Synthesis of stereodefined piperidines from aziridines and their transformation into conformationally constrained amino acids, amino alcohols and 2,7-diazabicyclo[3.3.1]nonanes

Journal of Organic Chemistry

Volumn 75, Issue 22, 2010, Pages 7734-7744

  Vervisch, Karel ^a   D'Hooghe, Matthias ^a   Törnroos, Karl W ^b   De Kimpe, Norbert ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ALCOHOLS; AZIRIDINES; CARBONITRILES; CARBOXYMETHYL; CHLOROMETHYL; MICROWAVE-ASSISTED; REGIOSPECIFIC; RING OPENING;

AMINO ACIDS; CARBOXYLIC ACIDS; METHANOL;

ORGANIC COMPOUNDS;

1 (4 CHLOROBENZYL) 2 CHLOROMETHYL 4 PHENYLPIPERIDINE 4 CARBOXYLIC ACID; 1 (4 CHLOROBENZYL) 2 CYANOMETHYL 4 PHENYLPIPERIDINE 4 CARBONITRILE; 1 (4 CHLOROBENZYL) 2 CYANOMETHYL 4 PHENYLPIPERIDINE 4 CARBOXYLIC ACID; 1 (4 CHLOROBENZYL) 2 CYANOMETHYL 4 PHEPHENYLPIPERIDINE 4 CARBONITRIE; 1 (4 CHLOROBENZYL) 2 HYDROXYMETHYL 4 PHENYLPIPERIDINE 4 CARBONITRILE; 1 (4 CHLOROBENZYL) 2 HYDROXYMETHYL 4 PHENYLPIPERIDINE 4 CARBOXYLATE; 1 (4 CHLOROBENZYL) 2 HYDROXYMETHYL 4 PHENYLPIPERIDINE CARBONITRILE; 1 (4 CHLOROBENZYL) 2 HYDROXYMETHYL 4 PIPERIDINE 4 CARBOXYLATE; 1 (4 CHLOROBENZYL) 5 PHENYLAZEPANE 3,5 DICARBONITRILE; 1 (4 CHLOROBENZYL) 6 HYDROXY 4 PHENYLAZEPANE 4 CARBONITRILE; 1 BENZYL 2 CHLOROMETHYL 4 PHENYLPIPERIDINE 4 CARBONITRILE; 2 (4 METHYLBENZYL) 5 PHENYL 2,7 DIAZABICYCLO[3.3.1]NONANE; 2 ACETOXYMETHYL 1 (4 CHLOROBENZYL) 4 PHENYLPIPERIDINE 4 CARBONITRILE; 2 CARBOXYMETHYL 1 (4 CHLOROBENZYL) 4 PHENYLPIPERIDINE 4 CARBOXYLIC ACID; 2,7 DIAZABICYCLO[3.3.1]NONANE DERIVATIVE; 4 AMINOMETHYL 1 ARYLMETHYL 2 METHYL 4 PHENYLPIPERIDINE; 4 AMINOMETHYL 2 METHYL 1 (4 METHYLBENZYL) 4 PHENYLPIPERIDINE; 6 ACETOXY 1 (4 CHLOROBENZYL) 4 PHENYLAZEPANE 4 CARBONITRILE; AMINO ACID DERIVATIVE; AMINOALCOHOL; AZIRIDINE DERIVATIVE; CYANIDE; NONANE; PIPERIDINE DERIVATIVE; TERT BUTYL 2 (4 METHYLBENZYL) 5 PHENYL 2,7 DIAZABICYCLO [3.3.1]NONANE 7 CARBOXYLATE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; CONFORMATION; CYCLIZATION; SYNTHESIS;

AMINO ACIDS; AMINO ALCOHOLS; AZIRIDINES; BICYCLO COMPOUNDS, HETEROCYCLIC; MOLECULAR CONFORMATION; NITRILES; PIPERIDINES; STEREOISOMERISM;

EID: 78449241433     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo101646u     Document Type: Article

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