Rapid analysis of the expression of heterologous proteins in Escherichia coli using pyrolysis mass spectrometry and Fourier transform infrared spectroscopy with chemometrics: application to α2-interferon production

Journal of Biotechnology

Volumn 72, Issue 3, 1999, Pages 157-168

  McGovern, Aoife C ^a   Ernill, Richard ^b   Kara, Bo V ^b   Kell, Douglas B ^a   Goodacre, Royston ^a  

^a ABERYSTWYTH UNIVERSITY   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Bioprocess; Chemometrics; FT IR; Heterologous proteins; Interferon; PyMS

Indexed keywords

BOND STRENGTH (CHEMICAL); ESCHERICHIA COLI; FOURIER TRANSFORM INFRARED SPECTROSCOPY; LEAST SQUARES APPROXIMATIONS; MASS SPECTROMETRY; NEURAL NETWORKS; PROTEINS; PYROLYSIS; REGRESSION ANALYSIS;

CHEMOMETRICS; HETEROLOGOUS PROTEINS;

BIOTECHNOLOGY;

ALPHA2 INTERFERON; RECOMBINANT PROTEIN;

ARTICLE; BIOPROCESS; CHEMOMETRIC ANALYSIS; CONTROLLED STUDY; ESCHERICHIA COLI; FOURIER TRANSFORMATION; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYROLYSIS; REFLECTOMETRY; SUPERNATANT; TECHNIQUE;

CHEMISTRY, ANALYTICAL; ESCHERICHIA COLI; INTERFERON-ALPHA; MASS SPECTROMETRY; RECOMBINANT PROTEINS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

ESCHERICHIA COLI;

EID: 0033047595     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(99)00128-5     Document Type: Article

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