Matrix effects during monitoring of antibody and host cell proteins using attenuated total reflection spectroscopy

Biotechnology Progress

Volumn 29, Issue 1, 2013, Pages 265-274

  Capito, Florian ^a,b   Skudas, Romas ^b   Stanislawski, Bernd ^b   Kolmar, Harald ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Antibody; Attenuated total reflection; Host cell proteins; Matrix effects; Monitoring

Indexed keywords

ATTENUATED TOTAL REFLECTION SPECTROSCOPY; ATTENUATED TOTAL REFLECTIONS; CHEMOMETRICES; CONTAMINATION RISKS; ELISA ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEASIBILITY STUDIES; GENERAL MODEL; HOST CELL PROTEIN; MAMMALIAN CELLS; MATRIX EFFECTS; NS0 CELL CULTURE; ONLINE MONITORING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREDICTION ACCURACY; PROCESS CHANGE; PROTEIN PRECIPITATION; QUALITY ATTRIBUTES; QUANTIFICATION MODEL; REAL TIME MONITORING; REFERENCE VALUES; SODIUM DODECYL SULPHATE;

CONTINUOUS CELL CULTURE; ELECTROMAGNETIC WAVE REFLECTION; ELECTROPHORESIS; FORECASTING; MONITORING; RECOMBINANT PROTEINS; SODIUM;

ANTIBODIES;

MONOCLONAL ANTIBODY; PROTEIN;

ANIMAL; ARTICLE; CELL CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE; INFRARED SPECTROSCOPY; MOUSE; PRINCIPAL COMPONENT ANALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE; MICE; PRINCIPAL COMPONENT ANALYSIS; PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

MAMMALIA;

EID: 84873299873     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.1643     Document Type: Article

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