WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling

Biochemical and Biophysical Research Communications

Volumn 431, Issue 3, 2013, Pages 466-471

  Yan, Shan ^a,b   Willis, Jeremy ^a  

^a UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE   (United States)

^b University of North Carolina at Charlotte   (United States)

Author keywords

ATR; Chk1; DNA damage checkpoint; TopBP1; WD40; WDR18

Indexed keywords

ATR INTERACTING PROTEIN; BINDING PROTEIN; CELL PROTEIN; CHECKPOINT KINASE 1; TOPOISOMERASE II BETA BINDING PROTEIN; UNCLASSIFIED DRUG; WD40 REPEAT PROTEIN 18;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANIMALS; CARRIER PROTEINS; CELL CYCLE CHECKPOINTS; DNA DAMAGE; OOCYTES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; XENOPUS LAEVIS; XENOPUS PROTEINS;

EUKARYOTA;

EID: 84873707924     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.144     Document Type: Article

References (36)

1. Friedberg E.C. DNA damage and repair. Nature 2003, 421:436-440.
2. Kastan M.S., Bartek J. Cell-cycle checkpoints and cancer. Nature 2004, 432:316-323.
3. Harrison J.C., Haber J.E. Surviving the breakup: the DNA damage checkpoint. Annu. Rev. Genet. 2006, 40:209-235.
4. Harper J.W., Elledge S.J. The DNA damage response: ten years after. Mol. Cell 2007, 28:739-745.
5. Bartkova J., Horejsí Z., Koed K., Krämer A., Tort F., Zieger K., Guldberg P., Sehested M., Nesland J., Lukas C., Orntoft T., Lukas J., Bartek J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005, 434:864-870.
6. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
7. Cimprich K.A., Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9:616-627.
8. Choi J.H., Sancar A., Lindsey-Boltz L.A. The human ATR-mediated DNA damage checkpoint in a reconstituted system. Methods 2009, 48:3-7.
9. Zou L., Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548.
10. Lieberman H.B. Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity. J. Cell. Biochem. 2006, 97:690-697.
11. Kumagai A., Dunphy W.G. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell 2000, 6:839-849.
12. Garcia V., Furuya K., Carr A.M. Identification and functional analysis of TopBP1 and its homologs. DNA Repair (Amst.) 2005, 4:1227-1239.
13. Chen Y., Poon R.Y. The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability. Front. Biosci. 2008, 13:5016-5029.
14. Boddy M.N. Replication checkpoint enforced by kinases Cds1 and Chk1. Science 1998, 280:909-912.
15. Sokka M., Parkkinen S., Pospiech H., Syvaoja J.E. Function of TopBP1 in genome stability. Subcell. Biochem. 2010, 50:119-141.
16. Kumagai A., Lee J., Yoo H.Y., Dunphy W.G. TopBP1 activates the ATR-ATRIP complex. Cell 2006, 124:943-955.
17. Mordes D.A., Glick G.G., Zhao R., Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev. 2008, 22:1478-1489.
18. Delacroix S., Wagner J.M., Kobayashi M., Yamamoto K., Karnitz L.M. The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1. Genes Dev. 2007, 21:1472-1477.
19. Lee J., Kumagai A., Dunphy W.G. The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR. J. Biol. Chem. 2007, 282:28036-28044.
20. Yoo H.Y., Kumagai A., Shevchenko A., Dunphy W.G. Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J. Biol. Chem. 2007, 282:17501-17506.
21. Cescutti R., Negrini S., Kohzaki M., Halazonetis T.D. TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint. EMBO J. 2010, 29:3723-3732.
22. Gong Z., Kim J.E., Leung C.C., Glover J.N., Chen J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol. Cell 2010, 37:438-446.
23. Wang J., Gong Z., Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J. Cell Biol. 2011, 193:267-273.
24. Yan S., Lindsay H.D., Michael W.M. Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling. J. Cell Biol. 2006, 173:181-186.
25. Yan S., Michael W.M. TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks. J. Cell Biol. 2009, 184:793-804.
26. Van C., Yan S., Michael W.M., Waga S., Cimprich K.A. Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J. Cell Biol. 2010, 189:233-246.
27. Willis J., Destephanis D., Patel Y., Gowda V., Yan S. Study of the DNA damage checkpoint using Xenopus egg extracts. J. Vis. Exp. 2012, e4449.
28. Smith T.F., Gaitatzes C., Saxena K., Neer E.J. The WD repeat: a common architecture for diverse functions. Trends Biochem. Sci. 1999, 24:181-185.
29. Stirnimann C.U., Petsalaki E., Russell R.B., Muller C.W. WD40 proteins propel cellular networks. Trends Biochem. Sci. 2010, 35:565-574.
30. Xu C., Min J. Structure and function of WD40 domain proteins. Protein Cell 2011, 2:202-214.
31. Finkbeiner E., Haindl M., Muller S. The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex. EMBO J. 2011, 30:1067-1078.
32. Castle C.D., Cassimere E.K., Denicourt C. LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis. Mol. Biol. Cell 2012, 23:716-728.
33. Saka Y., Esashi F., Matsusaka T., Mochida S., Yanagida M. Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev. 1997, 11:3387-3400.
34. Taricani L., Wang T.S. Rad4TopBP1, a scaffold protein, plays separate roles in DNA damage and replication checkpoints and DNA replication. Mol. Biol. Cell 2006, 17:3456-3468.
35. Lebofsky R., Takahashi T., Walter J.C. DNA replication in nucleus-free Xenopus egg extracts. Methods Mol. Biol. 2009, 521:229-252.
36. Michael W.M., Ott R., Fanning E., Newport J. Activation of the DNA replication checkpoint through RNA synthesis by primase. Science 2000, 289:2133-2137.