Structural basis for NKG2A/CD94 recognition of HLA-E

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 18, 2008, Pages 6696-6701

  Kaiser, Brett K ^a   Pizarro, Juan Carlos ^a,b   Kerns, Julie ^a   Strong, Roland K ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Crystallography; Immunology; Immunoreceptors; NKG2A

Indexed keywords

CD94 ANTIGEN; HLA E ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2A; CAPSID PROTEIN; HLA ANTIGEN CLASS 1; IMMUNOGLOBULIN RECEPTOR; MUTANT PROTEIN; NATURAL KILLER CELL ACTIVATING RECEPTORS; VP23 PROTEIN, HUMAN HERPESVIRUS 1;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTALLOGRAPHY; GENE MAPPING; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; IMMUNOLOGY; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT;

PRIMATES;

AMINO ACID SEQUENCE; ANTIGENS, CD94; CAPSID PROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, IMMUNOLOGIC; SEQUENCE ALIGNMENT;

EID: 44349121055     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802736105     Document Type: Article

References (37)

1. Natarajan K, Dimasi N, Wang J, Mariuzza RA, Margulies DH (2002) Structure and function of natural killer cell receptors: Multiple molecular solutions to self, nonself discrimination. Annu Rev Immunol 20:853-885.
2. Braud VM, et al. (1998) HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391:795-799.
3. Lee N, et al. (1998) HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A. Proc Natl Acad Sci USA 95:5199-5204.
4. Kaiser BK, et al. (2005) Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics. J Immunol 174:2878-2884.
5. Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL (2002) Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296:1323-1326.
6. Smith HR, et al. (2002) Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc Natl Acad Sci USA 99:8826-8831.
7. Borrego F, Ulbrecht M, Weiss EH, Coligan JE, Brooks AG (1998) Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. J Exp Med 187:813-818.
8. Llano M, et al. (1998) HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: Preferential response to an HLA-G-derived nonamer. Eur J Immunol 28:2854-2863.
9. O'Callaghan CA, et al. (1998) Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E. Mol Cell 1:531-541.
10. Strong RK, et al. (2003) HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities. J Biol Chem 278:5082-5090.
11. Vales-Gomez M, Reyburn HT, Erskine RA, Lopez-Botet M, Strominger JL (1999) Kinetics and peptide dependency of the binding of the inhibitory NK receptor CD94/NKG2-A and the activating receptor CD94/NKG2-C to HLA-E. EMBO J 18:4250-4260.
12. Sullivan LC, et al. (2007) The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. Immunity 27:900-911.
13. Tomasec P, et al. (2000) Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 287:1031.
14. Ulbrecht M, et al. (2000) Cutting edge: The human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis. J Immunol 164:5019-5022.
15. Kraft JR, et al. (2000) Analysis of Qa-1. (b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes. J Exp Med 192:613-624.
16. Miller JD, et al. (2003) Analysis of HLA-E peptide-binding specificity and contact residues in bound peptide required for recognition by CD94/NKG2. J Immunol 171:1369-1375.
17. Li P, et al. (2001) Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat Immunol 2:443-451.
18. Wada H, Matsumoto N, Maenaka K, Suzuki K, Yamamoto K (2004) The inhibitory NK cell receptor CD94/NKG2A and the activating receptor CD94/NKG2C bind the top of HLA-E through mostly shared but partly distinct sets of HLA-E residues. Eur J Immunol 34:81-90.
19. Boyington JC, et al. (1999) Structure of CD94 reveals a novel C-type lectin fold: Implications for the NK cell-associated CD94/NKG2 receptors. Immunity 10:75-82.
20. + cytolytic T lymphocytes. Proc Natl Acad Sci USA 100:10896-10901.
21. Hoare HL, et al. (2006) Structural basis for a major histocompatibility complex class Ib-restricted T cell response. Nat Immunol 7:256-264.
22. Yang Z (1997) PAML: A program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci 13:555-556.
23. Pond SL, Frost SD (2005) DataMonkey: Rapid detection of selective pressure on individual sites of codon alignments. Bioinformatics 21:2531-2533.
24. Chapman TL, Heikeman AP, Bjorkman PJ (1999) The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity 11:603-613.
25. Cosman D, et al. (1997) A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 7:273-282.
26. Guma M, et al. (2006) Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts. Blood 107:3624-3631.
27. - NK cells. J Immunol 178:4473-4481.
28. DeLaBarre B, Brunger AT (2006) Considerations for the refinement of low-resolution crystal structures. Acta Crystallogr D 62:923-932.
29. McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK (2003) Symmetry recognizing asymmetry: Analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. Structure (London) 11:411-422.
30. McFarland BJ, Strong RK (2003) Thermodynamic analysis of degenerate recognition by the NKG2D immunoreceptor: Not induced fit but rigid adaptation. Immunity 19:803-812.
31. Kielczewska A, Kim HS, Lanier LL, Dimasi N, Vidal SM (2007) Critical residues at the Ly49 natural killer receptor's homodimer interface determine functional recognition of m157, a mouse cytomegalovirus MHC class I-like protein. J Immunol 178:369-377.
32. Lian RH, Li Y, Kubota S, Mager DL, Takei F (1999) Recognition of class I MHC by NK receptor Ly-49C: Identification of critical residues. J Immunol 162:7271-7276.
33. Wang J, et al. (2002) Binding of the natural killer cell inhibitory receptor Ly49A to its major histocompatibility complex class I ligand. Crucial contacts include both H-2Dd AND beta 2-microglobulin. J Biol Chem 277:1433-1442.
34. Collaborative Computational Project, Number 4 (1994) The CCP4 suite: Programs for protein crystallography. Acta Crystallogr D 50:760-763.
35. Emsley P, Cowtan K (2004) Coot: Model-building tools for molecular graphics. Acta Crystallogr D 60:2126-2132.
36. Holm L, Sander C (1994) The FSSP database of structurally aligned protein fold families. Nucleic Acids Res 22:3600-3609.
37. Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG (1997) The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25:4876-4882.