Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes

Journal of Nutrition

Volumn 136, Issue 12, 2006, Pages 2965-2969

  Kim, Hye Kyeong ^a,c   Della Fera, MaryAnne ^a   Lin, Ji ^a,d   Baile, Clifton A ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c Seoul National University   (South Korea)

^d Aduro BioTech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; ALPHA TOCOPHEROL; DOCOSAHEXAENOIC ACID; FISH OIL; GLYCEROL 3 PHOSPHATE DEHYDROGENASE;

ADIPOCYTE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL STRAIN 3T3; CONCENTRATION RESPONSE; ENZYME ACTIVITY; LIPOLYSIS; MITOSIS; MOUSE; NONHUMAN; PROADIPOCYTE;

BOS TAURUS; RODENTIA;

EID: 33845303165     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.12.2965     Document Type: Article

References (35)

1. Hainault I, Carlotti M, Hajduch E, Guichard C, Lavau M. Fish oil in a high lard diet prevents obesity, hyperlipidemia, and adipocyte insulin resistance in rats. Ann N Y Acad Sci. 1993;683:98-101.
2. Parrish CC, Pathy DA, Angel A. Dietary fish oils limit adipose tissue hypertrophy in rats. Metabolism. 1990;39:217-9.
3. Baillie RA, Takada R, Nakamura M, Clarke SD. Coordinate induction of peroxisomal acyl-CoA oxidase and UCP-3 by dietary fish oil: a mechanism for decreased body fat deposition. Prostaglandins Leukot Essent Fatty Acids. 1999;60:351-6.
4. Peyron-Caso E, Quignard-Boulange A, Laromiguiere M, Feing-Kwon-Chan S, Veronese A, Ardoun B, Slama G, Rizkalla SW. Dietary fish oil increases lipid mobilization but does not decrease lipid storage-related enzyme activities in adipose tissue of insulin-resistant, sucrose-fed rats. J Nutr. 2003;133:2239-43.
5. Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell. 1996;87:377-89.
6. Ntambi JM, Kim YC. Adipocyte differentiation and gene expression. J Nutr. 2000;130:S3122-6.
7. Amri EZ, Ailhaud G, Grimaldi P. Fatty acids as signal transducing molecules: involvement in the differentiation of preadipose to adipose cells. J Lipid Res. 1994;35:930-7.
8. Brodie AE, Manning VA, Ferguson KR, Jewell DE, Hu CY. Conjugated linolenic acid inhibits differentiation of pre- and postconfluent 3T3-L1 adipocytes but inhibits cell proliferation only in preconfluent cells. J Nutr. 1999;129:602-6.
9. Kang K, Liu W, Albright KJ, Park Y, Pariza MW. trans-10,cis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPARr expression. Biochem Biophys Res Commun. 2003;303:795-9.
10. Chamras H, Ardashian A, Heber D, Glaspy JA. Fatty acid modulation of MCF-7 human breast cancer cell proliferation, apoptosis, and differentiation. J Nutr Biochem. 2002;13:711-6.
11. Dommels YE, Haring MM, Keestra NG, Alink GM, van Bladeren PJ, van Ommen B. The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effect on cell proliferation, PGE2 synthesis and cytotoxicity in human colorectal carcinoma cell lines. Carcinogenesis. 2003;24:385-92.
12. Calviello G, Palozza P, Maggiano N, Piccioni E, Franceschelli P, Frattucci A, Di Nicuolo F, Bartoli GM. Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. Lipids. 1999;34:599-604.
13. Chajes V, Sattler W, Stranzl A, Kostner GM. Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: relationship to peroxides and vitamin E. Breast Cancer Res Treat. 1995;34:199-212.
14. Merendino N, Molinari R, Loppi B, Pessina G, D'Aquino M, Tomassi G, Velottia F. Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. Ann N Y Acad Sci. 2003;1010:361-4.
15. Connolly JM, Gilhooly EM, Rose DP. Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cell growth and apoptosis in nude mice. Nutr Cancer. 1999;35:44-9.
16. Stillwell W, Ehringer W, Jenski LJ. Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells. Lipids. 1993;28:103-8.
17. Prins JB, Walker NI, Winterford CM, Cameron DP. Human adipocyte apoptosis occurs in malignancy. Biochem Biophys Res Commun. 1994;205:625-30.
18. Kim HK, Nelson-Dooley C, Della-Fera MA, Yang JY, Zhang WZ, Hartzel DL, Hamrick MW, Baile CA. Genistein decreases food intake, body weight, and fat pad weight and causes adipose tissue apoptosis in ovariectomized female mice. J Nutr. 2006;136:409-14.
19. Hemati N, Ross SE, Erickson RL, Groblewski GE, MacDougald OA. Signaling pathways through which insulin regulates CCAAT/enhancer binding protein alpha (C/EBPalpha) phosphorylation and gene expression in 3T3-L1 adipocytes. Correlation with GLUT4 gene expression. J Biol Chem. 1997;272:25913-9.
20. Suryawan A, Hu CY. Effect of serum on differentiation of porcine adipose stromal-vascular cells in primary culture. Comp Biochem Physiol Comp Physiol. 1993;105:485-92.
21. Wise LS, Green H. Participation of one isoenzyme of cytosolic glycerophosphate dehydrogenase in adipose conversion of 3T3 cells. J Biol Chem. 1979;254:273-5.
22. Kuriki K, Negaya T, Tokudome Y, Imaeda N, Fujiwara N, Sato J, Goto C, Ikeda M, Maki S, et al. Plasma concentration of (n-3) highly unsaturated fatty acids are good biomarkers of relative dietary fatty acid intakes: a cross-sectional study. J Nutr. 2003;133:3643-50.
23. Mook S, Halkes CJM, Bilecen S, Cabezas MC. In vivo regulation of plasma free fatty acids in insulin resistance. Metabolism. 2004;53:1197-201.
24. Madsen L, Peterson RK, Kristiansen K. Regulation of adipocyte differentiation and function by polyunsaturated fatty acids. Biochim Biophys Acta. 2005;1740:266-86.
25. Okuno M, Kajiwara K, Imai S, Kobayashi T, Honma N, Maki T, Suruga K, Goda T, Takase S, et al. Perilla oil prevents the excessive growth of visceral adipose tissue in rats by down-regulating adipocyte differentiation. J Nutr. 1997;127:1752-7.
26. Awad AB, Begdache LA, Fink CS. Effect of sterol and fatty acids on growth and triglyceride accumulation in 3T3-L1 cells. J Nutr Biochem. 2000;11:153-8.
27. Evans M, Geigerman C, Cook J, Curtis L, Kuebler B, McIntosh M. Conjugated linoleic acid suppresses triglyceride accumulation and induce apoptosis in 3T3-L1 preadipocytes. Lipids. 2000;35:899-910.
28. Tang Q, Otto TC, Lane MD. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci USA. 2003;100:44-9.
29. Danesch U, Weber PC, Sellmayer A. Differential effects of n-6 and n-3 polyunsaturated fatty acids on cell growth and early gene expression in Swiss 3T3 fibroblasts. J Cell Physiol. 1996;168:618-24.
30. Swamy MV, Cooma I, Patlolla JM, Smi B, Reddy BS, Rao CV. Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and docosahexaenoic acid; novel strategies for colon cancer prevention and treatment. Mol Cancer Ther. 2004;3:215-21.
31. Bremer J, Norum KR. Metabolism of very long-chain monounsaturated fatty acids (22:1) and the adaptation to their presence in the diet. J Lipid Res. 1982;23:243-56.
32. Raclot T, Groscolas R. Individual fish-oil n-3 polyunsaturated fatty acid deposition and mobilization rates for adipose tissue of rats in a nutritional steady state. Am J Clin Nutr. 1994;60:72-8.
33. Tsuboyama-Kasaoka N, Takahashi M, Kim H, Ezaki O. Upregulation of liver uncoupling protein-2 mRNA by either fish oil feeding or fibrate administration in mice. Biochem Biophys Res Commun. 1999;257:879-85.
34. Flachs P, Horakova O, Brauner P, Rossiesisl M, Franssen-van HN, Ruzickova J, Sponarova J, Drahota Z, Vlcek C, et al. Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Diabetologia. 2005;48:2365-75.
35. Kim HJ, Takahashi M, Ezaki O. Fish oil feeding decrease mature sterol regulatory element-binding protein 1(SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for downregulation of lipogenic enzyme mRNAs. J Biol Chem. 1999;274:25892-8.