-
1
-
-
0027493485
-
Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl- phosphatidylinositolanchored proteins
-
Shenoy-Scaria, A. M., L. K. Gauen, J. Kwong, A. S. Shaw, and D. M. Lublin. 1993. Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositolanchored proteins. Mol. Cell. Biol. 13: 6385-6392.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 6385-6392
-
-
Shenoy-Scaria, A.M.1
Gauen, L.K.2
Kwong, J.3
Shaw, A.S.4
Lublin, D.M.5
-
2
-
-
0021285532
-
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation
-
Cross, F. R., E. A. Garber, D. Pellman, and H. Hanafusa. 1984. A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation. Mol. Cell. Biol. 4: 1834-1842.
-
(1984)
Mol. Cell. Biol.
, vol.4
, pp. 1834-1842
-
-
Cross, F.R.1
Garber, E.A.2
Pellman, D.3
Hanafusa, H.4
-
3
-
-
3042615397
-
Src-family kinases: Rheostats of immune cell signaling
-
Lowell, C. A. 2004. Src-family kinases: rheostats of immune cell signaling. Mol. Immunol. 41: 631-643.
-
(2004)
Mol. Immunol.
, vol.41
, pp. 631-643
-
-
Lowell, C.A.1
-
4
-
-
39149139617
-
Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling
-
Zhu, J. W., T. Brdicka, T. R. Katsumoto, J. Lin, and A. Weiss. 2008. Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity 28: 183-196.
-
(2008)
Immunity
, vol.28
, pp. 183-196
-
-
Zhu, J.W.1
Brdicka, T.2
Katsumoto, T.R.3
Lin, J.4
Weiss, A.5
-
5
-
-
79959358205
-
Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148
-
Stepanek, O., T. Kalina, P. Draber, T. Skopcova, K. Svojgr, P. Angelisova, V. Horejsi, A. Weiss, and T. Brdicka. 2011. Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148. J. Biol. Chem. 286: 22101-22112.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 22101-22112
-
-
Stepanek, O.1
Kalina, T.2
Draber, P.3
Skopcova, T.4
Svojgr, K.5
Angelisova, P.6
Horejsi, V.7
Weiss, A.8
Brdicka, T.9
-
6
-
-
0027389272
-
CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck
-
Sieh, M., J. B. Bolen, and A. Weiss. 1993. CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J. 12: 315-321.
-
(1993)
EMBO J.
, vol.12
, pp. 315-321
-
-
Sieh, M.1
Bolen, J.B.2
Weiss, A.3
-
7
-
-
0024829259
-
A protein tyrosine kinase involved in regulation of pp60c-src function
-
Okada, M., and H. Nakagawa. 1989. A protein tyrosine kinase involved in regulation of pp60c-src function. J. Biol. Chem. 264: 20886-20893.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 20886-20893
-
-
Okada, M.1
Nakagawa, H.2
-
8
-
-
0023649622
-
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src
-
Piwnica-Worms, H., K. B. Saunders, T. M. Roberts, A. E. Smith, and S. H. Cheng. 1987. Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell 49: 75-82.
-
(1987)
Cell
, vol.49
, pp. 75-82
-
-
Piwnica-Worms, H.1
Saunders, K.B.2
Roberts, T.M.3
Smith, A.E.4
Cheng, S.H.5
-
9
-
-
38349014380
-
Src family kinases: Regulation of their activities, levels and identification of new pathways
-
Ingley, E. 2008. Src family kinases: regulation of their activities, levels and identification of new pathways. Biochim. Biophys. Acta 1784: 56-65.
-
(2008)
Biochim. Biophys. Acta
, vol.1784
, pp. 56-65
-
-
Ingley, E.1
-
10
-
-
0036330594
-
Effect of autophosphorylation on the catalytic and regulatory properties of protein tyrosine kinase Src
-
Sun, G., L. Ramdas, W. Wang, J. Vinci, J. McMurray, and R. J. Budde. 2002. Effect of autophosphorylation on the catalytic and regulatory properties of protein tyrosine kinase Src. Arch. Biochem. Biophys. 397: 11-17.
-
(2002)
Arch. Biochem. Biophys.
, vol.397
, pp. 11-17
-
-
Sun, G.1
Ramdas, L.2
Wang, W.3
Vinci, J.4
McMurray, J.5
Budde, R.J.6
-
11
-
-
0033997615
-
Tyrosine kinase SYK: Essential functions for immunoreceptor signalling
-
Turner, M., E. Schweighoffer, F. Colucci, J. P. Di Santo, and V. L. Tybulewicz. 2000. Tyrosine kinase SYK: essential functions for immunoreceptor signalling. Immunol. Today 21: 148-154.
-
(2000)
Immunol. Today
, vol.21
, pp. 148-154
-
-
Turner, M.1
Schweighoffer, E.2
Colucci, F.3
Di Santo, J.P.4
Tybulewicz, V.L.5
-
12
-
-
0028209548
-
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
-
Iwashima, M., B. A. Irving, N. S. van Oers, A. C. Chan, and A. Weiss. 1994. Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263: 1136-1139.
-
(1994)
Science
, vol.263
, pp. 1136-1139
-
-
Iwashima, M.1
Irving, B.A.2
Van Oers, N.S.3
Chan, A.C.4
Weiss, A.5
-
13
-
-
0028783396
-
Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling
-
Kurosaki, T., S. A. Johnson, L. Pao, K. Sada, H. Yamamura, and J. C. Cambier. 1995. Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J. Exp. Med. 182: 1815-1823.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1815-1823
-
-
Kurosaki, T.1
Johnson, S.A.2
Pao, L.3
Sada, K.4
Yamamura, H.5
Cambier, J.C.6
-
14
-
-
57749116005
-
Molecular mechanism of the Syk activation switch
-
Tsang, E., A. M. Giannetti, D. Shaw, M. Dinh, J. K. Tse, S. Gandhi, H. Ho, S. Wang, E. Papp, and J. M. Bradshaw. 2008. Molecular mechanism of the Syk activation switch. J. Biol. Chem. 283: 32650-32659.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 32650-32659
-
-
Tsang, E.1
Giannetti, A.M.2
Shaw, D.3
Dinh, M.4
Tse, J.K.5
Gandhi, S.6
Ho, H.7
Wang, S.8
Papp, E.9
Bradshaw, J.M.10
-
15
-
-
0036866477
-
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop
-
Rolli, V., M. Gallwitz, T. Wossning, A. Flemming, W. W. Schamel, C. Zürn, and M. Reth. 2002. Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop. Mol. Cell 10: 1057-1069.
-
(2002)
Mol. Cell
, vol.10
, pp. 1057-1069
-
-
Rolli, V.1
Gallwitz, M.2
Wossning, T.3
Flemming, A.4
Schamel, W.W.5
Zürn, C.6
Reth, M.7
-
16
-
-
77952887713
-
The SYK tyrosine kinase: A crucial player in diverse biological functions
-
Mócsai, A., J. Ruland, and V. L. Tybulewicz. 2010. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat. Rev. Immunol. 10: 387-402.
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 387-402
-
-
Mócsai, A.1
Ruland, J.2
Tybulewicz, V.L.3
-
17
-
-
0032534071
-
Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling
-
Keshvara, L. M., C. C. Isaacson, T. M. Yankee, R. Sarac, M. L. Harrison, and R. L. Geahlen. 1998. Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J. Immunol. 161: 5276-5283.
-
(1998)
J. Immunol.
, vol.161
, pp. 5276-5283
-
-
Keshvara, L.M.1
Isaacson, C.C.2
Yankee, T.M.3
Sarac, R.4
Harrison, M.L.5
Geahlen, R.L.6
-
18
-
-
0031552069
-
Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk
-
Furlong, M. T., A. M. Mahrenholz, K. H. Kim, C. L. Ashendel, M. L. Harrison, and R. L. Geahlen. 1997. Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochim. Biophys. Acta 1355: 177-190.
-
(1997)
Biochim. Biophys. Acta
, vol.1355
, pp. 177-190
-
-
Furlong, M.T.1
Mahrenholz, A.M.2
Kim, K.H.3
Ashendel, C.L.4
Harrison, M.L.5
Geahlen, R.L.6
-
19
-
-
20344406482
-
Intramolecular regulatory switch in ZAP-70: Analogy with receptor tyrosine kinases
-
Brdicka, T., T. A. Kadlecek, J. P. Roose, A. W. Pastuszak, and A. Weiss. 2005. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Mol. Cell. Biol. 25: 4924-4933.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 4924-4933
-
-
Brdicka, T.1
Kadlecek, T.A.2
Roose, J.P.3
Pastuszak, A.W.4
Weiss, A.5
-
20
-
-
77952299611
-
The Src, Syk, and Tec family kinases: Distinct types of molecular switches
-
Bradshaw, J. M. 2010. The Src, Syk, and Tec family kinases: distinct types of molecular switches. Cell. Signal. 22: 1175-1184.
-
(2010)
Cell. Signal.
, vol.22
, pp. 1175-1184
-
-
Bradshaw, J.M.1
-
21
-
-
0032532359
-
Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity
-
Zhang, J., T. Kimura, and R. P. Siraganian. 1998. Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activity. J. Immunol. 161: 4366-4374.
-
(1998)
J. Immunol.
, vol.161
, pp. 4366-4374
-
-
Zhang, J.1
Kimura, T.2
Siraganian, R.P.3
-
22
-
-
0030956912
-
Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate phosphorylation by Syk protein-tyrosine kinase
-
Couture, C., S. Williams, N. Gauthier, P. Tailor, and T. Mustelin. 1997. Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate phosphorylation by Syk protein-tyrosine kinase. Eur. J. Biochem. 246: 447-451.
-
(1997)
Eur. J. Biochem.
, vol.246
, pp. 447-451
-
-
Couture, C.1
Williams, S.2
Gauthier, N.3
Tailor, P.4
Mustelin, T.5
-
23
-
-
0026353504
-
Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking
-
Gold, M. R., L. Matsuuchi, R. B. Kelly, and A. L. DeFranco. 1991. Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking. Proc. Natl. Acad. Sci. USA 88: 3436-3440.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 3436-3440
-
-
Gold, M.R.1
Matsuuchi, L.2
Kelly, R.B.3
Defranco, A.L.4
-
24
-
-
0028014460
-
Signal transduction by lymphocyte antigen receptors
-
Weiss, A., and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76: 263-274.
-
(1994)
Cell
, vol.76
, pp. 263-274
-
-
Weiss, A.1
Littman, D.R.2
-
25
-
-
0026522204
-
Profound block in thymocyte development in mice lacking p56lck
-
Molina, T. J., K. Kishihara, D. P. Siderovski, W. van Ewijk, A. Narendran, E. Timms, A. Wakeham, C. J. Paige, K. U. Hartmann, A. Veillette, et al. 1992. Profound block in thymocyte development in mice lacking p56lck. Nature 357: 161-164.
-
(1992)
Nature
, vol.357
, pp. 161-164
-
-
Molina, T.J.1
Kishihara, K.2
Siderovski, D.P.3
Van Ewijk, W.4
Narendran, A.5
Timms, E.6
Wakeham, A.7
Paige, C.J.8
Hartmann, K.U.9
Veillette, A.10
-
26
-
-
84869144892
-
Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency
-
Hauck, F., C. Randriamampita, E. Martin, S. Gerart, N. Lambert, A. Lim, J. Soulier, Z. Maciorowski, F. Touzot, D. Moshous, et al. 2012. Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency. J. Allergy Clin. Immunol. 130: 1144-1152, e11.
-
(2012)
J. Allergy Clin. Immunol.
, vol.130
, pp. 1144-1152
-
-
Hauck, F.1
Randriamampita, C.2
Martin, E.3
Gerart, S.4
Lambert, N.5
Lim, A.6
Soulier, J.7
MacIorowski, Z.8
Touzot, F.9
Moshous, D.10
-
27
-
-
0026705903
-
Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
-
Straus, D. B., and A. Weiss. 1992. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70: 585-593.
-
(1992)
Cell
, vol.70
, pp. 585-593
-
-
Straus, D.B.1
Weiss, A.2
-
28
-
-
0028988692
-
The role of Ig beta in precursor B cell transition and allelic exclusion
-
Papavasiliou, F., Z. Misulovin, H. Suh, and M. C. Nussenzweig. 1995. The role of Ig beta in precursor B cell transition and allelic exclusion. Science 268: 408-411.
-
(1995)
Science
, vol.268
, pp. 408-411
-
-
Papavasiliou, F.1
Misulovin, Z.2
Suh, H.3
Nussenzweig, M.C.4
-
29
-
-
0028784215
-
Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
-
Hibbs, M. L., D. M. Tarlinton, J. Armes, D. Grail, G. Hodgson, R. Maglitto, S. A. Stacker, and A. R. Dunn. 1995. Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell 83: 301-311.
-
(1995)
Cell
, vol.83
, pp. 301-311
-
-
Hibbs, M.L.1
Tarlinton, D.M.2
Armes, J.3
Grail, D.4
Hodgson, G.5
Maglitto, R.6
Stacker, S.A.7
Dunn, A.R.8
-
30
-
-
0030740148
-
Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
-
Chan, V. W., F. Meng, P. Soriano, A. L. DeFranco, and C. A. Lowell. 1997. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity 7: 69-81.
-
(1997)
Immunity
, vol.7
, pp. 69-81
-
-
Chan, V.W.1
Meng, F.2
Soriano, P.3
Defranco, A.L.4
Lowell, C.A.5
-
31
-
-
0032550365
-
A double-edged kinase Lyn: A positive and negative regulator for antigen receptormediated signals
-
Nishizumi, H., K. Horikawa, I. Mlinaric-Rascan, and T. Yamamoto. 1998. A double-edged kinase Lyn: a positive and negative regulator for antigen receptormediated signals. J. Exp. Med. 187: 1343-1348.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1343-1348
-
-
Nishizumi, H.1
Horikawa, K.2
Mlinaric-Rascan, I.3
Yamamoto, T.4
-
32
-
-
12444331082
-
Lyn tyrosine kinase: Accentuating the positive and the negative
-
Xu, Y., K. W. Harder, N. D. Huntington, M. L. Hibbs, and D. M. Tarlinton. 2005. Lyn tyrosine kinase: accentuating the positive and the negative. Immunity 22: 9-18.
-
(2005)
Immunity
, vol.22
, pp. 9-18
-
-
Xu, Y.1
Harder, K.W.2
Huntington, N.D.3
Hibbs, M.L.4
Tarlinton, D.M.5
-
33
-
-
0037342034
-
Essential role of Src-family protein tyrosine kinases in NF-kappa B activation during B cell development
-
Saijo, K., C. Schmedt, I. H. Su, H. Karasuyama, C. A. Lowell, M. Reth, T. Adachi, A. Patke, A. Santana, and A. Tarakhovsky. 2003. Essential role of Src-family protein tyrosine kinases in NF-kappa B activation during B cell development. Nat. Immunol. 4: 274-279.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 274-279
-
-
Saijo, K.1
Schmedt, C.2
Su, I.H.3
Karasuyama, H.4
Lowell, C.A.5
Reth, M.6
Adachi, T.7
Patke, A.8
Santana, A.9
Tarakhovsky, A.10
-
34
-
-
0037121973
-
Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity
-
Hibbs, M. L., K. W. Harder, J. Armes, N. Kountouri, C. Quilici, F. Casagranda, A. R. Dunn, and D. M. Tarlinton. 2002. Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J. Exp. Med. 196: 1593-1604.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1593-1604
-
-
Hibbs, M.L.1
Harder, K.W.2
Armes, J.3
Kountouri, N.4
Quilici, C.5
Casagranda, F.6
Dunn, A.R.7
Tarlinton, D.M.8
-
35
-
-
0028180858
-
+ mobilization through distinct pathways
-
+ mobilization through distinct pathways. EMBO J. 13: 1341-1349.
-
(1994)
EMBO J.
, vol.13
, pp. 1341-1349
-
-
Takata, M.1
Sabe, H.2
Hata, A.3
Inazu, T.4
Homma, Y.5
Nukada, T.6
Yamamura, H.7
Kurosaki, T.8
-
36
-
-
0030795735
-
Molecular mechanisms in B cell antigen receptor signaling
-
Kurosaki, T. 1997. Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9: 309-318.
-
(1997)
Curr. Opin. Immunol.
, vol.9
, pp. 309-318
-
-
Kurosaki, T.1
-
37
-
-
70350356241
-
Autoinhibition and adapter function of Syk
-
Kulathu, Y., G. Grothe, and M. Reth. 2009. Autoinhibition and adapter function of Syk. Immunol. Rev. 232: 286-299.
-
(2009)
Immunol. Rev.
, vol.232
, pp. 286-299
-
-
Kulathu, Y.1
Grothe, G.2
Reth, M.3
-
38
-
-
61849141064
-
Tyrosine kinases and their substrates in B lymphocytes
-
Kurosaki, T., and M. Hikida. 2009. Tyrosine kinases and their substrates in B lymphocytes. Immunol. Rev. 228: 132-148.
-
(2009)
Immunol. Rev.
, vol.228
, pp. 132-148
-
-
Kurosaki, T.1
Hikida, M.2
-
39
-
-
0031568534
-
Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction
-
Zoller, K. E., I. A. MacNeil, and J. S. Brugge. 1997. Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction. J. Immunol. 158: 1650-1659.
-
(1997)
J. Immunol.
, vol.158
, pp. 1650-1659
-
-
Zoller, K.E.1
MacNeil, I.A.2
Brugge, J.S.3
-
40
-
-
0029952988
-
The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling
-
Chu, D. H., H. Spits, J. F. Peyron, R. B. Rowley, J. B. Bolen, and A. Weiss. 1996. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J. 15: 6251-6261.
-
(1996)
EMBO J.
, vol.15
, pp. 6251-6261
-
-
Chu, D.H.1
Spits, H.2
Peyron, J.F.3
Rowley, R.B.4
Bolen, J.B.5
Weiss, A.6
-
41
-
-
0030888193
-
B cell development under the condition of allelic inclusion
-
Sonoda, E., Y. Pewzner-Jung, S. Schwers, S. Taki, S. Jung, D. Eilat, and K. Rajewsky. 1997. B cell development under the condition of allelic inclusion. Immunity 6: 225-233.
-
(1997)
Immunity
, vol.6
, pp. 225-233
-
-
Sonoda, E.1
Pewzner-Jung, Y.2
Schwers, S.3
Taki, S.4
Jung, S.5
Eilat, D.6
Rajewsky, K.7
-
42
-
-
78651105533
-
The effects of membrane compartmentalization of csk on TCR signaling
-
Otáhal, P., S. Pata, P. Angelisová, V. Hořejší, and T. Brdička. 2011. The effects of membrane compartmentalization of csk on TCR signaling. Biochim. Biophys. Acta 1813: 367-376.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 367-376
-
-
Otáhal, P.1
Pata, S.2
Angelisová, P.3
Hořejš í, V.4
Brdička, T.5
-
43
-
-
0027264816
-
Use of fura red as an intracellular calcium indicator in frog skeletal muscle fibers
-
Kurebayashi, N., A. B. Harkins, and S. M. Baylor. 1993. Use of fura red as an intracellular calcium indicator in frog skeletal muscle fibers. Biophys. J. 64: 1934-1960.
-
(1993)
Biophys. J.
, vol.64
, pp. 1934-1960
-
-
Kurebayashi, N.1
Harkins, A.B.2
Baylor, S.M.3
-
44
-
-
0030029143
-
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
-
Hanke, J. H., J. P. Gardner, R. L. Dow, P. S. Changelian, W. H. Brissette, E. J. Weringer, B. A. Pollok, and P. A. Connelly. 1996. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271: 695-701.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 695-701
-
-
Hanke, J.H.1
Gardner, J.P.2
Dow, R.L.3
Changelian, P.S.4
Brissette, W.H.5
Weringer, E.J.6
Pollok, B.A.7
Connelly, P.A.8
-
45
-
-
0041932075
-
The orally available spleen tyrosine kinase inhibitor 2-[7-(3, 4-dimethoxyphenyl)-imidazo [1, 2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents
-
Yamamoto, N., K. Takeshita, M. Shichijo, T. Kokubo, M. Sato, K. Nakashima, M. Ishimori, H. Nagai, Y. F. Li, T. Yura, and K. B. Bacon. 2003. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)- imidazo [1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J. Pharmacol. Exp. Ther. 306: 1174-1181.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.306
, pp. 1174-1181
-
-
Yamamoto, N.1
Takeshita, K.2
Shichijo, M.3
Kokubo, T.4
Sato, M.5
Nakashima, K.6
Ishimori, M.7
Nagai, H.8
Li, Y.F.9
Yura, T.10
Bacon, K.B.11
-
47
-
-
0022802257
-
Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
-
Cumano, A., and K. Rajewsky. 1986. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J. 5: 2459-2468.
-
(1986)
EMBO J.
, vol.5
, pp. 2459-2468
-
-
Cumano, A.1
Rajewsky, K.2
-
48
-
-
0033063429
-
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor
-
Schindler, T., F. Sicheri, A. Pico, A. Gazit, A. Levitzki, and J. Kuriyan. 1999. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol. Cell 3: 639-648.
-
(1999)
Mol. Cell
, vol.3
, pp. 639-648
-
-
Schindler, T.1
Sicheri, F.2
Pico, A.3
Gazit, A.4
Levitzki, A.5
Kuriyan, J.6
-
49
-
-
58649122152
-
Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state
-
Williams, N. K., I. S. Lucet, S. P. Klinken, E. Ingley, and J. Rossjohn. 2009. Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state. J. Biol. Chem. 284: 284-291.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 284-291
-
-
Williams, N.K.1
Lucet, I.S.2
Klinken, S.P.3
Ingley, E.4
Rossjohn, J.5
-
50
-
-
0033152210
-
Structural analysis of the lymphocytespecific kinase Lck in complex with non-selective and Src family selective kinase inhibitors
-
Zhu, X., J. L. Kim, J. R. Newcomb, P. E. Rose, D. R. Stover, L. M. Toledo, H. Zhao, and K. A. Morgenstern. 1999. Structural analysis of the lymphocytespecific kinase Lck in complex with non-selective and Src family selective kinase inhibitors. Structure 7: 651-661.
-
(1999)
Structure
, vol.7
, pp. 651-661
-
-
Zhu, X.1
Kim, J.L.2
Newcomb, J.R.3
Rose, P.E.4
Stover, D.R.5
Toledo, L.M.6
Zhao, H.7
Morgenstern, K.A.8
-
51
-
-
0024044570
-
Antibody engineering for the analysis of affinity maturation of an anti-hapten response
-
Allen, D., T. Simon, F. Sablitzky, K. Rajewsky, and A. Cumano. 1988. Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J. 7: 1995-2001.
-
(1988)
EMBO J.
, vol.7
, pp. 1995-2001
-
-
Allen, D.1
Simon, T.2
Sablitzky, F.3
Rajewsky, K.4
Cumano, A.5
-
52
-
-
0037392942
-
The specificities of protein kinase inhibitors: An update
-
Bain, J., H. McLauchlan, M. Elliott, and P. Cohen. 2003. The specificities of protein kinase inhibitors: an update. Biochem. J. 371: 199-204.
-
(2003)
Biochem. J.
, vol.371
, pp. 199-204
-
-
Bain, J.1
McLauchlan, H.2
Elliott, M.3
Cohen, P.4
-
53
-
-
0028355565
-
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling
-
Kurosaki, T., M. Takata, Y. Yamanashi, T. Inazu, T. Taniguchi, T. Yamamoto, and H. Yamamura. 1994. Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J. Exp. Med. 179: 1725-1729.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1725-1729
-
-
Kurosaki, T.1
Takata, M.2
Yamanashi, Y.3
Inazu, T.4
Taniguchi, T.5
Yamamoto, T.6
Yamamura, H.7
-
54
-
-
0028787398
-
The catalytic activity of Src-family tyrosine kinase is required for B cell antigen receptor signaling
-
Takata, M., and T. Kurosaki. 1995. The catalytic activity of Src-family tyrosine kinase is required for B cell antigen receptor signaling. FEBS Lett. 374: 407-411.
-
(1995)
FEBS Lett.
, vol.374
, pp. 407-411
-
-
Takata, M.1
Kurosaki, T.2
-
55
-
-
0031569176
-
Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45-B cells
-
Pao, L. I., and J. C. Cambier. 1997. Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45-B cells. J. Immunol. 158: 2663-2669.
-
(1997)
J. Immunol.
, vol.158
, pp. 2663-2669
-
-
Pao, L.I.1
Cambier, J.C.2
-
56
-
-
0037204949
-
B cell antigen receptor signaling: Roles in cell development and disease
-
Gauld, S. B., J. M. Dal Porto, and J. C. Cambier. 2002. B cell antigen receptor signaling: roles in cell development and disease. Science 296: 1641-1642.
-
(2002)
Science
, vol.296
, pp. 1641-1642
-
-
Gauld, S.B.1
Dal Porto, J.M.2
Cambier, J.C.3
-
57
-
-
79956307046
-
Regulation of BCR signaling
-
Kurosaki, T. 2011. Regulation of BCR signaling. Mol. Immunol. 48: 1287-1291.
-
(2011)
Mol. Immunol.
, vol.48
, pp. 1287-1291
-
-
Kurosaki, T.1
-
58
-
-
7944235830
-
Src-family kinases in B-cell development and signaling
-
Gauld, S. B., and J. C. Cambier. 2004. Src-family kinases in B-cell development and signaling. Oncogene 23: 8001-8006.
-
(2004)
Oncogene
, vol.23
, pp. 8001-8006
-
-
Gauld, S.B.1
Cambier, J.C.2
-
59
-
-
0028793187
-
Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases
-
Johnson, S. A., C. M. Pleiman, L. Pao, J. Schneringer, K. Hippen, and J. C. Cambier. 1995. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. J. Immunol. 155: 4596-4603.
-
(1995)
J. Immunol.
, vol.155
, pp. 4596-4603
-
-
Johnson, S.A.1
Pleiman, C.M.2
Pao, L.3
Schneringer, J.4
Hippen, K.5
Cambier, J.C.6
-
60
-
-
0033697728
-
CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification
-
Fujimoto, M., Y. Fujimoto, J. C. Poe, P. J. Jansen, C. A. Lowell, A. L. DeFranco, and T. F. Tedder. 2000. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity 13: 47-57.
-
(2000)
Immunity
, vol.13
, pp. 47-57
-
-
Fujimoto, M.1
Fujimoto, Y.2
Poe, J.C.3
Jansen, P.J.4
Lowell, C.A.5
Defranco, A.L.6
Tedder, T.F.7
-
61
-
-
0035451678
-
A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice
-
Hasegawa, M., M. Fujimoto, J. C. Poe, D. A. Steeber, C. A. Lowell, and T. F. Tedder. 2001. A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. J. Immunol. 167: 2469-2478.
-
(2001)
J. Immunol.
, vol.167
, pp. 2469-2478
-
-
Hasegawa, M.1
Fujimoto, M.2
Poe, J.C.3
Steeber, D.A.4
Lowell, C.A.5
Tedder, T.F.6
-
62
-
-
77953911933
-
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
-
Nika, K., C. Soldani, M. Salek, W. Paster, A. Gray, R. Etzensperger, L. Fugger, P. Polzella, V. Cerundolo, O. Dushek, et al. 2010. Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity 32: 766-777.
-
(2010)
Immunity
, vol.32
, pp. 766-777
-
-
Nika, K.1
Soldani, C.2
Salek, M.3
Paster, W.4
Gray, A.5
Etzensperger, R.6
Fugger, L.7
Polzella, P.8
Cerundolo, V.9
Dushek, O.10
-
63
-
-
0031042637
-
Syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction
-
El-Hillal, O., T. Kurosaki, H. Yamamura, J. P. Kinet, and A. M. Scharenberg. 1997. syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction. Proc. Natl. Acad. Sci. USA 94: 1919-1924.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 1919-1924
-
-
El-Hillal, O.1
Kurosaki, T.2
Yamamura, H.3
Kinet, J.P.4
Scharenberg, A.M.5
-
64
-
-
0028125752
-
Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor
-
Flaswinkel, H., and M. Reth. 1994. Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor. EMBO J. 13: 83-89.
-
(1994)
EMBO J.
, vol.13
, pp. 83-89
-
-
Flaswinkel, H.1
Reth, M.2
-
65
-
-
0032055963
-
Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction
-
Pao, L. I., S. J. Famiglietti, and J. C. Cambier. 1998. Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction. J. Immunol. 160: 3305-3314.
-
(1998)
J. Immunol.
, vol.160
, pp. 3305-3314
-
-
Pao, L.I.1
Famiglietti, S.J.2
Cambier, J.C.3
-
66
-
-
0034717038
-
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor
-
Gaul, B. S., M. L. Harrison, R. L. Geahlen, R. A. Burton, and C. B. Post. 2000. Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. J. Biol. Chem. 275: 16174-16182.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16174-16182
-
-
Gaul, B.S.1
Harrison, M.L.2
Geahlen, R.L.3
Burton, R.A.4
Post, C.B.5
-
67
-
-
0029788103
-
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases
-
Latour, S., L. M. Chow, and A. Veillette. 1996. Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J. Biol. Chem. 271: 22782-22790.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 22782-22790
-
-
Latour, S.1
Chow, L.M.2
Veillette, A.3
-
68
-
-
0033198133
-
CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cells
-
Zhang, J., and R. P. Siraganian. 1999. CD45 is essential for Fc epsilon RI signaling by ZAP70, but not Syk, in Syk-negative mast cells. J. Immunol. 163: 2508-2516.
-
(1999)
J. Immunol.
, vol.163
, pp. 2508-2516
-
-
Zhang, J.1
Siraganian, R.P.2
-
69
-
-
58249092059
-
Digital signaling and hysteresis characterize ras activation in lymphoid cells
-
Das, J., M. Ho, J. Zikherman, C. Govern, M. Yang, A. Weiss, A. K. Chakraborty, and J. P. Roose. 2009. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell 136: 337-351.
-
(2009)
Cell
, vol.136
, pp. 337-351
-
-
Das, J.1
Ho, M.2
Zikherman, J.3
Govern, C.4
Yang, M.5
Weiss, A.6
Chakraborty, A.K.7
Roose, J.P.8
-
70
-
-
84865298239
-
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise
-
Birtwistle, M. R., J. Rauch, A. Kiyatkin, E. Aksamitiene, M. Dobrzy-nski, J. B. Hoek, W. Kolch, B. A. Ogunnaike, and B. N. Kholodenko. 2012. Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst. Biol. 6: 109.
-
(2012)
BMC Syst. Biol.
, vol.6
, pp. 109
-
-
Birtwistle, M.R.1
Rauch, J.2
Kiyatkin, A.3
Aksamitiene, E.4
Dobrzy-Nski, M.5
Hoek, J.B.6
Kolch, W.7
Ogunnaike, B.A.8
Kholodenko, B.N.9
-
71
-
-
73949093141
-
A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor
-
Poderycki, M., Y. Tomimori, T. Ando, W. Xiao, M. Maeda-Yamamoto, K. Sauer, Y. Kawakami, and T. Kawakami. 2010. A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor. J. Immunol. 184: 84-93.
-
(2010)
J. Immunol.
, vol.184
, pp. 84-93
-
-
Poderycki, M.1
Tomimori, Y.2
Ando, T.3
Xiao, W.4
Maeda-Yamamoto, M.5
Sauer, K.6
Kawakami, Y.7
Kawakami, T.8
-
72
-
-
27744592100
-
Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI
-
Xiao, W., H. Nishimoto, H. Hong, J. Kitaura, S. Nunomura, M. Maeda-Yamamoto, Y. Kawakami, C. A. Lowell, C. Ra, and T. Kawakami. 2005. Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J. Immunol. 175: 6885-6892.
-
(2005)
J. Immunol.
, vol.175
, pp. 6885-6892
-
-
Xiao, W.1
Nishimoto, H.2
Hong, H.3
Kitaura, J.4
Nunomura, S.5
Maeda-Yamamoto, M.6
Kawakami, Y.7
Lowell, C.A.8
Ra, C.9
Kawakami, T.10
-
73
-
-
79953072735
-
Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals
-
McCaig, A. M., E. Cosimo, M. T. Leach, and A. M. Michie. 2011. Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals. Br. J. Haematol. 153: 199-211.
-
(2011)
Br. J. Haematol.
, vol.153
, pp. 199-211
-
-
McCaig, A.M.1
Cosimo, E.2
Leach, M.T.3
Michie, A.M.4
-
74
-
-
74549193848
-
Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib
-
Song, Z., P. Lu, R. R. Furman, J. P. Leonard, P. Martin, L. Tyrell, F. Y. Lee, D. M. Knowles, M. Coleman, and Y. L. Wang. 2010. Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib. Clin. Cancer Res. 16: 587-599.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 587-599
-
-
Song, Z.1
Lu, P.2
Furman, R.R.3
Leonard, J.P.4
Martin, P.5
Tyrell, L.6
Lee, F.Y.7
Knowles, D.M.8
Coleman, M.9
Wang, Y.L.10
-
75
-
-
77954315861
-
Spleen tyrosine kinases: Biology, therapeutic targets and drugs
-
Riccaboni, M., I. Bianchi, and P. Petrillo. 2010. Spleen tyrosine kinases: biology, therapeutic targets and drugs. Drug Discov. Today 15: 517-530.
-
(2010)
Drug Discov. Today
, vol.15
, pp. 517-530
-
-
Riccaboni, M.1
Bianchi, I.2
Petrillo, P.3
|