Quantitative assessment of UVA-riboflavin corneal cross-linking using nonlinear optical microscopy

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 7, 2011, Pages 4231-4238

  Chai, Dongyul ^a   Gaster, Ronald N ^a   Roizenblatt, Roberto ^a   Juhasz, Tibor ^a   Brown, Donald J ^a   Jester, James V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOFLAVIN; CROSS LINKING REAGENT; VITAMIN B COMPLEX;

ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE IMAGING; COLLAGEN CROSS LINKAGE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA; CORNEA EPITHELIUM; FLUORESCENCE MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RABBIT; RADIATION EXPOSURE; RIGIDITY; ULTRAVIOLET A RADIATION; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; KERATOCONUS; METABOLISM; METHODOLOGY; MICROSCOPY; PATHOLOGY; PHOTOTHERAPY; ULTRAVIOLET RADIATION;

ANIMALS; CORNEA; CROSS-LINKING REAGENTS; DISEASE MODELS, ANIMAL; KERATOCONUS; MICROSCOPY; RABBITS; RIBOFLAVIN; ULTRAVIOLET RAYS; ULTRAVIOLET THERAPY; VITAMIN B COMPLEX;

EID: 80052326555     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-7105     Document Type: Article

References (32)

1. Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42:297-319.
2. Klintworth GK, Damms T. Corneal dystrophies and keratoconus. Curr Opin Ophthalmol. 1995;6:44-56.
3. Kennedy RH, Bourne WM, Dyer JA. A 48-year clinical and epidemiologic study of keratoconus. Am J Ophthalmol. 1986;101:267-273.
4. Tuft SJ, Moodaley LC, Gregory WM, Davison CR, Buckley RJ. Prognostic factors for the progression of keratoconus. Ophthalmology. 1994;101:439-447.
5. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627.
6. McCall AS, Kraft S, Edelhauser HF, et al. Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA). Invest Ophthalmol Vis Sci. 2010;51:129-138.
7. Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg. 2003;29:1780-1785.
8. Vinciguerra P, Albe E, Trazza S, et al. Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology. 2009;116:369-378.
9. Vinciguerra P, Albe E, Trazza S, Seiler T, Epstein D. Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmol. 2009;127:1258-1265.
10. Wollensak G. Crosslinking treatment of progressive keratoconus: new hope. Curr Opin Ophthalmol. 2006;17:356-360.
11. Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg. 2008;34:796-801.
12. Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T. Safety of UVAriboflavin cross-linking of the cornea. Cornea. 2007;26:385-389.
13. Kohlhaas M, Spoerl E, Schilde T, Unger G, Wittig C, Pillunat LE. Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg. 2006;32:279-283.
14. Schilde T, Kohlhaas M, Spoerl E, Pillunat LE. Enzymatic evidence of the depth dependence of stiffening on riboflavin/UVA treated corneas (in German). Ophthalmologe. 2008;105:165-169.
15. Fujimori E. Cross-linking and fluorescence changes of collagen by glycation and oxidation. Biochim Biophys Acta. 1989;998:105-110.
16. Raub CB, Putnam AJ, Tromberg BJ, George SC. Predicting bulk mechanical properties of cellularized collagen gels using multiphoton microscopy. Acta Biomater. 2010;6:4657-4665.
17. Raub CB, Suresh V, Krasieva T, et al. Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. Biophys J. 2007;92:2212-2222.
18. Richards-Kortum R, Sevick-Muraca E. Quantitative optical spectroscopy for tissue diagnosis. Annu Rev Phys Chem. 1996;47:555-606.
19. Fujimori E. Cross-linking of collagen CNBr peptides by ozone or UV light. FEBS Lett. 1988;235:98-102.
20. Glassman W, Byam-Smith M, Garfield RE. Changes in rat cervical collagen during gestation and after antiprogesterone treatment as measured in vivo with light-induced autofluorescence. Am J Obstet Gynecol. 1995;173:1550-1556.
21. Meerwaldt R, Graaff R, Oomen PH, et al. Simple non-invasive assessment of advanced glycation endproduct accumulation. Diabetologia. 2004;47:1324-1330.
22. Monnier VM, Kohn RR, Cerami A. Accelerated age-related browning of human collagen in diabetes mellitus. Proc Natl Acad Sci U S A. 1984;81:583-587.
23. Goldich Y, Barkana Y, Morad Y, Hartstein M, Avni I, Zadok D. Can we measure corneal biomechanical changes after collagen crosslinking in eyes with keratoconus?-a pilot study. Cornea. 2009;28:498-502.
24. Vinciguerra P, Albe E, Mahmoud AM, Trazza S, Hafezi F, Roberts CJ. Intra-and postoperative variation in ocular response analyzer parameters in keratoconic eyes after corneal cross-linking. J Refract Surg. 2010;26:669-676.
25. Sondergaard AP, Hjortdal J, Breitenbach T, Ivarsen A. Corneal distribution of riboflavin prior to collagen cross-linking. Curr Eye Res. 2010;35:116-121.
26. Kampik D, Ralla B, Keller S, Hirschberg M, Friedl P, Geerling G. Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery. Invest Ophthalmol Vis Sci. 2010;51:3929-3934.
27. Spoerl E, Raiskup F, Kampik D, Geerling G. Correlation between UV absorption and riboflavin concentration in different depths of the cornea in CXL. Curr Eye Res. 2010;35:1040-1041; author reply 1042-1043.
28. Ahearne M, Yang Y, Then KY, Liu KK. An indentation technique to characterize the mechanical and viscoelastic properties of human and porcine corneas. Ann Biomed Eng. 2007;35:1608-1616.
29. Studer H, Larrea X, Riedwyl H, Buchler P. Biomechanical model of human cornea based on stromal microstructure. J Biomech. 2010;54:836-842.
30. Elsheikh A, Brown M, Alhasso D, Rama P, Campanelli M, Garway-Heath D. Experimental assessment of corneal anisotropy. J Ref Surg. 2008;24:178-187.
31. Elsheikh A, Anderson K. Comparative study of strip extensometry and inflation tests. J Roy Soc Interface. 2005;2:177-185.
32. Steven P, Hovakimyan M, Guthoff RF, Huttmann G, Stachs O. Imaging corneal crosslinking by autofluorescence 2-photon microscopy, second harmonic generation, and fluorescence lifetime measurements. J Cataract Refract Surg. 2010;36:2150-2159.