Leptin-induced increase in body fat content of rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 304, Issue 3, 2013, Pages

  Harris, Ruth B S ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Body composition; Forebrain; Hindbrain; Mutein leptin

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; BODY FAT; BODY MASS; BODY WEIGHT; BRAIN FOURTH VENTRICLE; BRAIN STEM; CALORIC INTAKE; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; FOREBRAIN; HYPERINSULINEMIA; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; RETROPERITONEAL FAT; RHOMBENCEPHALON;

ADIPOSE TISSUE; ANIMALS; INFUSIONS, INTRAVENTRICULAR; LEPTIN; MALE; RATS; RATS, SPRAGUE-DAWLEY; RHOMBENCEPHALON;

EID: 84873360376     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00251.2012     Document Type: Article

References (46)

1. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptides 17: 305-311, 1996.
2. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med 12: 917-924, 2006.
3. Bjorbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS. Identification of SOCS3as a potential mediator of central leptin resistance. Mol Cell 1: 619-625, 1998.
4. Buettner C, Muse ED, Cheng A, Chen L, Scherer T, Pocai A, Su K, Cheng B, Li X, Harvey-White J, Schwartz GJ, Kunos G, Rossetti L. Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms. Nat Med 14: 667-675, 2008.
5. Choi YH, Li C, Hartzell DL, Little DE, Della-Fera MA, Baile CA. Icv leptin effects on spontaneous physical activity and feeding behavior in rats. Behav Brain Res 188: 100-108, 2008.
6. Chotiwat C, Harris RB. Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats. Am J Physiol Regul Integr Comp Physiol 295: R1762-R1773, 2008.
7. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Eng J Med 334: 292-295, 1996.
8. Devarajan E, Huang S. Stat3 as a central regulator of tumor metastases. Curr Mol Med 9: 626-633, 2009.
9. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105: 1827-1832, 2000.
10. Fruhbeck G. Peripheral actions of leptin, and its involvement in disease. Nutr Rev 60: S47-S55; discussion S68-S84, 85-47, 2002.
11. Guan XM, Hess JF, Yu H, Hey PJ, van der Ploeg LH. Differential expression of mrna for leptin receptor isoforms in the rat brain. Mol Cell Endocrinol 133: 1-7, 1997.
12. Gullicksen PS, Flatt WP, Dean RG, Hartzell DL, Baile CA. Energy metabolism and expression of uncoupling proteins 1, 2, and 3 after 21 days of recovery from intracerebroventricular mouse leptin in rats. Physiol Behav 75: 473-482, 2002.
13. Hakansson ML, Brown H, Ghilardi N, Skoda RC, Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 18: 559-572, 1998.
14. Haring SJ, Harris RB. The relation between dietary fructose, dietary fat and leptin responsiveness in rats. Physiol Behav 104: 914-922, 2-11.
15. Harris RB. Growth measurements in sprague-dawley rats fed diets of very low fat concentration. J Nutr 121: 1075-1080, 1991.
16. Harris RB. Factors influencing energy intake of rats fed either a high-fat or a fat mimetic diet. Int J Obes Relat Metab Disord 18: 632-640, 1994.
17. Harris RB, Apolzan JW. Changes in glucose tolerance and leptin responsiveness of rats offered a choice of lard, sucrose and chow. Am J Physiol Regul Integr Comp Physiol 302: R1327-R1339, 2012.
18. Harris RB, Bartness TJ, Grill HJ. Leptin responsiveness in chronically decerebrate rats. Endocrinology 148: 4623-4633, 2007.
19. Harris RB, Mitchell TD, Kelso EW, Flatt WP. Changes in environmental temperature influence leptin responsiveness in low- and high-fat-fed mice. Am J Physiol Regul Integr Comp Physiol 293: R106-R115, 2007.
20. Harris RB, Zhou J, Redmann SM Jr,. Smagin GN, Smith SR, Rodgers E, and Zachwieja JJ: A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology 139: 8-19, 1998.
21. Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ. Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab 11: 77-83, 2010.
22. Horn CC, Kaplan JM, Grill HJ, Friedman MI. Brain fos-like immunoreactivity in chronic decerebrate and neurologically intact rats given 2,5-anhydro-D-mannitol. Brain Res 801: 107-115, 1998.
23. Huo L, Maeng L, Bjorbaek C, Grill HJ. Leptin and the control of food intake: Neurons in the nucleus of the solitary tract are activated by both gastric distension and leptin. Endocrinology 148: 2189-2197, 2007.
24. Kim KS, Yoon YR, Lee HJ, Yoon S, Kim SY, Shin SW, An JJ, Kim MS, Choi SY, Sun W, Baik JH. Enhanced hypothalamic leptin signaling in mice lacking dopamine d2 receptors. J Biol Chem 285: 8905-8917, 2010.
25. Levin BE, Dunn-Meynell AA, Banks WA. Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset. Am J Physiol Regul Integr Comp Physiol 286: R143-R150, 2004.
26. Maness LM, Kastin AJ, Farrell CL, Banks WA. Fate of leptin after intracerebroventricular injection into the mouse brain. Endocrinology 139: 4556-4562, 1998.
27. Miragaya JR, Harris RB. Antagonism of corticotrophin-releasing factor receptors in the fourth ventricle modifies responses to mild but not restraint stress. Am J Physiol Regul Integr Comp Physiol 295: R404-R416, 2008.
28. Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 272: 10585-10593, 1997.
29. Munzberg H, Flier JS, Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145: 4880-4889, 2004.
30. Nicolas CS, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, Collett VJ, Hildebrandt L, Seaton G, Choi SL, Sim SE, Bradley C, Lee K, Zhuo M, Kaang BK, Gressens P, Dournaud P, Fitzjohn SM, Bortolotto ZA, Cho K, Collingridge GL: The JAK/STAT. pathway is involved in synaptic plasticity. Neuron 73: 374-390, 2012.
31. Oufkir T, Vaillancourt C. Phosphorylation of JAK2 by serotonin (2A)-HT receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell. Placenta 32: 1033-1040, 2011.
32. Pal R, Sahu A. Leptin signaling in the hypothalamus during chronic central leptin infusion. Endocrinology 144: 3789-3798, 2003.
33. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
34. Penn DM, Jordan LC, Kelso EW, Davenport JE, Harris RB. Effects of central or peripheral leptin administration on norepinephrine turnover in defined fat depots. Am J Physiol Regul Integr Comp Physiol 291: R1613- R1621, 2006.
35. Pocai A, Morgan K, Buettner C, Gutierrez-Juarez R, Obici S, Rossetti L. Central leptin acutely reverses diet-induced hepatic insulin resistance. Diabetes 54: 3182-3189, 2005.
36. Ruiter M, Duffy P, Simasko S, Ritter RC. Increased hypothalamic signal transducer and activator of transcription 3 phosphorylation after hindbrain leptin injection. Endocrinology 151: 1509-1519, 2010.
37. Scarpace PJ, Matheny M, Pollock BH, Tumer N. Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol Endocrinol Metab 273: E226-E230, 1997.
38. Scarpace PJ, Matheny M, Tumer N. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience 104: 1111-1117, 2001.
39. Shi ZQ, Nelson A, Whitcomb L, Wang J, Cohen AM. Intracerebroven-tricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats. Metab Clin Exper 47: 1274-1280, 1998.
40. Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138: 3395- 3401, 1997.
41. Skibicka KP, Grill HJ. Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Endocrinology 150: 1705-1711, 2009.
42. Solomon G, Niv-Spector L, Gonen-Berger D, Callebaut I, Djiane J, Gertler A. Preparation of leptin antagonists by site-directed mutagenesis of human, ovine, rat, and mouse leptin's site I.I.I.: Implications on blocking undesired leptin action in vivo. Ann NY Acad Sci 1091: 531-539, 2006.
43. Wang T, Hartzell DL, Rose BS, Flatt WP, Hulsey MG, Menon NK, Makula RA, Baile CA. Metabolic responses to intracerebroventricular leptin and restricted feeding. Physiol Behav 65: 839-848, 1999.
44. Widdowson PS, Upton R, Buckingham R, Arch J, Williams G. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes 46: 1782-1785, 1997.
45. Zhang Y, Matheny M, Tumer N, Scarpace PJ. Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance. Neurobiol Aging 25: 1349-1360, 2004.
46. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.