Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: Long-term results

Journal of Cataract and Refractive Surgery

Volumn 34, Issue 5, 2008, Pages 796-801

  Raiskup Wolf, Frederik ^a   Hoyer, Anne ^a   Spoerl, Eberhard ^a   Pillunat, Lutz E ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; RIBOFLAVIN;

ADULT; ARTICLE; CATARACT; CROSS LINKING; DISEASE COURSE; ENDOTHELIAL DYSFUNCTION; FOLLOW UP; HUMAN; INTRAOCULAR PRESSURE; KERATOCONUS; KERATOMETRY; LONG TERM CARE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REFRACTION INDEX; RETROSPECTIVE STUDY; ULTRAVIOLET A RADIATION; VISUAL ACUITY;

ADULT; COLLAGEN; CORNEAL STROMA; DISEASE PROGRESSION; FOLLOW-UP STUDIES; HUMANS; KERATOCONUS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; RETROSPECTIVE STUDIES; RIBOFLAVIN; ULTRAVIOLET RAYS; VISUAL ACUITY;

EID: 42949106495     PISSN: 08863350     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrs.2007.12.039     Document Type: Article

References (31)

1. Pouliquen Y. Keratoconus; the Doyne Lecture. Eye 1 (1987) 1-14
2. Jiménez J.L.O., Jurado J.C.G., Rodriguez F.J.B., and Laborda D.S. Keratoconus: age of onset and natural history. Optom Vis Sci 74 (1997) 147-151
3. Kymes S.M., Walline J.J., Zadnik K., and Gordon M.O. Quality of life in keratoconus; the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study Group. Am J Ophthalmol 138 (2004) 527-535
4. Maeno A., Naor J., Lee H.M., et al. Three decades of corneal transplantation: indications and patient characteristics. Cornea 19 (2000) 7-11
5. Funderburgh J.L., Panjwani N., Conrad G.W., and Baum J. Altered keratan sulfate epitopes in keratoconus. Invest Ophthalmol Vis Sci 30 (1989) 2278-2281. http://www.iovs.org/cgi/reprint/30/10/2278 Accessed January 21, 2008
6. Rehany U., Lahav M., and Shoshan S. Collagenolytic activity in keratoconus. Ann Ophthalmol 14 (1982) 751-754
7. Sawaguchi S., Yue B.Y.J.T., Chang I., et al. Proteoglycan molecules in keratoconus corneas. Invest Ophthalmol Vis Sci 32 (1991) 1846-1853. http://www.iovs.org/cgi/reprint/32/6/1846 Accessed January 21, 2008
8. Wollensak J., and Buddecke E. Biochemical studies on human corneal proteoglycans-a comparison of normal and keratoconic eyes. Graefes Arch Clin Exp Ophthalmol 228 (1990) 517-523
9. Kao W.W.-Y., Vergnes J.-P., Ebert J., et al. Increased collagenase and gelatinase activities in keratoconus. Biochem Biophys Res Commun 107 (1982) 929-936
10. Sawaguchi S., Yue B.Y.J.T., Sugar J., and Gilboy J. Lysosomal enzyme abnormalities in keratoconus. Arch Ophthalmol 107 (1989) 1507-1510
11. Zhou L., Sawaguchi S., Twining S.S., et al. Expression of degradative enzymes and protease inhibitors in corneas with keratoconus. Invest Ophthalmol Vis Sci 39 (1998) 1117-1124. http://www.iovs.org/cgi/reprint/39/7/1117 Accessed January 21, 2008
12. Kenney M.C., Nesburn A.B., Burgeson R.E., et al. Abnormalities of the extracellular matrix in keratoconus corneas. Cornea 16 (1997) 345-351
13. Daxer A., and Fratzl P. Collagen fibril orientation in the human corneal stroma and its implication in keratoconus. Invest Ophthalmol Vis Sci 38 (1997) 121-129. http://www.iovs.org/cgi/reprint/38/1/121 Accessed January 21, 2008
14. Meek K.M., Tuft S.J., Huang Y., et al. Changes in collagen orientation and distribution in keratoconus corneas. Invest Ophthalmol Vis Sci 46 (2005) 1948-1956. http://www.iovs.org/cgi/reprint/46/6/1948 Accessed January 21, 2008
15. Radner W., Zehetmayer M., Skorpik C., and Mallinger R. Zur Anordnung der kollagenen Lamellen beim Keratokonus. [SEM findings in keratoconus]. Spektrum Augenheilkd 10 (1996) 156-160
16. Wollensak G. Crosslinking treatment of progressive keratoconus: new hope. Curr Opin Ophthalmol 17 (2006) 356-360
17. Spoerl E., Wollensak G., and Seiler T. Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 29 (2004) 35-40
18. Spörl E., Schreiber J., Hellmund K., et al. Untersuchungen zur Verfestigung der Hornhaut am Kaninchen. [Cross-linking effects in the cornea of rabbits]. Ophthalmologe 97 (2000) 203-206
19. Spoerl E., Huhle M., and Seiler T. Induction of cross-links in corneal tissue. Exp Eye Res 66 (1998) 97-103
20. Spörl E., Huhle M., Kasper M., and Seiler T. Erhöhung der Festigkeit der Hornhaut durch Vernetzung. [Artificial stiffening of the cornea by induction of intrastromal cross-links]. Ophthalmologe 94 (1997) 902-906
21. Kohlhaas M., Spoerl E., Schilde T., et al. Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg 32 (2006) 279-283
22. Suzuki M., Amano S., Honda N., et al. Longitudinal changes in corneal irregular astigmatism and visual acuity in eyes with keratoconus. Jpn J Ophthalmol 51 (2007) 265-269
23. Spoerl E., Mrochen M., Sliney D., et al. Safety of UVA-riboflavin cross-linking of the cornea. Cornea 26 (2007) 385-389
24. Wollensak G., Spoerl E., and Seiler T. Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135 (2003) 620-627
25. Caporossi A., Baiocchi S., Mazzotta C., et al. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A rays induced cross-linking of corneal collagen; preliminary refractive results in an Italian study. J Cataract Refract Surg 32 (2006) 837-845
26. Krumeich J.H., Daniel J., and Knülle A. Live-epikeratophakia for keratoconus. J Cataract Refract Surg 24 (1998) 456-463
27. Seiler T., and Hafezi F. Corneal cross-linking-induced stromal demarcation line. Cornea 25 (2006) 1057-1059
28. Barr J.T., Wilson B.S., Gordon M.O., et al. Estimation of the incidence and factors predictive of corneal scarring in the Collaborative Longitudinal Evaluation of keratoconus (CLEK) Study; the CLEK Study Group. Cornea 25 (2005) 16-25
29. Davis L.J., Schechtman K.B., Wilson B.S., et al. Longitudinal changes in visual acuity in keratoconus; the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study Group. Invest Ophthalmol Vis Sci 47 (2006) 489-500. http://www.iovs.org/cgi/reprint/47/2/489 Accessed January 21, 2008
30. McMahon T.T., Edrington T.B., Szczotka-Flynn L., et al. Longitudinal changes in corneal curvature in keratoconus. Cornea 25 (2006) 296-305
31. Chan C.C.K., and Sharma M. Boxer Wachler BS. Effect of inferior-segment Intacs with and without C3-R on keratoconus. J Cataract Refract Surg 33 (2007) 75-80