Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood

European Journal of Immunology

Volumn 35, Issue 9, 2005, Pages 2608-2616

  Bratke, Kai ^a   Kuepper, Michael ^a   Bade, Britta ^a   Virchow Jr , J Christian ^a   Luttmann, Werner ^a  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

Author keywords

Cytotoxic T lymphocytes; Granzyme; Memory T cell; Natural killer cell; Perforin

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; GRANZYME A; GRANZYME B; GRANZYME K; PERFORIN; SERINE PROTEINASE; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; EXOCYTOSIS; FLOW CYTOMETRY; GRANULE CELL; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MEMORY CELL; NATURAL KILLER CELL; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TARGET CELL; VIRUS INFECTION;

ANTIGENS, CD11B; ANTIGENS, CD27; ANTIGENS, CD28; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GRANZYMES; HLA-DR ANTIGENS; HUMANS; IMMUNOPHENOTYPING; KILLER CELLS, NATURAL; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; RECEPTORS, CCR5; SERINE ENDOPEPTIDASES; T-LYMPHOCYTE SUBSETS;

EID: 26044436515     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200526122     Document Type: Article

References (36)

1. Trapani, J. A. and Smyth, M. J., Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2002. 2: 735-747.
2. Barry, M., Bleackley, R C., Cytotoxic lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2002. 2: 401-409.
3. Lieberman, J., The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat. Rev. Immunol. 2003. 3: 361-370.
4. Motyka, B., Korbutt, G., Pinkoski, M. J., Heibein, J. A., Caputo, A., Hobman, M., Barry, M. et al., Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell 2000. 103: 491-500.
5. Trapani, J. A., Sutton, V. R., Thia, K Y., Li, Y. Q., Froelich, C. J., Jans, D. A., Sandrin, M. S. and Browne, K. A., A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J. Cell Biol. 2003. 160: 223-233.
6. Veugelers, K., Motyka, B., Frantz, C., Shostak, I., Sawchuk, T. and Bleackley, R. C., The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis. Blood 2004. 103: 3845-3853.
7. Froelich, C. J., Orth, K, Turbov, J., Seth, P., Gottlieb, R., Babior, B., Shah, G. M. et al., New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J. Biol. Chem. 1996. 271: 29073-29079.
8. Browne, K. A., Blink, E., Sutton, V. R., Froelich, C. J., Jans, D. A. and Trapani, J. A., Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol. Cell. Biol. 1999. 19: 8604-8615.
9. Trapani, J. A., Granzymes: a family of lymphocyte granule serine proteases. Genome Biol. 2001. 2: 3014.1-3014.7.
10. Wilharm, E., Parry, M. A., Friebel, R., Tschesche, H., Matschiner, G., Sommerhoff, C. P. and Jenne, D. E., Generation of catalytically active granzyme K from Escherichia coli inclusion bodies and identification of efficient granzyme K inhibitors in human plasma. J. Biol. Chem. 1999. 274: 27331-27337.
11. Waugh, S. M., Harris, J. L., Fletterick, R. and Craik, C. S., The structure of the pro-apoptotic protease granyzme B reveals the molecular determinants of its specificity. Nat. Struct. Biol. 2000. 7: 762-765.
12. Estebanez-Perpina, E., Fuentes-Prior, P., Belorgey, D., Braun, M., Kiefersauer, R., Maskos, K., Huber, R. et al., Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue. Biol. Chem. 2000. 381: 1203-1214.
13. Bell, J. K., Goetz, D. H., Mahrus, S., Harris, J. L., Fletterick, R. J. and Craik, C. S.The oligomeric structure of human granyzme A is a determinant of its extended substrate specificity. Nat. Struct. Biol. 2003. 10: 527-534.
14. Hink-Schauer, C., Estebanez-Perpina, E., Kurschus, F. C., Bode, W. and Jenne, D. E., Crystal structure of the apoptosis-inducing human granzyme A dimer. Nat. Struct. Biol. 2003. 10: 535-540.
15. Lord, S. J., Rajotte, R. V., Korbutt, G. S. and Bleackley, R C., Granzyme B: a natural born killer. Immunol. Rev. 2003. 193: 31-38.
16. Lieberman, J. and Fan, Z., Nuclear war: the granzyme A-bomb. Curr. Opin. Immunol. 2003. 15: 553-559.
17. Hameed, A., Lowrey, D. M., Lichtenheld, M. G. and Podack, E. R., Characterization of three serine esterases isolated from human interleukin 2 activated killer cells. J. Immunol. 1988. 141: 3142-3147.
18. Shi, L., Kam, C. M., Powers, J. C., Aebersold, R. and Greenberg, A. H., Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J. Exp. Med. 1992. 176: 1521-1529.
19. MacDonald, G., Shi, L., Vande Velde, C., Lieberman, J. and Greenberg, A. H., Mitochondria-dependent and -independent regulation of granyzme B-induced apoptosis. J. Exp. Med. 1999. 189: 131-143.
20. Hink-Schauer, C., Estebanez-Perpina, E., Wilharm, E., Fuentes-Prior, P., Klinkert, W., Bode, W. and Jenne, D. E., The 2.2-A crystal structure of human pro-granyzme K reveals a rigid zymogen with unusual features. J. Biol. Chem. 2002. 277: 50923-50933.
21. Przetak, M. M., Yoast, S. and Schmidt, B. F., Cloning of cDNA for human granzyme 3. FEBS Lett. 1995. 364: 268-271.
22. Grossman, W. J., Verbsky, J. W., Tollefsen, B. L., Kemper, C., Atkinson, J. P. and Ley, T. J., Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 2004. 104: 2840-2848.
23. + T cells. J. Exp. Med. 1997. 186: 1407-1418.
24. + T cells from a memory to memory /effector phenotype. J. Immunol. 2002. 168: 5538-5550.
25. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
26. Campbell, J. J., Murphy, K. E., Kunkel, E. J., Brightling, C. E., Soler, D., Shen, Z., Boisvert, J. et al., CCR7 expression and memory T cell diversity in humans. J. Immunol. 2001. 166: 877-884.
27. + T cells. J. Immunol. 2002. 168: 2225-2232.
28. + T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function. Eur. J. Immunol. 2004. 34: 999-1010.
29. Smith, S. H., Brown, M. H., Rowe, D., Callard, R. E. and Beverley, P. C., Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1. Immunology 1986. 58: 63-70.
30. Sanders, M. E., Makgoba, M. W., Sharrow, S. O., Stephany, D., Springer, T. A., Young, H. A. and Shaw, S., Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-γ production. J. Immunol. 1988. 140: 1401-1407.
31. + pool with distinct phenotypic and migratory characteristics. J. Immunol. 2001. 167: 212-220.
32. dim NK cells. Eur. J. Immunol. 2001. 31: 3121-3126.
33. Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D. and Williams, L. T., A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc. Natl. Acad. Sci. USA 1998. 95: 258-263.
34. Campbell, J. J., Hedrick, J., Zlotnik, A., Siani, M. A., Thompson, D. A. and Butcher, E. C., Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 1998. 279: 381-384.
35. Campbell, J. J., Bowman, E. P., Murphy, K., Youngman, K R., Siani, M. A., Thompson, D. A., Wu, L., et al., 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3β receptor CCR7. J. Cell. Biol. 1998. 141: 1053-1059.
36. Luttmann, W., Herzog, V., Virchow, J. C., Jr, Matthys, H., Thierauch, K. H. and Kroegel, C., Prostacyclin modulates granulocyte/macrophage colony-stimulating factor release by human blood mononuclear cells. Pulm. Pharmacol. 1996. 9: 43-48.