Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 30, 2010, Pages 13206-13211

  Blum, Angela P ^a   Lester, Henry A ^b   Dougherty, Dennis A ^a  

^a California Institute of Technology   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CARBACHOL; CARBONYL DERIVATIVE; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR ALPHA4BETA2; NITROGEN; PYRIDINE; CARBON; FUSED HETEROCYCLIC RINGS; MESSENGER RNA; NICOTINIC AGENT; NICOTINIC RECEPTOR; PYRIDINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG TARGETING; HYDROGEN BOND; MUTAGENESIS; MUTATION; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN TARGETING; TOBACCO DEPENDENCE; ANIMAL; BINDING COMPETITION; CELL MEMBRANE POTENTIAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; FEMALE; GENETICS; METABOLISM; MICROINJECTION; OOCYTE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT; XENOPUS LAEVIS;

ACETYLCHOLINE; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; CARBACHOL; CARBON; FEMALE; HYDROGEN BONDING; MEMBRANE POTENTIALS; MICROINJECTIONS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; NICOTINE; NICOTINIC AGONISTS; OOCYTES; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RATS; RECEPTORS, NICOTINIC; RNA, MESSENGER; XENOPUS LAEVIS;

EID: 77955805594     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007140107     Document Type: Article

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