Safety and efficacy of epithelium-on corneal collagen cross-linking using a multifactorial approach to achieve proper stromal riboflavin saturation

Journal of Ophthalmology

Volumn 2012, Issue , 2012, Pages

  Stojanovic, Aleksandar ^a,b,c   Chen, Xiangjun ^b,c   Jin, Nan ^d   Zhang, Ting ^d   Stojanovic, Filip ^e   Raeder, Sten ^f,g   Utheim, Tor Paaske ^b,c,h  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b SynsLaser Kirurgi   (Norway)

^c SynsLaser Kirurgi AS   (Norway)

^d WENZHOU MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF TROMSØ   (Norway)

^f STAVANGER UNIVERSITY HOSPITAL   (Norway)

^g UNIVERSITY OF BERGEN   (Norway)

^h OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84873892014     PISSN: 2090004X     EISSN: 20900058     Source Type: Journal    
DOI: 10.1155/2012/498435     Document Type: Article

References (45)

1. L. Spadea, "Collagen crosslinking for ectasia following PRK performed in excimer laser-assisted keratoplasty for keratoconus," European Journal of Ophthalmology, vol. 22, no. 2, pp. 274-277, 2012.
2. C. Mazzotta, A. Balestrazzi, C. Traversi et al., "Treatment of progressive keratoconus by riboflavin-UVA-induced crosslinking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans," Cornea, vol. 26, no. 4, pp. 390-397, 2007.
3. F. Hafezi, J. Kanellopoulos, R.Wiltfang, and T. Seiler, "Corneal collagen crosslinking with riboflavin and ultraviolet A to treat induced keratectasia after laser in situ keratomileusis," Journal of Cataract&Refractive Surgery, vol. 33, no. 12, pp. 2035-2040, 2007.
4. G. Wollensak and E. Iomdina, "Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement," Journal of Cataract & Refractive Surgery, vol. 35, no. 3, pp. 540-546, 2009.
5. G. Wollensak, M. Wilsch, E. Spoerl, and T. Seiler, "Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA," Cornea, vol. 23, no. 5, pp. 503-507, 2004.
6. E. Spoerl, G. Wollensak, and T. Seiler, "Increased resistance of crosslinked cornea against enzymatic digestion," Current Eye Research, vol. 29, no. 1, pp. 35-40, 2004.
7. C. Mazzotta, C. Traversi, S. Baiocchi et al., "Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications," American Journal of Ophthalmology, vol. 146, no. 4, pp. 527-533, 2008.
8. G. Wollensak and B. Redl, "Gel electrophoretic analysis of corneal collagen after photodynamic cross-linking treatment," Cornea, vol. 27, no. 3, pp. 353-356, 2008.
9. C. Mazzotta, T. Caporossi, R. Denaro et al., "Morphological and functional correlations in riboflavin UV A corneal collagen cross-linking for keratoconus," Acta Ophthalmologica, vol. 90, no. 3, pp. 259-265, 2012.
10. G.Wollensak, E. Spoerl,M.Wilsch, and T. Seiler, "Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit," Journal of Cataract & Refractive Surgery, vol. 29, no. 9, pp. 1786-1790, 2003.
11. E. Spoerl, M. Mrochen, D. Sliney, S. Trokel, and T. Seiler, "Safety ofUVA-riboflavin cross-linking of the cornea," Cornea, vol. 26, no. 4, pp. 385-389, 2007.
12. M. Ahearne, Y. Yang, K. Y. Then, and K. K. Liu, "Nondestructive mechanical characterisation of UVA/riboflavin crosslinked collagen hydrogels," The British Journal of Ophthalmology, vol. 92, no. 2, pp. 268-271, 2008.
13. G. Wollensak, E. Spoerl, and T. Seiler, "Riboflavin/ultraviolet-A- induced collagen crosslinking for the treatment of keratoconus," American Journal of Ophthalmology, vol. 135, no. 5, pp. 620-627, 2003.
14. A. Caporossi, S. Baiocchi, C. Mazzotta, C. Traversi, and T. Caporossi, "Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen: preliminary refractive results in an Italian study," Journal of Cataract & Refractive Surgery, vol. 32, no. 5, pp. 837-845, 2006.
15. D. S. Grewal, G. S. Brar, R. Jain, V. Sood, M. Singla, and S. P. S. Grewal, "Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging," Journal of Cataract & Refractive Surgery, vol. 35, no. 3, pp. 425-432, 2009.
16. K. V. Zamora and J. J. Males, "Polymicrobial keratitis after a collagen cross-linking procedure with postoperative use of a contact lens: a case report," Cornea, vol. 28, no. 4, pp. 474-476, 2009.
17. J. J. Pérez-Santonja, A. Artola, J. Javaloy, J. L. Alió, and J. L. Abad, "Microbial keratitis after corneal collagen crosslinking," Journal of Cataract & Refractive Surgery, vol. 35, no. 6, pp. 1138-1140, 2009.
18. C. Mazzotta, A. Balestrazzi, S. Baiocchi, C. Traversi, and A. Caporossi, "Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus: in vivo confocal microscopic evaluation," Clinical & Experimental Ophthalmology, vol. 35, no. 6, pp. 580-582, 2007.
19. P. Eberwein, C. Auw-Hädrich, F. Birnbaum, P. C. Maier, and T. Reinhard, "Corneal melting after cross-linking and deep lamellar keratoplasty in a keratokonus patient," Klinische Monatsblatter für Augenheilkunde, vol. 225, no. 1, pp. 96-98, 2008.
20. B. S. Boxer Wachler, R. Pinelli, A. Ertan, and C. C. K. Chan, "Safety and efficacy of transepithelial crosslinking (C3-R/CXL)," Journal of Cataract & Refractive Surgery, vol. 36, no. 1, pp. 186-189, 2010.
21. S. Baiocchi, C. Mazzotta, D. Cerretani, T. Caporossi, and A. Caporossi, "Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium," Journal of Cataract & Refractive Surgery, vol. 35, no. 5, pp. 893-899, 2009.
22. K. Samaras, D. P. O'Brart, J. Doutch, S. Hayes, J. Marshall, and K.M.Meek, "Effect of epithelial retention and removal on riboflavin absorption in porcine corneas," Journal of Refractive Surgery, vol. 25, no. 9, pp. 771-775, 2009.
23. M. Filippello, E. Stagni, and D. O'Brart, "Transepithelial corneal collagen crosslinking: bilateral study," Journal of Cataract&Refractive Surgery, vol. 38, no. 2, pp. 283-291, 2012.
24. A. Kissner, E. Spoerl, R. Jung, K. Spekl, L. E. Pillunat, and F. Raiskup, "Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA/Riboflavin corneal collagen cross-linking," Current Eye Research, vol. 35, no. 8, pp. 715-721, 2010.
25. S. Hayes, D. P. O'Brart, L. S. Lamdin et al., "Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy," Journal of Cataract & Refractive Surgery, vol. 34, no. 4, pp. 657-661, 2008.
26. E. F. Bakke, A. Stojanovic, X. Chen, and L. Drolsum, "Penetration of riboflavin and postoperative pain in corneal collagen crosslinking: excimer laser superficial versus mechanical fullthickness epithelial removal," Journal of Cataract & Refractive Surgery, vol. 35, no. 8, pp. 1363-1366, 2009.
27. F. Raiskup and E. Spoerl, "Corneal cross-linking with hypoosmolar riboflavin solution in thin keratoconic corneas," American Journal of Ophthalmology, vol. 152, no. 1, pp. 28.e1-32.e1, 2011.
28. R. Pinelli, M. M. Al Marzouky, and H. I. El-Shawaf, "Tensioactive- mediated transepithelial corneal crosslinking - first laboratory report," European Ophthalmic Review, vol. 3, no. 2, pp. 67-70, 2009.
29. K. M. Bottós, J. L. Dreyfuss, C. V. S. Regatieri et al., "Immunofluorescence confocal microscopy of porcine corneas following collagen cross-linking treatment with riboflavin and ultraviolet A," Journal of Refractive Surgery, vol. 24, no. 7, pp. S715-S719, 2008.
30. K. E. Samaras and D. B. Lake, "Corneal collagen cross linking (CXL): a review," International Ophthalmology Clinics, vol. 50, no. 3, pp. 89-100, 2010.
31. A. Leccisotti and T. Islam, "Transepithelial corneal collagen cross-linking in keratoconus," Journal of Refractive Surgery, vol. 26, no. 12, pp. 942-948, 2010.
32. S. H. Cha, J. S. Lee, B. S. Oum, and C. D. Kim, "Corneal epithelial cellular dysfunction from benzalkonium chloride (BAC) in vitro," Clinical & Experimental Ophthalmology, vol. 32, no. 2, pp. 180-184, 2004.
33. B. Boxer Wachler, "Corneal Collagen Crosslinking with Riboflavin. A new treatment to strengthen the cornea for keratoectasia and keratoconus," Cataract & Refractive Surgery Today, vol. 1, pp. 73-74, 2005.
34. F. Raiskup, R. Pinelli, and E. Spoerl, "Riboflavin osmolarmodification for transepithelial corneal cross-linking," Current Eye Research, vol. 37, no. 3, pp. 234-238, 2012.
35. D. L.Meadows, J. R. Paugh, A. Joshi, and J.Mordaunt, "A novel method to evaluate residence time in humans using a nonpenetrating fluorescent tracer," Investigative Ophthalmology & Visual Science, vol. 43, no. 4, pp. 1032-1039, 2002.
36. F. Hafezi, M. Mrochen, H. P. Iseli, and T. Seiler, "Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas," Journal of Cataract & Refractive Surgery, vol. 35, no. 4, pp. 621-624, 2009.
37. G. Wollensak, H. Aurich, C. Wirbelauer, and S. Sel, "Significance of the riboflavin film in corneal collagen crosslinking," Journal of Cataract&Refractive Surgery, vol. 36, no. 1, pp. 114-120, 2010.
38. D. Asri, D. Touboul, P. Fournie et al., "Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus," Journal of Cataract & Refractive Surgery, vol. 37, pp. 2137-2143, 2011.
39. P. Vinciguerra, E. Albè, S. Trazza et al., "Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking," Ophthalmology, vol. 116, no. 3, pp. 369-378, 2009.
40. T. Seiler and F.Hafezi, "Corneal cross-linking-induced stromal demarcation line," Cornea, vol. 25, no. 9, pp. 1057-1059, 2006.
41. G. Wollensak, E. Iomdina, D. D. Dittert, and H. Herbst, "Wound healing in the rabbit cornea after corneal collagen cross-linking with riboflavin and UVA," Cornea, vol. 26, no. 5, pp. 600-605, 2007.
42. L. Kolozsvári, A. Nógrádi, B. Hopp, and Z. Bor, "UV absorbance of the human cornea in the 240- to 400-nm range," Investigative Ophthalmology&Visual Science, vol. 43, no. 7, pp. 2165-2168, 2002.
43. A. Ringvold, "Corneal epithelium and UV-protection of the eye," Acta Ophthalmologica Scandinavica, vol. 76, no. 2, pp. 149-153, 1998.
44. A. Podskochy, "Protective role of corneal epithelium against ultraviolet radiation damage," Acta Ophthalmologica Scandinavica, vol. 82, no. 6, pp. 714-717, 2004.
45. G. Wollensak, E. Spoerl, and T. Seiler, "Stress-strain measurements of human and porcine corneas after riboflavinultraviolet-A-induced cross-linking," Journal of Cataract & Refractive Surgery, vol. 29, no. 9, pp. 1780-1785, 2003.