-
1
-
-
0036265797
-
Human flavin-containing monooxygenase (form 3): Polymorphisms and variations in chemical metabolism
-
Cashman Jr. Human flavin-containing monooxygenase (form 3): polymorphisms and variations in chemical metabolism. Pharmacogenomics 2002; 3:325-339.
-
(2002)
Pharmacogenomics
, vol.3
, pp. 325-339
-
-
Cashman, J.R.1
-
2
-
-
0030833164
-
Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans
-
Overby LH, Carver GC, Philpot RM. Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans. Chem Biol Interact 1997; 106:29-45.
-
(1997)
Chem Biol Interact
, vol.106
, pp. 29-45
-
-
Overby, L.H.1
Carver, G.C.2
Philpot, R.M.3
-
3
-
-
0033523477
-
Mild trimethylaminuria caused by common variants in FMO3 gene
-
Zschocke J, Kohlmueller D, Quak E, Meissner T, Hoffmann GF, Mayatepek E. Mild trimethylaminuria caused by common variants in FMO3 gene. Lancet 1999; 354:834-835.
-
(1999)
Lancet
, vol.354
, pp. 834-835
-
-
Zschocke, J.1
Kohlmueller, D.2
Quak, E.3
Meissner, T.4
Hoffmann, G.F.5
Mayatepek, E.6
-
4
-
-
23044469807
-
Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants
-
Koukouritaki SB, Poch MT, Cabacungan ET, McCarver DG, Hines RN. Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. Mol Pharmacol 2005; 68:383-392.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 383-392
-
-
Koukouritaki, S.B.1
Poch, M.T.2
Cabacungan, E.T.3
McCarver, D.G.4
Hines, R.N.5
-
5
-
-
34250676097
-
Genetic polymorphisms of human flavin-containing monooxygenase 3: Implications for drug metabolism and clinical perspectives
-
Hisamuddin IM, Yang VW. Genetic polymorphisms of human flavin-containing monooxygenase 3: implications for drug metabolism and clinical perspectives. Pharmacogenomics 2007; 8:635-643.
-
(2007)
Pharmacogenomics
, vol.8
, pp. 635-643
-
-
Hisamuddin, I.M.1
Yang, V.W.2
-
6
-
-
0036152701
-
Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: Linkage and effects on in vivo and in vitro FMO activities
-
Park CS, Kang JH, Chung WG, Yi HG, Pie JE, Park DK, et al. Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities. Pharmacogenetics 2002; 12:77-80.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 77-80
-
-
Park, C.S.1
Kang, J.H.2
Chung, W.G.3
Yi, H.G.4
Pie, J.E.5
Park, D.K.6
-
7
-
-
0033959521
-
Population-specific polymorphisms of the human FMO3 gene: Significance for detoxication
-
Cashman JR, Akerman BR, Forrest SM, Treacy EP. Population-specific polymorphisms of the human FMO3 gene: significance for detoxication. Drug Metab Dispos 2000; 28:169-173.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 169-173
-
-
Cashman, J.R.1
Akerman, B.R.2
Forrest, S.M.3
Treacy, E.P.4
-
8
-
-
33847342912
-
Effect of genetic variants of the human flavin-containing monooxygenase 3 on N-and S-oxygenation activities
-
Shimizu M, Yano H, Nagashima S, Murayama N, Zhang J, Cashman JR, et al. Effect of genetic variants of the human flavin-containing monooxygenase 3 on N-and S-oxygenation activities. Drug Metab Dispos 2007; 35:328-330.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 328-330
-
-
Shimizu, M.1
Yano, H.2
Nagashima, S.3
Murayama, N.4
Zhang, J.5
Cashman, J.R.6
-
9
-
-
33845940735
-
Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants
-
Koukouritaki SB, Poch MT, Henderson MC, Siddens LK, Krueger SK, Vandyke JE, et al. Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. J Pharmacol Exp Ther 2007; 320:266-273.
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 266-273
-
-
Koukouritaki, S.B.1
Poch, M.T.2
Henderson, M.C.3
Siddens, L.K.4
Krueger, S.K.5
Vandyke, J.E.6
-
10
-
-
0037974644
-
Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: Comparative genetic and functional studies
-
Lattard V, Zhang J, Tran Q, Furnes B, Schlenk D, Cashman Jr. Two new polymorphisms of the FMO3 gene in Caucasian and African-American populations: comparative genetic and functional studies. Drug Metab Dispos 2003; 31:854-860.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 854-860
-
-
Lattard, V.1
Zhang, J.2
Tran, Q.3
Furnes, B.4
Schlenk, D.5
Cashman, J.R.6
-
11
-
-
12244306252
-
Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans
-
Furnes B, Feng J, Sommer SS, Schlenk D. Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans. Drug Metab Dispos 2003; 31:187-193.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 187-193
-
-
Furnes, B.1
Feng, J.2
Sommer, S.S.3
Schlenk, D.4
-
12
-
-
33751535481
-
Investigation of structure and function of a catalytically efficient variant of the human flavin-containing monooxygenase form 3
-
Borbas T, Zhang J, Cerny MA, Liko I, Cashman Jr. Investigation of structure and function of a catalytically efficient variant of the human flavin-containing monooxygenase form 3. Drug Metab Dispos 2006; 34:1995-2002.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1995-2002
-
-
Borbas, T.1
Zhang, J.2
Cerny, M.A.3
Liko, I.4
Cashman, J.R.5
-
14
-
-
28144440301
-
Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6
-
Dicke KE, Skrlin SM, Murphy SE. Nicotine and 4-(methylnitrosamino)-1-(3- pyridyl)-butanone metabolism by cytochrome P450 2B6. Drug Metab Dispos 2005; 33:1760-1764.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1760-1764
-
-
Dicke, K.E.1
Skrlin, S.M.2
Murphy, S.E.3
-
16
-
-
34548311575
-
Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10
-
Kaivosaari S, Toivonen P, Hesse LM, Koskinen M, Court MH, Finel M. Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10. Mol Pharmacol 2007; 72:761-768.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 761-768
-
-
Kaivosaari, S.1
Toivonen, P.2
Hesse, L.M.3
Koskinen, M.4
Court, M.H.5
Finel, M.6
-
18
-
-
3242664997
-
Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted
-
Yamanaka H, Nakajima M, Nishimura K, Yoshida R, Fukami T, Katoh M, et al. Metabolic profile of nicotine in subjects whose CYP2A6 gene is deleted. Eur J Pharm Sci 2004; 22:419-425.
-
(2004)
Eur J Pharm Sci
, vol.22
, pp. 419-425
-
-
Yamanaka, H.1
Nakajima, M.2
Nishimura, K.3
Yoshida, R.4
Fukami, T.5
Katoh, M.6
-
21
-
-
73949104432
-
Nicotine metabolism in African Americans and European Americans: Variation in glucuronidation by ethnicity and UGT2B10 haplotype
-
Berg JZ, Mason J, Boettcher AJ, Hatsukami DK, Murphy SE. Nicotine metabolism in African Americans and European Americans: variation in glucuronidation by ethnicity and UGT2B10 haplotype. J Pharmacol Exp Ther 2010; 332:202-209.
-
(2010)
J Pharmacol Exp Ther
, vol.332
, pp. 202-209
-
-
Berg, J.Z.1
Mason, J.2
Boettcher, A.J.3
Hatsukami, D.K.4
Murphy, S.E.5
-
22
-
-
0032705773
-
Ethnic differences in N-glucuronidation of nicotine and cotinine
-
Benowitz NL, Perez-Stable EJ, Fong I, Modin G, Herrera B, Jacob P 3rd. Ethnic differences in N-glucuronidation of nicotine and cotinine. J Pharmacol Exp Ther 1999; 291:1196-1203.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 1196-1203
-
-
Benowitz, N.L.1
Perez-Stable, E.J.2
Fong, I.3
Modin, G.4
Herrera, B.5
Jacob III, P.6
-
23
-
-
0026586611
-
Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3-hydroxycotinine in smokers
-
Byrd GD, Chang KM, Greene JM, deBethizy JD. Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3-hydroxycotinine in smokers. Drug Metab Dispos 1992; 20:192-197.
-
(1992)
Drug Metab Dispos
, vol.20
, pp. 192-197
-
-
Byrd, G.D.1
Chang, K.M.2
Greene, J.M.3
Debethizy, J.D.4
-
24
-
-
0027958225
-
Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
-
Benowitz NL, Jacob P 3rd, Fong I, Gupta S. Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J Pharmacol Exp Ther 1994; 268:296-303.
-
(1994)
J Pharmacol Exp Ther
, vol.268
, pp. 296-303
-
-
Benowitz, N.L.1
Jacob III, P.2
Fong, I.3
Gupta, S.4
-
25
-
-
13944284575
-
Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence
-
Malaiyandi V, Sellers EM, Tyndale RF. Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clin Pharmacol Ther 2005; 77:145-158.
-
(2005)
Clin Pharmacol Ther
, vol.77
, pp. 145-158
-
-
Malaiyandi, V.1
Sellers, E.M.2
Tyndale, R.F.3
-
26
-
-
79959805789
-
The contribution of common CYP2A6 alleles to variation in nicotine metabolism among european-americans
-
Bloom AJ, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, et al. The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenet Genomics 2011; 21:403-416.
-
(2011)
Pharmacogenet Genomics
, vol.21
, pp. 403-416
-
-
Bloom, A.J.1
Hinrichs, A.L.2
Wang, J.C.3
Von Weymarn, L.B.4
Kharasch, E.D.5
Bierut, L.J.6
-
27
-
-
33846536406
-
Novel genes identified in a high-density genome wide association study for nicotine dependence
-
Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum Mol Genet 2007; 16:24-35.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 24-35
-
-
Bierut, L.J.1
Madden, P.A.2
Breslau, N.3
Johnson, E.O.4
Hatsukami, D.5
Pomerleau, O.F.6
-
28
-
-
84863502226
-
Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus CYP2A6
-
Bloom AJ, Harari O, Martinez M, Madden PA, Martin NG, Montgomery GW, et al. Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6. Hum Mol Genet 2012; 21:3050-3062.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 3050-3062
-
-
Bloom, A.J.1
Harari, O.2
Martinez, M.3
Madden, P.A.4
Martin, N.G.5
Montgomery, G.W.6
-
29
-
-
33746512512
-
Principal components analysis corrects for stratification in genome-wide association studies
-
Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38:904-909.
-
(2006)
Nat Genet
, vol.38
, pp. 904-909
-
-
Price, A.L.1
Patterson, N.J.2
Plenge, R.M.3
Weinblatt, M.E.4
Shadick, N.A.5
Reich, D.6
-
30
-
-
34548420986
-
Analysis of [3, 3-d(2)]-nicotine and [3, 3-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry
-
Murphy SE, Villalta P, Ho SW, von Weymarn LB. Analysis of [3, 3-d(2)]-nicotine and [3, 3-d(2)]-cotinine by capillary liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 857:1-8.
-
(2007)
J Chromatogr B Analyt Technol Biomed Life Sci
, vol.857
, pp. 1-8
-
-
Murphy, S.E.1
Villalta, P.2
Ho, S.W.3
Von Weymarn, L.B.4
-
31
-
-
0242691208
-
A comparison of bayesian methods for haplotype reconstruction from population genotype data
-
Stephens M, Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 2003; 73:1162-1169.
-
(2003)
Am J Hum Genet
, vol.73
, pp. 1162-1169
-
-
Stephens, M.1
Donnelly, P.2
-
32
-
-
0035071957
-
A new statistical method for haplotype reconstruction from population data
-
Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68:978-989.
-
(2001)
Am J Hum Genet
, vol.68
, pp. 978-989
-
-
Stephens, M.1
Smith, N.J.2
Donnelly, P.3
-
33
-
-
13444269543
-
Haploview: Analysis and visualization of LD and haplotype maps
-
Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-265.
-
(2005)
Bioinformatics
, vol.21
, pp. 263-265
-
-
Barrett, J.C.1
Fry, B.2
Maller, J.3
Daly, M.J.4
-
34
-
-
84873080374
-
-
Exome Variant Server NHLBI GO Exome Sequencing Project (ESP), Seattle WA [accessed 7/1/2012]
-
Exome Variant Server, NHLBI GO Exome Sequencing Project (ESP), Seattle, WA. Available at: http://evs.gs.washington.edu/EVS/[accessed 7/1/2012].
-
-
-
-
35
-
-
0036786378
-
Interindividual differences of human flavin-containing monooxygenase 3: Genetic polymorphisms and functional variation
-
Cashman JR, Zhang J. Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation. Drug Metab Dispos 2002; 30:1043-1052.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 1043-1052
-
-
Cashman, J.R.1
Zhang, J.2
-
36
-
-
0036037640
-
Genetic polymorphisms of flavin-containing monooxygenase (FMO)
-
Krueger SK, Williams DE, Yueh MF, Martin SR, Hines RN, Raucy JL, et al. Genetic polymorphisms of flavin-containing monooxygenase (FMO). Drug Metab Rev 2002; 34:523-532.
-
(2002)
Drug Metab Rev
, vol.34
, pp. 523-532
-
-
Krueger, S.K.1
Williams, D.E.2
Yueh, M.F.3
Martin, S.R.4
Hines, R.N.5
Raucy, J.L.6
-
37
-
-
79957993750
-
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue
-
Innocenti F, Cooper GM, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, et al. Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genet 2011; 7:e1002078.
-
(2011)
PLoS Genet
, vol.7
-
-
Innocenti, F.1
Cooper, G.M.2
Stanaway, I.B.3
Gamazon, E.R.4
Smith, J.D.5
Mirkov, S.6
-
38
-
-
45149108420
-
Mapping the genetic architecture of gene expression in human liver
-
Schadt EE, Molony C, Chudin E, Hao K, Yang X, Lum PY, et al. Mapping the genetic architecture of gene expression in human liver. PLoS Biol 2008; 6:e107.
-
(2008)
PLoS Biol
, vol.6
-
-
Schadt, E.E.1
Molony, C.2
Chudin, E.3
Hao, K.4
Yang, X.5
Lum, P.Y.6
-
39
-
-
80054736636
-
Q172H replacement overcomes effects on the metabolism of cyclophosphamide and efavirenz caused by CYP2B6 variant with Arg262
-
Ariyoshi N, Ohara M, Kaneko M, Afuso S, Kumamoto T, Nakamura H, et al. Q172H replacement overcomes effects on the metabolism of cyclophosphamide and efavirenz caused by CYP2B6 variant with Arg262. Drug Metab Dispos 2011; 39:2045-2048.
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 2045-2048
-
-
Ariyoshi, N.1
Ohara, M.2
Kaneko, M.3
Afuso, S.4
Kumamoto, T.5
Nakamura, H.6
-
40
-
-
2442642701
-
Alternative processing events in human FMO genes
-
Lattard V, Zhang J, Cashman Jr. Alternative processing events in human FMO genes. Mol Pharmacol 2004; 65:1517-1525.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 1517-1525
-
-
Lattard, V.1
Zhang, J.2
Cashman, J.R.3
-
41
-
-
33746922400
-
Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors
-
Brody AL, Mandelkern MA, London ED, Olmstead RE, Farahi J, Scheibal D, et al. Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Arch Gen Psychiatry 2006; 63: 907-915.
-
(2006)
Arch Gen Psychiatry
, vol.63
, pp. 907-915
-
-
Brody, A.L.1
Mandelkern, M.A.2
London, E.D.3
Olmstead, R.E.4
Farahi, J.5
Scheibal, D.6
-
42
-
-
29944437885
-
Quantitative analysis of FMO gene mRNA levels in human tissues
-
Zhang J, Cashman Jr. Quantitative analysis of FMO gene mRNA levels in human tissues. Drug Metab Dispos 2006; 34:19-26.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 19-26
-
-
Zhang, J.1
Cashman, J.R.2
-
43
-
-
0030222251
-
Cerebral metabolism of imipramine and a purified flavin-containing monooxygenase from human brain
-
Bhagwat SV, Bhamre S, Boyd MR, Ravindranath V. Cerebral metabolism of imipramine and a purified flavin-containing monooxygenase from human brain. Neuropsychopharmacology 1996; 15:133-142.
-
(1996)
Neuropsychopharmacology
, vol.15
, pp. 133-142
-
-
Bhagwat, S.V.1
Bhamre, S.2
Boyd, M.R.3
Ravindranath, V.4
-
44
-
-
0038119910
-
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
-
Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Neuropharmacology 2003; 45:122-132.
-
(2003)
Neuropharmacology
, vol.45
, pp. 122-132
-
-
Miksys, S.1
Lerman, C.2
Shields, P.G.3
Mash, D.C.4
Tyndale, R.F.5
|