Synthesis of derivatives of the keto-pyrrolyl-difluorophenol scaffold: Some structural aspects for aldose reductase inhibitory activity and selectivity

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 4, 2013, Pages 869-873

  Kotsampasakou, Eleni ^a   Demopoulos, Vassilis J ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Aldehyde reductase; Aldose reductase; ARI; Diabetes mellitus; Friedel Crafts acylation reaction; Long term diabetes complications

Indexed keywords

(1,1' BIPHENYL) 4 YL[1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 2 YL]METHANONE; (4 BROMO 2 FLUOROPHENYL)[1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 2YL]METHANONE; (4 BROMO 2 FLUOROPHENYL)[1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 3 YL]METHANONE; 1 [1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 2 YL] 2,2,2 TRIFLUOROETHANONE; [1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 2 YL][4 (TRIFLUOROMETHOXY)PHENYL]METHANONE; [1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 3 YL][4 (TRIFLUOROMETHOXY)PHENYL]METHANONE; [1,1' BISPHENYL] 4 YL[1 (3,5 DIFLUORO 4 HYDROXYPHENYL) 1H PYRROL 3 YL]METHANONE; ALDEHYDE REDUCTASE; ALDEHYDE REDUCTASE 1; ALDOSE REDUCTASE INHIBITOR; GLUCURONATE REDUCTASE; KETO PYRROLYLDIFLUOROPHENOL DERIVATIVE; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; FRIEDEL CRAFTS REACTION; HYDROGEN BOND; IC 50; IN VITRO STUDY; MALE; NONHUMAN; RAT;

ALDEHYDE REDUCTASE; ANIMALS; ENZYME INHIBITORS; FEMALE; MALE; PHENOL; PROTEIN BINDING; PYRROLES; RATS;

EID: 84873323064     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.015     Document Type: Article

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