Synthesis and biological evaluation of 2′-oxo-2,3-dihydro-3′H- spiro[chromene-4,5′-[1,3]oxazolidin]-3′yl]acetic acid derivatives as aldose reductase inhibitors

Archiv der Pharmazie

Volumn 344, Issue 6, 2011, Pages 372-385

  Rapposelli, Simona ^a   Da Settimo, Federico ^a   Digiacomo, Maria ^a   La Motta, Concettina ^a   Lapucci, Annalina ^a   Sartini, Stefania ^a   Vanni, Michael ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Aldose reductase; Aldose reductase inhibitors (ARI); Benzopyran, Spiro oxazolidinone

Indexed keywords

[2 (2,4 DICHLOROPHENYL) 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [2 (4 CHLOROPHENYL) 2 METHYL 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [2 (4 CHLOROPHENYL) 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [2 (4 METHOXYPHENYL) 2 METHYL 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [2 (4 METHOXYPHENYL) 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [6 BROMO 2 (2,4 DICHLOROPHENYL) 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [6 BROMO 2 (2,4 DIFLUOROPHENYL) 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [6 BROMO 2 (4 BROMO 2 FLUOROPHENYL) 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [6 BROMO 2 (4 CHLOROPHENYL) 2 METHYL 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [6 BROMO 2 (4 CHLOROPHENYL) 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [6 BROMO 2 (4 METHOXYPHENYL) 2 METHYL 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; [6 BROMO 2 (4 METHOXYPHENYL) 2' OXO 2,3 DIHYDRO 3' H SPIRO[CHROMENE 4,5' [1,3]OXAZOLIDIN] 3' YL]ACETIC ACID; ACETIC ACID DERIVATIVE; ALDEHYDE REDUCTASE; EPALRESTAT; FIDARESTAT; MINALRESTAT; RANIRESTAT; SORBINIL; TOLRESTAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SPECTROPHOTOMETRY;

ALDEHYDE REDUCTASE; BENZOPYRANS; ENZYME INHIBITORS; IMIDAZOLIDINES; INHIBITORY CONCENTRATION 50; NADP; OXAZOLIDINONES; OXIDATION-REDUCTION; SPECTROPHOTOMETRY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79958212516     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000302     Document Type: Article

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