메뉴 건너뛰기




Volumn 21, Issue 7, 2011, Pages 403-416

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans

Author keywords

cotinine; cytochrome P450 2A6; nicotine metabolism

Indexed keywords

COTININE; CYTOCHROME P450 2A6; DEUTERIUM OXIDE; NICOTINE;

EID: 79959805789     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328346e8c0     Document Type: Article
Times cited : (76)

References (55)
  • 2
    • 70149090145 scopus 로고    scopus 로고
    • The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    • Saccone NL,Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res 2009; 69:6848-6856.
    • (2009) Cancer Res , vol.69 , pp. 6848-6856
    • Saccone, N.L.1    Wang, J.C.2    Breslau, N.3    Johnson, E.O.4    Hatsukami, D.5    Saccone, S.F.6
  • 4
    • 33751401307 scopus 로고    scopus 로고
    • New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure
    • DOI 10.1016/j.drugalcdep.2006.06.017, PII S0376871606002791
    • Strasser AA, Lerman C, Sanborn PM, Pickworth WB, Feldman EA. New lower nicotine cigarettes can produce compensatory smoking and increased carbon monoxide exposure. Drug Alcohol Depend 2007; 86:294-300. (Pubitemid 44821611)
    • (2007) Drug and Alcohol Dependence , vol.86 , Issue.2-3 , pp. 294-300
    • Strasser, A.A.1    Lerman, C.2    Sanborn, P.M.3    Pickworth, W.B.4    Feldman, E.A.5
  • 6
    • 4644255903 scopus 로고    scopus 로고
    • Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
    • DOI 10.1097/00008571-200409000-00006
    • Schoedel KA, Hoffmann EB, Rao Y, Sellers EM, Tyndale RF. Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. Pharmacogenetics 2004; 14:615-626. (Pubitemid 39281816)
    • (2004) Pharmacogenetics , vol.14 , Issue.9 , pp. 615-626
    • Schoedel, K.A.1    Hoffmann, E.B.2    Rao, Y.3    Sellers, E.M.4    Tyndale, R.F.5
  • 7
    • 14144253640 scopus 로고    scopus 로고
    • Metabolism and disposition kinetics of nicotine
    • DOI 10.1124/pr.57.1.3
    • Hukkanen J, Jacob P III, Benowitz NL. Metabolism and disposition kinetics of nicotine. Pharmacol Rev 2005; 57:79-115. (Pubitemid 40283970)
    • (2005) Pharmacological Reviews , vol.57 , Issue.1 , pp. 79-115
    • Hukkanen, J.1    Jacob III, P.2    Benowitz, N.L.3
  • 9
    • 5544281923 scopus 로고    scopus 로고
    • Characterization of CYP2A6 involved in 30-hydroxylation of cotinine in human liver microsomes
    • Nakajima M, Yamamoto T, Nunoya K, Yokoi T, Nagashima K, Inoue K, et al. Characterization of CYP2A6 involved in 30-hydroxylation of cotinine in human liver microsomes. J Pharmacol Exp Ther 1996; 277:1010-1015.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1010-1015
    • Nakajima, M.1    Yamamoto, T.2    Nunoya, K.3    Yokoi, T.4    Nagashima, K.5    Inoue, K.6
  • 10
    • 29644442957 scopus 로고    scopus 로고
    • Identification of N-(hydroxymethyl) norcotinine as a major product of cytochrome P450 2A6, but not cytochrome P450 2A13-catalyzed cotinine metabolism
    • DOI 10.1021/tx0501381
    • Brown KM, VonWeymarn LB, Murphy SE. Identification of N-(hydroxymethyl) norcotinine as a major product of cytochrome P450 2A6, but not cytochrome P450 2A13-catalyzed cotinine metabolism. Chem Res Toxicol 2005; 18:1792-1798. (Pubitemid 43023037)
    • (2005) Chemical Research in Toxicology , vol.18 , Issue.12 , pp. 1792-1798
    • Brown, K.M.1    Von Weymarn, L.B.2    Murphy, S.E.3
  • 13
    • 33750531834 scopus 로고    scopus 로고
    • CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during Ad libitum smoking
    • DOI 10.1158/1055-9965.EPI-05-0723
    • Malaiyandi V, Goodz SD, Sellers EM, Tyndale RF. CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking. Cancer Epidemiol Biomarkers Prev 2006; 15:1812-1819. (Pubitemid 44664253)
    • (2006) Cancer Epidemiology Biomarkers and Prevention , vol.15 , Issue.10 , pp. 1812-1819
    • Malaiyandi, V.1    Goodz, S.D.2    Sellers, E.M.3    Tyndale, R.F.4
  • 16
    • 33645525613 scopus 로고    scopus 로고
    • Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy
    • Malaiyandi V, Lerman C, Benowitz NL, Jepson C, Patterson F, Tyndale RF. Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy. Mol Psychiatry 2006; 11:400-409.
    • (2006) Mol Psychiatry , vol.11 , pp. 400-409
    • Malaiyandi, V.1    Lerman, C.2    Benowitz, N.L.3    Jepson, C.4    Patterson, F.5    Tyndale, R.F.6
  • 17
    • 34147195806 scopus 로고    scopus 로고
    • Overview of the pharmacogenomics of cigarette smoking
    • DOI 10.1038/sj.tpj.6500436, PII 6500436
    • Ho MK, Tyndale RF. Overview of the pharmacogenomics of cigarette smoking. Pharmacogenomics J 2007; 7:81-98. (Pubitemid 46577845)
    • (2007) Pharmacogenomics Journal , vol.7 , Issue.2 , pp. 81-98
    • Ho, M.K.1    Tyndale, R.F.2
  • 19
    • 0036389893 scopus 로고    scopus 로고
    • Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity
    • Oscarson M, McLellan RA, Asp V, Ledesma M, Bernal Ruiz ML, Sinues B, et al. Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity. Hum Mutat 2002; 20:275-283.
    • (2002) Hum Mutat , vol.20 , pp. 275-283
    • Oscarson, M.1    McLellan, R.A.2    Asp, V.3    Ledesma, M.4    Bernal Ruiz, M.L.5    Sinues, B.6
  • 21
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • DOI 10.1038/ng1847, PII NG1847
    • Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006; 38:904-909. (Pubitemid 44141658)
    • (2006) Nature Genetics , vol.38 , Issue.8 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 24
    • 0037757965 scopus 로고    scopus 로고
    • Effects of polymorphism in promoter region of human CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro
    • DOI 10.1016/S0009-9236(03)00090-0
    • Yoshida R, Nakajima M, Nishimura K, Tokudome S, Kwon JT, Yokoi T. Effects of polymorphism in promoter region of human CYP2A6 gene (CYP2A6*9) on expression level of messenger ribonucleic acid and enzymatic activity in vivo and in vitro. Clin Pharmacol Ther 2003; 74:69-76. (Pubitemid 36776178)
    • (2003) Clinical Pharmacology and Therapeutics , vol.74 , Issue.1 , pp. 69-76
    • Yoshida, R.1    Nakajima, M.2    Nishimura, K.3    Tokudome, S.4    Kwon, J.-T.5    Yokoi, T.6
  • 27
    • 0025022689 scopus 로고
    • The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
    • Yamano S, Tatsuno J, Gonzalez FJ. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry 1990; 29:1322-1329. (Pubitemid 20053858)
    • (1990) Biochemistry , vol.29 , Issue.5 , pp. 1322-1329
    • Yamano, S.1    Gonzalez, F.J.2
  • 28
    • 37549037484 scopus 로고    scopus 로고
    • Identification of novel CYP2A6*1B variants: The CYP2A6*1B allele is associated with faster in vivo nicotine metabolism
    • Mwenifumbo JC, Lessov-Schlaggar CN, Zhou Q, Krasnow RE, Swan GE, Benowitz NL, et al. Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism. Clin Pharmacol Ther 2008; 83:115-121.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 115-121
    • Mwenifumbo, J.C.1    Lessov-Schlaggar, C.N.2    Zhou, Q.3    Krasnow, R.E.4    Swan, G.E.5    Benowitz, N.L.6
  • 29
    • 68149165614 scopus 로고    scopus 로고
    • Predicting the effects of coding nonsynonymous variants on protein function using the SIFT algorithm
    • Kumar P, Henikoff S, Ng PC. Predicting the effects of coding nonsynonymous variants on protein function using the SIFT algorithm. Nat Protoc 2009; 4:1073-1081.
    • (2009) Nat Protoc , vol.4 , pp. 1073-1081
    • Kumar, P.1    Henikoff, S.2    Ng, P.C.3
  • 31
  • 32
    • 42949141477 scopus 로고    scopus 로고
    • Novel arid established CYP2A6 alleles impair in vivo nicotine metabolism in a population of black African descent
    • DOI 10.1002/humu.20698
    • Mwenifumbo JC, Al Koudsi N, Ho MK, Zhou Q, Hoffmann EB, Sellers EM, et al. Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. Hum Mutat 2008; 29:679-688. (Pubitemid 351614592)
    • (2008) Human Mutation , vol.29 , Issue.5 , pp. 679-688
    • Mwenifumbo, J.C.1    Al Koudsi, N.2    Man, K.H.3    Zhou, Q.4    Hoffmann, E.B.5    Sellers, E.M.6    Tyndale, R.F.7
  • 35
    • 0019515321 scopus 로고
    • Debrisoquine hydroxylation capacity: Problems of assessment in two populations
    • Inaba T, Otton SV, Kalow W. Debrisoquine hydroxylation capacity: problems of assessment in two populations. Clin Pharmacol Ther 1981; 29:218-223. (Pubitemid 11139899)
    • (1981) Clinical Pharmacology and Therapeutics , vol.29 , Issue.2 , pp. 218-223
    • Inaba, T.1    Otton, S.V.2    Kalow, W.3
  • 36
    • 0032426427 scopus 로고    scopus 로고
    • Determination of drug-metabolizing enzyme activity in vivo: Pharmacokinetic and statistical issues
    • DOI 10.1080/004982598238895
    • Tucker GT, Rostami-Hodjegan A, Jackson PR. Determination of drugmetabolizing enzyme activity in vivo: pharmacokinetic and statistical issues. Xenobiotica 1998; 28:1255-1273. (Pubitemid 29017142)
    • (1998) Xenobiotica , vol.28 , Issue.12 , pp. 1255-1273
    • Tucker, G.T.1    Rostami-Hodjegan, A.2    Jackson, P.R.3
  • 37
    • 29644437407 scopus 로고    scopus 로고
    • 3′-UTR polymorphism in the human CYP2A6 gene affects mRNA stability and enzyme expression
    • DOI 10.1016/j.bbrc.2005.12.035, PII S0006291X05027968
    • Wang J, Pitarque M, Ingelman-Sundberg M. 30-UTR polymorphism in the human CYP2A6 gene affects mRNA stability and enzyme expression. Biochem Biophys Res Commun 2006; 340:491-497. (Pubitemid 43021775)
    • (2006) Biochemical and Biophysical Research Communications , vol.340 , Issue.2 , pp. 491-497
    • Wang, J.1    Pitarque, M.2    Ingelman-Sundberg, M.3
  • 41
    • 0032931833 scopus 로고    scopus 로고
    • Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
    • DOI 10.1007/s002040050588
    • Yamazaki H, Inoue K, Hashimoto M, Shimada T. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol 1999; 73:65-70. (Pubitemid 29226163)
    • (1999) Archives of Toxicology , vol.73 , Issue.2 , pp. 65-70
    • Yamazaki, H.1    Inoue, K.2    Hashimoto, M.3    Shimada, T.4
  • 42
    • 28144440301 scopus 로고    scopus 로고
    • Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6
    • DOI 10.1124/dmd.105.006718
    • Dicke KE, Skrlin SM, Murphy SE. Nicotine and 4-(methylnitrosamino)-1-(3- pyridyl)-butanone metabolism by cytochrome P450 2B6. Drug Metab Dispos 2005; 33:1760-1764. (Pubitemid 41697258)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.12 , pp. 1760-1764
    • Dicke, K.E.1    Skrlin, S.M.2    Murphy, S.E.3
  • 44
    • 0028798734 scopus 로고
    • Expression and alternative splicing of the cytochrome P-450 CYP2A7
    • Ding S, Lake BG, Friedberg T, Wolf CR. Expression and alternative splicing of the cytochrome P-450 CYP2A7. Biochem J 1995; .306. (Pt 1):161-166.
    • (1995) Biochem J , vol.306 , Issue.PART 1 , pp. 161-166
    • Ding, S.1    Lake, B.G.2    Friedberg, T.3    Wolf, C.R.4
  • 45
    • 13944284575 scopus 로고    scopus 로고
    • Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence
    • DOI 10.1016/j.clpt.2004.10.011
    • Malaiyandi V, Sellers EM, Tyndale RF. Implications of CYP2A6 genetic variation for smoking behaviors and nicotine dependence. Clin Pharmacol Ther 2005; 77:145-158. (Pubitemid 40269130)
    • (2005) Clinical Pharmacology and Therapeutics , vol.77 , Issue.3 , pp. 145-158
    • Malaiyandi, V.1    Sellers, E.M.2    Tyndale, R.F.3
  • 46
    • 77951916017 scopus 로고    scopus 로고
    • Hepatic CYP2A6 levels and nicotine metabolism: Impact of genetic, physiological, environmental, and epigenetic factors
    • Al Koudsi N, Hoffmann EB, Assadzadeh A, Tyndale RF. Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors. Eur J Clin Pharmacol 2010; 66:239-251.
    • (2010) Eur J Clin Pharmacol , vol.66 , pp. 239-251
    • Al Koudsi, N.1    Hoffmann, E.B.2    Assadzadeh, A.3    Tyndale, R.F.4
  • 49
    • 34047230804 scopus 로고    scopus 로고
    • Urine nicotine metabolites and smoking behavior in a multiracial/ multiethnic national sample of young adults
    • DOI 10.1093/aje/kwm010
    • Kandel DB, Hu MC, Schaffran C, Udry JR, Benowitz NL. Urine nicotine metabolites and smoking behavior in a multiracial/multiethnic national sample of young adults. Am J Epidemiol 2007; 165:901-910. (Pubitemid 46536667)
    • (2007) American Journal of Epidemiology , vol.165 , Issue.8 , pp. 901-910
    • Kandel, D.B.1    Hu, M.-C.2    Schaffran, C.3    Udry, J.R.4    Benowitz, N.L.5
  • 50
    • 0024360316 scopus 로고
    • Elimination of cotinine from body fluids: Disposition in smokers and nonsmokers
    • Haley NJ, Sepkovic DW, Hoffmann D. Elimination of cotinine from body fluids: disposition in smokers and nonsmokers. Am J Public Health 1989; 79:1046-1048. (Pubitemid 19207445)
    • (1989) American Journal of Public Health , vol.79 , Issue.8 , pp. 1046-1048
    • Haley, N.J.1    Sepkovic, D.W.2    Hoffmann, D.3
  • 51
    • 0025610293 scopus 로고
    • Disposition of nicotine and eight metabolites in smokers and nonsmokers: Identification in smokers of two metabolites that are longer lived than cotinine
    • Kyerematen GA, Morgan ML, Chattopadhyay B, DeBethizy JD, Vesell ES. Disposition of nicotine and eight metabolites in smokers and nonsmokers: identification in smokers of two metabolites that are longer lived than cotinine. Clin Pharmacol Ther 1990; 48:641-651.
    • (1990) Clin Pharmacol Ther , vol.48 , pp. 641-651
    • Kyerematen, G.A.1    Morgan, M.L.2    Chattopadhyay, B.3    Debethizy, J.D.4    Vesell, E.S.5
  • 52
    • 0034124565 scopus 로고    scopus 로고
    • Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism
    • Benowitz NL, Jacob P III. Effects of cigarette smoking and carbon monoxide on nicotine and cotinine metabolism. Clin Pharmacol Ther 2000; 67:653-659. (Pubitemid 30416081)
    • (2000) Clinical Pharmacology and Therapeutics , vol.67 , Issue.6 , pp. 653-659
    • Benowitz, N.L.1    Jacob III, P.2
  • 53


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.