Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin

European Journal of Pharmacology

Volumn 701, Issue 1-3, 2013, Pages 82-86

  Costa, Rute A P ^a   Fernandes, Mariana P ^a   De Souza Pinto, Nadja C ^b   Vercesi, Aníbal E ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cell necrosis; l Carnitine; Mitochondrial permeability transition; Piracetam; Simvastatin

Indexed keywords

CARNITINE; PIRACETAM; SIMVASTATIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG POTENTIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL PERMEABILITY; MONOTHERAPY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATE CANCER;

CARNITINE; CELL LINE, TUMOR; CYCLOSPORINE; DRUG SYNERGISM; HUMANS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NECROSIS; PIRACETAM; SIMVASTATIN; SUPEROXIDES;

EID: 84873461054     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.01.001     Document Type: Article

References (61)

1. R. Barazzoni, M. Zanetti, G.G. Cappellari, A. Semolic, M. Boschelle, E. Codarin, A. Pirulli, L. Cattin, and G. Guarnieri Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-kappaB inhibitor (IkappaB)-nuclear factor-kappaB (NFkappaB) activation in rat muscle, in the absence of mitochondrial dysfunction Diabetologia 55 2012 773 782
2. J. Bhuiyan, and D.W. Seccombe The effects of 3-hydroxy-3-methylglutaryl- CoA reductase inhibition on tissue levels of carnitine and carnitine acyltransferase activity in the rabbit Lipids 31 1996 867 870
3. Z. Binienda, B. Przybyla-Zawislak, A. Virmani, and L. Schmued l-Carnitine and neuroprotection in the animal model of mitochondrial dysfunction Ann. NY Acad. Sci. 1053 2005 174 182
4. Z.K. Binienda Neuroprotective effects of l-carnitine in induced mitochondrial dysfunction Ann. NY Acad. Sci. 993 289-295 2003 289 345 (discussion)
5. L.B. Brill 2nd, and J.P. Bennett Jr. Dependence on electron transport chain function and intracellular signaling of genomic responses in SH-SY5Y cells to the mitochondrial neurotoxin MPP(+) Exp. Neurol. 181 2003 25 38
6. C.B. Campos, G.R. Degasperi, D.S. Pacifico, L.C. Alberici, R.S. Carreira, F. Guimaraes, R.F. Castilho, and A.E. Vercesi Ibuprofen-induced Walker 256 tumor cell death: cytochrome c release from functional mitochondria and enhancement by calcineurin inhibition Biochem. Pharmacol. 68 2004 2197 2206
7. 2+: effect of coenzyme Q redox state Free Radical Biol. Med. 18 1995 55 59
8. R. Collins, J. Armitage, S. Parish, P. Sleigh, and R. Peto MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial Lancet 361 2003 2005 2016
9. G.A. Cook, B. Khan, and M. Heimberg Feeding of lovastatin to rats increases the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase Biochem. Biophys. Res. Commun. 150 1988 1077 1082
10. D. Elinos-Calderon, Y. Robledo-Arratia, V. Perez-De La Cruz, J. Pedraza-Chaverri, S.F. Ali, and A. Santamaria Early nerve ending rescue from oxidative damage and energy failure by L: -carnitine as post-treatment in two neurotoxic models in rat: recovery of antioxidant and reductive capacities Exp. Brain Res. 197 2009 287 296
11. A. Endo The discovery and development of HMG-CoA reductase inhibitors J. Lipid Res. 33 1992 1569 1582
12. 2+ plus prooxidants J. Biol. Chem. 265 1990 19955 19960
13. Figueira, T.R., Barros, M.H., Camargo. A.A., Castilho, R.F., Ferreira, J.C., Kowaltowski, A.J., Sluse, F.E., Souza-Pinto, N.C., Vercesi, A.E. Mitochondria as a source of reactiveoxygen and nitrogen species: from molecular mechanisms to human health. Antioxid. Redox. Signal, 10.1089/ars.2012.4729, in press
14. T.R. Figueira, D.R. Melo, A.E. Vercesi, and R.F. Castilho Safranine as a fluorescent probe for the evaluation of mitochondrial membrane potential in isolated organelles and permeabilized cells Methods Mol. Biol. 810 2012 103 117
15. S. Ghavami, B. Yeganeh, G.L. Stelmack, H.H. Kashani, P. Sharma, R. Cunnington, S. Rattan, K. Bathe, T. Klonisch, I.M. Dixon, D.H. Freed, and A.J. Halayko Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts Cell Death Dis. 3 2012 e330
16. S. Ghosh, G. Kewalramani, G. Yuen, T. Pulinilkunnil, D. An, S.M. Innis, M.F. Allard, R.B. Wambolt, D. Qi, A. Abrahani, and B. Rodrigues Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary omega-6 polyunsaturated fatty acids Free Radical Biol. Med. 41 2006 1413 1424
17. 2+-stimulated generation of reactive oxygen species by the respiratory chain Biochemistry 38 1999 13279 13287
18. I. Gulcin Antioxidant and antiradical activities of l-carnitine Life Sci. 78 2006 803 811
19. M. Guzman, J.P. Cortes, and J. Castro Effects of lovastatin on hepatic fatty acid metabolism Lipids 28 1993 1087 1093
20. M. Hsu, L. Muchova, I. Morioka, R.J. Wong, H. Schroder, and D.K. Stevenson Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo Biochem. Biophys. Res. Commun. 343 2006 738 744
21. D.R. Hunter, R.A. Haworth, and J.H. Southard Relationship between configuration, function, and permeability in calcium-treated mitochondria J. Biol. Chem. 251 1976 5069 5077
22. D.W. Jun, W.K. Cho, J.H. Jun, H.J. Kwon, K.S. Jang, H.J. Kim, H.J. Jeon, K.N. Lee, H.L. Lee, O.Y. Lee, B.C. Yoon, H.S. Choi, J.S. Hahm, and M.H. Lee Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction Liver Int. 31 2011 1315 1324
23. P. Kaufmann, M. Torok, A. Zahno, K.M. Waldhauser, K. Brecht, and S. Krahenbuhl Toxicity of statins on rat skeletal muscle mitochondria Cell Mol. Life Sci. 63 2006 2415 2425
24. U. Keil, I. Scherping, S. Hauptmann, K. Schuessel, A. Eckert, and W.E. Muller Piracetam improves mitochondrial dysfunction following oxidative stress Br. J. Pharmacol. 147 2006 199 208
25. 2+-dependent mitochondrial formation of reactive oxygen species Am. J. Physiol. Gastrointest. Liver Physiol. 302 2012 G723 G731
26. A.J. Kowaltowski, R.F. Castilho, and A.E. Vercesi Mitochondrial permeability transition and oxidative stress FEBS Lett. 495 2001 12 15
27. H.B. Kwak, A. Thalacker-Mercer, E.J. Anderson, C.T. Lin, D.A. Kane, N.S. Lee, R.N. Cortright, M.M. Bamman, and P.D. Neufer Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes Free Radical Biol. Med. 52 2012 198 207
28. J.J. Lemasters, T.P. Theruvath, Z. Zhong, and A.L. Nieminen Mitochondrial calcium and the permeability transition in cell death Biochim. Biophys. Acta 1787 2009 1395 1401
29. J. Li, Y.M. Sun, L.F. Wang, Z.Q. Li, W. Pan, and H.Y. Cao Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease Clin. Cardiol. 33 2010 222 227
30. M. Madesh, and K.A. Balasubramanian Activation of liver mitochondrial phospholipase A2 by superoxide Arch. Biochem. Biophys. 346 1997 187 192
31. V. Manfredini, G.B. Biancini, C.S. Vanzin, A.M. Dal Vesco, F. Cipriani, L. Biasi, R. Tremea, M. Deon, C. Peralba Mdo, M. Wajner, and C.R. Vargas Simvastatin treatment prevents oxidative damage to DNA in whole blood leukocytes of dyslipidemic type 2diabetic patients Cell Biochem. Funct. 28 2010 360 366
32. S.W. Marcella, A. David, P.A. Ohman-Strickland, J. Carson, and G.G. Rhoads Statin use and fatal prostate cancer: a matched case-control study Cancer 118 2011 4046 4052
33. A.M. Mondul, S.J. Weinstein, J. Virtamo, and D. Albanes Serum total and HDL cholesterol and risk of prostate cancer Cancer Causes Control 22 2011 1545 1552
34. S. Moretti, G. Famularo, S. Marcellini, A. Boschini, G. Santini, V. Trinchieri, L. Lucci, E. Alesse, and C. De Simone l-Carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine Antioxid. Redox. Signal 4 2002 391 403
35. M. Nishimura, Y. Okimura, H. Fujita, H. Yano, J. Lee, E. Suzaki, M. Inoue, K. Utsumi, and J. Sasaki Mechanism of 3-nitropropionic acid-induced membrane permeability transition of isolated mitochondria and its suppression by l-carnitine Cell Biochem. Funct. 26 2008 881 891
36. K.A. Oliveira, K.G. Zecchin, L.C. Alberici, R.F. Castilho, and A.E. Vercesi Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction J. Bioenerg. Biomembr. 40 2008 307 314
37. A. Panov, S. Dikalov, N. Shalbuyeva, G. Taylor, T. Sherer, and J.T. Greenamyre Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication J. Biol. Chem. 280 2005 42026 42035
38. C.M. Payne, C. Weber, C. Crowley-Skillicorn, K. Dvorak, H. Bernstein, C. Bernstein, H. Holubec, B. Dvorakova, and H. Garewal Deoxycholate induces mitochondrial oxidative stress and activates NF-kappaB through multiple mechanisms in HCT-116 colon epithelial cells Carcinogenesis 28 2007 215 222
39. A. Rasola, M. Sciacovelli, B. Pantic, and P. Bernardi Signal transduction to the permeability transition pore FEBS Lett 584 2010 1989 1996
40. 2+ influx in endoplasmic reticulum: a comparison with mitochondria Biochem. J. 338 1999 221 227 Pt 1
41. A. Ruiz-Ramirez, M. Chavez-Salgado, J.A. Peneda-Flores, E. Zapata, F. Masso, and M. El-Hafidi High-sucrose diet increases ROS generation, FFA accumulation, UCP2 level, and proton leak in liver mitochondria Am. J. Physiol. Endocrinol. Metab. 301 2011 E1198 E1207
42. G. Sener, K. Paskaloglu, H. Satiroglu, I. Alican, A. Kacmaz, and A. Sakarcan l-Carnitine ameliorates oxidative damage due to chronic renal failure in rats J. Cardiovasc. Pharmacol. 43 2004 698 705
43. W. Shen, K. Liu, C. Tian, L. Yang, X. Li, J. Ren, L. Packer, E. Head, E. Sharman, and J. Liu Protective effects of R-alpha-lipoic acid and acetyl-l-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid J. Cell Biochem. 104 2008 1232 1243
44. J. Shepherd, S.M. Cobbe, I. Ford, C.G. Isles, A.R. Lorimer, P.W. MacFarlane, J.H. McKillop, and C.J. Packard Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group N. Engl. J. Med. 333 1995 1301 1307
45. D. Silva-Adaya, V. Perez-De La Cruz, M.N. Herrera-Mundo, K. Mendoza-Macedo, J. Villeda-Hernandez, Z. Binienda, S.F. Ali, and A. Santamaria Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of l-carnitine J. Neurochem. 105 2008 677 689
46. 2+ signaling alteration in skeletal muscle Biochem. Biophys. Res. Commun. 329 2005 1067 1075
47. M.E. Solesio, S. Saez-Atienzar, J. Jordan, and M.F. Galindo Nitropropionioc acid induces autophagy by mitochondrial permeability transition pore formation rather than activation of the mitochondrial fission pathway Br. J. Pharmacol. 2012
48. J. Toman, and G. Fiskum Influence of aging on membrane permeability transition in brain mitochondria J. Bioenerg. Biomembr. 43 2011 3 10
49. A.M. Tonin, M. Grings, E.N. Busanello, A.P. Moura, G.C. Ferreira, C.M. Viegas, C.G. Fernandes, P.F. Schuck, and M. Wajner Long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies induce oxidative stress in rat brain Neurochem. Int. 56 2010 930 936
50. E. Vamos, K. Voros, L. Vecsei, and P. Klivenyi Neuroprotective effects of l-carnitine in a transgenic animal model of Huntington's disease Biomed. Pharmacother. 64 2010 282 286
51. A.V. Vaseva, N.D. Marchenko, K. Ji, S.E. Tsirka, S. Holzmann, and U.M. Moll p53 opens the mitochondrial permeability transition pore to trigger Necrosis Cell 149 2012 1536 1548
52. 2+ efflux from swelling and membrane damage Arch. Biochem. Biophys. 232 1984 86 91
53. A. Virmani, F. Gaetani, and Z. Binienda Effects of metabolic modifiers such as carnitines, coenzyme Q10, and PUFAs against different forms of neurotoxic insults: metabolic inhibitors, MPTP, and methamphetamine Ann. NY Acad. Sci. 1053 2005 183 191
54. A. Virmani, F. Gaetani, Z. Binienda, A. Xu, H. Duhart, and S.F. Ali Role of mitochondrial dysfunction in neurotoxicity of MPP+: partial protection of PC12 cells by acetyl-l-carnitine Ann. NY Acad. Sci. 1025 2004 267 273
55. A. Virmani, F. Gaetani, S. Imam, Z. Binienda, and S. Ali The protective role of l-carnitine against neurotoxicity evoked by drug of abuse, methamphetamine, could be related to mitochondrial dysfunction Ann. NY Acad. Sci. 965 2002 225 232
56. A. Virmani, F. Gaetani, S. Imam, Z. Binienda, and S. Ali Possible mechanism for the neuroprotective effects of l-carnitine on methamphetamine- evoked neurotoxicity Ann. NY Acad. Sci. 993 197-207 2003 198 287 (Discussion)
57. D. Yao, W. Shi, Y. Gou, X. Zhou, T. Yee, Y. Zhou, and Z. Liu Fatty acid-mediated intracellular iron translocation: a synergistic mechanism of oxidative injury Free Radical Biol. Med. 39 2005 1385 1398
58. K. Yapar, A. Kart, M. Karapehlivan, O. Atakisi, R. Tunca, S. Erginsoy, and M. Citil Hepatoprotective effect of l-carnitine against acute acetaminophen toxicity in mice Exp. Toxicol. Pathol. 59 2007 121 128
59. J. Ye, J. Li, Y. Yu, Q. Wei, W. Deng, and L. Yu l-Carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway Regul. Pept. 161 2010 58 66
60. H. Zhang, H. Jia, J. Liu, N. Ao, B. Yan, W. Shen, X. Wang, X. Li, and C. Luo Combined R-alpha-lipoic acid and acetyl-l-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease J. Cell Mol. Med. 14 2010 215 225
61. H. Zhou, X. Liu, L. Liu, Z. Yang, S. Zhang, M. Tang, Y. Tang, Q. Dong, and R. Hu Oxidative stress and apoptosis of human brain microvascular endothelial cells induced by free fatty acids J. Int. Med. Res. 37 2009 1897 1903