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Volumn 10, Issue 1, 2013, Pages 55-67

Daclizumab Therapy for Multiple Sclerosis

Author keywords

Autoimmunity; Biological therapy; CD25; IL 2; Multiple sclerosis

Indexed keywords

BETA INTERFERON; CD56 ANTIGEN; CYCLOSPORIN; DACLIZUMAB; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; STEROID;

EID: 84873145686     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-012-0147-4     Document Type: Review
Times cited : (82)

References (96)
  • 1
    • 0017652369 scopus 로고
    • Functional and morphologic characterization of human T cells continuously grown in vitro
    • Ruscetti FW, Morgan DA, Gallo RC. Functional and morphologic characterization of human T cells continuously grown in vitro. J Immunol 1977; 119: 131-138.
    • (1977) J Immunol , vol.119 , pp. 131-138
    • Ruscetti, F.W.1    Morgan, D.A.2    Gallo, R.C.3
  • 2
    • 0018589972 scopus 로고
    • Revised nomenclature for antigen-nonspecific T-cell proliferation and helper factors
    • Mizel SB, Farrar JJ. Revised nomenclature for antigen-nonspecific T-cell proliferation and helper factors. Cell Immunol 1979; 48: 433-436.
    • (1979) Cell Immunol , vol.48 , pp. 433-436
    • Mizel, S.B.1    Farrar, J.J.2
  • 3
    • 78649875958 scopus 로고    scopus 로고
    • Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response
    • Feinerman O, Jentsch G, Tkach KE, et al. Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response. Mol Syst Biol 2010; 6: 437.
    • (2010) Mol Syst Biol , vol.6 , pp. 437
    • Feinerman, O.1    Jentsch, G.2    Tkach, K.E.3
  • 5
    • 0031786786 scopus 로고    scopus 로고
    • The use of antibodies against the IL-2 receptor in transplantation
    • Waldmann TA, O'Shea J. The use of antibodies against the IL-2 receptor in transplantation. Curr Opin Immunol 1998; 10: 507-512.
    • (1998) Curr Opin Immunol , vol.10 , pp. 507-512
    • Waldmann, T.A.1    O'Shea, J.2
  • 6
    • 0036200407 scopus 로고    scopus 로고
    • The IL-2/IL-15 receptor systems: targets for immunotherapy
    • Waldmann TA. The IL-2/IL-15 receptor systems: targets for immunotherapy. J Clin Immunol 2002; 22: 51-56.
    • (2002) J Clin Immunol , vol.22 , pp. 51-56
    • Waldmann, T.A.1
  • 7
    • 0024815233 scopus 로고
    • A humanized antibody that binds to the interleukin 2 receptor
    • Queen C, Schneider WP, Selick HE, et al. A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci U S A 1989; 86: 10029-10033.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 10029-10033
    • Queen, C.1    Schneider, W.P.2    Selick, H.E.3
  • 8
    • 27944505913 scopus 로고    scopus 로고
    • Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors
    • Wang X, Rickert M, Garcia KC. Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science 2005; 310: 1159-1163.
    • (2005) Science , vol.310 , pp. 1159-1163
    • Wang, X.1    Rickert, M.2    Garcia, K.C.3
  • 9
    • 0031934575 scopus 로고    scopus 로고
    • Interleukin-2, interleukin-15, and their receptors
    • Waldmann T, Tagaya Y, Bamford R. Interleukin-2, interleukin-15, and their receptors. Int Rev Immunol 1998; 16: 205-226.
    • (1998) Int Rev Immunol , vol.16 , pp. 205-226
    • Waldmann, T.1    Tagaya, Y.2    Bamford, R.3
  • 10
    • 15444374646 scopus 로고    scopus 로고
    • Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • Setoguchi R, Hori S, Takahashi T, Sakaguchi S. Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 2005; 201: 723-735.
    • (2005) J Exp Med , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 12
    • 0023775236 scopus 로고
    • Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2
    • Waldmann TA, Goldman CK, Bongiovanni KF, et al. Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2. Blood 1988; 72: 1805-1816.
    • (1988) Blood , vol.72 , pp. 1805-1816
    • Waldmann, T.A.1    Goldman, C.K.2    Bongiovanni, K.F.3
  • 13
    • 77955506880 scopus 로고    scopus 로고
    • An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells
    • Martin JF, Perry JS, Jakhete NR, Wang X, Bielekova B. An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells. J Immunol 2010; 185: 1311-1320.
    • (2010) J Immunol , vol.185 , pp. 1311-1320
    • Martin, J.F.1    Perry, J.S.2    Jakhete, N.R.3    Wang, X.4    Bielekova, B.5
  • 14
    • 0034353413 scopus 로고    scopus 로고
    • Daclizumab (Zenapax) inhibits early interleukin-2 receptor signal transduction events
    • Goebel J, Stevens E, Forrest K, Roszman TL. Daclizumab (Zenapax) inhibits early interleukin-2 receptor signal transduction events. Transpl Immunol 2000; 8: 153-159.
    • (2000) Transpl Immunol , vol.8 , pp. 153-159
    • Goebel, J.1    Stevens, E.2    Forrest, K.3    Roszman, T.L.4
  • 15
    • 0031770389 scopus 로고    scopus 로고
    • Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac
    • Lehky TJ, Levin MC, Kubota R, et al. Reduction in HTLV-I proviral load and spontaneous lymphoproliferation in HTLV-I-associated myelopathy/tropical spastic paraparesis patients treated with humanized anti-Tac. Ann Neurol 1998; 44: 942-947.
    • (1998) Ann Neurol , vol.44 , pp. 942-947
    • Lehky, T.J.1    Levin, M.C.2    Kubota, R.3
  • 16
    • 13044311376 scopus 로고    scopus 로고
    • Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial
    • Nussenblatt RB, Fortin E, Schiffman R, et al. Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial. Proc Natl Acad Sci U S A 1999; 96: 7462-7466.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7462-7466
    • Nussenblatt, R.B.1    Fortin, E.2    Schiffman, R.3
  • 17
    • 10744222484 scopus 로고    scopus 로고
    • Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration
    • Nussenblatt RB, Thompson DJ, Li Z, et al. Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration. J Autoimmun 2003; 21: 283-293.
    • (2003) J Autoimmun , vol.21 , pp. 283-293
    • Nussenblatt, R.B.1    Thompson, D.J.2    Li, Z.3
  • 18
    • 2942537826 scopus 로고    scopus 로고
    • Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon-beta
    • Bielekova B, Richert N, Howard T, et al. Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon-beta. Proc Natl Acad Sci U S A 2004; 101: 8705-8708.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8705-8708
    • Bielekova, B.1    Richert, N.2    Howard, T.3
  • 19
    • 9644265478 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody
    • Rose JW, Watt HE, White AT, Carlson NG. Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody. Ann Neurol 2004; 56: 864-867.
    • (2004) Ann Neurol , vol.56 , pp. 864-867
    • Rose, J.W.1    Watt, H.E.2    White, A.T.3    Carlson, N.G.4
  • 20
    • 65249138318 scopus 로고    scopus 로고
    • Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis
    • Bielekova B, Howard T, Packer AN, et al. Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis. Arch Neurol 2009; 66: 483-489.
    • (2009) Arch Neurol , vol.66 , pp. 483-489
    • Bielekova, B.1    Howard, T.2    Packer, A.N.3
  • 21
    • 34548142973 scopus 로고    scopus 로고
    • Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results
    • Rose JW, Burns JB, Bjorklund J, Klein J, Watt HE, Carlson NG. Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results. Neurology 2007; 69: 785-789.
    • (2007) Neurology , vol.69 , pp. 785-789
    • Rose, J.W.1    Burns, J.B.2    Bjorklund, J.3    Klein, J.4    Watt, H.E.5    Carlson, N.G.6
  • 22
    • 82955225356 scopus 로고    scopus 로고
    • Intrathecal effects of daclizumab treatment of multiple sclerosis
    • Bielekova B, Richert N, Herman ML, et al. Intrathecal effects of daclizumab treatment of multiple sclerosis. Neurology 2011; 77: 1877-1886.
    • (2011) Neurology , vol.77 , pp. 1877-1886
    • Bielekova, B.1    Richert, N.2    Herman, M.L.3
  • 23
    • 77949301468 scopus 로고    scopus 로고
    • Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta
    • Wynn D, Kaufman M, Montalban X, et al. Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. Lancet Neurol 2010; 9: 381-390.
    • (2010) Lancet Neurol , vol.9 , pp. 381-390
    • Wynn, D.1    Kaufman, M.2    Montalban, X.3
  • 24
    • 74249097818 scopus 로고    scopus 로고
    • Monoclonal antibodies in MS: mechanism of action
    • Bielekova B, Becker B. Monoclonal antibodies in MS: mechanism of action. Neurology 2010; 74(supplement 1): S31-S40.
    • (2010) Neurology , vol.74 , Issue.SUPPL. 1
    • Bielekova, B.1    Becker, B.2
  • 25
    • 33751002069 scopus 로고    scopus 로고
    • IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis
    • Wakabayashi K, Lian ZX, Moritoki Y, et al. IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis. Hepatology 2006; 44: 1240-1249.
    • (2006) Hepatology , vol.44 , pp. 1240-1249
    • Wakabayashi, K.1    Lian, Z.X.2    Moritoki, Y.3
  • 26
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995; 3: 521-530.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 27
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 1991; 352: 621-624.
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 29
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    • Suzuki H, Kundig TM, Furlonger C, et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995; 268: 1472-1476.
    • (1995) Science , vol.268 , pp. 1472-1476
    • Suzuki, H.1    Kundig, T.M.2    Furlonger, C.3
  • 30
    • 38449083826 scopus 로고    scopus 로고
    • IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells
    • Turka LA, Walsh PT. IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci 2008; 13: 1440-1446.
    • (2008) Front Biosci , vol.13 , pp. 1440-1446
    • Turka, L.A.1    Walsh, P.T.2
  • 32
    • 0348047537 scopus 로고    scopus 로고
    • The main function of IL-2 is to promote the development of T regulatory cells
    • Malek TR. The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol 2003; 74: 961-965.
    • (2003) J Leukoc Biol , vol.74 , pp. 961-965
    • Malek, T.R.1
  • 33
    • 0036839102 scopus 로고    scopus 로고
    • Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    • Almeida AR, Legrand N, Papiernik M, Freitas AA. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 2002; 169: 4850-4860.
    • (2002) J Immunol , vol.169 , pp. 4850-4860
    • Almeida, A.R.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 34
    • 0033199317 scopus 로고    scopus 로고
    • Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
    • van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK, Baltimore D. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 1999; 11: 281-288.
    • (1999) Immunity , vol.11 , pp. 281-288
    • van Parijs, L.1    Refaeli, Y.2    Lord, J.D.3    Nelson, B.H.4    Abbas, A.K.5    Baltimore, D.6
  • 35
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse T lymphocytes for apoptosis
    • Lenardo MJ. Interleukin-2 programs mouse T lymphocytes for apoptosis. Nature 1991; 353: 858-861.
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 36
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • Hafler DA, Compston A, Sawcer S, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007; 357: 851-862.
    • (2007) N Engl J Med , vol.357 , pp. 851-862
    • Hafler, D.A.1    Compston, A.2    Sawcer, S.3
  • 37
    • 34548367511 scopus 로고    scopus 로고
    • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    • Lowe CE, Cooper JD, Brusko T, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007; 39: 1074-1082.
    • (2007) Nat Genet , vol.39 , pp. 1074-1082
    • Lowe, C.E.1    Cooper, J.D.2    Brusko, T.3
  • 38
    • 58949100205 scopus 로고    scopus 로고
    • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    • Maier LM, Lowe CE, Cooper J, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS genetics 2009; 5: e1000322.
    • (2009) PLoS Genetics , vol.5
    • Maier, L.M.1    Lowe, C.E.2    Cooper, J.3
  • 39
    • 33846805925 scopus 로고    scopus 로고
    • CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes
    • Caudy AA, Reddy ST, Chatila T, Atkinson JP, Verbsky JW. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol 2007; 119: 482-487.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 482-487
    • Caudy, A.A.1    Reddy, S.T.2    Chatila, T.3    Atkinson, J.P.4    Verbsky, J.W.5
  • 40
    • 0033920789 scopus 로고    scopus 로고
    • Human IL-2 receptor alpha chain deficiency
    • Roifman CM. Human IL-2 receptor alpha chain deficiency. Pediatr Res 2000; 48: 6-11.
    • (2000) Pediatr Res , vol.48 , pp. 6-11
    • Roifman, C.M.1
  • 41
    • 0030903027 scopus 로고    scopus 로고
    • Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor
    • Sharfe N, Dadi HK, Shahar M, Roifman CM. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor. Proc Natl Acad Sci U S A 1997; 94: 3168-3171.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3168-3171
    • Sharfe, N.1    Dadi, H.K.2    Shahar, M.3    Roifman, C.M.4
  • 42
    • 33645812129 scopus 로고    scopus 로고
    • Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2R-alpha-targeted therapy (daclizumab) in multiple sclerosis
    • Bielekova B, Catalfamo M, Reichert-Scrivner S, et al. Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2R-alpha-targeted therapy (daclizumab) in multiple sclerosis. PNAS 2006; 103: 5941-5946.
    • (2006) Pnas , vol.103 , pp. 5941-5946
    • Bielekova, B.1    Catalfamo, M.2    Reichert-Scrivner, S.3
  • 43
    • 65249155884 scopus 로고    scopus 로고
    • Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis
    • Oh U, Blevins G, Griffith C, et al. Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis. Arch Neurol 2009; 66: 471-479.
    • (2009) Arch Neurol , vol.66 , pp. 471-479
    • Oh, U.1    Blevins, G.2    Griffith, C.3
  • 44
    • 0038350650 scopus 로고    scopus 로고
    • Anti-CD25 monoclonal antibody therapy affects the death signals of graft-infiltrating cells after clinical heart transplantation
    • Baan CC, Balk AH, van Riemsdijk IC, et al. Anti-CD25 monoclonal antibody therapy affects the death signals of graft-infiltrating cells after clinical heart transplantation. Transplantation 2003; 75: 1704-1710.
    • (2003) Transplantation , vol.75 , pp. 1704-1710
    • Baan, C.C.1    Balk, A.H.2    van Riemsdijk, I.C.3
  • 45
    • 79955700857 scopus 로고    scopus 로고
    • A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy
    • Wuest SC, Edwan JH, Martin JF, et al. A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy. Nat Med 2011; 17: 604-609.
    • (2011) Nat Med , vol.17 , pp. 604-609
    • Wuest, S.C.1    Edwan, J.H.2    Martin, J.F.3
  • 46
    • 0035424543 scopus 로고    scopus 로고
    • NK cells and NKT cells in innate defense against viral infections
    • Biron CA, Brossay L. NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol 2001; 13: 458-464.
    • (2001) Curr Opin Immunol , vol.13 , pp. 458-464
    • Biron, C.A.1    Brossay, L.2
  • 47
    • 84857872642 scopus 로고    scopus 로고
    • Unraveling human natural killer cell deficiency
    • Orange JS. Unraveling human natural killer cell deficiency. J Clin Invest 2012; 122: 798-801.
    • (2012) J Clin Invest , vol.122 , pp. 798-801
    • Orange, J.S.1
  • 48
    • 50949124847 scopus 로고    scopus 로고
    • Human natural killer cells
    • Caligiuri MA. Human natural killer cells. Blood 2008; 112: 461-469.
    • (2008) Blood , vol.112 , pp. 461-469
    • Caligiuri, M.A.1
  • 50
    • 0025885273 scopus 로고
    • Accumulation of CD16-CD56+ natural killer cells with high affinity interleukin 2 receptors in human early pregnancy decidua
    • Nishikawa K, Saito S, Morii T, et al. Accumulation of CD16-CD56+ natural killer cells with high affinity interleukin 2 receptors in human early pregnancy decidua. Int Immunol 1991; 3: 743-750.
    • (1991) Int Immunol , vol.3 , pp. 743-750
    • Nishikawa, K.1    Saito, S.2    Morii, T.3
  • 51
    • 33947233249 scopus 로고    scopus 로고
    • Maternal acceptance of the fetus: true human tolerance
    • Guleria I, Sayegh MH. Maternal acceptance of the fetus: true human tolerance. J Immunol 2007; 178: 3345-3351.
    • (2007) J Immunol , vol.178 , pp. 3345-3351
    • Guleria, I.1    Sayegh, M.H.2
  • 52
    • 0034740653 scopus 로고    scopus 로고
    • CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells
    • Jacobs R, Hintzen G, Kemper A, et al. CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells. Eur J Immunol 2001; 31: 3121-3127.
    • (2001) Eur J Immunol , vol.31 , pp. 3121-3127
    • Jacobs, R.1    Hintzen, G.2    Kemper, A.3
  • 53
    • 0037606040 scopus 로고    scopus 로고
    • CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity
    • Fehniger TA, Cooper MA, Nuovo GJ, et al. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 2003; 101: 3052-3057.
    • (2003) Blood , vol.101 , pp. 3052-3057
    • Fehniger, T.A.1    Cooper, M.A.2    Nuovo, G.J.3
  • 54
    • 0027216144 scopus 로고
    • Cytokine production by CD16-CD56bright natural killer cells in the human early pregnancy decidua
    • Saito S, Nishikawa K, Morii T, et al. Cytokine production by CD16-CD56bright natural killer cells in the human early pregnancy decidua. Int Immunol 1993; 5: 559-563.
    • (1993) Int Immunol , vol.5 , pp. 559-563
    • Saito, S.1    Nishikawa, K.2    Morii, T.3
  • 57
    • 79960547202 scopus 로고    scopus 로고
    • Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis
    • Jiang W, Chai NR, Maric D, Bielekova B. Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis. J Immunol 2011; 187: 781-790.
    • (2011) J Immunol , vol.187 , pp. 781-790
    • Jiang, W.1    Chai, N.R.2    Maric, D.3    Bielekova, B.4
  • 58
    • 63649099411 scopus 로고    scopus 로고
    • Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A
    • Bovenschen N, Quadir R, van den Berg AL, et al. Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. J Biol Chem 2009; 284: 3504-3512.
    • (2009) J Biol Chem , vol.284 , pp. 3504-3512
    • Bovenschen, N.1    Quadir, R.2    van den Berg, A.L.3
  • 59
    • 26044436515 scopus 로고    scopus 로고
    • Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood
    • Bratke K, Kuepper M, Bade B, Virchow JC Jr., Luttmann W. Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood. Eur J Immunol 2005; 35: 2608-2616.
    • (2005) Eur J Immunol , vol.35 , pp. 2608-2616
    • Bratke, K.1    Kuepper, M.2    Bade, B.3    Virchow Jr., J.C.4    Luttmann, W.5
  • 60
    • 0028281045 scopus 로고
    • Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells
    • Gong JH, Maki G, Klingemann HG. Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells. Leukemia 1994; 8: 652-658.
    • (1994) Leukemia , vol.8 , pp. 652-658
    • Gong, J.H.1    Maki, G.2    Klingemann, H.G.3
  • 61
    • 8444253252 scopus 로고    scopus 로고
    • CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation
    • Dalbeth N, Gundle R, Davies RJ, Lee YC, McMichael AJ, Callan MF. CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. J Immunol 2004; 173: 6418-6426.
    • (2004) J Immunol , vol.173 , pp. 6418-6426
    • Dalbeth, N.1    Gundle, R.2    Davies, R.J.3    Lee, Y.C.4    McMichael, A.J.5    Callan, M.F.6
  • 62
    • 0037438494 scopus 로고    scopus 로고
    • Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment
    • Rubenstein JL, Combs D, Rosenberg J, et al. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood 2003; 101: 466-468.
    • (2003) Blood , vol.101 , pp. 466-468
    • Rubenstein, J.L.1    Combs, D.2    Rosenberg, J.3
  • 63
    • 84864558396 scopus 로고    scopus 로고
    • Inhibition of LTi cell development by CD25 blockade Is associated with decreased intrathecal inflammation in multiple sclerosis
    • Perry JS, Han S, Xu Q, et al. Inhibition of LTi cell development by CD25 blockade Is associated with decreased intrathecal inflammation in multiple sclerosis. Sci Transl Med 2012; 4: 145ra06.
    • (2012) Sci Transl Med , vol.4
    • Perry, J.S.1    Han, S.2    Xu, Q.3
  • 64
    • 0025289835 scopus 로고
    • Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors
    • Caligiuri MA, Zmuidzinas A, Manley TJ, Levine H, Smith KA, Ritz J. Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. J Exp Med 1990; 171: 1509-1526.
    • (1990) J Exp Med , vol.171 , pp. 1509-1526
    • Caligiuri, M.A.1    Zmuidzinas, A.2    Manley, T.J.3    Levine, H.4    Smith, K.A.5    Ritz, J.6
  • 65
    • 84881479245 scopus 로고    scopus 로고
    • CD56bright natural killer cell expansion predicts response to daclizumab HYP treatment in RRMS: Results of the SELECT trial
    • 004
    • Elkins J, Sheridan J, Armaravadi L, Riester K, O'Neil G. CD56bright natural killer cell expansion predicts response to daclizumab HYP treatment in RRMS: Results of the SELECT trial. Neurology 2012; 78: S31. 004.
    • (2012) Neurology , vol.78
    • Elkins, J.1    Sheridan, J.2    Armaravadi, L.3    Riester, K.4    O'Neil, G.5
  • 66
    • 70349741303 scopus 로고    scopus 로고
    • Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis
    • Vandenbark AA, Huan J, Agotsch M, et al. Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis. J Neuroimmunol 2009; 215: 125-128.
    • (2009) J Neuroimmunol , vol.215 , pp. 125-128
    • Vandenbark, A.A.1    Huan, J.2    Agotsch, M.3
  • 67
    • 59449107122 scopus 로고    scopus 로고
    • NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis
    • Reis EA, Athanazio DA, Lima I, et al. NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis. Rheumatol Int 2008; 29(4): 469-475.
    • (2008) Rheumatol Int , vol.29 , Issue.4 , pp. 469-475
    • Reis, E.A.1    Athanazio, D.A.2    Lima, I.3
  • 68
    • 46849111602 scopus 로고    scopus 로고
    • Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells
    • De Jager PL, Rossin E, Pyne S, et al. Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain 2008; 131(pt 7): 1701-1711.
    • (2008) Brain , vol.131 , Issue.Pt 7 , pp. 1701-1711
    • de Jager, P.L.1    Rossin, E.2    Pyne, S.3
  • 69
    • 0018905585 scopus 로고
    • Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor
    • Benczur M, Petranyl GG, Palffy G, et al. Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor. Clin Exp Immunol 1980; 39: 657-662.
    • (1980) Clin Exp Immunol , vol.39 , pp. 657-662
    • Benczur, M.1    Petranyl, G.G.2    Palffy, G.3
  • 70
    • 0032526195 scopus 로고    scopus 로고
    • A role for natural killer cells in the immunopathogenesis of multiple sclerosis
    • Kastrukoff LF, Morgan NG, Zecchini D, et al. A role for natural killer cells in the immunopathogenesis of multiple sclerosis. J Neuroimmunol 1998; 86: 123-133.
    • (1998) J Neuroimmunol , vol.86 , pp. 123-133
    • Kastrukoff, L.F.1    Morgan, N.G.2    Zecchini, D.3
  • 72
    • 0035554678 scopus 로고    scopus 로고
    • Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
    • Granucci F, Vizzardelli C, Pavelka N, et al. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Nat Immunol 2001; 2: 882-888.
    • (2001) Nat Immunol , vol.2 , pp. 882-888
    • Granucci, F.1    Vizzardelli, C.2    Pavelka, N.3
  • 73
    • 52749087951 scopus 로고    scopus 로고
    • CD25 as an immune regulatory molecule expressed on myeloid dendritic cells
    • Driesen J, Popov A, Schultze JL. CD25 as an immune regulatory molecule expressed on myeloid dendritic cells. Immunobiology 2008; 213: 849-858.
    • (2008) Immunobiology , vol.213 , pp. 849-858
    • Driesen, J.1    Popov, A.2    Schultze, J.L.3
  • 74
    • 0036826914 scopus 로고    scopus 로고
    • IL-15-Ralpha recycles and presents IL-15 In trans to neighboring cells
    • Dubois S, Mariner J, Waldmann TA, Tagaya Y. IL-15-Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 2002; 17: 537-547.
    • (2002) Immunity , vol.17 , pp. 537-547
    • Dubois, S.1    Mariner, J.2    Waldmann, T.A.3    Tagaya, Y.4
  • 75
    • 33745224089 scopus 로고    scopus 로고
    • Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
    • Williams MA, Tyznik AJ, Bevan MJ. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature 2006; 441: 890-893.
    • (2006) Nature , vol.441 , pp. 890-893
    • Williams, M.A.1    Tyznik, A.J.2    Bevan, M.J.3
  • 76
    • 0032986802 scopus 로고    scopus 로고
    • Daclizumab rapidly saturates interleukin-2 receptor-alpha (CD25) on lymph node lymphocytes in children
    • Savo AM, Book BK, Henson S, Hakimi J, Pescovitz MD. Daclizumab rapidly saturates interleukin-2 receptor-alpha (CD25) on lymph node lymphocytes in children. Transplant Proc 1999; 31: 1182-1183.
    • (1999) Transplant Proc , vol.31 , pp. 1182-1183
    • Savo, A.M.1    Book, B.K.2    Henson, S.3    Hakimi, J.4    Pescovitz, M.D.5
  • 77
    • 78049385155 scopus 로고    scopus 로고
    • Lineage relationship analysis of RORgammat+ innate lymphoid cells
    • Sawa S, Cherrier M, Lochner M, et al. Lineage relationship analysis of RORgammat+ innate lymphoid cells. Science 2010; 330: 665-669.
    • (2010) Science , vol.330 , pp. 665-669
    • Sawa, S.1    Cherrier, M.2    Lochner, M.3
  • 78
    • 78650310810 scopus 로고    scopus 로고
    • The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
    • Spits H, Di Santo JP. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol 2011; 12: 21-27.
    • (2011) Nat Immunol , vol.12 , pp. 21-27
    • Spits, H.1    Di Santo, J.P.2
  • 79
    • 0033602163 scopus 로고    scopus 로고
    • Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    • Yokota Y, Mansouri A, Mori S, et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 1999; 397: 702-706.
    • (1999) Nature , vol.397 , pp. 702-706
    • Yokota, Y.1    Mansouri, A.2    Mori, S.3
  • 80
    • 33344475672 scopus 로고    scopus 로고
    • Lymphoid neogenesis in chronic inflammatory diseases
    • Aloisi F, Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006; 6: 205-217.
    • (2006) Nat Rev Immunol , vol.6 , pp. 205-217
    • Aloisi, F.1    Pujol-Borrell, R.2
  • 81
    • 78651500757 scopus 로고    scopus 로고
    • Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells
    • Lochner M, Ohnmacht C, Presley L, et al. Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells. J Exp Med 2011; 208: 125-134.
    • (2011) J Exp Med , vol.208 , pp. 125-134
    • Lochner, M.1    Ohnmacht, C.2    Presley, L.3
  • 82
    • 84865411384 scopus 로고    scopus 로고
    • Cutting edge: lymphoid tissue inducer cells maintain memory cd4 t cells within secondary lymphoid tissue
    • Withers DR, Gaspal FM, Mackley EC, et al. Cutting edge: lymphoid tissue inducer cells maintain memory cd4 t cells within secondary lymphoid tissue. J Immunol 2012; 189(5): 2094-2098.
    • (2012) J Immunol , vol.189 , Issue.5 , pp. 2094-2098
    • Withers, D.R.1    Gaspal, F.M.2    Mackley, E.C.3
  • 84
    • 80052927697 scopus 로고    scopus 로고
    • Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
    • Howell OW, Reeves CA, Nicholas R, et al. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain 2011; 134(9): 2755-2771.
    • (2011) Brain , vol.134 , Issue.9 , pp. 2755-2771
    • Howell, O.W.1    Reeves, C.A.2    Nicholas, R.3
  • 85
    • 34249700046 scopus 로고    scopus 로고
    • Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
    • Magliozzi R, Howell O, Vora A, et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007; 130(pt 4): 1089-1104.
    • (2007) Brain , vol.130 , Issue.Pt 4 , pp. 1089-1104
    • Magliozzi, R.1    Howell, O.2    Vora, A.3
  • 86
    • 1242340285 scopus 로고    scopus 로고
    • Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis
    • Magliozzi R, Columba-Cabezas S, Serafini B, Aloisi F. Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis. J Neuroimmunol 2004; 148: 11-23.
    • (2004) J Neuroimmunol , vol.148 , pp. 11-23
    • Magliozzi, R.1    Columba-Cabezas, S.2    Serafini, B.3    Aloisi, F.4
  • 87
    • 0026537494 scopus 로고
    • The interleukin-2 receptor in human monocytes and macrophages: regulation of expression and release of the alpha and beta chains (p55 and p75)
    • Scheibenbogen C, Keilholz U, Richter M, Andreesen R, Hunstein W. The interleukin-2 receptor in human monocytes and macrophages: regulation of expression and release of the alpha and beta chains (p55 and p75). Res Immunol 1992; 143: 33-37.
    • (1992) Res Immunol , vol.143 , pp. 33-37
    • Scheibenbogen, C.1    Keilholz, U.2    Richter, M.3    Andreesen, R.4    Hunstein, W.5
  • 88
    • 0026524058 scopus 로고
    • The monocyte interleukin-2 receptor light chain: production of cell-associated and soluble interleukin-2 receptor by monocytes
    • Kniep EM, Strelow I, Lohmann-Matthes ML. The monocyte interleukin-2 receptor light chain: production of cell-associated and soluble interleukin-2 receptor by monocytes. Immunology 1992; 75: 299-304.
    • (1992) Immunology , vol.75 , pp. 299-304
    • Kniep, E.M.1    Strelow, I.2    Lohmann-Matthes, M.L.3
  • 89
    • 63149109244 scopus 로고    scopus 로고
    • Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses
    • Maier LM, Anderson DE, Severson CA, et al. Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses. J Immunol 2009; 182: 1541-1547.
    • (2009) J Immunol , vol.182 , pp. 1541-1547
    • Maier, L.M.1    Anderson, D.E.2    Severson, C.A.3
  • 90
    • 21044443402 scopus 로고    scopus 로고
    • Search for organising principles: understanding in systems biology
    • Mesarovic MD, Sreenath SN, Keene JD. Search for organising principles: understanding in systems biology. Syst Biol (Stevenage) 2004; 1: 19-27.
    • (2004) Syst Biol (Stevenage) , vol.1 , pp. 19-27
    • Mesarovic, M.D.1    Sreenath, S.N.2    Keene, J.D.3
  • 91
    • 84863608009 scopus 로고    scopus 로고
    • Journal club: intrathecal effects of daclizumab treatment of multiple sclerosis
    • Schneider R, Arbour N. Journal club: intrathecal effects of daclizumab treatment of multiple sclerosis. Neurology 2012; 78: e131-e133.
    • (2012) Neurology , vol.78
    • Schneider, R.1    Arbour, N.2
  • 93
    • 84873144554 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of daclizumab HYP monotherapy in relapsing-remitting multiple sclerosis: primary results of the SELECT trial
    • 005
    • Gold R, Giovannoni G, Selmaj K, et al. A randomized, double-blind, placebo-controlled study to evaluate the safety and efficacy of daclizumab HYP monotherapy in relapsing-remitting multiple sclerosis: primary results of the SELECT trial. Neurology 2012; 78: S01. 005.
    • (2012) Neurology , vol.78
    • Gold, R.1    Giovannoni, G.2    Selmaj, K.3
  • 94
    • 77954169111 scopus 로고    scopus 로고
    • Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation
    • Moroso V, Metselaar HJ, Mancham S, et al. Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation. Liver Transpl 2010; 16: 895-908.
    • (2010) Liver Transpl , vol.16 , pp. 895-908
    • Moroso, V.1    Metselaar, H.J.2    Mancham, S.3
  • 95
    • 0033609459 scopus 로고    scopus 로고
    • Cytomegalovirus infections after treatment with daclizumab, an anti IL-2 receptor antibody, for prevention of renal allograft rejection
    • Hengster P, Pescovitz MD, Hyatt D, Margreiter R. Cytomegalovirus infections after treatment with daclizumab, an anti IL-2 receptor antibody, for prevention of renal allograft rejection. Roche Study Group. Transplantation 1999; 68: 310-313.
    • (1999) Roche Study Group. Transplantation , vol.68 , pp. 310-313
    • Hengster, P.1    Pescovitz, M.D.2    Hyatt, D.3    Margreiter, R.4
  • 96
    • 0742322211 scopus 로고    scopus 로고
    • Interleukin 2 receptor antagonists for renal transplant recipients: a meta-analysis of randomized trials
    • Webster AC, Playford EG, Higgins G, Chapman JR, Craig JC. Interleukin 2 receptor antagonists for renal transplant recipients: a meta-analysis of randomized trials. Transplantation 2004; 77: 166-176.
    • (2004) Transplantation , vol.77 , pp. 166-176
    • Webster, A.C.1    Playford, E.G.2    Higgins, G.3    Chapman, J.R.4    Craig, J.C.5


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