Effect of enzymatically modified isoquercitrin on preneoplastic liver cell lesions induced by thioacetamide promotion in a two-stage hepatocarcinogenesis model using rats

Toxicology

Volumn 305, Issue , 2013, Pages 30-40

  Fujii, Yuta ^a   Kimura, Masayuki ^a   Ishii, Yuji ^b   Yamamoto, Ryuichi ^a   Morita, Reiko ^a,c   Hayashi, Shim mo ^d   Suzuki, Kazuhiko ^a   Shibutani, Makoto ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d SAN EI GEN F F I INC   (Japan)

Author keywords

Apoptosis; Death receptor 5 (DR5); Enzymatically modified isoquercitrin (EMIQ); Inflammation; Liver tumor promotion; Thioacetamide (TAA)

Indexed keywords

4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; CD163 ANTIGEN; CYCLOOXYGENASE 2; DEATH RECEPTOR 5; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; ISOQUERCITRIN; THIOACETAMIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CD3+ T LYMPHOCYTE; CELL COUNT; CELL PROLIFERATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CARCINOGENICITY; ENZYME MODIFICATION; LIVER; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL DAMAGE; LIVER PROTECTION; LIVER REGENERATION; LYMPHOCYTE; MACROPHAGE; MALE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRECANCER; PRIORITY JOURNAL; RAT; TUMOR CELL; TUMOR PROMOTION; UPREGULATION;

ANIMALS; APOPTOSIS; CARCINOGENS; CELL LINE, TUMOR; DEOXYGUANOSINE; DIETHYLNITROSAMINE; GLUTATHIONE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LIVER NEOPLASMS, EXPERIMENTAL; LYMPHOCYTES; MACROPHAGES; MALE; PRECANCEROUS CONDITIONS; PROLIFERATING CELL NUCLEAR ANTIGEN; QUERCETIN; RATS; RATS, INBRED F344; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; THIOACETAMIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84873258932     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.01.002     Document Type: Article

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