Cross-linking with ultraviolet-A and riboflavin reduces corneal permeability

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 12, 2011, Pages 9275-9278

  Stewart, Jay M ^a   Lee, On Tat ^a   Wong, Fergus F ^a   Schultz, David S ^a   Lamy, Ricardo ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUPRENORPHINE; CARPROFEN; CEFAZOLIN; ERYTHROMYCIN; FLUORESCEIN; PILOCARPINE; RIBOFLAVIN; COLLAGEN; CROSS LINKING REAGENT; MIOTIC AGENT; PHOTOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR EYE CHAMBER; ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA PERMEABILITY; CORNEA THICKNESS; CROSS LINKING; DEBRIDEMENT; DIFFUSION; DRUG PENETRATION; FEMALE; NONHUMAN; PRIORITY JOURNAL; PUPIL; RABBIT; ULTRAVIOLET A RADIATION; ANIMAL; CORNEA; CORNEA STROMA; DRUG EFFECT; METABOLISM; PERMEABILITY; SPECTROFLUOROMETRY; ULTRAVIOLET RADIATION;

ANIMALS; COLLAGEN; CORNEA; CORNEAL STROMA; CROSS-LINKING REAGENTS; DEBRIDEMENT; FEMALE; FLUORESCEIN; MIOTICS; PERMEABILITY; PHOTOSENSITIZING AGENTS; PILOCARPINE; PUPIL; RABBITS; RIBOFLAVIN; SPECTROMETRY, FLUORESCENCE; ULTRAVIOLET RAYS;

EID: 84856276888     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8155     Document Type: Article

References (27)

1. Caporossi A, Baiocchi S, Mazzotta C, Traversi C, Caporossi T. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg. 2006; 32:837-845.
2. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620-627.
3. Wittig-Silva C, Whiting M, Lamoureux E, Lindsay RG, Sullivan LJ, Snibson GR. A randomized controlled trial of corneal collagen cross-linking in progressive keratoconus: preliminary results. J Refract Surg. 2008;24:S720-S725.
4. Lamy R, Fonseca Netto C, Pecego MG, et al. Corneal collagen crosslinking with riboflavin and ultraviolet radiation for keratoconus treatment: preliminary results of a Brazilian study. Rev Bras Oftalmol. 2008;67:231-235.
5. Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg. 2008;34:796-801.
6. Vinciguerra P, Albe E, Trazza S, Seiler T, Epstein D. Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmol. 2009;127:1258-1265.
7. Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg. 2003;29:1780-1785.
8. Wollensak G, Iomdina E. Long-term biomechanical properties of rabbit cornea after photodynamic collagen crosslinking. Acta Ophthalmol. 2009;87:48-51.
9. McCall AS, Kraft S, Edelhauser HF, et al. Mechanisms of corneal tissue cross-linking in response to treatment with topical riboflavin and long-wavelength ultraviolet radiation (UVA). Invest Ophthalmol Vis Sci. 2010;51:129-138.
10. Spoerl E, Huhle M, Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res. 1998;66:97-103.
11. Makdoumi K, Mortensen J, Crafoord S. Infectious keratitis treated with corneal crosslinking. Cornea. 2010;29:1353-1358.
12. Hersh PS, Greenstein SA, Fry KL. Corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg. 2011;37:149-160.
13. Krueger RR, Ramos-Esteban JC, Kanellopoulos AJ. Staged intrastromal delivery of riboflavin with UVA cross-linking in advanced bullous keratopathy: laboratory investigation and first clinical case. J Refract Surg. 2008;24:S730-S736.
14. Bailey AJ, Sims TJ, Avery NC, Halligan EP. Non-enzymic glycation of fibrous collagen: reaction products of glucose and ribose. Biochem J. 1995;305:385-390.
15. Malik NS, Moss SJ, Ahmed N, Furth AJ, Wall RS, Meek KM. Ageing of the human corneal stroma: structural and biochemical changes. Biochim Biophys Acta. 1992;1138:222-228.
16. Sady C, Khosrof S, Nagaraj R. Advanced Maillard reaction and crosslinking of corneal collagen in diabetes. Biochem Biophys Res Commun. 1995;214:793-797.
17. Stewart JM, Schultz DS, Lee OT, Trinidad ML. Collagen cross-links reduce corneal permeability. Invest Ophthalmol Vis Sci. 2009;50: 1606-1612.
18. Boubriak OA, Urban JP, Akhtar S, Meek KM, Bron AJ. The effect of hydration and matrix composition on solute diffusion in rabbit sclera. Exp Eye Res. 2000;71:503-514.
19. Sweeney DF, Xie RZ, O'Leary DJ, et al. Nutritional requirements of the corneal epithelium and anterior stroma: clinical findings. Invest Ophthalmol Vis Sci. 1998;39:284-291.
20. Bock RH, Maumenee AE. Corneal fluid metabolism; experiments and observations. A M A Arch Ophthalmol. 1953;50:282-285.
21. Hedbys BO, Mishima S. Flow of water in the corneal stroma. Exp Eye Res. 1962;1:262-275.
22. Wiig H. Cornea fluid dynamics. II. Evidence for transport of radiolabelled albumin in rabbits by bulk flow. Exp Eye Res. 1990;50: 261-267.
23. Hosoya K, Lee VH, Kim KJ. Roles of the conjunctiva in ocular drug delivery: a review of conjunctival transport mechanisms and their regulation. Eur J Pharm Biopharm. 2005;60:227-240.
24. Mazzotta C, Traversi C, Baiocchi S, et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol. 2008;146:527-533.
25. Jiang J, Gill HS, Ghate D, et al. Coated microneedles for drug delivery to the eye. Invest Ophthalmol Vis Sci. 2007;48:4038-4043.
26. Anumolu SS, Singh Y, Gao D, Stein S, Sinko PJ. Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response. J Control Release. 2009;137: 152-159.
27. Stewart JM, Schultz DS, Lee OT, Trinidad ML. Exogenous collagen cross-linking reduces scleral permeability: modeling the effects of age-related cross-link accumulation. Invest Ophthalmol Vis Sci. 2009;50:352-357.