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Volumn 14, Issue 1-2, 2010, Pages 215-225

Combined R-α-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease

Author keywords

Acetyl L carnitine; Lipoic acid; Mitochondrial dysfunction; Oxidative damage; Parkinson's disease

Indexed keywords

ACETYLCARNITINE; ALPHA SYNUCLEIN; ANTIOXIDANT; ROTENONE; THIOCTIC ACID; UBIQUITIN; UNCOUPLING PROTEIN;

EID: 77951950272     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00390.x     Document Type: Article
Times cited : (69)

References (35)
  • 1
  • 2
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease
    • discussion S-8
    • Jenner P. Oxidative stress in Parkinson's disease. Ann Neurol. 2003, 53:S26-36. discussion S-8
    • (2003) Ann Neurol. , vol.53
    • Jenner, P.1
  • 3
    • 21844441151 scopus 로고    scopus 로고
    • Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease
    • Liu J, Ames BN. Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease. Nutr Neurosci. 2005, 8:67-89.
    • (2005) Nutr Neurosci. , vol.8 , pp. 67-89
    • Liu, J.1    Ames, B.N.2
  • 4
    • 36949012725 scopus 로고    scopus 로고
    • The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview
    • Liu J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res. 2008, 33:194-203.
    • (2008) Neurochem Res. , vol.33 , pp. 194-203
    • Liu, J.1
  • 5
    • 0037379314 scopus 로고    scopus 로고
    • Bioenergetic approaches for neuroprotection in Parkinson's disease
    • discussion S-8
    • Beal MF. Bioenergetic approaches for neuroprotection in Parkinson's disease. Ann Neurol. 2003, 53:S39-47. discussion S-8
    • (2003) Ann Neurol. , vol.53
    • Beal, M.F.1
  • 6
    • 0031594295 scopus 로고    scopus 로고
    • Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice
    • Beal MF, Matthews RT, Tieleman A. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 1998, 783:109-14.
    • (1998) Brain Res. , vol.783 , pp. 109-114
    • Beal, M.F.1    Matthews, R.T.2    Tieleman, A.3
  • 7
    • 0036771852 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline
    • Shults CW, Oakes D, Kieburtz K. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002, 59:1541-50.
    • (2002) Arch Neurol. , vol.59 , pp. 1541-1550
    • Shults, C.W.1    Oakes, D.2    Kieburtz, K.3
  • 8
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • St-Pierre J, Drori S, Uldry M. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006, 127:397-408.
    • (2006) Cell. , vol.127 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3
  • 9
    • 33749042331 scopus 로고    scopus 로고
    • Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    • Cui L, Jeong H, Borovecki F. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell. 2006, 127:59-69.
    • (2006) Cell. , vol.127 , pp. 59-69
    • Cui, L.1    Jeong, H.2    Borovecki, F.3
  • 11
    • 1542723493 scopus 로고    scopus 로고
    • Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
    • Suh JH, Shenvi SV, Dixon BM. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA. 2004, 101:3381-6.
    • (2004) Proc Natl Acad Sci USA. , vol.101 , pp. 3381-3386
    • Suh, J.H.1    Shenvi, S.V.2    Dixon, B.M.3
  • 12
    • 0036240776 scopus 로고    scopus 로고
    • Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites
    • Liu J, Atamna H, Kuratsune H. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Ann New York Acad Sci. 2002, 959:133-66.
    • (2002) Ann New York Acad Sci. , vol.959 , pp. 133-166
    • Liu, J.1    Atamna, H.2    Kuratsune, H.3
  • 13
    • 0038433337 scopus 로고    scopus 로고
    • Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells
    • Mazzio E, Yoon KJ, Soliman KF. Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells. Biochem Pharmaco. 2003, 66:297-306.
    • (2003) Biochem Pharmaco. , vol.66 , pp. 297-306
    • Mazzio, E.1    Yoon, K.J.2    Soliman, K.F.3
  • 15
    • 0036778280 scopus 로고    scopus 로고
    • Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy
    • Bharat S, Cochran BC, Hsu M. Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. Neurotoxicology. 2002, 23:479-86.
    • (2002) Neurotoxicology. , vol.23 , pp. 479-486
    • Bharat, S.1    Cochran, B.C.2    Hsu, M.3
  • 16
    • 34347369328 scopus 로고    scopus 로고
    • Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acid
    • Karunakaran S, Diwakar L, Saeed U. Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acid. FASEB J. 2007, 21:2226-36.
    • (2007) FASEB J. , vol.21 , pp. 2226-2236
    • Karunakaran, S.1    Diwakar, L.2    Saeed, U.3
  • 17
    • 0037104723 scopus 로고    scopus 로고
    • An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    • Sherer TB, Betarbet R, Stout AK. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci. 2002, 22:7006-15.
    • (2002) J Neurosci. , vol.22 , pp. 7006-7015
    • Sherer, T.B.1    Betarbet, R.2    Stout, A.K.3
  • 18
    • 34147196228 scopus 로고    scopus 로고
    • Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts
    • Janssen AJ, Trijbels FJ, Sengers RC. Spectrophotometric assay for complex I of the respiratory chain in tissue samples and cultured fibroblasts. Clin Chem. 2007, 53:729-34.
    • (2007) Clin Chem. , vol.53 , pp. 729-734
    • Janssen, A.J.1    Trijbels, F.J.2    Sengers, R.C.3
  • 19
    • 0025806764 scopus 로고
    • Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1
    • Smiley ST, Reers M, Mottola-Hartshorn C. Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1. Proc Natl Acad Sci USA. 1991, 88:3671-5.
    • (1991) Proc Natl Acad Sci USA. , vol.88 , pp. 3671-3675
    • Smiley, S.T.1    Reers, M.2    Mottola-Hartshorn, C.3
  • 20
    • 18644370269 scopus 로고    scopus 로고
    • A newly established neuronal rho-0 cell line highly susceptible to oxidative stress accumulates iron and other metals. Relevance to the origin of metal ion deposits in brains with neurodegenerative disorders
    • Fukuyama R, Nakayama A, Nakase T. A newly established neuronal rho-0 cell line highly susceptible to oxidative stress accumulates iron and other metals. Relevance to the origin of metal ion deposits in brains with neurodegenerative disorders. J Biol Chem. 2002, 277:41455-62.
    • (2002) J Biol Chem. , vol.277 , pp. 41455-41462
    • Fukuyama, R.1    Nakayama, A.2    Nakase, T.3
  • 21
    • 0027249757 scopus 로고
    • Evaluation of 2′,7′-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells
    • Royall JA, Ischiropoulos H. Evaluation of 2′,7′-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Arch Biochem Biophys. 1993, 302:348-55.
    • (1993) Arch Biochem Biophys. , vol.302 , pp. 348-355
    • Royall, J.A.1    Ischiropoulos, H.2
  • 22
    • 20944451305 scopus 로고    scopus 로고
    • Heterogeneity in DNA damage using the comet assay
    • Olive PL, Durand RE. Heterogeneity in DNA damage using the comet assay. Cytometry A. 2005, 66:1-8.
    • (2005) Cytometry A. , vol.66 , pp. 1-8
    • Olive, P.L.1    Durand, R.E.2
  • 23
    • 33644778845 scopus 로고    scopus 로고
    • Parkin enhances mitochondrial biogenesis in proliferating cells
    • Kuroda Y, Mitsui T, Kunishige M. Parkin enhances mitochondrial biogenesis in proliferating cells. Hum Mol Genet. 2006, 15:883-95.
    • (2006) Hum Mol Genet. , vol.15 , pp. 883-895
    • Kuroda, Y.1    Mitsui, T.2    Kunishige, M.3
  • 24
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
    • Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005, 39:359-407.
    • (2005) Annu Rev Genet. , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 25
    • 0036829946 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative strategies for Parkinson's disease
    • Dawson TM, Dawson VL. Neuroprotective and neurorestorative strategies for Parkinson's disease. Nat Neurosci. 2002, 5:1058-61.
    • (2002) Nat Neurosci. , vol.5 , pp. 1058-1061
    • Dawson, T.M.1    Dawson, V.L.2
  • 26
    • 20544431978 scopus 로고    scopus 로고
    • Neuroprotective therapy in Parkinson's disease and motor complications: a search for a pathogenesis-targeted, disease-modifying strategy
    • Olanow CW, Jankovic J. Neuroprotective therapy in Parkinson's disease and motor complications: a search for a pathogenesis-targeted, disease-modifying strategy. Mov Disord. 2005, 20:S3-10.
    • (2005) Mov Disord. , vol.20
    • Olanow, C.W.1    Jankovic, J.2
  • 27
    • 0345601861 scopus 로고    scopus 로고
    • Can we prevent Parkinson's and Alzheimer's disease
    • Kedar NP. Can we prevent Parkinson's and Alzheimer's disease. J Postgrad Med. 2003, 49:236-45.
    • (2003) J Postgrad Med. , vol.49 , pp. 236-245
    • Kedar, N.P.1
  • 28
    • 33750710080 scopus 로고    scopus 로고
    • Protein oxidation and aging
    • Stadtman ER. Protein oxidation and aging. Free Radic Res. 2006, 40:1250-8.
    • (2006) Free Radic Res. , vol.40 , pp. 1250-1258
    • Stadtman, E.R.1
  • 29
    • 0037133319 scopus 로고    scopus 로고
    • Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha -lipoic acid
    • Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci USA. 2002, 99:1876-81.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , pp. 1876-1881
    • Liu, J.1    Killilea, D.W.2    Ames, B.N.3
  • 30
    • 0037133283 scopus 로고    scopus 로고
    • Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid
    • Liu J, Head E, Gharib AM. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc Natl Acad Sci USA. 2002, 99:2356-61.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , pp. 2356-2361
    • Liu, J.1    Head, E.2    Gharib, A.M.3
  • 31
    • 0037133304 scopus 로고    scopus 로고
    • Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress
    • Hagen TM, Liu J, Lykkesfeldt J. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc Natl Acad Sci USA. 2002, 99:1870-5.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , pp. 1870-1875
    • Hagen, T.M.1    Liu, J.2    Lykkesfeldt, J.3
  • 32
    • 0032497504 scopus 로고    scopus 로고
    • Parkinson's disease. First of two parts
    • Lang AE, Lozano AM. Parkinson's disease. First of two parts. N Engl J Med. 1998, 339:1044-53.
    • (1998) N Engl J Med. , vol.339 , pp. 1044-1053
    • Lang, A.E.1    Lozano, A.M.2
  • 33
    • 0032531924 scopus 로고    scopus 로고
    • Parkinson's disease. Second of two parts
    • Lang AE, Lozano AM. Parkinson's disease. Second of two parts. N Engl J Med. 1998, 339:1130-43.
    • (1998) N Engl J Med. , vol.339 , pp. 1130-1143
    • Lang, A.E.1    Lozano, A.M.2
  • 34
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies
    • Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA. 1998, 279:1200-5.
    • (1998) JAMA. , vol.279 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.