Sesamin protects mouse liver against nickel-induced oxidative DNA damage and apoptosis by the PI3K-Akt pathway

Journal of Agricultural and Food Chemistry

Volumn 61, Issue 5, 2013, Pages 1146-1154

  Liu, Chan Min ^a   Zheng, Gui Hong ^a   Ming, Qing Lei ^a   Chao, Cheng ^a   Sun, Jian Mei ^a  

^a JIANGSU NORMAL UNIVERSITY   (China)

Author keywords

Akt; apoptosis; DNA injury; liver; nickel; sesamin

Indexed keywords

AKT; AMINOTRANSFERASE ACTIVITIES; ANTIOXIDANT ACTIVITIES; ANTIOXIDANT ENZYME; CASPASE-3; DIAGNOSTIC INDICATORS; DOSE-DEPENDENT MANNER; EXPRESSION LEVELS; HEPATOTOXICITY; HISTOPATHOLOGICAL ANALYSIS; KUNMING MOUSE; LIGNANS; LIPID PEROXIDATION LEVELS; LIVER DAMAGE; MOUSE LIVER; NICKEL SULFATE; OXIDATIVE DNA DAMAGE; PHOSPHORYLATED PROTEINS; PROTECTIVE EFFECTS; REACTIVE OXYGEN SPECIES; REDUCED GLUTATHIONE; SESAMIN; SIGNALING EVENTS; SIGNALING PATHWAYS; TUNEL ASSAY; UNDERLYING MECHANISM;

CELL DEATH; DNA; ENZYMES; LIVER; MAMMALS; OILSEEDS; PHOSPHORYLATION; PROTEINS;

NICKEL;

1,3 DIOXOLANE DERIVATIVE; 8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CASP3 PROTEIN, MOUSE; CASPASE 3; DEOXYGUANOSINE; DRUG DERIVATIVE; GLUTATHIONE; LIGNAN; NICKEL; NICKEL SULFATE; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; SESAMIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL; APOPTOSIS; ARTICLE; BLOOD; DNA DAMAGE; DRUG EFFECT; GENETICS; LIPID PEROXIDATION; LIVER; MALE; METABOLISM; MOUSE; NICK END LABELING; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASPARTATE AMINOTRANSFERASES; BLOTTING, WESTERN; CASPASE 3; DEOXYGUANOSINE; DIOXOLES; DNA DAMAGE; GLUTATHIONE; IN SITU NICK-END LABELING; LIGNANS; LIPID PEROXIDATION; LIVER; MALE; MICE; NICKEL; ONCOGENE PROTEIN V-AKT; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

MUS; SESAMUM INDICUM;

EID: 84873334113     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf304562b     Document Type: Article

References (51)

1. Ikeda, S.; Kagaya, M.; Kobayashi, K.; Tohyama, T.; Kiso, Y.; Higuchi, N.; Yamashita, K. Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid J. Nutr. Sci. Vitaminol. 2003, 49, 270-276
2. Nakai, M.; Harada, M.; Nakahara, K.; Akimoto, K.; Shibata, H.; Miki, W.; Kiso, Y. Novel antioxidative metabolites in rat liver with ingested sesamin J. Agric. Food Chem. 2003, 51, 1666-1670
3. Lee, W. J.; Ou, H. C.; Wu, C. M.; Lee, I. T.; Lin, S. Y.; Lin, L. Y.; Tsai, K. L.; Lee, S. D.; Sheu, W. H. Sesamin mitigates inflammation and oxidative stress in endothelial cells exposed to oxidized low-density lipoprotein J. Agric. Food Chem. 2009, 57, 11406-11417
4. Lee, C. C.; Liu, K. J.; Wu, Y. C.; Lin, S. J.; Chang, C. C.; Huang, T. S. Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression and proangiogenic activity in breast cancer cells Inflammation 2011, 34, 209-221
5. Hsieh, P. F.; Hou, C. W.; Yao, P. W.; Wu, S. P.; Peng, Y. F.; Shen, M. L.; Lin, C. H.; Chao, Y. Y.; Chang, M. H.; Jeng, K. C. Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation J. Neuroinflammation 2011, 8, 57
6. Matsumura, Y.; Kita, S.; Morimoto, S.; Akimoto, K.; Furuya, M.; Oka, N.; Tanaka, T. Antihype rtensive effect of sesamin. I. Protection against deoxycor ticosterone acetate-salt-induced hypertensi on and cardiova scular hypertrophy Biol. Pharm. Bull. 1995, 18, 1016-1019
7. Wu, X.; Kong, X.; Zhou, Y.; Huang, K.; Yang, J.; Li, X. Sesamin exerts renoprotective effects by enhancing NO bioactivity in renovascular hypertensive rats fed with high-fat-sucrose diet Eur. J. Pharmacol. 2012, 683, 231-237
8. Kong, X.; Yang, J.; Guo, L.; Xiong, Y.; Wu, X.; Huang, K.; Zhou, Y. Sesamin improves endothelial dysfunction in renovascular hypertensive rats fed with a high-fat, high-sucrose diet Eur. J. Pharmacol. 2009, 620, 84-89
9. Peñalvo, J. L.; Hopia, A.; Adlercreutz, H. Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice Eur. J. Nutr. 2006, 45, 439-444
10. Hirose, N.; Doi, F.; Ueki, T.; Akazawa, K.; Chijiiwa, K.; Sugano, M.; Akimoto, K.; Shimizu, S.; Yamada, H. Suppressive effect of sesamin against 7,12-dimethylbenz[a]anthracene induced rat mammary carcinogenesis Anticancer Res. 1992, 12, 1259-1265
11. Kushiro, M.; Masaoka, T.; Hageshita, S.; Takahashi, Y.; Ide, T.; Sugano, M. Comparative effect of sesamin and episesamin on the activity and gene expresion of enzymes in fatty acid oxidation and synthesis in rat liver J. Nutr. Biochem. 2002, 13, 289-295
12. 4-induced hepatic oxidative stress in rats Phytother. Res. 2009, 23, 251-256
13. Khan, M. M.; Ishrat, T.; Ahmad, A.; Hoda, M. N.; Khan, M. B.; Khuwaja, G.; Srivastava, P.; Raza, S. S.; Islam, F.; Ahmad, S. Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats Chem.-Biol. Interact. 2010, 183, 255-263
14. Yasuda, K.; Ikushiro, S.; Kamakura, M.; Ohta, M.; Sakaki, T. Metabolism of sesamin by cytochrome P450 in human liver microsomes Drug Metab. Dispos. 2012, 40, 1917-1926
15. Utsunomiya, T.; Chavali, S. R.; Zhong, W. W.; Forse, R. A. Effects of sesamin-supplemented dietary fat emulsions on the ex vivo production of lipopolysaccharide-induced prostanoids and tumor necrosis factor alpha in rats Am. J. Clin. Nutr. 2000, 72, 804-808
16. Hemalatha, S.; Raghunath, M.; Ghafoorunissa Dietary sesame oils inhibits iron-induced oxidative stress in rats Br. J. Nutr. 2004, 92, 581-587
17. Tsuruoka, N.; Kidokoro, A.; Matsumoto, I.; Abe, K.; Kiso, Y. Modulating effect of sesamin, a functional lignan in sesame seeds, on the transcription levels of lipid- and alcohol-metabolizing enzymes in rat liver: a DNA microarray study Biosci., Biotechnol., Biochem. 2005, 69, 179-188
18. Denkhaus, E.; Salnikow, K. Nickel essentiality, toxicity, and carcinogenicity Crit. Rev. Oncol. Hematol. 2002, 42, 35-56
19. Das, K. K.; Das, S. N.; Dhundasi, S. A. Nickel, its adverse health effects and oxidative stress Indian J. Med. Res. 2008, 128, 412-425
20. Valko, M.; Rhodes, C. J.; Moncol, J.; Izakovic, M.; Mazur, M. Free radicals, metals and antioxidants in oxidative stress-induced cancer Chem.-Biol. Interact. 2006, 160, 1-40
21. Kasprzak, K. S.; Jaruga, P.; Zastawny, T. H.; North, S. L.; Riggs, C. W.; Olinski, R.; Dizdaroglu, M. Oxidative DNA base damage and its repair in kidneys and livers of nickel(II)-treated male F344 rats Carcinogenesis 1997, 18, 271-277
22. Cameron, K. S.; Buchner, V.; Tchounwou, P. B. Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: a literature review Rev. Environ. Health 2011, 26, 81-92
23. Permenter, M. G.; Lewis, J. A.; Jackson, D. A. Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line PLoS One 2011, 6, e27730
24. Qu, W.; Kasprzak, K. S.; Kadiiska, M.; Liu, J.; Chen, H.; Maciag, A.; Mason, R. P.; Waalkes, M. P. Mechanisms of arsenic-induced cross-tolerance to nickel cytotoxicity, genotoxicity, and apoptosis in rat liver epithelial cells Toxicol. Sci. 2001, 63, 189-195
25. Porta, C.; Figlin, R. A. Phosphatidylinositol-3-kinase/Akt signaling pathway and kidney cancer, and the therapeutic potential of phosphatidylinositol-3-kinase/Akt inhibitors J. Urol. 2009, 182, 2569-2577
26. Franke, T. F.; Hornik, C. P.; Segev, L.; Shostak, G. A.; Sugimoto, C. PI3K/Akt and apoptosis: size matters Oncogene 2003, 22, 8983-8998
27. Liu, C. M.; Ma, J. Q.; Sun, Y. Z. Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway Toxicol. Appl. Pharmacol. 2012, 258, 330-342
28. Pulido, M. D.; Parrish, A. R. Metal-induced apoptosis: mechanisms Mutat. Res. 2003, 533, 227-241
29. Eckers, A.; Reimann, K.; Klotz, L. O. Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3′-kinase/Akt signaling Biometals 2009, 22, 307-316
30. Rana, S. V. Metals and apoptosis: recent developments J. Trace Elem. Med. Biol. 2008, 22, 262-284
31. Harris, G. K.; Shi, X. Signaling by carcinogenic metals and metal-induced reactive oxygen species Mutat. Res. 2003, 533, 183-200
32. S6k-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells Cancer Res. 2004, 64, 94-101
33. Lu, H.; Shi, X.; Costa, M.; Huang, C. Carcinogenic effect of nickel compounds Mol. Cell. Biochem. 2005, 279, 45-67
34. 4-induced acute liver injury in mice J. Agric. Food Chem. 2011, 59, 12821-12829
35. Pari, L.; Prasath, A. Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats Chem.-Biol. Interact. 2008, 173, 77-83
36. Liu, C. M.; Ma, J. Q.; Sun, Y. Z. Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead Exp. Toxicol. Pathol. 2012, 64, 575-582
37. Liu, C. M.; Ma, J. Q.; Sun, Y. Z. Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats Food Chem. Toxicol. 2011, 49, 3119-3127
38. Helbock, H. J.; Beckman, K. B.; Shigenaga, M. K.; Walter, P. B.; Woodall, A. A.; Yeo, H. C.; Ames, B. N. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-deoxyguanine Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 288-293
39. Ghouri, N.; David, P.; Naveed, S. Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data Hepatology 2010, 52, 1156-1161
40. Toyokuni, S.; Okamoto, K.; Yodoi, J.; Hiai, H. Persistent oxidative stress in cancer FEBS Lett. 1995, 358, 1-3
41. Franco, R.; Sánchez-Olea, R.; Reyes-Reyes, E. M.; Panayiotidis, M. I. Environmental toxicity, oxidative stress and apoptosis: ménage à trois Mutat. Res. 2009, 674, 3-22
42. Lawen, A. Apoptosis-an introduction Bioessays 2003, 25, 888-896
43. Cempel, M.; Janicka, K. Distribution of nickel, zinc and copper in rat organs after oral administration of nickel(II) chloride Biol. Trace Elem. Res. 2002, 90, 215-226
44. Sidhu, P.; Garg, M. L.; Dhawan, D. K. Protective role of zinc in nickel induced hepatotoxicity in rats Chem.-Biol. Interact. 2004, 150, 199-209
45. Pari, L.; Amudha, K. Hepatoprotective role of naringin on nickel-induced toxicity in male Wistar rats Eur. J. Pharmacol. 2011, 650, 364-370
46. Hori, H.; Takayanagi, T.; Kamada, Y.; Shimoyoshi, S.; Ono, Y.; Kitagawa, Y.; Shibata, H.; Nagao, M.; Fujii, W.; Sakakibara, Y. Genotoxicity evaluation of sesamin and episesamin Mutat. Res. 2011, 719, 21-28
47. Lynn, S.; Yew, F. H.; Chen, K. S.; Jan, K. Y. Reactive oxygen species are involved in nickel inhibition of DNA repair Environ. Mol. Mutagen. 1997, 29, 208-216
48. M'Bemba-Meka, P.; Lemieux, N.; Chakrabarti, S. K. Role of oxidative stress, mitochondrial membrane potential, and calcium homeostasis in nickel sulphate-induced human lymphocyte death in vitro Chem.-Biol. Interact. 2005, 156, 69-80
49. Yoshioka, N.; Nakashima, H.; Hosoda, K.; Eitaki, Y.; Shimada, N.; Omae, K. Urinary excretion of an oxidative stress marker, 8-hydroxyguanine (8-OH-Gua), among nickel-cadmium battery workers J. Occup. Health 2008, 50, 229-235
50. Kasprzak, K. S.; Sunderman, F. W., Jr.; Salnikow, K. Nickel carcinogenesis Mutat. Res. 2003, 533, 67-97
51. Misra, M.; Rodriguez, R. E.; Kasprzak, K. S. Nickel induced lipid peroxidation in the rat: correlation with nickel effect on antioxidant dense systems Toxicology 1990, 41, 601-611