Mathematical models to describe iontophoretic transport in vitro and in vivo and the effect of current application on the skin barrier

Advanced Drug Delivery Reviews

Volumn 65, Issue 2, 2013, Pages 315-329

  Gratieri, Taís ^a   Kalia, Yogeshvar N ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Equivalent circuit; Iontophoresis; Membrane transport models; Pharmacokinetics; Skin; Transdermal delivery

Indexed keywords

BIOLOGICAL STRUCTURES; CIRCUIT ELEMENTS; CONSTANT PHASE ELEMENT; CURRENT FLOWS; ELECTRONEUTRALITY; ELECTROTRANSPORT; EQUIVALENT CIRCUIT MODEL; HYDROPHILIC MOLECULES; IN-VITRO; IN-VIVO; INTERCELLULAR LIPIDS; ION MOTIONS; ION TRANSPORT PATHWAYS; IONTOPHORESIS; IONTOPHORETIC DELIVERY; IONTOPHORETIC TRANSPORT; MATHEMATICAL DESCRIPTIONS; MEMBRANE CHARGE; MEMBRANE TRANSPORT MODEL; NERNST-PLANCK EQUATIONS; OBSERVED DATA; PARALLEL ARRANGEMENT; PASSIVE DIFFUSIONS; PHARMACOKINETIC MODEL; PHYSICOCHEMICAL PROPERTY; PHYSIOLOGICAL CONDITION; RELATIVE CONTRIBUTION; SOLVENT FLOW; STRATUM CORNEUM; SYSTEMIC CIRCULATION; THEORETICAL FRAMEWORK; THERAPEUTIC AGENTS; TRANSDERMAL DELIVERY; TRANSPORT PATHWAYS;

ELECTRIC FIELDS; ELECTRIC POTENTIAL; ELECTROOSMOSIS; ELECTROPHORESIS; ELECTROTHERAPEUTICS; EQUIVALENT CIRCUITS; PHARMACOKINETICS; SKIN;

MATHEMATICAL MODELS;

ALNIDITAN; APOMORPHINE; ARBUTAMINE; FENTANYL; GROWTH HORMONE RELEASING FACTOR; LIPID; SOLVENT;

AQUEOUS SOLUTION; CELL MEMBRANE POTENTIAL; COMPARTMENT MODEL; CONCEPTUAL FRAMEWORK; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ELECTRIC CURRENT; ELECTRIC FIELD; ELECTRIC POTENTIAL; ELECTROOSMOSIS; EPIDERMIS; HUMAN; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; ION TRANSPORT; IONTOPHORESIS; IONTOPHORETIC CURRENT; MACROMOLECULE; MATHEMATICAL ANALYSIS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MATHEMATICAL PARAMETERS; MEMBRANE TRANSPORT; NONHUMAN; PHARMACOKINETICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; SKIN ABSORPTION; SKIN CONDUCTANCE; SKIN ELECTROPHYSIOLOGY; SKIN PERMEABILITY; SKIN STRUCTURE; STEADY STATE; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION; TRANSPORT KINETICS;

ADMINISTRATION, CUTANEOUS; ANIMALS; BIOLOGICAL TRANSPORT; DRUG DELIVERY SYSTEMS; HUMANS; IONTOPHORESIS; MODELS, THEORETICAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; SKIN; SKIN ABSORPTION; SOLUBILITY;

EID: 84873526414     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.04.012     Document Type: Review

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