Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 1, 2008, Pages 111-125

  Shi, Yanrong ^a   Liu, Xiaoguang ^a   Gebremedhin, Debebe ^b   Falck, John R ^c   Harder, David R ^b   Koehler, Raymond C ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Cerebral circulation; Epoxygenase; Functional activation; Nitric oxide; Vibrissae

Indexed keywords

ADENOSINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR; ARACHIDONIC ACID DERIVATIVE; CALCIUM; EPOXYICOSATRIENOIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; ASTROCYTE; BRAIN BLOOD FLOW; BRAIN CIRCULATION; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SOMATOSENSORY CORTEX; VIBRISSA;

8,11,14-EICOSATRIENOIC ACID; ANIMALS; ARACHIDONIC ACIDS; CEREBELLAR CORTEX; CEREBROVASCULAR CIRCULATION; MALE; NEUROEFFECTOR JUNCTION; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, PURINERGIC P1; SIGNAL TRANSDUCTION; VASODILATION; VASODILATOR AGENTS; VIBRISSAE;

EID: 37549048669     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600511     Document Type: Article

References (40)

1. Alkayed NJ, Birks EK, Narayanan J, Petrie KA, Kohler-Cabot AE, Harder DR (1997) Role of P-450 arachidonic acid expoygenase in the response of cerebral blood flow to glutamate in rats. Stroke 28:1066-72
2. Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR (1996) Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke 27:971-9
3. Alloisio S, Cugnoli C, Ferroni S, Nobile M (2004) Differential modulation of ATP-induced calcium signalling by A1 and A2 adenosine receptors in cultured cortical astrocytes. Br J Pharmacol 141:935-42
4. Amruthesh SC, Boerschel MF, McKinney JS, Willoughby KA, Ellis EF (1993) Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes. J Neurochem 61:150-9
5. Buerk DG, Ances BM, Greenberg JH, Detre JA (2003) Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in rats. Neuroimage 18:1-9
6. Di Tullio MA, Tayebati SK, Amenta F (2004) Identification of adenosine A1 and A3 receptor subtypes in rat pial and intracerebral arteries. Neurosci Lett 366:48-52
7. Dirnagl U, Niwa K, Lindauer U, Villringer A (1994) Coupling of cerebral blood flow to neuronal activation: role of adenosine and nitric oxide. Am J Physiol Heart Circ Physiol 267:H296-301
8. Fields RD, Burnstock G (2006) Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci 7:423-36
9. Filosa JA, Bonev AD, Nelson MT (2004) Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. Circ Res 95:e73-81
10. Gauthier KM, Deeter C, Krishna UM, Reddy YK, Bondlela M, Falck JR, Campbell WB (2002) 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circ Res 90:1028-36
11. Gauthier KM, Jagadeesh SG, Falck JR, Campbell WB (2003) 14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries. Hypertension 42:555-61
12. Gebremedhin D, Ma Y-H, Falck JR, Roman RJ, VanRollins M, Harder DR (1992) Mechanism of action of cerebral epoxyeicosatrienoic acids on cerebral arterial smooth muscle. Am J Physiol Heart Circ Physiol 263:H519-25
13. + channels in rat hippocampal astrocytes. J Neurosci 23:1678-87
14. Iliff JJ, D'Ambrosio R, Ngai AC, Winn HR (2003) Adenosine receptors mediate glutamate-evoked arteriolar dilation in the rat cerebral cortex. Am J Physiol Heart Circ Physiol 284:H1631-7
15. Irikura K, Maynard KI, Moskowitz MA (1994) Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissal stimulation. J Cereb Blood Flow Metab 14:45-8
16. Jimenez AI, Castro E, Mirabet M, Franco R, Delicado EG, Miras-Portugal MT (1999) Potentiation of ATP calcium responses by A2B receptor stimulation and other signals coupled to Gs proteins in type-1 cerebellar astrocytes. Glia 26:119-28
17. Joseph SM, Buchakjian MR, Dubyak GR (2003) Colocalization of ATP release sites and ecto-ATPase activity at the extracellular surface of human astrocytes. J Biol Chem 278:23331-42
18. Ko KR, Ngai AC, Winn HR (1990) Role of adenosine in regulation of regional cerebral blood flow in sensory cortex. Am J Physiol Heart Circ Physiol 259:H1703-8
19. Koehler RC, Gebremedhin D, Harder DR (2006) Role of astrocytes in cerebrovascular regulation. J Appl Physiol 100:307-17
20. Lindauer U, Megow D, Matsuda H, Dirnagl U (1999) Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex. Am J Physiol Heart Circ Physiol 277:H799-811
21. Melani A, Gianfriddo M, Vannucchi MG, Cipriani S, Baraldi PG, Giovannini MG, Pedata F (2006) The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia. Brain Res 1073-1074:470-80
22. Meno JR, Crum AV, Winn HR (2001) Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. Am J Physiol Heart Circ Physiol 281:H2018-27
23. Meno JR, Nguyen TS, Jensen EM, Alexander WG, Groysman L, Kung DK, Ngai AC, Britz GW, Winn HR (2005) Effect of caffeine on cerebral blood flow response to somatosensory stimulation. J Cereb Blood Flow Metab 25:775-84
24. Metea MR, Newman EA (2006) Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. J Neurosci 26:2862-70
25. Nakao Y, Itoh Y, Kuang TY, Cook M, Jehle J, Sokoloff L (2001) Effects of anesthesia on functional activation of cerebral blood flow and metabolism. Proc Natl Acad Sci USA 98:7593-8
26. Newman EA (2005) Calcium increases in retinal glial cells evoked by light-induced neuronal activity. J Neurosci 25:5502-10
27. Ngai AC, Coyne EF, Meno JR, West GA, Winn HR (2001) Receptor subtypes mediating adenosine-induced dilation of cerebral arterioles. Am J Physiol Heart Circ Physiol 280:H2329-35
28. Niwa K, Araki E, Morham SG, Ross ME, Iadecola C (2000) Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J Neurosci 20:763-70
29. Niwa K, Haensel C, Ross ME, Iadecola C (2001) Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation. Circ Res 88:600-8
30. Ohata H, Cao S, Koehler RC (2006) Contribution of adenosine A2A and A2B receptors and heme oxygenase to AMPA-induced dilation of pial arterioles in rats. Am J Physiol Regul Integr Comp Physiol 291:R728-35
31. Peng X, Carhuapoma JR, Bhardwaj A, Alkayed NJ, Falck JR, Harder DR, Traystman RJ, Koehler RC (2002) Suppression of cortical functional hyperemia to vibrissal stimulation in the rat by epoxygenase inhibitors. Am J Physiol Heart Circ Physiol 283:H2029-37
32. Peng X, Zhang C, Alkayed NJ, Harder DR, Koehler RC (2004) Dependency of cortical functional hyperemia to forepaw stimulation on epoxygenase and nitric oxide synthase activities in rats. J Cereb Blood Flow Metab 24:509-17
33. Pilitsis JG, Kimelberg HK (1998) Adenosine receptor mediated stimulation of intracellular calcium in acutely isolated astrocytes. Brain Res 798:294-303
34. Rzigalinski BA, Willoughby KA, Hoffman SW, Falck JR, Ellis EF (1999) Calcium influx factor, further evidence it is 5,6-epoxyeicosatrienoic acid. J Biol Chem 274:175-182
35. Shin HK, Shin YW, Hong KW (2000) Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol 278:H339-44
36. Shivachar AC, Willoughby KA, Ellis EF (1995) Effect of protein kinase C modulators on 14,15-epoxyeicosatrienoic acid incorporation into astroglial phospholipids. J Neurochem 65:338-46
37. Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M (2003) Signaling at the gliovascular interface. J Neurosci 23:9254-62
38. Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M (2006) Astrocyte-mediated control of cerebral blood flow. Nat Neurosci 9:260-7
39. Wang H, Hitron IM, Iadecola C, Pickel VM (2005) Synaptic and vascular associations of neurons containing cyclooxygenase-2 and nitric oxide synthase in rat somatosensory cortex. Cereb Cortex 15:1250-60
40. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T, Carmignoto G (2003) Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 6:43-50