Interleukin-2, interleukin-15, and their receptors

International Reviews of Immunology

Volumn 16, Issue 3-4, 1998, Pages 205-226

  Waldmann, Thomas ^a   Tagaya, Yutaka ^a   Bamford, Richard ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Interleukin 15; Interleukin 2; Mast cells; Monoclonal antibodies; mRNA translation

Indexed keywords

EID: 0031934575     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830189809042995     Document Type: Article

References (69)

1. Bazan, J. F. (1990). Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87: 6934-6938.
2. Sato, N. and Miyajima, A. (1994). Multimeric cytokine receptors: Common versus specific functions. Curr. Opin. Cell Biol. 6: 174-179.
3. Kishimoto, T., Taga, T., and Akira, S (1994). Cytokine signal transduction. Cell 76: 253-262.
4. Kondo, M., Takeshita, T., Ishii, N , Nakamura, M., Watanabe, S., Arai, K.-I., and Sugamura, K. (1993). Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 262: 1874-1877.
5. Noguchi, M., Nakamura, Y., Russell, S. M., Ziegler, S. F., Tsang, M., Cao, X., and Leonard, W. J. (1993). Interleukin 2 receptor γ chain. A functional component of the interleukin-7 receptor. Science 262: 1877-1880.
6. Schorle, H., Holtschke, T., Hünig, T., Schimpl, A., and Horak, I. (1991). Development and function of T-cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621-624.
7. Noguchi, M., Yi, H., Rosenblatt, H. M., Filipovich, A. H., Adelstein, S., Modi, W. S., McBride, O. W., and Leonard, W. J. (1993). Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73: 147-157.
8. Burton, J. D., Bamford, R. N., Peters, C., Grant, A. J., Kurys, G., Goldman, C. K., Brennan, J., Roessler, E., and Waldmann, T. A. (1994). A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91: 4935-4939.
9. Bamford, R. N., Grant, A. J , Burton, J. D., Peters, C., Kurys, G., Goldman, C. K., Brennan, J., Roessler, E., and Waldmann, T. A. (1994). The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91: 4940-4944.
10. Grabstein, K. H., Eisenman, J., Shanebeck, K., Rauch, C., Srinivasan, S., Fung, V., Beers, C., Richardson, J., Schoenborn, M. A., Ahdieh, M., Johnson, L., Alderson, M. R., Watson, J. D., Anderson, D. M., and Giri, J. G. (1994). Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264: 965-968.
11. Giri, J. G., Ahdieh, M., Eisenman, J., Shanebeck, K., Grabstein, K., Kumaki, S., Namen, A., Park, L. S., Cosman, D., and Anderson, D. (1994). Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13: 2822-2830.
12. Fraser, J. D., Irving, B. A., Crabtree, G. R., and Weiss, A. (1991). Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251: 313-316.
13. Lindstein, T., June, C. H., Ledbetter, J. A., Steib, G., and Thompson, C. B. (1989). Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-345.
14. Bamford, R. N., Battiata, A. P., Burton, J. D., Sharma, H., and Waldmann, T. A. (1996). IL-15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus Type I R region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. Proc. Natl. Acad. Sci. USA 93: 2897-2902.
15. Tagaya, Y., Bamford, R. N., DeFilippis, A. P., and Waldmann, T. A. (1996). IL-15: A pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 4: 329-336.
16. Tagaya, Y., Buton, J. D., Miyamoto, Y., and Waldmann, T. A. (1996). Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells. EMBO J. 15: 4928-4939.
17. Waldmann, T. A. (1991). The interleukin-2 receptor. J. Biol. Chem. 266: 2681-2684.
18. Taniguchi, T. and Minami, Y. (1993). The IL-2/IL-2 receptor system: A current overview. Cell 73: 5-8.
19. Waldmann, T. A. (1993). 1992 Stohlman memorial lecture: targeting IL-2 receptor. Leukemia 7(SuppL 2): S151-S156.
20. Goldsmith, M. A. and Greene, W. C. (1994). Interleukin-2 and the interleukin-2 receptor. In: Thomson A. W., ed. The Cytokine Handbook, 2nd ed. London: The Academic Press, pp. 57-80.
21. Robb, R. J., Kutny, R. M., and Chowdhry, V. (1983). Purification and partial sequence analysis of human T-cell growth factor. Proc. Natl. Acad. Sci. USA 80: 5990-5994.
22. Seigel, L. J., Harper, M. E., Wong, S. F., Gallo, R. C., Nash, W. G., and O'Brien, S. J. (1984). Gene for T-cell growth factor: Location on human chromosome 4q and Feline chromosome BI. Science 223: 175-178.
23. Anderson, D. M., Johnson, L., Glaccum, M. B., Copeland, M. G., Gilbert, D. J., Jenkins, N. A., Valentine, V., Kirstein, M. N., Shapiro, D. N., Morris, S. W., Grabstein, K., and Cosman, D. (1995). Chromosomal assignment and genomic structure of Il 15. Genomics 25: 701-706.
24. Crabtree, G. R. (1989). Contingent genetic events in T lymphocyte activation. Science 243: 355-361.
25. Muegge, K. and Durum, S. K. (1989). From cell code to gene code: Cytokines and transcription factors. New Biol. 1: 239-251.
26. Bamford, R. N., Battiata, A. P., and Waldmann, T. A. (1996). IL-15: The role of translational regulation in their expression. J. Leukocyte Biol. 59: 476-480.
27. Shaw, G. and Kamen, R. (1986). A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659-667.
28. Flamand, L., Stefanescu, I., and Menezes, J. (1996). Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J. Clin. Invest. 97: 1373-1381.
29. Carson, W. E., Ross, M. E., Baiocchi, R. A., Marien, M. J., Boiani, N., Grabstein, K., and Caligiuri, M. A. (1995). Endogenous production of interleukin 15 by activated monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro. J. Clin. Invest. 96: 2578-2582.
30. Doherty, T. M., Seder, R. A., and Sher, A. (1996). Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156: 735-741.
31. Nishimura, H., Hiromatsu, K., Kobyashi, N., Grabstein, K. H., Paxton, R., Sugamura, K., Bluestone, J. A., and Yoshikai, Y. (1996). IL-15 is a novel growth factor for murine γδ T cells induced by Salmonella infection. J. Immunol. 156, 663-669.
32. Kozak, M. (1987). An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acid Res. 15: 8125-8148.
33. Kozak, M. (1991). An analysis of vertebrate mRNA sequences: Intimations of translational control. J. Cell Biol. 115: 887-903.
34. Kozak, M. (1992). A consideration of alternative models for the initiation of translation in eukaryotes. Crit. Rev Biochem. Mol. Biol. 27: 385-402.
35. Weinberg, A. D. and Swain, S. L. (1990). IL-2 receptor (Tac antigen) protein expression is down-regulated by the 5′-untranslated region of the mRNA. J. Immunol. 144: 4712-4720.
36. Bamford, R. N., DeFilippis, A. P., and Waldmann, T. A. (1996). Elements of the 5′ UTR signal peptide and 3′ coding sequence of IL-15 participate post-transcriptional regulation. Late-breaking abstract (LB167), FASEB joint meetings, New Orleans.
37. + cells. J. Immunol. 126: 1393-1397.
38. Leonard, W. J., Depper, J. M., Crabtree, G. R., Rudikoff, S., Pumphrey, J., Robb, R. J., Kronke, M., Svetlik, P. B., Peffer, N. J., Waldmann, T. A., and Greene, W. C. (1984). Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311: 626-630.
39. Tsudo, M., Kozak, R. W., Goldman, C K., and Waldmann, T. A. (1986). Demonstration of a non-Tac peptide that binds interleukin-2: A potential participant in a multichain interleukin-2 receptor complex. Proc. Natl. Acad. Sci. USA 83: 9694-9698.
40. Hatakeyama, M., Tsudo, M., Minamoto, S., Kono, T., Doi, T., Miyata, T., Miyasaka, M., and Taniguchi, T. (1989). Interleukin-2 receptor β chain gene: Generation of three receptor forms by cloned human α and β chain cDNAs. Science 244: 551-556.
41. Takeshita, T., Asao, H., Ohtani, K., Ishii, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, M., and Sugamura, K. (1992). Cloning of the γ chain of the human IL-2 receptor. Science 257: 379-382.
42. Giri, J. G., Kumaki, S., Ahdieh, M., Friend, D. J., Loomis, A., Shanebeck, K., DuBose, R , Cosman, D., Park, L. S., and Anderson, D. M. (1995). Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J. 14: 3654-3663.
43. Anderson, D. M., Kumaki, S., Ahdieh, M., Bertles, J., Tometsko, M., Loomis, A., Giri, J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Valentine, V , Shapiro, D. N., Morris, S. W., Park, L. S., and Cosman, D. (1995). Functional characterization of human interleukin 15Rα chain and close linkage of Il 15RA and Il 2RA genes. J. Biol. Chem. 270: 29862-29869.
44. Witthuhn, B. A., Silvennoinen, O., Miura, O., Lai, K. S., Cwik, C., Liu, E. T., and Ihle, J. N. (1994). Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 270: 153-157.
45. Johnston, J. A., Bacon, C. M., Finbloom, D. S., Rees, R. C., Kaplan, D., Shibuya, K., Ortaldo, J. R., Gupta, S., Chen, Y. Q., Giri, J. D., and O'Shea, J. J. (1995). Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15. Proc. Natl. Acad. Sci. USA 92: 8705-8709.
46. Miyazaki, T., Liu, Z.-J., Kawahara, A., Minami, Y., Yamada, K., Tsujimoto, Y , Barsoumian, E L., Perlmutter, R. M., and Taniguchi, T. (1995). Three distinct IL-2 signaling pathways mediated by bcl-2. c-myc and lck cooperate in hematopoietic cell proliferation. Cell 81: 223-231.
47. Lin, J.-X., Migone, T.-S., Tsang, M., Friedmann, M., Weatherbee, J. A., Zhou, L., Yamauchi, A., Bloom, E. T., Meitz. J , John, S., and Leonard, W. J. (1995). The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2: 331-339.
48. Wilkinson, P. C. and Liew, F. Y. (1995). Chemoattraction of human blood T lymphocytes by interleukin-15. J. Exp. Med. 181: 1255-1259.
49. McInnes, I. B., Al-Mughales, J., Field, M., Leung, B. P., Huang, F.-P., Dixon, R., Sturrock, R. D., Wilkinson, P. C., and Liew, F. Y. (1996). The role of interleukin 15 in T-cell migration and activation in rheumatoid arthritis. Nature Med. 2: 175-182.
50. Carson, W. E., Giri, J. G., Lindermann, M. J., Linett, M. L., Ahdieh, M., Paxton, R , Anderson, D., Eisenmann, J., Grabstein, K., and Caligiuri, M. A. (1994). Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the Il-2 receptor. J. Exp. Med 180: 1395-1403.
51. Armitage, R. J., Macduff, B. M., Eisenman, J., Paxton, R., and Grabstein, K. H. (1995). IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J. Immunol. 154: 483-490.
52. Sadlack, B., Merz, H., Schorle, H., Schimpi, A., Feller, A. C., and Horak, I. (1993). Ulcerative cholitis-like disease in mice with disrupted interleukin-2 gene. Cell 75: 253-261.
53. Willerford, D. M., Chen, J. Z., Ferry, J. A., Davidson, L., Ma, A., and Alt, F. W. (1995). Interleukin-2 receptor-alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-530.
54. Suzuki, H., Kündig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R., Simard, J. J. L., Ohashi, P. S., Griesser, H., Taniguchi, T., Paige, C. J., and Mak, T. W. (1995). Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268: 1472-1476.
55. Lenardo, M. J., Boehme, S., Chen, L., Combadiere, B., Fisher, G., Freedman, M., McFarand, N., Pelfrey, C., and Zheng, L. (1995) Autocrine feedback death and the regulation of mature T lymphocyte antigen responses. Intern. Rev. Immunol. 13: 114-134.
56. Lenardo, M. J. (1991) Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353: 858-861.
57. + cells. European J. Immunol. 26: 2263-2270.
58. Kabelitz, D., Pohl, T., and Pechhold, K. (1993). Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol. Today 14: 338-339.
59. Quinn, L. S., Haugk, K. L., and Grabstein, K. H. (1995). Interleukin-15: a novel anabolic cytokine for skeletal muscle. Endocrinology 136: 3669-3672.
60. Agostini, C., Trentin, L., Facco, M., Sancetta, R., Cerutti, A., Tassinari, C., Cimarosto, L., Adami, F., Cipriani, A., Zambello, R., and Semenzato, G. (1996). Role of IL-15, IL-2 and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis. J. Immunol. 157: 910-918.
61. Waldmann, T. A., Goldman, C., Top, L., Grant, A., Burton, J., Bamford, R., Roessler, E., Horak, I., Zaknoen, S., Kasten-Sportes, C., White, J., England, R., Horak, E., Martinucci, J., Tinubu, S. A., Mishra, B., Junghans, R., Dipre, M., Carrasquillo, J., Ryenolds, J., Gansow, O., and Nelson, D. (1993). The interleukin-2 receptor: A target for immunotherapy. Ann. NY Acad. Sci. 685: 603-610.
62. Waldmann, T. A., White, J. D., Carrasquillo, J. A., Reynolds, J. C., Paik, C. H., Gansow, O. A., Brechbiel, M. W., Jaffe, E. S., Fleisher, T. A., Goldman, C. K., Top, L. E., Bamford, R., Zaknoen, S., Roessler, E., Kasten-Sportes, C., England, R., Litou, H., Johnson. J. A., Jackson-White, T., Manns, A., Hanchard, B., Junghans, R. P., and Nelson, D. L. (1995). Radioimmunotherapy of interleukin-2Rα - expressing adult T-cell leukemia with yttrium-90 - labeled anti-Tac. Blood 86: 4063-4075.
63. Tsudo, M., Kitamura, F., and Miyasaka, M. (1989). Characterization of the interleukin 2 receptor β chain using three distinct monoclonal antibodies Proc. Natl. Acad. Sci. USA 86: 1982-1986.
64. Tsudo, M., Goldman, C. K., Bongivanni, K. F., Chang, W. C., Winton, E. F., Yagita, M., Grim, E. A., and Waldmann, T. A. (1987). The P75 peptideis a receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells. Proc. Natl. Acad. Sci. USA 84: 5391-5398.
65. Yoon, H. J., Sugamura, K., and Loughran, T. P., Jr. (1990). Activation of leukemic large granular lymphocytes by interleukin-2 via p75 interleukin-2 receptor. Leukemia 4: 848-850.
66. Thomis, D. C., Gurniak, C. B., Tivol, E., Scharpe, A. H., and Berg, L. J. (1995). Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science 270: 794-797.
67. Nosaka, T., van Deursen, J. M. A., Tripp, R. A., Thierfelder, W. E., Witthuhn, B. A., McMickle, A. P., Doherty, P. C., Grosveld, G. C., and Ihle, J. N. (1995). Defective lymphoid development in mice lacking Jak3. Science 270: 800-802.
68. Russel, S. M., Tayebi, N., Nakajima, H., Riedy, M. C., Roberts, J. L., Aman, M. J., Migone, T.-S., Nogouchi, M., Markert, N. L., Buckley, R. H., O'Shea, J. J., and Leonard, W. J. (1995). Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 70: 797-800.
69. Macchi, P., Villa, A., Gillani, S., Sacco, M. G., Frattini, A., Porta, F., Ugazlo, A. G., Johnston, J. A., Candotti, F., O'Shea, J. J., Vessoni, P., and Notaragelo, L. D. (1995). Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature 377: 65-68.