H, Monta Y, Odake S, Suda E, Shimizu I, Morikawa T, Nagbai Y. Inhibition of corneal ulceration by tetrapeptidyl hydroxamic acid. Jpn J Ophthalmol. 1995;39:35-42.
10. Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine cornea after riboflavin/UVA induced crosslinking. J Cataract Refract Surg. 2003;29: 1780-1785.
11. Charulatha V, Rajaram A. Crosslinking density and resorption of dimethyl suberimidate-treated collagen. J Biomed Mater Res. 1997;36:478-486.
12. Gnädinger MC, Itoi M, Slansky HH, Dohlman CH. The role of collagenase in the alkali-burned cornea. Am J Ophthalmol. 1969;68:478-483.
13. McCulley JP, Slansky HH, Paven-Langston D, Dohlman CH. Collagenolytic activity in experimental Herpes simplex keratitis. Arch Ophthalmol. 1970;84:516-519.
14. Abalain JH, Dossou H, Colin J, Floch HH. Levels of collagen degradation products (telopeptides) in the tear film of patients with keratoconus. Cornea. 2000;19:474-476.
15. Fujisato T, Tomihata K, Tabata Y, Iwamoto Y, Burczak K, Ikada Y. Cross-linking of amniotic membranes. J Biomater Sci Polymer Edn. 1999;11:1171-1181.
16. Nimni ME. The cross-linking and structure modification of the collagen matrix in the design of cardiovascular prosthesis. J Cardiac Surg. 1988;3:523-531.
17. Weadock KS, Miller EJ, Bellincampi LD, Zwadsky JP, Dunn MG. Physical crosslinking of collagen fibers: Comparison of ultraviolet irradiation and dehydrothermal treatment. J Biomed Mat Res. 1995;29:1373-1379.
18. Weadock KS, Miller EJ, Keuffel E, Dunn MG. Effect of physical crosslinking methods on collagen-fiber durability in proteolytic solutions. J Biomed Mat Res. 1996;32:221-226.
19. Hu Y, Webb E, Singh J, Morgan BA, Gainor JA, Gordon TD, Siahaan TJ. Rapid determination of substrate specifity of Clostridium histolyticum β-collagenase using an immobilized peptide library. J Biol Chem. 2002;277:8366-8371.
20. French MF, Bhown A, Van Wart HE. Identification of Clostridium histolyticum collagenase hyperreactive sites in type I, II, and III collagens: Lack of correlation with local triple helical stability. J Protein Chem. 1992;11: 83-97.
21. Mallya SK, Mookhtiar KA, van Wart HE. Kinetics of hydrolysis of type I, II, and III collagens by the class I and II Clostridium histolyticum collagenases. J Protein Chem. 1992;11:99-107.
22. Carlson EC, Waring GO. Ultrastructural analyses of enzyme-treated microfibrils in rabbit corneal stroma. Invest Ophthalmol Vis Sc. 1988;29:578-585.
23. Spoerl E, Schreiber J, Hellmund K, Seiler T, Knuschke P. Untersuchungen zur Verfestigung der Hornhaut am Kaninchen. Ophthalmologe. 2000;97:203-206.
24. Müller LJ, Pels E, Vrensen GFJM. The specific architecture of the anterior stroma acccounts for maintenance of corneal curvature. Br J Ophthalmol. 2001;85:437-443.
25. Ohan MP, Weadock KS, Dunn MG. Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen. J Biomed Mater Res. 2002;60:384-391.