-
1
-
-
4644255903
-
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
-
Schoedel, K.A., Hoffmann, E.B., Rao, Y., Sellers, E.M. and Tyndale, R.F. (2004) Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. Pharmacogenetics, 14, 615-626.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 615-626
-
-
Schoedel, K.A.1
Hoffmann, E.B.2
Rao, Y.3
Sellers, E.M.4
Tyndale, R.F.5
-
2
-
-
0142247254
-
Nicotine metabolite ratio as a predictor of cigarette consumption
-
Benowitz, N.L., Pomerleau, O.F., Pomerleau, C.S. and Jacob, P. 3rd. (2003) Nicotine metabolite ratio as a predictor of cigarette consumption. Nicotine Tob. Res., 5, 621-624.
-
(2003)
Nicotine Tob. Res.
, vol.5
, pp. 621-624
-
-
Benowitz, N.L.1
Pomerleau, O.F.2
Pomerleau, C.S.3
Jacob III, P.4
-
3
-
-
0033947490
-
Nicotine blood levels and subjective craving for cigarettes
-
Jarvik, M.E., Madsen, D.C., Olmstead, R.E., Iwamoto-Schaap, P.N., Elins, J.L. and Benowitz, N.L. (2000) Nicotine blood levels and subjective craving for cigarettes. Pharmacol. Biochem. Behav., 66, 553-558.
-
(2000)
Pharmacol. Biochem. Behav.
, vol.66
, pp. 553-558
-
-
Jarvik, M.E.1
Madsen, D.C.2
Olmstead, R.E.3
Iwamoto-Schaap, P.N.4
Elins, J.L.5
Benowitz, N.L.6
-
4
-
-
33751401307
-
New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure
-
Strasser, A.A., Lerman, C., Sanborn, P.M., Pickworth, W.B. and Feldman, E.A. (2007) New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Drug Alcohol Depend., 86, 294-300.
-
(2007)
Drug Alcohol Depend
, vol.86
, pp. 294-300
-
-
Strasser, A.A.1
Lerman, C.2
Sanborn, P.M.3
Pickworth, W.B.4
Feldman, E.A.5
-
5
-
-
2942573215
-
Evaluation of carcinogen exposure in people who used 'reduced exposure' tobacco products
-
Hatsukami, D.K., Lemmonds, C., Zhang, Y., Murphy, S.E., Le, C., Carmella, S.G. and Hecht, S.S. (2004) Evaluation of carcinogen exposure in people who used 'reduced exposure' tobacco products. J. Natl Cancer Inst., 96, 844-852.
-
(2004)
J. Natl Cancer Inst.
, vol.96
, pp. 844-852
-
-
Hatsukami, D.K.1
Lemmonds, C.2
Zhang, Y.3
Murphy, S.E.4
Le, C.5
Carmella, S.G.6
Hecht, S.S.7
-
6
-
-
79959805789
-
The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans
-
Bloom, J., Hinrichs, A.L., Wang, J.C., von Weymarn, L.B., Kharasch, E.D., Bierut, L.J., Goate, A. and Murphy, S.E. (2011) The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenet. Genomics, 21, 403-416.
-
(2011)
Pharmacogenet. Genomics
, vol.21
, pp. 403-416
-
-
Bloom, J.1
Hinrichs, A.L.2
Wang, J.C.3
von Weymarn, L.B.4
Kharasch, E.D.5
Bierut, L.J.6
Goate, A.7
Murphy, S.E.8
-
7
-
-
14144253640
-
Metabolism and disposition kinetics of nicotine
-
Hukkanen, J., Jacob, P. 3rd and Benowitz, N.L. (2005) Metabolism and disposition kinetics of nicotine. Pharmacol. Rev., 57, 79-115.
-
(2005)
Pharmacol. Rev.
, vol.57
, pp. 79-115
-
-
Hukkanen, J.1
Jacob III, P.2
Benowitz, N.L.3
-
8
-
-
33846932361
-
The role of CYP2A6 in the emergence of nicotine dependence in adolescents
-
Audrain-McGovern, J., Al Koudsi, N., Rodriguez, D., Wileyto, E.P., Shields, P.G. and Tyndale, R.F. (2007) The role of CYP2A6 in the emergence of nicotine dependence in adolescents. Pediatrics, 119, e264-e274.
-
(2007)
Pediatrics
, vol.119
-
-
Audrain-McGovern, J.1
Al Koudsi, N.2
Rodriguez, D.3
Wileyto, E.P.4
Shields, P.G.5
Tyndale, R.F.6
-
9
-
-
10444269359
-
Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers
-
O'Loughlin, J., Paradis, G., Kim, W., DiFranza, J., Meshefedjian, G., McMillan-Davey, E., Wong, S., Hanley, J. and Tyndale, R.F. (2004) Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. Tob. Control, 13, 422-428.
-
(2004)
Tob. Control
, vol.13
, pp. 422-428
-
-
O'Loughlin, J.1
Paradis, G.2
Kim, W.3
DiFranza, J.4
Meshefedjian, G.5
McMillan-Davey, E.6
Wong, S.7
Hanley, J.8
Tyndale, R.F.9
-
10
-
-
77951748276
-
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior
-
Thorgeirsson, T.E., Gudbjartsson, D.F., Surakka, I., Vink, J.M., Amin, N., Geller, F., Sulem, P., Rafnar, T., Esko, T., Walter, S. et al. (2010) Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat. Genet., 42, 448-453.
-
(2010)
Nat. Genet.
, vol.42
, pp. 448-453
-
-
Thorgeirsson, T.E.1
Gudbjartsson, D.F.2
Surakka, I.3
Vink, J.M.4
Amin, N.5
Geller, F.6
Sulem, P.7
Rafnar, T.8
Esko, T.9
Walter, S.10
-
11
-
-
77951711343
-
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
-
Tobacco and Genetics Consortium
-
Tobacco and Genetics Consortium. (2010) Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat. Genet., 42, 441-447.
-
(2010)
Nat. Genet.
, vol.42
, pp. 441-447
-
-
-
12
-
-
0027504164
-
Why some people smoke and others do not: new perspectives
-
Pomerleau, O.F., Collins, A.C., Shiffman, S. and Pomerleau, C.S. (1993) Why some people smoke and others do not: new perspectives. J. Consult. Clin. Psychol., 61, 723-731.
-
(1993)
J. Consult. Clin. Psychol.
, vol.61
, pp. 723-731
-
-
Pomerleau, O.F.1
Collins, A.C.2
Shiffman, S.3
Pomerleau, C.S.4
-
13
-
-
13944284575
-
Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence
-
Malaiyandi, V., Sellers, E.M. and Tyndale, R.F. (2005) Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clin. Pharmacol. Ther., 77, 145-158.
-
(2005)
Clin. Pharmacol. Ther.
, vol.77
, pp. 145-158
-
-
Malaiyandi, V.1
Sellers, E.M.2
Tyndale, R.F.3
-
14
-
-
79953768162
-
Associations of CYP2A6 genotype with smoking behaviors in southern China
-
Liu, T., David, S.P., Tyndale, R.F., Wang, H., Zhou, Q., Ding, P., He, Y.H., Yu, X.Q., Chen, W., Crump, C. et al. (2011) Associations of CYP2A6 genotype with smoking behaviors in southern China. Addiction, 106, 985-994.
-
(2011)
Addiction
, vol.106
, pp. 985-994
-
-
Liu, T.1
David, S.P.2
Tyndale, R.F.3
Wang, H.4
Zhou, Q.5
Ding, P.6
He, Y.H.7
Yu, X.Q.8
Chen, W.9
Crump, C.10
-
15
-
-
33645525613
-
Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy
-
Malaiyandi, V., Lerman, C., Benowitz, N.L., Jepson, C., Patterson, F. and Tyndale, R.F. (2006) Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy. Mol. Psychiatry, 11, 400-409.
-
(2006)
Mol. Psychiatry
, vol.11
, pp. 400-409
-
-
Malaiyandi, V.1
Lerman, C.2
Benowitz, N.L.3
Jepson, C.4
Patterson, F.5
Tyndale, R.F.6
-
16
-
-
77249134594
-
Rare variants create synthetic genome-wide associations
-
Dickson, S.P., Wang, K., Krantz, I., Hakonarson, H. and Goldstein, D.B. (2010) Rare variants create synthetic genome-wide associations. PLoS Biol., 8, e1000294.
-
(2010)
PLoS Biol
, vol.8
-
-
Dickson, S.P.1
Wang, K.2
Krantz, I.3
Hakonarson, H.4
Goldstein, D.B.5
-
17
-
-
79851487366
-
The importance of synthetic associations will only be resolved empirically
-
Goldstein, D.B. (2011) The importance of synthetic associations will only be resolved empirically. PLoS Biol., 9, e1001008.
-
(2011)
PLoS Biol
, vol.9
-
-
Goldstein, D.B.1
-
18
-
-
49449098182
-
What is the expectation maximization algorithm?
-
Do, C.B. and Batzoglou, S. (2008) What is the expectation maximization algorithm? Nat. Biotechnol., 26, 897-899.
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 897-899
-
-
Do, C.B.1
Batzoglou, S.2
-
19
-
-
0025022689
-
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
-
Yamano, S., Tatsuno, J. and Gonzalez, F.J. (1990) The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry, 29, 1322-1329.
-
(1990)
Biochemistry
, vol.29
, pp. 1322-1329
-
-
Yamano, S.1
Tatsuno, J.2
Gonzalez, F.J.3
-
20
-
-
72549097005
-
Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions
-
Gertz, J., Gerke, J.P. and Cohen, B.A. (2010) Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions. Theor. Popul. Biol., 77, 1-5.
-
(2010)
Theor. Popul. Biol.
, vol.77
, pp. 1-5
-
-
Gertz, J.1
Gerke, J.P.2
Cohen, B.A.3
-
21
-
-
77951916017
-
Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors
-
Al Koudsi, N., Hoffmann, E.B., Assadzadeh, A. and Tyndale, R.F. (2010) Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors. Eur. J. Clin. Pharmacol., 66, 239-251.
-
(2010)
Eur. J. Clin. Pharmacol.
, vol.66
, pp. 239-251
-
-
Al Koudsi, N.1
Hoffmann, E.B.2
Assadzadeh, A.3
Tyndale, R.F.4
-
22
-
-
22944464615
-
A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity
-
Fukami, T., Nakajima, M., Higashi, E., Yamanaka, H., McLeod, H.L. and Yokoi, T. (2005) A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity. Biochem. Pharmacol., 70, 801-808.
-
(2005)
Biochem. Pharmacol.
, vol.70
, pp. 801-808
-
-
Fukami, T.1
Nakajima, M.2
Higashi, E.3
Yamanaka, H.4
McLeod, H.L.5
Yokoi, T.6
-
23
-
-
38549137889
-
A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent
-
Ho, M.K., Mwenifumbo, J.C., Zhao, B., Gillam, E.M. and Tyndale, R.F. (2008) A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent. Pharmacogenet. Genomics, 18, 67-75.
-
(2008)
Pharmacogenet. Genomics
, vol.18
, pp. 67-75
-
-
Ho, M.K.1
Mwenifumbo, J.C.2
Zhao, B.3
Gillam, E.M.4
Tyndale, R.F.5
-
24
-
-
42949141477
-
Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent
-
Mwenifumbo, J.C., Al Koudsi, N., Ho, M.K., Zhou, Q., Hoffmann, E.B., Sellers, E.M. and Tyndale, R.F. (2008) Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. Hum. Mutat., 29, 679-688.
-
(2008)
Hum. Mutat.
, vol.29
, pp. 679-688
-
-
Mwenifumbo, J.C.1
Al Koudsi, N.2
Ho, M.K.3
Zhou, Q.4
Hoffmann, E.B.5
Sellers, E.M.6
Tyndale, R.F.7
-
25
-
-
3042689406
-
Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6)
-
von Richter, O., Pitarque, M., Rodriguez-Antona, C., Testa, A., Mantovani, R., Oscarson, M. and Ingelman-Sundberg, M. (2004) Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6). Pharmacogenetics, 14, 369-379.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 369-379
-
-
von Richter, O.1
Pitarque, M.2
Rodriguez-Antona, C.3
Testa, A.4
Mantovani, R.5
Oscarson, M.6
Ingelman-Sundberg, M.7
-
26
-
-
23444446891
-
Three haplotypes associated with CYP2A6 phenotypes in Caucasians
-
Haberl, M., Anwald, B., Klein, K., Weil, R., Fuss, C., Gepdiremen, A., Zanger, U.M., Meyer, U.A. and Wojnowski, L. (2005) Three haplotypes associated with CYP2A6 phenotypes in Caucasians. Pharmacogenet. Genomics, 15, 609-624.
-
(2005)
Pharmacogenet. Genomics
, vol.15
, pp. 609-624
-
-
Haberl, M.1
Anwald, B.2
Klein, K.3
Weil, R.4
Fuss, C.5
Gepdiremen, A.6
Zanger, U.M.7
Meyer, U.A.8
Wojnowski, L.9
-
27
-
-
34047151263
-
A novel duplication type of CYP2A6 gene in African-American population
-
Fukami, T., Nakajima, M., Yamanaka, H., Fukushima, Y., McLeod, H.L. and Yokoi, T. (2007) A novel duplication type of CYP2A6 gene in African-American population. Drug Metab. Dispos., 35, 515-520.
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 515-520
-
-
Fukami, T.1
Nakajima, M.2
Yamanaka, H.3
Fukushima, Y.4
McLeod, H.L.5
Yokoi, T.6
-
28
-
-
0035064372
-
Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk
-
Tyndale, R.F. and Sellers, E.M. (2001) Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk. Drug Metab. Dispos., 29, 548-552.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 548-552
-
-
Tyndale, R.F.1
Sellers, E.M.2
-
29
-
-
33846536406
-
Novel genes identified in a high-density genome wide association study for nicotine dependence
-
Bierut, L.J., Madden, P.A., Breslau, N., Johnson, E.O., Hatsukami, D., Pomerleau, O.F., Swan, G.E., Rutter, J., Bertelsen, S., Fox, L. et al. (2007) Novel genes identified in a high-density genome wide association study for nicotine dependence. Hum. Mol. Genet., 16, 24-35.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 24-35
-
-
Bierut, L.J.1
Madden, P.A.2
Breslau, N.3
Johnson, E.O.4
Hatsukami, D.5
Pomerleau, O.F.6
Swan, G.E.7
Rutter, J.8
Bertelsen, S.9
Fox, L.10
-
30
-
-
70149090145
-
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
-
Saccone, N.L., Wang, J.C., Breslau, N., Johnson, E.O., Hatsukami, D., Saccone, S.F., Grucza, R.A., Sun, L., Duan, W., Budde, J. et al. (2009) The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res., 69, 6848-6856.
-
(2009)
Cancer Res
, vol.69
, pp. 6848-6856
-
-
Saccone, N.L.1
Wang, J.C.2
Breslau, N.3
Johnson, E.O.4
Hatsukami, D.5
Saccone, S.F.6
Grucza, R.A.7
Sun, L.8
Duan, W.9
Budde, J.10
-
31
-
-
33846510020
-
Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
-
Saccone, S.F., Hinrichs, A.L., Saccone, N.L., Chase, G.A., Konvicka, K., Madden, P.A., Breslau, N., Johnson, E.O., Hatsukami, D., Pomerleau, O. et al. (2007) Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum. Mol. Genet., 16, 36-49.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 36-49
-
-
Saccone, S.F.1
Hinrichs, A.L.2
Saccone, N.L.3
Chase, G.A.4
Konvicka, K.5
Madden, P.A.6
Breslau, N.7
Johnson, E.O.8
Hatsukami, D.9
Pomerleau, O.10
-
32
-
-
34247553633
-
Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples
-
Saccone, S.F., Pergadia, M.L., Loukola, A., Broms, U., Montgomery, G.W., Wang, J.C.,Agrawal,A., Dick,D.M., Heath, A.C., Todorov,A.A. et al. (2007) Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. Am. J. Hum. Genet., 80, 856-866.
-
(2007)
Am. J. Hum. Genet.
, vol.80
, pp. 856-866
-
-
Saccone, S.F.1
Pergadia, M.L.2
Loukola, A.3
Broms, U.4
Montgomery, G.W.5
Wang, J.C.6
Agrawal, A.7
Dick, D.M.8
Heath, A.C.9
Todorov, A.A.10
-
33
-
-
66649097962
-
Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
-
Saccone,N.L., Saccone, S.F., Hinrichs,A.L., Stitzel, J.A.,Duan, W., Pergadia, M.L., Agrawal, A., Breslau, N., Grucza, R.A., Hatsukami, D. et al. (2009) Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am. J. Med. Genet. B Neuropsychiatr. Genet., 150B, 453-466.
-
(2009)
Am. J. Med. Genet. B Neuropsychiatr. Genet.
, vol.150 B
, pp. 453-466
-
-
Saccone, N.L.1
Saccone, S.F.2
Hinrichs, A.L.3
Stitzel, J.A.4
Duan, W.5
Pergadia, M.L.6
Agrawal, A.7
Breslau, N.8
Grucza, R.A.9
Hatsukami, D.10
-
34
-
-
13444269543
-
Haploview: analysis and visualization of LD and haplotype maps
-
Barrett, J.C., Fry, B., Maller, J. and Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics, 21, 263-265.
-
(2005)
Bioinformatics
, vol.21
, pp. 263-265
-
-
Barrett, J.C.1
Fry, B.2
Maller, J.3
Daly, M.J.4
|