Docosahexaenoic acid increases cellular adiponectin mrna and secreted adiponectin protein, as well as pparg mrna, in 3t3-l1 adipocytes

Applied Physiology, Nutrition and Metabolism

Volumn 35, Issue 6, 2010, Pages 783-789

  Oster, Richard T ^a   Tishinsky, Justine M ^a   Yuan, Zongfei ^a   Robinson, Lindsay E ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

3T3 L1 adipocytes; Adiponectin; Docosahexaenoic acid; Eicosapentaenoic acid; N 3 fatty acids; Peroxisome proliferator activated receptor g

Indexed keywords

2,2 BIS(4 GLYCIDYLOXYPHENYL)PROPANE; 2,2-BIS(4-GLYCIDYLOXYPHENYL)PROPANE; ADIPONECTIN; ADIPONECTIN, MOUSE; DOCOSAHEXAENOIC ACID; EPOXIDE; ICOSAPENTAENOIC ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADIPOCYTE; ANIMAL; ARTICLE; CELL STRAIN 3T3; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; OSMOLARITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION;

3T3-L1 CELLS; ADIPOCYTES; ADIPONECTIN; ANIMALS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION; MICE; OSMOLAR CONCENTRATION; PPAR GAMMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 78650302579     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/H10-076     Document Type: Article

References (35)

1. Akbiyik, F., Ray, D.M., Bozkaya, H., and Demirpence, E. 2004. Ligand- and species dependent activation of PPARα. Cell. Physiol. Biochem. 14(4-6): 269-276. doi:10.1159/000080336. PMID:15319530.
2. Bergen, W.G., and Mersmann, H.J. 2005. Comparative aspects of lipid metabolism: impact on contemporary research and use of animal models. J. Nutr. 135(11): 2499-2502. PMID:16251600.
3. Bernlohr, D.A., Bolanowski, M.A., Kelly, T.J., Jr., and Lane, M.D. 1985. Evidence for an increase in transcription of specific mRNAs during differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 260(9): 5563-5567. PMID:3988766.
4. Bueno, A.A., Oyama, L.M., de Oliveira, C., Pisani, L.P., Ribeiro, E.B., Silveira, V.L., and Oller do Nascimento, C.M. 2008. Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. Pflugers Arch. 455(4): 701-709.doi:10.1007/s00424-007- 0330-3. PMID:17717684.
5. Combs, T.P., Wagner, J.A., Berger, J., Doebber, T., Wang, W.J., Zhang, B.B., et al. 2002. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARg agonists: a potential mechanism of insulin sensitization. Endocrinology, 143(3): 998-1007. doi:10.1210/en.143.3.998. PMID:11861525.
6. Flachs, P., Mohamed-Ali, V., Horakova, O., Rossmeisl, M., Hosseinzadeh- Attar, M.J., Hensler, M., et al. 2006. Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia, 49(2): 394-397. doi:10.1007/ s00125-005-0053-y. PMID:16397791.
7. Ford, E.S., Giles, W.H., and Mokdad, A.H. 2004. Increasing prevalence of the metabolic syndrome among US adults. Diabetes Care, 27(10): 2444-2449. doi:10.2337/diacare.27.10.2444. PMID:15451914.
8. Jump, D.B., and Clarke, S.D. 1999. Regulation of gene expression by dietary fat. Annu. Rev. Nutr. 19(1): 63-90. doi:10.1146/ annurev.nutr.19.1.63. PMID:10448517.
9. Kadowaki, T., and Yamauchi, T. 2005. Adiponectin and adiponectin receptors. Endocr. Rev. 26(3): 439-451. doi:10.1210/er.2005- 0005. PMID:15897298.
10. Kim, H.K., Della-Fera, M., Lin, J., and Baile, C.A. 2006. Docosahexaenoic acid inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 preadipocytes. J. Nutr. 136(12): 2965- 2969. PMID:17116704.
11. Körner, A., Wabitsch, M., Seidel, B., Fischer-Posovszky, P., Berthold, A., Stumvoll, M., et al. 2005. Adiponectin expression in humans is dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight. Biochem. Biophys. Res. Commun. 337(2): 540-550. doi:10.1016/j.bbrc.2005.09.064. PMID:16202386.
12. Krebs, J.D., Browning, L.M., McLean, N.K., Rothwell, J.L., Mishra, G.D., Moore, C.S., and Jebb, S.A. 2006. Additive benefits of long-chain n-3 polyunsaturated fatty acids and weightloss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women. Int. J. Obes. (London), 30(10): 1535-1544. doi:10.1038/sj.ijo.0803309. PMID: 16552404.
13. Lau, D.C., Dhillon, B., Yan, H., Szmitko, P.E., and Verma, S. 2005. Adipokines: molecular links between obesity and atheroslcerosis. Am. J. Physiol. Heart Circ. Physiol. 288(5): H2031- H2041. doi:10.1152/ajpheart.01058.2004. PMID:15653761.
14. Li, H., Ruan, X.Z., Powis, S.H., Fernando, R., Mon, W.Y., Wheeler, D.C., et al. 2005. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR γdependent mechanism. Kidney Int. 67(3): 867-874.doi:10. 1111/j.1523 1755.2005.00151.x. PMID:15698426.
15. Lorente-Cebrián, S., Pérez-Matute, P., Martínez, J.A., Marti, A., and Moreno-Aliaga, M.J. 2006. Effects of eicosapentaenoic acid (EPA) on adiponectin gene expression and secretion in primary cultured rat adipocytes. J. Physiol. Biochem. 62(2): 61-69. doi:10.1007/BF03174067. PMID:17217160.
16. Ma, H., Shieh, K.-J., Chen, L., Qiao, T., and Chuang, M.-Y. 2006. Application of real-time polymerase chain reaction (RT-PCR). J. Am. Sci. 2(3): 1-5.
17. Mori, T.A., Bao, D.Q., Burke, V., Puddey, I.B., and Beilin, L.J. 1999. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension, 34(2): 253-260.PMID:10454450.
18. Mori, T.A., Burke, V., Puddey, I.B., Watts, G.F., O'Neal, D.N., Best, J.D., and Beilin, L.J. 2000. Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. Am. J. Clin. Nutr. 71(5): 1085- 1094.PMID:10799369.
19. Neschen, S., Morino, K., Rossbacher, J.C., Pongratz, R.L., Cline, G.W., Sono, S., et al. 2006. Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-g-dependent mechanism in mice. Diabetes, 55(4): 924-928.doi:10.2337/ diabetes.55.04.06.db05-0985. PMID:16567512.
20. Nettleton, J.A., and Katz, R. 2005. n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J. Am. Diet. Assoc. 105(3): 428-440. doi:10.1016/j.jada.2004.11.029. PMID: 15746832.
21. Ohashi, A., Matsushita, Y., Kimura, K., Miyashita, K., and Saito, M. 2004. Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin. J. Nutr. Sci. Vitaminol. (Tokyo), 50(6): 416-421. PMID:15895517.
22. Olshansky, S.J., Passaro, D.J., Hershow, R.C., Layden, J., Carnes, B.A., Brody, J., et al. 2005. A potential decline in life expectancy in the United States in the 21st century. N. Engl. J. Med. 352(11): 1138-1145.doi:10.1056/NEJMsr043743. PMID: 15784668.
23. Rasouli, N., Yao-Borengasser, A., Miles, L.M., Elbein, S.C., and Kern, P.A. 2006. Increased plasma adiponectin in response to pioglitazone does not result from increased gene expression. Am. J. Physiol. Endocrinol. Metab. 290(1): E42-E46. doi:10. 1152/ajpendo.00240.2005. PMID:16118250.
24. Robinson, L.E., and Graham, T.E. 2004. Metabolic syndrome, a cardiovascular disease risk factor: role of adipocytokines and impact of diet and physical activity. Can. J. Appl. Physiol. 29(6): 808-829PMID:15630152.
25. Rossi, A.S., Lombardo, Y.B., Lacorte, J.M., Chicco, A.G., Rouault, C., Slama, G., and Rizkalla, S.W. 2005. Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrosefed, insulin-resistant rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289(2): R486-R494. PMID:16014450.
26. Saravanan, N., Haseeb, A., Ehtesham, N.Z., and Ghafoorunissa. 2005. Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue. Eur. J. Endocrinol. 153(1): 159-165. doi:10.1530/eje.1.01946. PMID:15998628.
27. Skurk, T., Alberti-Huber, C., Herder, C., and Hauner, H. 2007. Relationship between adipocyte size and adipokine expression and secretion. J. Clin. Endocrinol. Metab. 92(3): 1023-1033. doi:10. 1210/jc.2006-1055. PMID:17164304.
28. Soares, A.F., Guichardant, M., Cozzone, D., Bernoud-Hubac, N., Bouzaïdi-Tiali, N., Lagarde, M., and Géloën, A. 2005. Effects of oxidative stress on adiponectin secretion and lactate production in 3T3-L1 adipocytes. Free Radic. Biol. Med. 38(7): 882- 889. doi:10.1016/j.freeradbiomed.2004.12.010. PMID:15749384.
29. Tishinsky, J.M., Ma, D.W.L., and Robinson, L.E. 2010. Eicosapentaenoic acid rosiglitazone increase adiponectin in an additive and PPARg-dependent manner in human adipocytes. Obesity (Silver Spring). [Epub ahead of print.] doi:10.1038/oby.2010. 186. PMID:20814411.
30. Wang, Z.V., Schraw, T.D., Kim, J.Y., Khan, T., Rajala, M.W., Follenzi, A., and Scherer, P.E. 2007. Secretion of the adipocytespecific secretory protein adiponectin critically depends on thiolmediated protein retention. Mol. Cell. Biol. 27(10): 3716-3731. doi:10.1128/MCB.00931-06. PMID:17353260.
31. Weldon, S.M., Mullen, A.C., Loscher, C.E., Hurley, L.A., and Roche, H.M. 2007. Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid. J. Nutr. Biochem. 18(4): 250-258. doi:10.1016/j.jnutbio.2006.04.003. PMID:16781858.
32. Yano, M., Kishida, E., Iwasaki, M., Kojo, S., and Masuzawa, Y. 2000. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. J. Nutr. 130(5): 1095-1101.PMID:10801904.
33. Yokomori, N., Tawata, M., and Onaya, T. 1999. A transcriptional repressor regulates mouse GLUT4 gene expression during the differentiation of 3T3-L1 cells. Diabetes, 48(12): 2471-2474. doi:10.2337/diabetes.48.12.2471. PMID:10580438.
34. Yu, Y.H., Lin, E.C., Wu, S.C., Cheng, W.T., Mersmann, H.J., Wang, P.H., and Ding, S.T. 2008. Docosahexaenoic acid regulates adipogenic genes in myoblasts via porcine peroxisome proliferator- activated receptor g. J. Anim. Sci. 86(12): 3385-3392. doi:10.2527/jas.2008-1051. PMID:18676720.
35. Yuan, Z., Tie, A., Tarnopolsky, M., and Bakovic, M. 2006. Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1. Physiol. Genomics, 26(1): 76-90.doi:10.1152/physiolgenomics.00107.2005. PMID: 16609143.