The role of nonenzymatic glycation and carbonyls in collagen cross-linking for the treatment of keratoconus

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 9, 2011, Pages 6363-6369

  Brummer, Gage ^a,b   Littlechild, Stacy ^a,b   McCall, Scott ^a,b   Zhang, Yuntao ^a   Conrad, Gary W ^a,b  

^a KANSAS STATE UNIVERSITY   (United States)

^b MOUNT DESERT ISLAND BIOLOGICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMINOGUANIDINE; COLLAGEN TYPE 1; COPPER ION; PYRIDOXAL; RIFAMPICIN; COPPER; CROSS LINKING REAGENT; GUANIDINE DERIVATIVE; PHOTOSENSITIZING AGENT; RIBOFLAVIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA SURGERY; CORNEAL CROSS LINKING; GLYCATION; KERATOCONUS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RABBIT; SQUALUS; TENSILE STRENGTH; ANIMAL; CORNEA STROMA; DOGFISH; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; PROTEIN CARBONYLATION; ULTRAVIOLET RADIATION;

ANIMALS; COLLAGEN TYPE I; COPPER; CORNEAL STROMA; CROSS-LINKING REAGENTS; DOGFISH; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOSYLATION END PRODUCTS, ADVANCED; GUANIDINES; KERATOCONUS; PHOTOSENSITIZING AGENTS; PROTEIN CARBONYLATION; PYRIDOXAL; RABBITS; RIBOFLAVIN; RIFAMPIN; TENSILE STRENGTH; ULTRAVIOLET RAYS;

EID: 80053543136     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-7585     Document Type: Article

References (38)

1. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen cross linking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627.
2. Wollensak G, Wilsch M, Spoerl E, Seiler T. Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA. Cornea. 2004;23:503-507.
3. Wollensak G. Crosslinking treatment of progressive keratoconus: new hope. Curr Opin Ophthalmol. 2006;17:356-360.
4. Mazzotta C, Balestrazzi A, Baiocchi S, Traversi C, Caporossi A. Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus: in vivo confocal microscopic evaluation. Clin Exp Ophthalmol. 2007;35:580-582.
5. Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T. Safety of UVA riboflavin cross-linking of the cornea. Cornea. 2007;26:385-389.
6. Wollensak G. Corneal collagen crosslinking: new horizons. Expert Rev Ophthalmol. 2010;5:201-215.
7. McCall AS, Kraft S, Edelhauser H, et al. Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA). Invest Ophthalmol Vis Sci. 2010;51:129-138.
8. Daxer A, Misof K, Grabner G, Ettl A, Fratzl P. Collagen fibrils in the human corneal stroma: structure and aging. Invest Ophthalmol Vis Sci. 1998;39:644-48.
9. Zhang Y, Conrad A, Conrad GW. Effects of ultraviolet-A and riboflavin on the interaction of collagen and proteoglycans during corneal cross-linking. J Biol Chem. 2011;286:13011-130122.
10. Ikawa M, Snell EE. Oxidative deamination of amino acids by pyridoxal and metal salts. J Am Chem Soc. 1954;76:4900-4902.
11. Bilski P, Li MY, Ehrenshaft M, Daub ME, Chignell CF. Vitamin B6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants. Photochem Photobiol. 2000;7:129-134.
12. Goldberg T, Cai W, Peppa M, et al. Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc. 2004; 104:1287-1291.
13. Dyer D, Blackledge S, Thorpe S, Baynes J. Formation of pentosidine during nonenzymatic browning of protein by glucose: identification of glucose and other carbohydrates as possible precursors of pentosidine in vivo. J Biol Chem. 1991;266:11654-11660.
14. Glomb MA, Monnier VM. Mechanism of protein modification by glyoxal and glycoaldehyde, reactive intermediates of the Maillard reaction. J Biol Chem. 1995;270:10017-10026.
15. Skovsted IC, Christensen M, Breinholt J. Characteristion of anovel age-compound derived from lysine and 3-deoxyglucasone. Cell Mol Biol. 1998;44:1159-1163.
16. Vlassara H. Advanced glycation end-products and atherosclerosis. Ann Med. 1996;28:419-426.
17. Reiser KM, Amigable M, Last JA. Nonenzymaticglycation of type I collagen: the effects of aging on preferential glycation sites. J Biol Chem. 1992;267:24207-24216.
18. Malik NS, Moss SJ, Ahmed N, Furth AJ, Wall RS, Meek KM. Ageing of the human corneal stroma: structural and biochemical changes. Biochim Biophys Acta. 1992;1138:222-228.
19. Sady C, Khosrot S, Nagaraj R. Advanced Maillard reaction and crosslinking of corneal collagen in diabetes. Biochem Biophys Res Comm. 1995;214:793-797.
20. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev. 2004;84:649-698.
21. Chakravarti S, Petroll WM, Hassell JR, et al. Corneal opacity in lumican-null mice: defects in collagen fibril structures and packing in the posterior stroma. Invest Ophthalmol Vis Sci. 2000;41:3365-3373.
22. Skamarauskas JT, McKay AG, Hunt JV. Aminoguanidine and its pro-oxidant effects on an experimental model of protein glycation. Free Radic Biol Med. 1996;21:801-812.
23. Brownlee M, Vlassara H, Kooney A, Ulrich P, Cerami A. Aminoguanidine prevents diabetes-induced arterial wall protein crosslinking. Science. 1986;232:1629-1632.
24. Golegaonkar SB, Bhonsle HS, Boppana R, Kulkarni MJ. Discovery of rifampicin as a new anti-glycating compound by matrix-assisted laser desorption/ionization mass spectrometry-based insulin glycation assay. Eur J Mass Spectrom. 2010;16:221-226.
25. Asif M, Egan J, Vasan S, et al. An advanced glycation end product cross-link breaker can reverse age-related increases in myocardial stiffness. Proc Natl Acad Sci U S A. 2000;97:2809-2813.
26. Giardino I, Fard AK, Hatchell DL, Brownlee M. Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. Diabetes. 1998;47:1114-1120.
27. 6 coenzyme pyridoxal 5-phosphate and its Schiff bases in solution. J Phys Chem B. 2008;112:5867-5873.
28. Kato Y, Uchida K, Kawakishi S. Aggregation of collagen exposed to UVA in the presence of riboflavin: a plausible role of tyrosine modification. Photochem Photobiol. 1994;59:343-349.
29. Wright A, Bubb WA, Hawkins CL, Davies MJ. Singlet oxygenmediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues. Photochem Photobiol. 2002;76:35-46.
30. Gruschwitz R, Friedrichs J, Valtink M, et al. Alignment and cellmatrix interactions of human corneal endothelial cells on nanostructured collagen type I matrices. Invest Ophthalmol Vis Sci. 2010;51:6303-6310.
31. Ulbrich S, Friedrichs J, Valtink M, et al. Retinal pigment epithelium cell alignment on nanostructured collagen matrices. Cells Tissues Organs. In press.
32. Seiler T, Huhle S. Manifest diabetes and keratoconus. Graefes Arch Clin Exp Ophthalmol. 2000;238:822-825.
33. Dawczynski J, Franke S, Blum M, et al. Advanced glycation endproducts in corneas of patients with keratoconus. Graefe's Arch Clin Exp Opthalmol. 2002;240:296-301.
34. Spoerl E, Raiskup-Wolf F. Cigarette smoking is negatively associated with keratoconus. J Refract Surg. 2008;24:S737-S740.
35. Nicholl ID, Bucala R. Advanced glycation end products and cigarette smoking. Cell Mol Biol. 1998;44:1025-1033.
36. Elsheikh A, Geraghty B, Rama P, Campanelli M, Meek KM. Characterization of age-related variation in corneal biomechanical properties. J R Soc Interface. 2010;7:1475-1485.
37. Spoerl E, Zubaty V, Terai N, Pillunat LE, Raiskup F. Influence of high-dose cortisol on the biomechanics of incubated porcine corneal strips. J Refract Surg. 2009;25:S794-S798.
38. Bai P, Phua K, Hardt T, Cernadas M, Brodsky B. Glycation alters collagen fibril organization. Connect Tissue Res. 1992;28:1-12.