Survivin-ΔEx3 and survivin-2B: Two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties

Cancer Research

Volumn 59, Issue 24, 1999, Pages 6097-6102

  Mahotka, Csaba ^a   Wenzel, Michael ^a   Springer, Erik ^a   Gabbert, Helmut E ^a   Gerharz, Claus D ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

SURVIVIN; BIRC5 PROTEIN, HUMAN; DNA; ISOPROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER RESISTANCE; EXON; FETUS DEVELOPMENT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRON; KIDNEY CARCINOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; GENETICS; KIDNEY TUMOR; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN SYNTHESIS; SEQUENCE HOMOLOGY;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; APOPTOSIS; BASE SEQUENCE; CARCINOMA, RENAL CELL; DNA, NEOPLASM; HUMANS; KIDNEY NEOPLASMS; MICROTUBULE-ASSOCIATED PROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR CELLS, CULTURED;

EID: 0033571983     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Rudin, C. M., and Thompson, C. B. Apoptosis and disease: regulation and clinical relevance of programmed cell death. Annu. Rev. Med., 48: 267-281, 1997.
2. LaCasse, E. C., Baird, S., Korneluk, R. G., and Mackenzie, A. E. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene, 17: 3247-3259, 1998.
3. Rothe, M., Pan, M. G., Henzel, W. J., Ayres, T. M., and Goeddel, D. V. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell, 83: 1243-1252, 1995.
4. Ambrosini, G., Adida, C., and Altieri, D. C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med., 3: 917-921, 1997.
5. Tamm, I., Wang, Y., Sausville, E., Scudiero, D. A., Vigna, N., Oltersdorf, T., and Reed, J. C. IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res., 58: 5315-5320, 1998.
6. Cohen, G. M. Caspases: the executioners of apoptosis. Biochem. J., 326: 1-16, 1997.
7. Adida, C., Crotty, P. L., McGrath, J., Berrebi, D., Diebold, J., and Altieri, D. C. Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am. J. Pathol., 152: 43-19, 1998.
8. Adida, C., Berrebi, D., Peuchmaur, M., Reyes-Mugica, M., and Altieri, D. C. Anti-apoptosis gene, survivin, and prognosis of neuroblastoma. Lancet, 351: 882-883, 1998.
9. Kawasaki, H., Altieri, D. C., Lu, C. D., Toyoda, M., Tenjo, T., and Tanigawa, N. Inhibition of apoplosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res., 58: 5071-5074, 1998.
10. Gerharz, C. D., Moll, R., Störkel, S., Ramp, U., Thoenes, W., and Gabbert, H. E. Ultrastructural appearance and cytoskeletal architecture of the clear cell, chromophilic and chromophobe cell variants of human renal cell carcinomas in vivo and in vitro. Am. J. Pathol., 142: 851-859, 1993.
11. Ramp, U., Jaquet, K., Reinecke, P., Nitsch, T., Gabbert, H. E., and Gerharz, C. D. Acquisition of TGF-β1 resistance: an important progression factor in human renal cell carcinoma. Lab. Investig., 76: 739-749, 1997.
12. Müller, M., Strand, S., Hug, H., Heinemann, E. M., Walczak, H., Hofmann, W. J., Stremmel, W., Krammer, P. H., and Galle, P. R. Drag-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin. Investig., 99: 403-413, 1997.
13. Staden, R. Computer methods to locate signals in nucleic acid sequences. Nucleic Acids Res., 12: 505-519, 1984.
14. Mount, S. M. A catalogue of splice junction sequences. Nucleic Acids Res., 10: 459-472, 1982.
15. Li, F., Ambrosini, G., Chu, E. Y., Plescia, J., Tognin, S., Marchisio, P. C., and Altieri, D. C. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature (Lond.), 396: 580-584, 1998.
16. Andrade, F., Roy, S., Nicholson, D., Thornberry, N., Rosen, A., and Casciola-Rosen, L. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity, 8: 451-460, 1998.
17. Jiang, Z., and Wu, J. Y. Alternative splicing and programmed cell death. Proc. Soc. Exp. Biol. Med., 220: 64-72, 1998.
18. Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G., and Thompson, C. B. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74: 597-608, 1993.
19. Srinivasula, S. M., Ahmad, M., Guo, Y., Zhan, Y., Lazebnik, Y., Fernandes-Alnemri, T., and Alnemri, E. S. Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res., 59: 999-1002, 1999.
20. Ambrosini, G., Adida, C., Sirugo, G., and Altieri, D. C. Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting. J. Biol. Chem., 273: 11177-11182, 1998.
21. Bairoch, A. PROSITE: a dictionary of sites and patterns in proteins. Nucleic Acids Res., 19: 2241-2245, 1991.
22. Thompson, J. D., Higgins, D. G., and Gibson, T. J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22: 4673-4680, 1994.