Human and bovine milk gangliosides differ in their fatty acid composition

Journal of Nutrition

Volumn 134, Issue 11, 2004, Pages 3016-3020

  Bode, Lars ^a,b   Beermann, Christopher ^a   Mank, Marko ^a   Kohn, Gerhard ^a   Boehm, Günther ^a  

^a Numico Research Germany   (Germany)

^b BURNHAM INSTITUTE   (United States)

Author keywords

Bovine milk; Fatty acid composition; Gangliosides; Human milk

Indexed keywords

GANGLIOSIDE; GANGLIOSIDE GD3; GANGLIOSIDE GM3; LONG CHAIN FATTY ACID; MILK FAT; MONOSIALOGANGLIOSIDE; SIALIC ACID ALPHA2,3 GALACTOSE BETA1,4 GLUCOSE BETA1,1 CERAMIDE; SIALIC ACID DERIVATIVE; TRICOSANOIC ACID; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL FEEDING; BREAST FEEDING; CATTLE; FOOD ANALYSIS; HUMAN; INFANT NUTRITION; LIPID COMPOSITION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MILK; NONHUMAN; SPECIES DIFFERENCE; STATISTICAL SIGNIFICANCE;

BOS TAURUS; BOVINAE; SIA;

EID: 7944236169     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.11.3016     Document Type: Article

References (30)

1. Kolstø Otnaass, A. B., Lægreid, A. & Ertresvåg, K. (1983) Inhibition of enferotoxin from Escherichia coli and Vibrio choterae by gangliosides from human milk. Infect. Immun. 40: 563-569.
2. Idota, T. & Kawakami, H. (1995) Inhibitory effects of milk gangliosides on the adhesion of Escherichia coli to human intestinal carcinoma cells. Biosci. Biotechnol. Biochem. 59: 69-72.
3. Rueda, R., Sabatel, J. L., Maldonado, J., Molina-Font, J. A. & Gil, A. (1998) Addition of gangliosides to an adapted milk formula modifies levels of fecal Escherichia coli in preterm newborn infants. J. Pediatr. 133: 90-94.
4. Vesper, H., Schmelz, E. M., Nikolova-Karakashian, M. N., Dillehay, D. L., Lynch, D. V. & Merrill, A. H., Jr. (1999) Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J. Nutr. 129: 1239-1250.
5. Pan, X. L. & Izumi, T. (2000) Variations of the ganglioside compositions of human milk, cow's milk and infant milk formula. Early Hum. Dev. 57: 25-31.
6. Rueda, R., Puente, R., Hueso, P., Maldonado, J. & Gil, A. (1995) New data on content and distribution of gangliosides in human milk. Biol. Chem. Hoppe-Seyler 376: 723-727.
7. Puente, R., Garcia-Pardo, L. A. & Hueso, P. (1992) Gangliosides in bovine milk. Changes in content and distribution of individual ganglioside levels during lactation. Biol. Chem. Hoppe-Seyler 373: 283-288.
8. Sánchez-Diaz, A., Ruano, M. J., Lorente, F. & Hueso, P. (1997) A critical analysis of total sialic acid and sialoglycoconjugate contents of bovine milk-based infant formulas. J. Pediatr. Gastroenterol. Nutr. 24: 405-410.
9. Lloyd, K. O. & Furukawa, K. (1998) Biosynthesis and functions of gangliosides: recent advances. Glycoconj. J. 15: 627-636.
10. Keenan, T. W. (1974) Composition and synthesis of gangliosides in mammary gland and milk of the bovine. Biochim. Biophys. Acta. 33: 255-270.
11. Schwarzmann, G. (2001) Uptake and metabolism of exogenous glycosphingolipids by cultured cells. Semin. Cell Dev. Biol. 12: 163-171.
12. Tsui, Z. C., Hou, W. H., Yang, L. & Zhu, Z. M. (1990) Effect of a cell differentiation inducer, ganglioside GM3, on the neutral glycosphingolipid composition and cell membrane fluidity of a human promyelocytic leukemia cell line HL-60. In Vivo 4: 205-208.
13. Kappel, T., Anken, R. H., Hanke, W. & Rahmann, H. (2000) Gangliosides affect membrane-channel activities dependent on ambient temperature. Cell. Mol. Neurobiol. 20: 579-590.
14. Brown, D. A. & London, E. (2002) Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 275: 17221-17224.
15. Van Meer, G. & Lisman, Q. (2002) Sphingolipid transport; rafts and translocators. J. Biol. Chem. 277: 25855-25858.
16. Perry, D. K. & Hannun, Y. A. (1998) The role of ceramide in cell siqnaling. Biochim. Biophys. Acta 1436: 233-243.
17. Springer, S. (1997) Human milk banking in Germany. J. Hum. Lact. 13: 65-68.
18. Bligh, E. G. & Dyer, W. J. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37: 911-917.
19. Uadisch, S. & Gillard, B. (1985) A solvent partition method for microscale ganglioside purification. Anal. Biochem. 146: 220-231.
20. 18 cartridges during the isolation of gangliosides. J. Neurochem. 35: 266-269.
21. Müthing, J. (1996) High-resolution thin-layer chromatography of gangliosides. J. Chromatogr. A 7: 3-25.
22. Svennerholm, L. (1957) Quantitative estimation of sialic acids, II. A colorimetric resorcinol-hydrochloric acid method. Biochim. Biophys. Acta 24: 604-611.
23. Skipski, V. P. (1975) Thin-layer chromatography of neutral glycosphingolipids. Methods Enzymol. 35: 396-425.
24. Karas, M., Bahr, U., Hillenkamp, F., Tsarbopoulos, A. & Pramanik, B. N. (1995) Matrix dependence of metastable fragmentation of glycoproteins in MALDI TOF mass-spectrometry. Anal. Chem. 67: 675-679.
25. Lepage, G. & Roy, C. C. (1986) Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid. Res. 27: 114-120.
26. Kohn, G., Van der Ploeg, P., Möbius, M. & Sawatzki, G. (1996) Influence of the derivatization procedure on the results of the gaschromatographic fatty acid analysis of human milk and infant formulae. Z. Ernährungswiss. 35: 226-234.
27. Jensen, R. G., Bitman, J., Carlson, S. E., Couch, S. C., Hamosh, M. & Newburg, D. S. (1995) Human milk lipids. In: Handbook of Milk Composition (Jensen, R. G., ed.), pp. 495-542. Academic Press, New York, NY.
28. Jensen, R. G. & Newburg, D. S. (1995) Bovine milk lipids. In: Handbook of Milk Composition (Jensen, R. G., ed.), pp. 543-575. Academic Press, New York, NY.
29. Martin, M. J., Martin-Sosa, S., Alonso, J. M. & Hueso, P. (2003) Enterotoxigenic Escherichia coli strains bind bovine milk gangliosides in a ceramide-dependent process. Lipids 38: 761-8.
30. Ladisch, S., Hasegawa, A., Li, R. & Kiso, M. (1995) Immunosuppressive activity of chemically synthesized gangliosides. Biochemistry 34: 1197-1202.