Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells

Fitoterapia

Volumn 83, Issue 1, 2012, Pages 67-73

  Chen, Hong Ying ^a,b   Ye, Xiao Li ^a   Cui, Xue Long ^c   He, Kai ^a   Jin, Ya Nan ^a   Chen, Zhu ^a   Li, Xue Gang ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b SOUTHWEST UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Chongqing Shizhu Huanglian Co Ltd   (China)

Author keywords

Cytotoxicity; Glucose lowering; HepG2 cells; Rhizoma Coptis

Indexed keywords

8 OXO COPTISINE; ALCOHOL; ALKALOID; BERBERINE; BERBERINE DERIVATIVE; BEROLINE; CHOLINE; COLUMBAMINE; COPTISINE; EPIBERBERINE; FERULIC ACID; GLUCOSE; GROENLANDICINE; HYDROCHLORIC ACID; JATRORRHIZINE; MAGNOFLORINE; MONOMER; OXYBERBERINE; PALMATINE; PLANT EXTRACT; RHIZOMA COPTIS EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL PROLIFERATION; CELL STRAIN HEPG2; CHEMICAL COMPOSITION; COLUMN CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COUNTER CURRENT CHROMATOGRAPHY; CYTOTOXICITY; DRUG ISOLATION; FRACTIONATION; GLYCEMIC CONTROL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH SPEED COUNTER CURRENT CHROMATOGRAPHY; HUMAN; HUMAN CELL; MEDICINAL PLANT; PHYTOCHEMISTRY; PRIORITY JOURNAL; RHIZOMA COPTIS; RHIZOME;

ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; COPTIS; GLUCOSE; HEP G2 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; MOLECULAR STRUCTURE; RHIZOME;

COPTIS;

EID: 83055186675     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2011.09.014     Document Type: Article

References (34)

1. Y. Zhou, L. Xia, and X.L. Tong Experiences of Professor Tong using Coptis to treat diabetes J New Chin Med 42 2010 129 130
2. Y.L. Yu, S.S. Lu, S. Yu, Y.C. Liu, P. Wang, and L. Xie Huang-Lian-Jie-Du-Decoction modulates glucagon-like peptide-1 secretion in diabetic rats J Ethnopharmacol 124 2009 444 449
3. Z. Zhen, B. Chang, M. Li, F.M. Lian, L.A. Chen, and L. Dong Anti-diabetic effects of a Coptis chinensis containing new traditional Chinese medicine formula in type 2 diabetic rats Am J Chin Med 39 2011 53 63
4. C.H. Li, and K.Y. Zhou Study advances on the effects and mechanisms of active constituents of Coptidis Rhizoma Li Shi Zhen Med Med Res 21 2010 466 468
5. M.H. Jang, H.Y. Kim, K.S. Kang, T. Yokozawa, and J.H. Park Hydroxyl radical scavenging activities of isoquinoline alkaloids isolated from Coptis chinensis Arch Pharm Res 32 2009 341 345
6. L.J. Yuan, D.W. Tu, X.L. Ye, and J.P. Wu Hypoglycemic and hypocholesterolemic effects of Coptis chinensis Franch inflorescence Plant Foods Hum Nutr 61 2006 139 144
7. X.P. An, and Q.R. Cui Study advances on antidiabetes of Rhizoma Coptidis Gansu J Tradit Chin Med 21 2008 57 58
8. N. Shen, C.N. Li, Y. Huan, and Z.F. Shen Advances of the mechanism study on berberine in the control of blood glucose and lipid as well as metabolism disorders Acta Pharm Sin 45 2010 699 704
9. H.A. Jung, N.Y. Yoon, H.J. Bae, B.S. Min, and J.S. Choi Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase Arch Pharm Res 31 2008 1405 1412
10. H.A. Jung, B.S. Min, T. Yokozawa, J.H. Lee, Y.S. Kim, and J.S. Choi Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids Biol Pharm Bull 32 2009 1433 1438
11. Y. Fu, B.R. Hu, Q. Tang, Q. Fu, Q.Y. Zhang, and J.Zh. Xiang Effect of jatrorrhizine, berberine, Huanglian decoction and compound-mimic prescription on blood glucose in mice Chin Tradit Herb Drugs 36 2005 548 551
12. J.C. Li, X.L. Meng, X.J. Fan, X.R. Lai, Y. Zhang, and Y. Zeng Pharmacodyamic material basis of Rhizoma Coptidis on insulin resistance China J Chin Mater Med 35 2010 1855 1858
13. B.L. Ma, Y.M. Ma, R. Shi, T.M. Wang, N. Zhang, and C.H. Wang Identification of the toxic constituents in Rhizoma Coptidis J Ethnopharmacol 2010 357 364
14. S.H. Qiu, H.B. Tang, F.Y. Li, J.R. Xiao, and B.Y. Chen Experimental study of the acute toxicity on conunon-used bitter and cold medicines Cent S Pharm 2 2004 37 38
15. Y. Yang, X.L. Ye, J. Zheng, B.S. Zhang, and X.G. Li Synthesis of 8-alkylberberine Chin J Org Chem 27 2007 1438 1440
16. X.A. Xia, J.H. Yan, Y.F. Shen, K.X. Tang, J. Yin, and Y.H. Zhang Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis PLoS One 6 2011
17. F.Q. Yang, F.Y. Zhang, R. Zhang, and Y. Ito Application of analytical and preparative high-speed counter-current chromatography for separation of alkaloids from Coptis chinensis Franch J Chromatogr A 829 1998 137 141 (Pubitemid 29005085)
18. X.K. Zheng, Y.J. Li, L. Zhang, W.S. Feng, and X. Zhang Antihyperglycemic activity of Selaginella tamariscina (Beauv.) Spring J Ethnopharmacol 2011 531 537
19. Y.Y. You, T.Z. Wang, L. Chen, and W.B. Wu Studies on the alkaloids of Coptis linearisepala West China J Pharm Sci 20 2005 505 506
20. W. Jiang, C.H. Wang, and Z.T. Wang Water-soluble chemical constituents of Angelica Sinensis (Oliv.) Diels Chin Pharm J 45 2010 101 103
21. J. Tong, Z.Q. Xing, and S. Lu Studies of tracking choline synthesis temperature by NMR Acad J Liaoning Univ 24 1997 25 30
22. N. O'Donoghue, T. Sweeney, R. Donagh, K.J. Clarke, and R.K. Porter Control of choline oxidation in rat kidney mitochondria Biochim Biophys Acta 1787 2009 1135 1139
23. C. Liapi, A. Kyriakaki, A. Zarros, P. Galanopoulou, H. Al-Humadi, and I. Dontas Choline-deprivation alters crucial brain enzyme activities in a rat model of diabetic encephalopathy Metab Brain Dis 25 2010 269 276
24. P. Wu, L. Feng, Sh Yao, Y. Liu, J. Jiang, and K. Hu Effect of dietary choline on growth, intestinal enzyme activities and relative expressions of target of rapamycin and eIF4E-binding protein2 gene in muscle, hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian) Aquaculture 317 2011 107 116
25. O. Georgina, D. Marianela, and R. Marisa Oxidative damage lipid peroxidation in the kidney of choline-deficient rats Front Biosci 12 2007 1174 1183
26. H.J. Pan, Y.M. Lin, Y.Q.E. Chen, D.E. Vance, and E.H. Leiter Adverse hepatic and cardiac responses to rosiglitazone in a new mouse model of type 2 diabetes: relation to dysregulated phosphatidylcholine metabolism Vascul Pharmacol 45 2006 65 71 (Pubitemid 43963486)
27. H.L. Xu Studies on alkaloids of Asteropyrum cavaleriei (Lévl. et Vant.) Drumm. et Hutch China J Chin Mater Med 25 2000 486 488
28. Y. Fu, B.R. Hu, Q. Tang, Q. Fu, Q.Y. Zhang, and J.Z. Xiang Isoquinoline alkaloids from the Rhizoma of Coptis chinensis Chin J Nat Med 5 2007 348 350
29. J.Y. Zhu, X.F. Qin, X. Chen, X.G. Li, Z. Chen, and F.L. He Synergism of alkaloids from Coptis Rhizoma Shi Zhen Med Mater Med Res 21 2010 2282 2284
30. T.M. Hung, J.P. Lee, B.S. Min, J.S. Choi, M.K. Na, and X.F. Zhang Magnoflorine from Coptidis Rhizoma protects high density lipoprotein during oxidant stress Biol Pharm Bull 30 2007 1157 1160 (Pubitemid 46883884)
31. M.S. Balasubashini, R. Rukkumani, and V.P. Menon Protective effects of ferulic acid on hyperlipidemic diabetic rats Acta Diabetol 40 2003 118 122 (Pubitemid 37288120)
32. P.K. Prabhakar, and M. Doble Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes Phytomedicine 16 2009 1119 1126
33. Y. Yang, B.S. Zhang, and X.G. Li Study on toxicity of berberrubine J S Med Univ 29 2009 2349 2350
34. X.L. Tong Problems in diabetes treatment with traditional Chinese medicines Chin J New Drugs 19 2010 1201 1203