Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

Journal of Biological Chemistry

Volumn 288, Issue 4, 2013, Pages 2559-2570

  Harpsøe, Kasper ^a   Hald, Helle ^a,b   Timmermann, Daniel B ^b   Jensen, Marianne L ^b   Dyhring, Tino ^b   Nielsen, Elsebet Ø ^b   Peters, Dan ^b   Balle, Thomas ^c   Gajhede, Michael ^a   Kastrup, Jette S ^a   Ahring, Philip K ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Aniona ApS   (Denmark)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION PATTERNS; BINDING AFFINITIES; HIGH AFFINITY; HOMOLOGY MODELS; LIGAND BINDING DOMAIN; MOLECULAR DETERMINANTS; MOLECULAR DOCKING; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); PATCH CLAMP; SPECIFIC INTERACTION; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; BINDING ENERGY; ELECTROPHYSIOLOGY;

AMINO ACIDS;

CYTISINE; EPIBATIDINE; ISOLEUCINE; LEUCINE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA2; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA4BETA2; NS 3861; SERINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHIMERA; CONTROLLED STUDY; DRUG EFFICACY; EMBRYO; FEMALE; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; STRUCTURE ANALYSIS; WILD TYPE;

ALKALOIDS; ANIMALS; AZABICYCLO COMPOUNDS; AZOCINES; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ELECTROPHYSIOLOGY; HEK293 CELLS; HUMANS; LIGANDS; MODELS, CHEMICAL; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; QUINOLIZINES; RECEPTORS, NICOTINIC; THIOPHENES; XENOPUS LAEVIS;

EID: 84873851066     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.436337     Document Type: Article

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