Fatty acids acutely enhance insulin-induced oxidative stress and cause insulin resistance by increasing mitochondrial reactive oxygen species (ROS) generation and nuclear factor-κB inhibitor (IκB)-nuclear factor-κB (NFκB) activation in rat muscle, in the absence of mitochondrial dysfunction

Diabetologia

Volumn 55, Issue 3, 2012, Pages 773-782

  Barazzoni, R ^a   Zanetti, M ^a   Cappellari, G Gortan ^a   Semolic, A ^a   Boschelle, M ^a   Codarin, E ^a   Pirulli, A ^a   Cattin, L ^a   Guarnieri, G ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Fatty acids; Inflammation; Insulin; Insulin resistance; Mitochondria; Oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; DNA; FATTY ACID; GLUCOSE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; REACTIVE OXYGEN METABOLITE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERINSULINEMIA; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRACELLULAR SIGNALING; MALE; MITOCHONDRIAL TOXICITY; MUSCLE MITOCHONDRION; NONHUMAN; NUCLEOTIDE METABOLISM; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; RAT; SKELETAL MUSCLE; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; ANTIOXIDANTS; DIET, HIGH-FAT; FATTY ACIDS, NONESTERIFIED; HYPOGLYCEMIC AGENTS; I-KAPPA B PROTEINS; INFUSIONS, INTRAVENOUS; INSULIN RESISTANCE; INSULIN, REGULAR, HUMAN; MALE; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; NF-KAPPA B; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; XANTHINE OXIDASE;

EID: 84856730254     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2396-x     Document Type: Article

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