Glial S100B protein modulates mutant ataxin-1 aggregation and toxicity: TRTK12 peptide, a potential candidate for SCA1 therapy

Cerebellum

Volumn 10, Issue 2, 2011, Pages 254-266

  Vig, Parminder J S ^a,b   Hearst, Scoty ^a,b   Shao, Qingmei ^a   Lopez, Mariper E ^a   Murphy II, Henry A ^a   Safaya, Eshan ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Ataxin 1; Bergmann glia; Cerebellum; Neurodegeneration; Purkinje cells; S100B; Spinocerebellar ataxia 1; Vacuoles

Indexed keywords

ATAXIN 1; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; MUTANT PROTEIN; NEUROPROTECTIVE AGENT; POLYGLUTAMINE; PROTEIN S100B; TRTK12 PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL NUCLEUS INCLUSION BODY; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DENDRITIC CELL; DENDRITIC SPINE; DRUG MECHANISM; DRUG PROTEIN BINDING; GENE EXPRESSION; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PURKINJE CELL; ROTAROD TEST; SPINOCEREBELLAR ATAXIA TYPE 1; SPINOCEREBELLAR DEGENERATION;

ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; INCLUSION BODIES; MICE; MICE, TRANSGENIC; MUTATION; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEUROGLIA; NUCLEAR PROTEINS; OLIGOPEPTIDES; PURKINJE CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S100 PROTEINS; SPINOCEREBELLAR ATAXIAS; VACUOLES;

EID: 79960775251     PISSN: 14734222     EISSN: 14734230     Source Type: Journal    
DOI: 10.1007/s12311-011-0262-5     Document Type: Article

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