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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1507-1510

Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2- phenylbutyl)aziridines and evaluation of their antimalarial activity

(9) D'Hooghe, Matthias a Vervisch, Karel a Törnroos, Karl W b Verhaeghe, Tom a Desmet, Tom a Lategan, Carmen c Smith, Peter J c Chibale, Kelly d De Kimpe, Norbert a

a GHENT UNIVERSITY (Belgium)

b UNIVERSITY OF BERGEN (Norway)

c UNIVERSITY OF CAPE TOWN (South Africa)

d UNIVERSITY OF CAPE TOWN (South Africa)

Author keywords

1 Azabicyclo 2.2.1 heptanes; Antimalarial agents; Aziridines; Ligand docking; Plasmepsin II; Ring transformation

Indexed keywords

ALUMINUM LITHIUM HYDRIDE; AZIRIDINE DERIVATIVE; CHLOROQUINE; EMETINE; HEPTANE DERIVATIVE; LIGAND; PLASMEPSIN II;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; CYTOTOXICITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SYNTHESIS; FEMALE; IC 50; IN VITRO STUDY; ISOMER; MOLECULAR DOCKING; NONHUMAN; PLASMODIUM FALCIPARUM;

ALUMINUM COMPOUNDS; ANTIMALARIALS; AZIRIDINES; BICYCLO COMPOUNDS; CYCLIZATION; HEPTANES; HUMANS; LIGANDS; LITHIUM COMPOUNDS; MOLECULAR DOCKING SIMULATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873734550 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.12.029 Document Type: Article

Times cited : (8)

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