Reduction of mutant ataxin-7 expression restores motor function and prevents cerebellar synaptic reorganization in a conditional mouse model of SCA7

Human Molecular Genetics

Volumn 22, Issue 5, 2013, Pages 890-903

  Furrer, Stephanie A ^a   Waldherr, Sarah M ^a   Mohanachandran, Mathini S ^a   Baughn, Travis D ^a   Nguyen, Kien Thiet ^a   Sopher, Bryce L ^a   Damian, Vincent A ^a   Garden, Gwenn A ^a   La spada, Albert R ^a,b,c,d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 7; CRE RECOMBINASE; MOLECULAR LAYER; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLIMBING FIBER; CONTROLLED STUDY; CORTICAL THICKNESS (BRAIN); FEMALE; GENE MUTATION; GLIA CELL; MALE; MOTOR PERFORMANCE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PURKINJE CELL; SPINOCEREBELLAR ATAXIA TYPE 7; SPINOCEREBELLAR DEGENERATION; SYNAPSE;

ANIMALS; CEREBELLUM; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; LOCOMOTION; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; PEPTIDES; PURKINJE CELLS; SPINOCEREBELLAR ATAXIAS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84873457317     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds495     Document Type: Article

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