Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein

Journal of Biological Chemistry

Volumn 287, Issue 28, 2012, Pages 23283-23293

  Rucktooa, Prakash ^a   Haseler, Claire A ^b   Van Elk, René ^c   Smit, August B ^c   Gallagher, Timothy ^b   Sixma, Titia K ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE-BINDING PROTEINS; APLYSIA CALIFORNICA; BINDING MODES; BINDING PROPERTIES; COCRYSTAL STRUCTURE; LIGAND COMPLEXES; MUTATIONAL ANALYSIS; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); STRUCTURAL CHARACTERIZATION; TOBACCO SMOKING;

BINDING ENERGY; COMPLEXATION; PYRIDINE; TOBACCO;

CRYSTAL STRUCTURE;

ACETYLCHOLINE BINDING PROTEIN; BINDING PROTEIN; BUNGAROTOXIN RECEPTOR; CYTISINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2; UNCLASSIFIED DRUG; VARENICLINE;

APLYSIA; ARTICLE; BINDING AFFINITY; BINDING KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; LIGAND BINDING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; RECEPTOR BLOCKING; THERMODYNAMICS;

ACETYLCHOLINE; ALKALOIDS; ANIMALS; APLYSIA; AZOCINES; BENZAZEPINES; BINDING SITES; BINDING, COMPETITIVE; CARRIER PROTEINS; CELL LINE; HEK293 CELLS; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTATION; NICOTINE; NICOTINIC AGONISTS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; QUINOLIZINES; QUINOXALINES; RECEPTORS, NICOTINIC; SMOKING CESSATION;

APLYSIA CALIFORNICA; NICOTIANA TABACUM;

EID: 84863624888     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.360347     Document Type: Article

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