Anti-diabetic activities of Gegen Qinlian Decoction in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes

Phytomedicine

Volumn 20, Issue 3-4, 2013, Pages 221-229

  Zhang, Chang Hua ^a,b   Xu, Guo Liang ^b   Liu, Yu Hui ^b   Rao, Yi ^b   Yu, Ri Yue ^b   Zhang, Zhong Wei ^b   Wang, Yue Sheng ^b,c   Tao, Liang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

3T3 L1 cells; Anti diabetic activities; Diabetic rats; Gegen Qinlian Decoction

Indexed keywords

ADIPONECTIN; ANTIDIABETIC AGENT; GEGEN QINLIAN DECOCTION; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C; INSULIN; LACTATE DEHYDROGENASE; PLANT MEDICINAL PRODUCT; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; ARTICLE; BODY WEIGHT; CHEMICAL COMPOSITION; DRUG EFFECT; DRUG SYNTHESIS; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSULIN BLOOD LEVEL; LIPID DIET; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STREPTOZOCIN DIABETES;

3T3-L1 CELLS; ADIPOCYTES; ADIPONECTIN; ANIMALS; AZO COMPOUNDS; BODY WEIGHT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; GENE EXPRESSION; GLUCOSE; HYPOGLYCEMIC AGENTS; MALE; MICE; PHYTOTHERAPY; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

RATTUS;

EID: 84873714741     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.11.002     Document Type: Article

References (60)

1. R.C. Andrews, and B.R. Walker Glucocorticoids and insulin resistance: old hormones, new targets Clinical Science (London) 96 1999 513 523
2. F. Abbasi, J.W. Chu, C. Lamendola, T. McLaughlin, J. Hayden, G.M. Reaven, and P.D. Reaven Discrimination between obesity and insulin resistance in the relationship with adiponectin Diabetes 53 2004 585 590
3. D.A. Bernlohr, M.A. Bolanowski, T.J. Kelly Jr., and M.D. Lane Evidence for an increase in transcription of specific mRNAs during differentiation of 3T3-L1 preadipocytes Journal of Biological Chemistry 260 1985 5563 5567
4. H.Y. Chen, X.L. Ye, X.L. Cui, K. He, Y.N. Jin, Z. Chen, and X.G. Li Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells Fitoterapia 83 2012 67 73
5. M. Evans, C. Geigerman, J. Cook, L. Curtis, B. Kuebler, and M. McIntosh Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes Lipids 35 2000 899 910
6. M. Fasshauer, J. Klein, S. Neumann, M. Eszlinger, and R. Paschke Adiponectin gene expression is inhibited by l-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes FEBS Letters 507 2001 142 146
7. B. Fève Adipogenesis: cellular and molecular aspects Best Practice and Research. Clinical Endocrinology and Metabolism 19 2005 483 499
8. M. Fasshauer, S. Kralisch, M. Klier, U. Lossner, M. Bluher, J. Klein, and R. Paschke Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes Biochemical and Biophysical Research Communications 301 2003 1045 1050
9. A. Guilherme, J.V. Virbasius, V. Puri, and M.P. Czech Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes Nature Reviews Molecular Cell Biology 9 2008 367 377
10. D.A. Guo, A. Lu, and L. Liu Modernization of traditional Chinese medicine Journal of Ethnopharmacology 141 2012 547 548
11. F.M. Gregoire, C.M. Smas, and H.S. Sul Understanding adipocyte differentiation Physiological Reviews 78 1998 783 809
12. J.T. Hwang, M.S. Lee, H.J. Kim, M.J. Sung, H.Y. Kim, M.S. Kim, and D.Y. Kwon Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways Phytotherapy Research 23 2009 262 266
13. M.L. He, Y. Wang, J.S. You, P.S. Mir, and T.A. McAllister Effect of a seaweed extract on fatty acid accumulation and glycerol-3-phosphate dehydrogenase activity in 3T3-L1 adipocytes Lipids 44 2009 125 132
14. H. Hui, G. Tang, and V.L. Go Hypoglycemic herbs and their action mechanisms Chinese Medicine 4 2009 11
15. Q. Jia, X. Liu, X. Wu, R. Wang, X. Hu, Y. Li, and C. Huang Hypoglycemic activity of a polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetic rats Phytomedicine 16 2009 744 750
16. B.B. Kahn Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance Cell 92 1998 593 596
17. K.A. Kang, S. Chae, Y.S. Koh, J.S. Kim, J.H. Lee, H.J. You, and J.W. Hyun Protective effect of puerariae radix on oxidative stress induced by hydrogen peroxide and streptozotocin Biological and Pharmaceutical Bulletin 28 2005 1154 1160
18. H.K. Kim, M. Della-Fera, J. Lin, and C.A. Baile Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes Journal of Nutrition 136 2006 2965 2969
19. C.T. Keith, A.A. Borisy, and B.R. Stockwell Multicomponent therapeutics for networked systems Nature Reviews Drug Discovery 4 2005 71 78
20. S.H. Kim, E.J. Shin, E.D. Kim, T. Bayaraa, S.C. Frost, and C.K. Hyun Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes Biological and Pharmaceutical Bulletin 30 2007 2120 2125
21. T. Kawada, N. Aoki, Y. Kamei, K. Maeshige, S. Nishiu, and E. Sugimoto Comparative investigation of vitamins and their analogues on terminal differentiation, from preadipocytes to adipocytes, of 3T3-L1 cells Comparative Biochemistry and Physiology. A: Comparative Physiology 96 1990 323 326
22. J. Kamon, T. Naitoh, M. Kitahara, and N. Tsuruzoe Prostaglandin F(2)alpha enhances glucose consumption through neither adipocyte differentiation nor GLUT1 expression in 3T3-L1 cells Cellular Signalling 13 2001 105 109
23. E.W. Kraegen, P.W. Clark, A.B. Jenkins, E.A. Daley, D.J. Chisholm, and L.H. Storlien Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats Diabetes 40 1991 1397 1403
24. M.S. Lee, C.T. Kim, I.H. Kim, and Y. Kim Inhibitory effects of green tea catechin on the lipid accumulation in 3T3-L1 adipocytes Phytotherapy Research 23 2009 1088 1091
25. H. Masuno, J. Iwanami, T. Kidani, K. Sakayama, and K. Honda Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway Toxicological Sciences 84 2005 319 327
26. D.M. Muoio, and C.B. Newgard Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes Nature Reviews Molecular Cell Biology 9 2008 193 205
27. D.M. Minich, R.H. Lerman, G. Darland, J.G. Babish, L.M. Pacioretty, J.S. Bland, and M.L. Tripp Hop and acacia phytochemicals decreased lipotoxicity in 3T3-L1 adipocytes, db/db mice, and individuals with metabolic syndrome Journal of Nutrition and Metabolism 2010 2010 PII: 467316
28. B.A. Nelson, K.A. Robinson, and M.G. Buse High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes Diabetes 49 2000 981 991
29. R.T. Oster, J.M. Tishinsky, Z. Yuan, and L.E. Robinson Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARγ mRNA, in 3T3-L1 adipocytes Applied Physiology, Nutrition, and Metabolism 35 2010 783 789
30. J.Q. Pan, C. Han, H.C. Liu, J.W. Du, and K.J. Li experimental study on hypoglycemic effects of gegenqinliangtang (GGQLT) Chinese New Drugs Journal 9 2000 167 170
31. X. Peng, J. Ma, J. Chao, Z. Sun, R.C. Chang, I. Tse, E.T. Li, F. Chen, and M. Wang Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption Journal of Agricultural and Food Chemistry 58 2010 6692 6696
32. M.J. Reed, K. Meszaros, L.J. Entes, M.D. Claypool, J.G. Pinkett, D. Brignetti, J. Luo, A. Khandwala, and G.M. Reaven Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes Diabetologia 42 1999 102 106
33. C.Y. Song, Y.H. Ni, J.B. Fu, J. Wang, Y. Cheng, and X. Tang The effect of Coptis Decoction on insulin-dependent diabetic models of mice Information on Traditional Chinese Medicine 29 2012 120 122
34. J. Sun, Y. Bi, L. Guo, X. Qi, J. Zhang, G. Li, G. Tian, F. Ren, and Z. Li Buyang Huanwu Decoction promotes growth and differentiation of neural progenitor cells: using a serum pharmacological method Journal of Ethnopharmacology 113 2007 199 203
35. X. Sheng, Y. Zhang, Z. Gong, C. Huang, and Y.Q. Zang Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors PPAR Research 2008 2008 581348
36. H. Sakoda, T. Ogihara, M. Anai, M. Funaki, K. Inukai, H. Katagiri, Y. Fukushima, Y. Onishi, H. Ono, M. Fujishiro, M. Kikuchi, Y. Oka, and T. Asano Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction Diabetes 49 2000 1700 1708
37. T.D. Schmittgen, and K.J. Livak Analyzing real-time PCR data by the comparative CT method Nature Protocols 3 2008 1101 1108
38. W. Shang, Y. Yang, B. Jiang, H. Jin, L. Zhou, S. Liu, and M. Chen Ginsenoside Rb1 promotes adipogenesis in 3T3-L1 cells by enhancing PPARgamma2 and C/EBPalpha gene expression Life Sciences 80 2007 618 625
39. P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, and H.F. Lodish A novel serum protein similar to C1q, produced exclusively in adipocytes Journal of Biological Chemistry 270 1995 26746 26749
40. A.R. Saltiel, and C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 2001 799 806
41. K. Srinivasan, B. Viswanad, L. Asrat, C.L. Kaul, and P. Ramarao Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening Pharmacological Research 52 2005 313 320
42. X.L. Tong, L.H. Zhao, F.M. Lian, Q. Zhou, L. Xia, J.C. Zhang, X.Y. Chen, and H.Y. Ji Clinical observations on the dose-effect relationship of Gegen Qinlian Decoction on 54 out-patients with type 2 diabetes Journal of Traditional Chinese Medicine 31 2011 56 59
43. T.S. Tsao, H.F. Lodish, and J. Fruebis ACRP30, a new hormone controlling fat and glucose metabolism European Journal of Pharmacology 440 2002 213 221
44. Y. Unno, T. Akuta, Y. Sakamoto, S. Horiuchi, and T. Akaike Nitric oxide-induced downregulation of leptin production by 3T3-L1 adipocytes Nitric Oxide 15 2006 125 132
45. J. Wang, Z. Yuan, H.W. Kong, Y. Li, X. Lu, and G.W. Xu Exploring the mechanism of Rhizoma coptidis in treating type II diabetes mellitus based on metabolomics by gas chromatography-mass spectrometry Chinese Journal of Chromatography 30 2012 8 13
46. X.Y. Wang, L.Y. Xiao, and J.Q. Pan Effects of glycyrrhiza on rats with diabetes mellitus induced by d-galactose China Pharmaceuticals 16 2007 8 10
47. World Health Organization, 1985. Principles of laboratory animal care. World Health Organization Chronicle 39, 51-56.
48. H. Wagner, R. Bauer, D. Melchart, P.G. Xiao, and A. Staudinger Chromatographic Fingerprint Analysis of Herbal Medicines-Thin Layer and High Performance Liquid Chromatography of Chinese Drugs vol. I + II 2011 Springer Wien New York
49. T. Wu, J.P. Dorn, R.P. Donahue, C.T. Sempos, and M. Trevisan Associations of serum C-reactive protein with fasting insulin, glucose, and glycosylated hemoglobin: the Third National Health and Nutrition Examination Survey, 1988-1994 American Journal of Epidemiology 155 2002 65 71
50. Y. Wang, K. Cui, H. Zhao, D. Li, W. Wang, and Y. Zhu Bushen Ningxin Decoction pharmacological serum promotes the proliferation and suppresses the apoptosis of murine osteoblasts through MAPK pathway Journal of Ethnopharmacology 122 2009 221 226
51. M.E. Xu, S.Z. Xiao, Y.H. Sun, X.X. Zheng, Y. Ou-Yang, and C. Guan The study of anti-metabolic syndrome effect of puerarin in vitro Life Sciences 77 2005 3183 3196
52. W. Xie, W. Wang, H. Su, D. Xing, Y. Pan, and L. Du Effect of ethanolic extracts of Ananas comosus L. leaves on insulin sensitivity in rats and HepG2 Comparative Biochemistry and Physiology. Part C: Toxicology and Pharmacology 143 2006 429 435
53. G.Z. Yang, X.P. Gao, J.F. Yan, K.Q. Ou, Y.Z. Zhang, and J. Zhang Molecular mechanism of dexamethasone and insulin induce insulin resistance in 3T3-L1 adipocytes Journal of Southwest China Normal University (Natural Science) 28 2003 460 464
54. G.R. Zimmermann, J. Lehár, and C.T. Keith Multi-target therapeutics: when the whole is greater than the sum of the parts Drug Discovery Today 12 2007 34 42
55. X.X. Zhou, P.Q. Su, and Z. Liu Experimental study of total flavonoids from stems and leaves of scatellaria baicalensis in preventing and curing diabetes mellitus Traditional Chinese Drug Research & Clinical Pharmacology 17 2006 418 420
56. L.H. Zhao, F.M. Lian, H.Y. Ji, Q. Zhou, L. Xia, and X.L. Tong Clinical examples of treatment for type 2 diabetes by professor Tong Xiao-lin using Gegen Qinlian Decoction Chinese Journal of Experimental Traditional Medical Formulae 17 2011 249 251
57. Y. Zhou, H.R. Tan, J.Q. Pan, L.Y. Xiao, and C.Y. Lv Effects of GegenQinlian Decoction on lowering blood glucose and potentiating antioxidation in type 2 diabetic rats China New Medicine 2 2003 17 18
58. J. Zhang, Y.Z. Liu, Y.S. Wang, and A. Liu Simultaneous determination of 12 active components in Gegenqinlian decoction by HPLC Chinese Journal of Experimental Traditional Medical Formulae 17 2011 58 62
59. L. Zhou, Y. Yang, X. Wang, S. Liu, W. Shang, G. Yuan, F. Li, J. Tang, M. Chen, and J. Chen Berberine stimulates glucose transport through a mechanism distinct from insulin Metabolism: Clinical and Experimental 56 2007 405 412
60. W.L. Zhang, K.Y. Zheng, K.Y. Zhu, J.Y. Zhan, C.W. Bi, J.P. Chen, C.Y. Du, K.J. Zhao, D.T. Lau, T.T. Dong, and K.W. Tsim Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications Phytomedicine 19 2012 1042 1048