Bisphenol A accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway

Toxicological Sciences

Volumn 84, Issue 2, 2005, Pages 319-327

  Masuno, Hiroshi ^a   Iwanami, Jun ^b   Kidani, Teruki ^c   Sakayama, Kenshi ^c   Honda, Katsuhisa ^b  

^a EHIME PREFECTURAL UNIVERSITY OF HEALTH SCIENCES   (Japan)

^b EHIME UNIVERSITY   (Japan)

^c EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

3T3 L1 cells; Akt kinase; Bisphenols; LY294002; Terminal adipocyte differentiation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 NONYLPHENOL; 4 TERT OCTYLPHENOL; 4,4' ISOPROPYLIDENEDIPHENOL; ALKANE DERIVATIVE; CARBON; CYANIC ACID DERIVATIVE; FATTY ACID BINDING PROTEIN; HYDROXYL GROUP; LIPOPROTEIN LIPASE; MESSENGER RNA; PHENOL DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SULFUR; TRIACYLGLYCEROL;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FAT CONTENT; GENE EXPRESSION; LIPID STORAGE; MOUSE; NONHUMAN; STAINING; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3-L1 CELLS; ADIPOCYTES; ANIMALS; AZO COMPOUNDS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL DIFFERENTIATION; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ESTROGENS, NON-STEROIDAL; FATTY ACID-BINDING PROTEINS; LIPOPROTEIN LIPASE; MICE; MORPHOLINES; PHENOLS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; STAINING AND LABELING; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 17444394007     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi088     Document Type: Article

References (39)

1. Backer, J. M., Schroeder, G. G., Kahn, C. R., Myers, M. G., Jr., Wilden, P. A., Cahill, D. A., and White, M. F. (1992). Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. J. Biol. Chem. 267, 1367-1374.
2. Brede, C., Fjeldal, P., Skjevrak, I., and Herikstad, H. (2003). Increased migration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing. Food Addit. Contam. 20, 684-689.
3. Brotons, J. A., Olea-Serrano, F., Villalobos, M., Pedraza, V., and Olea, N. (1995). Xenoestrogens released from lacquer coatings in food cans. Environ. Health Perspect. 103, 608-612.
4. Burgering, B. M., and Coffer, P. J. (1995). Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376, 599-602.
5. Cornelius, P., MacDougald, O. M., and Lane, M. D. (1994). Regulation of adipocyte formation. Annu. Rev. Nutr. 14, 99-129.
6. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R., and Tsichilis, P. N. (1995). The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736.
7. Funabashi, T., Kawaguchi, M., and Kimura, F. (2001). The endocrine disrupters butyl benzyl phthalate and bisphenol A increase the expression of progesterone receptor messenger ribonucleic acid in the preoptic area of adult ovariectomized rats. Neuroendocrinology 74, 77-81.
8. Gilbert, J., Dore, J.-C., Bignon, E., Pons, M., and Ojasoo, T. (1994). Study of the effects of basic di- and tri-phenyl derivatives on malignant cell proliferation: An example of the application of correspondence factor analysis to structure-activity relationship (SAR). Quant. Struct. Act. Relat. 13, 262-274.
9. Goloubkova, T., Ribeiro, M. F., Rodrigues, L. P., Cecconello, A. L., and Spritzer, P. M. (2000). Effects of xenoestrogen bisphenol A on uterine and pituitary weight, serum prolactin levels and immunoreactive prolactin cells in ovariectomized Wistar rats. Arch. Toxicol. 74, 92-98.
10. Green, H., and Meuth, M. (1974). An established pre-adipose cell line and its differentiation in culture. Cell 3, 127-133.
11. Gregoire, F. M., Smas, C. M., and Sul, H. S. (1998). Understanding adipocyte differentiation. Physiol. Rev. 78, 783-809.
12. Hashimoto, Y., Moriguchi, Y., Oshima, H., Kawaguchi, M., Miyazaki, K., and Nakamura, M. (2001). Measurement of estrogenic activity of chemicals for the development of new dental polymers. Toxicol. in Vitro 15, 421-425.
13. Hinegardner, R. T. (1971). An improved fluorometric assay for DNA. Anal. Biochem. 39, 197-201.
14. Howdeshell, K. L., Hotchkiss, A. K., Thayer, K. A., Vandenbergh, J. G., and vom Saal, F. S. (1999). Exposure to bisphenol A advances puberty. Nature 401, 763-764.
15. Kapeller, R., Chen, K. S., Yoakim, M., Schaffhausen, B. S., Backer, J., White, M. F., Cantley, L. C., and Ruderman, N. B. (1991). Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Mol. Endocrinol. 5, 769-777.
16. Kohn, A. D., Summers, S. A., Birnbaum, M. J., and Roth, R. A. (1996). Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J. Biol. Chem. 271, 31372-31378.
17. Korach, K. S. (1993). Editorial: Surprising places of estrogenic activity. Endocrinology 132, 2277-2278.
18. Krishnan, A. V., Stathis, P., Permuth, S. F., Tokes, L., and Feldman, D. (1993). Bisphenol A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 132, 2279-2286.
19. Kuri-Harcuch, W., and Green, H. (1978). Adipose conversion of 3T3 cells depends on a serum factor. Proc. Natl. Acad. Sci. U.S.A. 75, 6107-6109.
20. Inoue, K., Kato, K., Yoshimura, Y., Makino, T., and Nakazawa, H. (2000). Determination of bisphenol A in human serum by high-performance liquid chromatography with multi-electrode electrochemical detection. J. Chromatogr. B Biomed. Sci. Appl. 749, 17-23.
21. Leclercq, G. (1992). Estrogens, antiestrogens and other estrogen compounds. In Antitumor Steroids (R. T. Blickenstaff, Ed.), pp. 11-64. Academic Press, New York.
22. Masuno, H., Blanchette-Mackie, E. J., Chemick, S. S., and Scow, R. O. (1990). Synthesis, of inactive nonsecretable high mannose-type lipoprotein lipase by cultured brown adipocytes of combined lipase-deficient cld/cld mice. J. Biol. Chem. 265, 1628-1638.
23. Masuno, H., Kidani, T., Sekiya, K., Sakayama, K., Shiosaka, T., Yamamoto, H., and Honda, K. (2002). Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes. J. Lipid Res. 43, 676-684.
24. Masuno, H., Okamoto, S., Iwanami, J., Honda, K., Shiosaka, T., Kidani, T., Sakayama, K., and Yamamoto, H. (2003). Effect of on cell proliferation and adipocyte formation in cultures of fully differentiated 3T3-L1 cells. Toxicol. Sci. 75, 314-320.
25. Olea, N., Pulgar, R., Perez, P., Olea-Serrano, F., Rivas, A., Novillo-Fertrell, A., Pedraza, V., Soto, A. M., and Sonnenschein, C. (1996). Estrogenicity of resin-based composites and sealants used in dentistry. Environ. Health Perspect. 104, 298-305.
26. Papaconstantinou, A. D., Umbreit, T. H., Fisher, B. R., Goering, P. L., Lappas, N. T., and Brown, K. M. (2000). Bisphenol A-induced increase in uterine weight and alterations in uterine morphology in ovariectomized B6C3F1 mice: role of the estrogen receptor. Toxicol. Sci. 56, 332-339.
27. Perez, P., Pulgar, R., Olea-Serrano, F., Villalobos, M., Rivas, A., Metzler, M., Pedraza, V., and Olea, N. (1998). The estrogenicity of bisphenol A-related diphenylalkanes with various substituents at the central carbon and the hydroxyl groups. Environ. Health Perspect. 106, 167-174.
28. Rivas, A., Lacroix, M., Olea-Serrano, F., Laios, I., Leclercq, G., and Olea, N. (2002). Estrogenic effect of a series of bisphenol analogues on gene and protein expression in MCF-7 breast cancer cells. J. Steroid Biochem. Mol. Biol. 82, 45-53.
29. Rubin, C. S., Hirsch, A., Fung, C., and Rosen, O. M. (1978). Formation of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J. Biol. Chem. 253, 7570-7579.
30. Rubin, B. S., Murray, M. K., Damassa, D. A., King, J. C., and Soto, A. M. (2001). Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ. Health Perspect. 109, 675-680.
31. Russell, T. R., and Ho, R.-H. (1976). Conversion of 3T3-L1 fibroblasts into adipose cells: Triggering of differentiation by prostaglandin F2α and 1-methyl-3-isobutylxanthin. Proc. Natl. Acad. Sci. U.S.A. 73, 4516-4520.
32. Sakurai, K., Kawazuma, M., Adachi T., Harigaya, T., Saito, Y., Hashimoto, N., and Mori, C. (2004). Bisphenol A affects glucose transport in mouse 3T3-F442A adipocytes. Br. J. Pharmacol. 141, 209-214.
33. Soto, A. M., Justicia, H., Wray, J. W., and Sonnenschein, C. (1991). p-Nonylphenol: An estrogenic xenobiotic released from "modified" polystyrene. Environ. Health Perspect. 92, 167-173.
34. Spooner, P. M., Chernick, S. S., Garrison, M. M., and Scow, R. O. (1979). Formation of lipoprotein lipase activity and accumulation of triacylglycerol in differentiating 3T3-L1 adipocytes. Effects of prostaglandin F2α, 1-methyl-3-isobutylxanthine, prolactin, and insulin. J. Biol. Chem. 254, 1305-1311.
35. Steinmetz, R., Mitchner, N. A., Grant, A., Allen, D. L., Bigsby, R. M., and Ben-Jonathan, N. (1998). The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract. Endocrinology 139, 2741-2747.
36. Toscani, A., Soprano, D. R., and Soprano, K. J. (1990). Sodium butyrate in combination with insulin or dexamethasone can terminally differentiate actively proliferating Swiss 3T3 cells into adipocytes. J. Biol. Chem. 265, 5722-5730.
37. White, R., Jobling, S., Hoare, S. A., Sumpter, J. P., and Parker, M. G. (1994). Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 135, 175-182.
38. White, M. F., and Kahn, C. R. (1994). The insulin signaling system. J. Biol. Chem. 269, 1-4.
39. Xia, X., and Serrero, G. (1999). Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitor. J. Cell Physiol. 178, 9-16.