The relation between dietary fructose, dietary fat and leptin responsiveness in rats

Physiology and Behavior

Volumn 104, Issue 5, 2011, Pages 914-922

  Haring, Samantha J ^a   Harris, Ruth B S ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Dietary fat; Food intake; STAT3; Triglycerides; Weight gain

Indexed keywords

FAT; FRUCTOSE; GLUCOSE; LEPTIN; STAT3 PROTEIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN STEM; BRAIN THIRD VENTRICLE; CONTROLLED STUDY; FAT INTAKE; FOOD INTAKE; HORMONE RESISTANCE; HYPOTHALAMUS; MALE; MEMBRANE PERMEABILITY; NONHUMAN; NUTRIENT CONTENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SUGAR INTAKE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; DIETARY FATS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; EATING; ENERGY INTAKE; FRUCTOSE; GENE EXPRESSION REGULATION; HYPOTHALAMUS; LEPTIN; MALE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TRIGLYCERIDES;

EID: 80053052166     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2011.05.032     Document Type: Article

References (52)

1. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
2. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996, 98:1101-1106.
3. Williams G., Bing C., Cai X.J., Harrold J.A., King P.J., Liu X.H. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav 2001, 74:683-701.
4. Dhillon H., Zigman J.M., Ye C., Lee C.E., McGovern R.A., Tang V., et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006, 49:191-203.
5. Figlewicz D.P., Evans S.B., Murphy J., Hoen M., Baskin D.G. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain Res 2003, 964:107-115.
6. Skibicka K.P., Grill H.J. Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Endocrinology 2009, 150:1705-1711.
7. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995, 269:543-546.
8. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995, 269:546-549.
9. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995, 269:540-543.
10. Heymsfield S.B., Greenberg A.S., Fujioka K., Dixon R.M., Kushner R., Hunt T., et al. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 1999, 282:1568-1575.
11. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New Engl J Med 1996, 334:292-295.
12. El-Haschimi K., Pierroz D.D., Hileman S.M., Bjorbaek C., Flier J.S. Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 2000, 105:1827-1832.
13. Lin S., Thomas T.C., Storlien L.H., Huang X.F. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord 2000, 24:639-646.
14. Lin L., Martin R., Schaffhauser A.O., York D.A. Acute changes in the response to peripheral leptin with alteration in the diet composition. Am J Physiol Regul Integr Comp Physiol 2001, 280:R504-R509.
15. Caro J.F., Kolaczynski J.W., Nyce M.R., Ohannesian J.P., Opentanova I., Goldman W.H., et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996, 348:159-161.
16. Munzberg H., Myers M.G. Molecular and anatomical determinants of central leptin resistance. Nat Neurosci 2005, 8:566-570.
17. Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1998, 1:619-625.
18. Bates S.H., Myers M.G. The role of leptin -- >STAT3 signaling in neuroendocrine function: an integrative perspective. J Mol Med 2004, 82:12-20.
19. Madiehe A.M., Schaffhauser A.O., Braymer D.H., Bray G.A., York D.A. Differential expression of leptin receptor in high- and low-fat-fed Osborne-Mendel and S5B/Pl rats. Obes Res 2000, 8:467-474.
20. Bray G.A. Fructose: should we worry?. Int J Obes (Lond) 2008, 32(Suppl 7):S127-S131.
21. Havel P.J. Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 2005, 63:133-157.
22. Bray G.A., Nielsen S.J., Popkin B.M. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr 2004, 79:537-543.
23. Haley S., Reed J., Lin B.-H., Cook A. Sweetner consumption in the United States. Distribution by demographic and product characteristics. United States Department of Agriculture 2005.
24. Bizeau M.E., Pagliassotti M.J. Hepatic adaptations to sucrose and fructose. Metabolism 2005, 54:1189-1201.
25. Teff K.L., Elliott S.S., Tschop M., Kieffer T.J., Rader D., Heiman M., et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab 2004, 89:2963-2972.
26. Chong M.F., Fielding B.A., Frayn K.N. Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr 2007, 85:1511-1520.
27. Le K.A., Faeh D., Stettler R., Ith M., Kreis R., Vermathen P., et al. A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr 2006, 84:1374-1379.
28. Bantle J.P., Raatz S.K., Thomas W., Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr 2000, 72:1128-1134.
29. Banks W.A., Coon A.B., Robinson S.M., Moinuddin A., Shultz J.M., Nakaoke R., et al. Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes 2004, 53:1253-1260.
30. Shapiro A., Mu W., Roncal C., Cheng K.Y., Johnson R.J., Scarpace P.J. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol 2008, 295:R1370-R1375.
31. Smagin G.N., Howell L.A., Redmann S., Ryan D.H., Harris R.B. Prevention of stress-induced weight loss by third ventricle CRF receptor antagonist. Am J Physiol 1999, 276:R1461-R1468.
32. Harris R.B., Mitchell T.D., Hebert S. Leptin-induced changes in body composition in high fat-fed mice. Exp Biol Med 2003, 228:24-32.
33. Wang T., Hartzell D.L., Rose B.S., Flatt W.P., Hulsey M.G., Menon N.K., et al. Metabolic responses to intracerebroventricular leptin and restricted feeding. Physiol Behav 1999, 65:839-848.
34. Kasser T.R., Harris R.B., Martin R.J. Level of satiety: fatty acid and glucose metabolism in three brain sites associated with feeding. Am J Physiol 1985, 248:R447-R452.
35. Harris R.B. Growth measurements in Sprague-Dawley rats fed diets of very low fat concentration. J Nutr 1991, 121:1075-1080.
36. Paxinos G., Watson C. The rat brain 1998, Academic Press, New York.
37. Ellacott K.L., Halatchev I.G., Cone R.D. Characterization of leptin-responsive neurons in the caudal brainstem. Endocrinology 2006, 147:3190-3195.
38. Botezelli J.D., Mora R.F., Dalia R.A., Moura L.P., Cambri L.T., Ghezzi A.C., et al. Exercise counteracts fatty liver disease in rats fed on fructose-rich diet. Lipids Health Dis 2010, 9:116.
39. Lim S., Zoellner J.M., Lee J.M., Burt B.A., Sandretto A.M., Sohn W., et al. Obesity and sugar-sweetened beverages in African-American preschool children: a longitudinal study. Obesity (Silver Spring) 2009, 17:1262-1268.
40. Nettleton J.A., Lutsey P.L., Wang Y., Lima J.A., Michos E.D., Jacobs D.R. Diet soda intake and risk of incident metabolic syndrome and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care 2009, 32:688-694.
41. Alzamendi A., Giovambattista A., Raschia A., Madrid V., Gaillard R.C., Rebolledo O., et al. Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats. Endocrine 2009, 35:227-232.
42. Lindqvist A., Baelemans A., Erlanson-Albertsson C. Effects of sucrose, glucose and fructose on peripheral and central appetite signals. Regul Pept 2008, 150:26-32.
43. Oron-Herman M., Kamari Y., Grossman E., Yeger G., Peleg E., Shabtay Z., et al. Metabolic syndrome: comparison of the two commonly used animal models. Am J Hypertens 2008, 21:1018-1022.
44. Gutman R.A., Basilico M.Z., Bernal C.A., Chicco A., Lombardo Y.B. Long-term hypertriglyceridemia and glucose intolerance in rats fed chronically an isocaloric sucrose-rich diet. Metabolism 1987, 36:1013-1020.
45. Cohen A.M., Teitelbaum A., Rosenman E. Diabetes induced by a high fructose diet. Metabolism 1977, 26:17-24.
46. Huang W., Dedousis N., Bandi A., Lopaschuk G.D., O'Doherty R.M. Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology 2006, 147:1480-1487.
47. Huang W., Metlakunta A., Dedousis N., Ortmeyer H.K., Stefanovic-Racic M., O'Doherty R.M. Leptin augments the acute suppressive effects of insulin on hepatic very low-density lipoprotein production in rats. Endocrinology 2009, 150:2169-2174.
48. Munzberg H., Flier J.S., Bjorbaek C. Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 2004, 145:4880-4889.
49. Rahmouni K., Sigmund C.D., Haynes W.G., Mark A.L. Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes 2009, 58:536-542.
50. Waterman R.A., Romsos D.R., Tsai A.C., Miller E.R., Leveille G.A. Effects of dietary carbohydrate source on growth, plasma metabolites and lipogenesis in rats, pigs, and chicks. Proc Soc Exp Biol Med 1975, 150:220-225.
51. Tappy L., Jequier E. Fructose and dietary thermogenesis. Am J Clin Nutr 1993, 58:766S-770S.
52. Vila L., Roglans N., Alegret M., Sanchez R.M., Vazquez-Carrera M., Laguna J.C. Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism. Hepatology 2008, 48:1506-1516.