Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor

European Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2010, Pages 1140-1145

  Carbone, Vincenzo ^a   Giglio, Marco ^a,b   Chung, Roland ^a   Huyton, Trevor ^c   Adams, Julian ^c   Maccari, Rosanna ^b   Ottana, Rosaria ^b   Hara, Akira ^d   El Kabbani, Ossama ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MESSINA   (Italy)

^c AUSTRALIAN SYNCHROTRON   (Australia)

^d GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

5 Arylidene 2,4 thiazolidinedione; Aldehyde reductase; Aldo keto reductase; Aldose reductase; Enzyme inhibition; Ternary complex

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 [(3 CARBOXYMETHOXY 4 METHOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 5 [(3 HYDROXY 4 METHOXYBENZYLIDENE) 2,4 DIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR INTERACTION; MOLECULAR MODEL; X RAY CRYSTALLOGRAPHY;

ALDEHYDE REDUCTASE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; THIAZOLIDINEDIONES;

EID: 75849163069     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.019     Document Type: Article

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